2F6U


Conserved Protein Domain Family
GGGPS_Afulg

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TIGR04146: GGGPS_Afulg 
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phosphoglycerol geranylgeranyltransferase
This enzyme, known also as GGGP synthase and GGGPS, catalyzes the stereospecific first step in the biosynthesis of the characteristic membrane diether lipids of archaea. Interestingly, the closest homologs outside this family are not the functionally equivalent enzymes of other archaea, but rather functionally distinct bacterial enzymes.
Statistics
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PSSM-Id: 275010
Aligned: 12 rows
Threshold Bit Score: 344.76
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2F6U_A         6 WRKWRHITKLDPDRTNTDEIIKAVADSGTDAVMISGTQNVTYEKARTLIEKVSQYGLPIVVEPSDPSNVVYD--VDYLFV 83  Archaeoglobus f...
A7I6L7         3 WKDWVHVTKLDPDKQLGPGDIDAIAASGTDALMLSGTLNVTKENLLALQKMIAQYDLPLVMEPAGPEAVLMEg-IEYVFV 81  Methanoregula b...
CBH38263       9 WKEWKHITKLDPDKQITEATLETIVESGTDAIMISGTQNITDKNVLQLTTLLKEYKIPKILEPATPDAVVYGd-IDYIFV 87  uncultured arch...
WP_013329863   5 WREWRHITKLDPDKSIRPGEVEAIATSGTDALMLSGTLNVTKENVTELREQVKEYGLPLVVEPADPSGVIFDd-IHGLFV 83  Methanoplanus p...
WP_011843613   5 WKTWAHVTKLDPDKRLPRGAVEEIATSGTDALMLSGTLNVTRENLQELLDLVSAYGLPLVVEPASPDCAIFDggIDHLFV 84  Methanoculleus ...
WP_011448039   5 WKTWAHVTKLDPDKHLTEDEIAEIATSGTDALILSGTLNITKDNMSQLRDQVKEYGLPLVVEPAGPESVIFHg-IDLLYV 83  Methanospirillu...
WP_012901522   4 WKKWRHVTKLDPDKPITPKAVAEIVDSGTDAIMVSGTQNITKENVARLAEMLKDYSIPKVLEPSGTDGLR-Dd-MDLLFV 81  Methanocella pa...
WP_012899010   4 WKKWRHVTKLDPDKPITPKAVAEIVDSGTDAIMVSGTQNITKENVARLVDMLAQYNIPKVLEPAGTPGMRSD--LDFAFI 81  Methanocella pa...
WP_012617953   5 WKDWVHVTKLDPDKSLPPAVIDEIATSGTDALMLSGTLNVTIENLGHLFKQVAQYGLPLVVEPAGPEAVLCEg-IDLLFV 83  Methanosphaerul...
WP_011833510   3 WQTWRHITKLDPDKVITKEEIAEIAASETDALMLSGTLDVTPENLAELYDNVRDAGLPLTVEPADPSCARFEg-IDYVFV 81  Methanocorpuscu...
WP_012036517   6 WKKWRHVTKLDPDKKITRQDIAAIVDSGTDAVMISGTQNITKENVGNMIDMLAEYSIPKVLEPSVSAIIRND--VDFIFV 83  Methanocella ar...
WP_012966498   1 MFDWKHITKLDPDRKNDEKIVKAVLESNTDAIMVSGTQNVTKEKVMELLKMLKEGDKPIIMEPSDPSNVVYDv-DYVF-V 78  Ferroglobus pla...
2F6U_A        84 PTVLNSADGDWITGKHAQWVRmHYENlQKFTEIIEsefiqiEGYIVLNPDSAVARVTKALCNIDKELAASYALVGEKLFN 163 Archaeoglobus f...
A7I6L7        82 PSVLNTTDVQWIVGKHRSWVQ-QQDGkIPWDMVVP------EAYIVLNPASSVGRVTKAVCDLKPAEVAAYTEVADRYFH 154 Methanoregula b...
CBH38263      88 PLVLNSMDLEWIIGKHVKWIK-THE--INWDRVIP------EGYIVLNPESAVAKLTKSVTNLTTEEVKAYAEYAEKYLH 158 uncultured arch...
WP_013329863  84 PSVLNTPEPVWIVGKHEYWVK-NTKN-IPWDLVVP------EAYIVLNPNSSVGRVTRAVCNLPAEDVAAFATVADRYFK 155 Methanoplanus p...
