Conserved Protein Domain Family
biosyn_clust_1
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TIGR04098: biosyn_clust_1 
biosynthesis cluster domain
Radical SAM family TIGR04043 is a marker for a widespread eight-gene probable biosynthetic cluster of unknown function. This protein family describes a domain that occurs as an additional protein for some of those clusters, but also as the N-terminal domain of large, multidomain polyketide synthases and in other contexts.
Links
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Statistics
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PSSM-Id: 274980
Aligned: 21 rows
Threshold Bit Score: 228.004
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAN85524      15 QAVTVRPGMCGPGS---LFVGQLGDWTWETVSAQCDTDVFAARDASGNPTYLAFYYFRVRGGRelhPGSLTFGDRLTVTS 91  Streptomyces at...
ZP_05781109   17 RQMLGMQQLGPHGLseqWLLGFCGDLHWGLIAGALGQESLRFRTADGRPLYAAFCATRLDLAP---TDPL-LGEALEIRS 92  Citreicella sp....
WP_011910373   6 HFTAGLPQLDIHTLsedWALATSLENHWILLARSMGLKPSEWLDSQGDRMYGAVIHLTTSFDL---AYPLREDEAFAADT 82  Rhodobacter sph...
WP_011801484  14 RYVAGMPNLCYNGLsenWLLKECGHRHWLAIAQAQGSQQPEFRDAQGRKVYAAFTLVRLSDAR---LEQIGEHDAFSITS 90  Polaromonas nap...
WP_011650430  26 HILLGMPHLNGNGLsetWLMKELGHRHWLMLACHLGLDNADFRTADGEEAYAAICATSLTDAR---FDVVQANDILTIHS 102 Rhizobium legum...
WP_012649746  27 HILLGMPQLTPFGLsetWLMKELGHRHWLLLARRMGMDDADFRTADGTETYAAICATSLTNAQ---LDRARPNQVLSIQS 103 Agrobacterium t...
WP_013168491  22 IVLLGMPQLSLSGLsesWLLKDLGHRHWMLLARLAGRAVPDFRDADGAPVYAAFCALSVKDAD---FAALGENDRLTIVS 98  Starkeya novella
WP_012591011  21 VVRLGMPHLSLGGLsetWLLKELGDRHWMLLAKLAGREIPDFRDESGARVYAAFAAVSIREAS---LASFVEHDELVIES 97  Methylocella si...
WP_012168596  26 EVMVGMPHLGFGGLsetWLLKECGHRHWLALAQAAGQRVPDFRDATGAPVYAAFCGVSLANAR---LDRVAENDTLIFAS 102 Azorhizobium ca...
WP_012754251  19 RHVLGMPHLCPSGLsenWLWKELGHRHWGLIATAFGRAEAGFGPAGEPPVYAAFRRISLQGGD---LGSVRENDALEVRS 95  Methylobacteriu...

AAN85524      92 GCYDQGTESVLTLHRIDRAGSDDAQrpldlhefyerprdgslyVENFNRWVTRSAPGSNEDLVKSSPPGFRNDGLPQLPA 171 Streptomyces at...
ZP_05781109   93 DLAVAGGARLGSRHLFLHRGREIGA------------------LRMLSTFVAHDETGSNRRIVRALPAR-NCALPMAEPG 153 Citreicella sp....
WP_011910373  83 RFLAIRKPHALSSTRFLVDGKEKAE------------------VRILSSFIKRKVRGSNKKFAKVR----DIWTAEDLDG 140 Rhodobacter sph...
WP_011801484  91 QCLPVGRAQHYSRHDLRVHGQRGAR------------------VEMLSAFVRREKPGNNRSVVRAAMTESKVNHDAMDQE 152 Polaromonas nap...
WP_011650430 103 RLSAVSRTRTSTRHELSVHGRSVGV------------------VELISTFVHRTIKDNNHSIARVTLRAPQGQRFq---- 160 Rhizobium legum...
WP_012649746 104 VLEPVSKTQVASRHRLLVDGEPIGD------------------VELLSAFVRRTRENDNVSIARVELPGTHRFPVRLENT 165 Agrobacterium t...
WP_013168491  99 DISRVSRTQSASRHRLSVAGKPVGE------------------VELVSAFVRRASGGGNHTVARVALDAFPPPTAPRTDG 160 Starkeya novella
WP_012591011  98 EITRISGAQFASLHRLSRRGRPAGV------------------IELVSVFVKRRVAGRNRSIMRTAL---DCFPPPEAAG 156 Methylocella si...
WP_012168596 103 TLARISATQFVSRHSVRAPDGVVAE------------------LELVSVFVKRQVEGRNRSVARVRPEGLP----PLDPG 160 Azorhizobium ca...
WP_012754251  96 TVTYLSETRVVSRHVAACRDRLVAD------------------VEMASVFVRRQAEGVNRSIARVRIEG-RGHAKPVLAA 156 Methylobacteriu...

