Conserved Protein Domain Family
intra_fol_E_lig
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TIGR04132: intra_fol_E_lig 
putative folate metabolism gamma-glutamate ligase
This protein family is related to CofE, a gamma-glutamyl ligase of coenzyme F420 biosynthesis. However, it occurs in a different gamma-glutamyl ligase context, polyglutamylated tetrahydrofolate biosynthesis-like regions in two widely separated lineages that both occur as intracellular bacteria - Chlamydia and Wolbachia.
Links
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Statistics
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PSSM-Id: 275005
Aligned: 4 rows
Threshold Bit Score: 427.32
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_010081866   1 MHVEAIYTHRIECGEVLEQVLDRYVSELlREEVVLAITSKIISICQKQVVCKTACSKEELIKREADAIVDVDHnsYGIYL 80  Wolbachia endos...
WP_010883397   1 MKITTVKTPKIYPYDDLYSILESSLPKL-NERSIVVITSKIVSLCEGAVVELEKVSKDELIKQEADAYVFVEK--YGIYL 77  Chlamydia pneum...
WP_010232289   1 MKITPIKTRKVFAHDSLQEIFQESLPPI-QERSIVVVSSKIVSLCEGAVADAQI-SKADLIKKEADAYLFCEG--SGIYL 76  Chlamydia murid...
WP_011006949   1 MKVSPIVTRRIHVHDDLYEILEESLPAL-SENTIIALSSKVLSLCEGAVVDTKTTTKEALIKQESDAYVYSPL--HDLYL 77  Chlamydophila c...

WP_010081866  81 TIKDNILIPSAGIDESNGNEMYILYPKDVQKTALSIWNYLKTKHCIKHLGILITDSNITPMRLGVTGVALGWCGFEPFYS 160 Wolbachia endos...
WP_010883397  78 TKKWGILIPSAGIDESNVEGYFVLYPRDFLLSVNTLGDWLRNFYHLEHCGIIISDSHTTPLRRGTMGLGLCWNGFFPLYN 157 Chlamydia pneum...
WP_010232289  77 TKKEGILIPSAGIDESNTDQAFVLYPKDLLRSCNQIGEWLKNYFRVKELGVIITDSHTTPMRRGVVGIGLCWYGFSPLHN 156 Chlamydia murid...
WP_011006949  78 TKKQGILIPSAGIDESNAQDYYVLYPRNLLASTNALGAWLKSFYHLENLGVIIVDSHTTPMRRGVLGLGLCWYGFSPLYS 157 Chlamydophila c...

WP_010081866 161 YIGKPDLYDQPLQVTQVNLLDALATSAVLVMGEGAEQTPMAIISGAPKIHFLTRPPTTEEEKSVKISMEEDLYSPLLMRA 240 Wolbachia endos...
WP_010883397 158 YVGKPDCFGRALKMTYSNLLDGLSAAAVLCMGEGDEQTPIAIIEEAPKITFHSSPTTLQDMSTLAIAEDEDLYGPLLQSM 237 Chlamydia pneum...
WP_010232289 157 YVGSLDCFDRPLKMTQSNLLDSLAAAAVVCMGEGNEQTPLAVIEQAPKVVYHQHPTSQEEYFSLRIDETEDLYGPLLHAV 236 Chlamydia murid...
WP_011006949 158 YVGKPDCFGRPLRMTQINLLDALAVSAVLCMGEGDEHTPLALVEDAPKITFHSSPTLQSDLSLLGIDETEDLYGPILSSV 237 Chlamydophila c...

WP_010081866 241 RWLK 244 Wolbachia endosymbiont of Drosophila melanogaster
WP_010883397 238 AWET 241 Chlamydia pneumoniae
WP_010232289 237 LWNQ 240 Chlamydia muridarum
WP_011006949 238 AWES 241 Chlamydophila caviae
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