WP_011843613  85 PSVLNTNDVRWIVGKHYAWLR-QASG-IDWEMVVP------EAYIVLNPNSAVGRVTGADCSLSTGDVAAFAQVADRYFR 156 Methanoculleus ...
WP_011448039  84 ASVMNTSDARWIVGKHRDWAM-NPD--IVWEKVIP------EAYIVLNPNSAVGRVTGADCGISAEEVAAYASIADHYFK 154 Methanospirillu...
WP_012901522  82 PSVLNTDVAFWFMGAHKIWVQ-HFD--IDWDRVVP------EAYIVLNPRSAVAIVTKAKTEITPREAAAYAECADRFFH 152 Methanocella pa...
WP_012899010  82 PSVFNTKNPKWLVGAHKDFVR-DFQI-DYWDKIIP------EAYIVLNPFSAVALVTRAQTGLGPKDAAAYAEVADRFFN 153 Methanocella pa...
WP_012617953  84 PSVMNSNSVQWIVGKHQQWAQ-QSS--IRWDKVIP------EAYIVLNSSSSVGKVTGADCGLTPAEAAAYASVADHYFR 154 Methanosphaerul...
WP_011833510  82 PSVFNAGHPAFITGLHKEWAQ-HAD--ILWDKVVQ------EAYVVLNPNSSVGKLTRAKCDLTPAEVAAYGIVAEKYYS 152 Methanocorpuscu...
WP_012036517  84 PSIFNTKYSKFAVGYHKDFVK-NYPD-EVLDKVIP------EAYIVLNPLSAVAIVTRAQTGISPREAAAYAELADRFFR 155 Methanocella ar...
WP_012966498  79 PVVLNSKRGEWITGKHAEWIRmNYEKlDAFRELFDrki-yfEGYIVLNENSAVGRVTEAICDLKKEEAASFAVVGEEILK 157 Ferroglobus pla...
2F6U_A       164 LPIIYIEYSGTYGNPELVAEVKKVLDKARLFYGGGIDSREKAREMLRYADTIIVGNVIYEK-GIDAFLETL 233 Archaeoglobus fulgidus
A7I6L7       155 FPIVYIEYSGTYGAPAVVKAAAEAIDHAILYYGGGINSAEKAAEMGKYADTIVVGNAVYDQ-GASVLKATV 224 Methanoregula boonei 6A8
CBH38263     159 LPIIYIEYSGTYGNSKLVKDLSELITEASLFYGGGIDTKERATEMRSYADVIIVGNVVYTN--EEKFLATV 227 uncultured archaeon
WP_013329863 156 FPIVYIEYSGTFGNPEIVKAASEAVEDALLYYGGGINSKEKAAEMAKYADTIVVGNAVYDN-GATVLRETV 225 Methanoplanus petrolearius
WP_011843613 157 FPIVYIEYSGTYGDPAIVQAASEAVENATLYYGGGIRSAEQAAEMGRYADTIVVGNAVYEE-GIDVLRATV 226 Methanoculleus marisnigri
WP_011448039 155 FPIVYIEYSGMYGNPDIVKRAGEAIDHAVLYYGGGIDSAEKAAEMAKYADTIVVGNAVYEK-GVKTLLETV 224 Methanospirillum hungatei
WP_012901522 153 FPVVYVEYSGTFGEPSLVKSVKERLHDARLFYGGGINSREKAEEMAQHADTIVVGNAVYESgGIEKLKETI 223 Methanocella paludicola
WP_012899010 154 FPIVYVEYSGVFGNPELVKAVKEKLHNSVLYYGGGIDCREKAEQMAKYANTIVVGNAVYKKgGVEMLKETI 224 Methanocella paludicola
WP_012617953 155 FPIVYVEYSGMYGDPKMVRSIAEVVDRAILYYGGGISSADKAAEMGRWADTIVVGNAVYDL-GPDVLRATV 224 Methanosphaerula palustris
WP_011833510 153 MPVLYIEYSGMYGDPAVTRAVSEALSTTRVFYGGGINSGAKAAEMGQYADTIVVGNAVYEA-GPAVLKETV 222 Methanocorpusculum labre...
WP_012036517 156 FPVVYIEYSGTYGNPELVKAVREKLTNTVLYYGGGIDSREKAETMAKYANTIVVGNAVYKKgGIEKLKETI 226 Methanocella arvoryzae
WP_012966498 158 LPIIYVEYSGTYGDPELVREVKSKLKKAKLFYGGGINSKERALEMLSAADAIVVGNVIYER-GIESYLDTI 227 Ferroglobus placidus
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