AAN85524     172 a---YSPRAVYREARTAHTFRALDEPGfr--lLPDTVEVEHPVDIVRDVNGVGLLYFASYFSMVDKA--ALALWRRL-GR 243 Streptomyces at...
ZP_05781109  154 lmalDARARDTSRALRGRT-------------VPLAGAQRIEPCHGLDFNAVGLLYFPSFTRLVETA-----------AR 209 Citreicella sp....
WP_011910373 141 -------ARIDAELERHHAMKSLP--------VEGVLAMDYEVNRIQDFNTADFLYFKNFVRIAKAS--EWRENRGK-AP 202 Rhodobacter sph...
WP_011801484 153 lataADAFVRHGRERRAGAWSEPPGVHsg-egGAGMHESVFMPCPNNDFNGADLLYFASFQAVVDRA--EWSWMVNA-QP 228 Polaromonas nap...
WP_011650430 161 ----PSRLAQNAADIRNGRLGTHFGFPvl--aNKALRTFRFDPSASQEFNGAGLFYFAEYQALADRAleDWFPRKGP--- 231 Rhizobium legum...
WP_012649746 166 -------LARIASDVRNGRCETHLGMAvg--dRDVLRDFRFQPATTQEFNGAGLLYFVHFQAFVARAleSW--------F 228 Agrobacterium t...
WP_013168491 161 -------LASLAAELRAGRRERHFGFDlhaaeAETSAAFEIDPCPAQDFNGAGFLYFSSFVAFVDRA--EW---HFD-GR 227 Starkeya novella
WP_012591011 157 p---SFTAAATAARIRAGAFEQHFGFSrs--dSREIGRLLINPCPSQDFNGADFLYFTSFQSFVDRT--EWELLAPErGL 229 Methylocella si...
WP_012168596 161 e---VSRTSALAAALRGGEWDTHMGFArt--qAHECARVMLTPCPSQDFNGAHFLYFAAFQAFADRA--EWELL----AP 229 Azorhizobium ca...
WP_012754251 157 --------MPIQPSITEHEFLGAVAAPe----ERELGTLVVEPCPHLDFNGAGLLYFSSFVAAVDRA--EW---RFL-GS 218 Methylobacteriu...

AAN85524     244 SDraflrrvVVDQQMCYLGNADLDSVLTLGARvRVSTETPGeELVDVVISDRDSGRVIAVSTL 306 Streptomyces atroolivaceus
ZP_05781109  210 TTa-----pIRMRELVYLGNLDAGTAVHVLRA------------GRETLVARDDGSLIARAVE 255 Citreicella sp. SE45
WP_011910373 203 RL-------NSRREVWYFGNVEDGERVLAHVA-RASDACAT------ELVDA-EGRRLCLSLA 250 Rhodobacter sphaeroides
WP_011801484 229 PGrp---aaIIEREMVFYGNMNLGDSVRTSLG-VHDSGGMH-LSHRSELRRGSDNARIAEVYT 286 Polaromonas naphthalenivorans
WP_011650430 232 ---------VVRKDVFFLGNIEQNERVFFDLL-DFSEEQKT---VHGQLRRE-NGKVIAKIFG 280 Rhizobium leguminosarum
WP_012649746 229 PDgaf--rnITRRDSFFLGNAGIGEPLSVELT-AMDRRTMS---VACNLRRS-DGDLIGRVFL 284 Agrobacterium tumefaciens
WP_013168491 228 RAer---atTLARDVFFHGNVDPGERLRVRWL-AARRGEGR-LVHRCLLERAGDGARLAEAFT 285 Starkeya novella
WP_012591011 230 S--------TQARDIVYRGNIEPGDKIVVMLS-AIRQGEGT-LAHWSQITRDSDGAHLADIFT 282 Methylocella silvestris
WP_012168596 230 PAgt----lTLARDLVYHGNIEPGERLAACLL-GVRETPGE-LAHWLRLARE-DGTPLADIFT 285 Azorhizobium caulinodans
WP_012754251 219 RSgn---yaTRVRRALFHANVEMGDGLLVRML-ASGDEASC---CHRALLSTEDGKLLAEIVT 274 Methylobacterium extorquens
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