Conserved Protein Domain Family
activase_YjjW

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TIGR04041: activase_YjjW 
glycine radical enzyme activase, YjjW family
Members of this family are radical SAM enzymes, designated YjjW in E. coli, that are paired with and appear to activate a glycyl radical enzyme of unknown function, designated YjjI. This activase and its target are found in Clostridial species as well as E. coli and cousins. Members of this family may be misannotated as pyruvate formate lyase activating enzyme. [Protein fate, Protein modification and repair]
Statistics
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PSSM-Id: 274938
Aligned: 19 rows
Threshold Bit Score: 414.724
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDQ02340      21 SATVTKILNFSCVDGPGNRLVIFLQGCNFDCKSCHNPHTIGQCDSCGLCIPSCPAQALS-LHEtdgsGLIHWDKDLCIEC 99  Shewanella bent...
EDS11747       4 TAPVNRIIPFSTVDGPGSRTSVFFQACNIACAYCHNPETQNMCRNCGACVPGCPEGALS-MAD----GRVVWDPDKCVEC 78  Anaerotruncus c...
EDN00726       4 AAPVNRIIPISTVDGPGCRTAVFLQGCNLSCAYCHNPETQNLCTGCGLCADHCPSGALErCPD----GGVVWNPERCTGC 79  Pseudoflavonifr...
EEJ21346      19 VAPVNKIIPFSLVDGPGSRTAVFLQGCNIRCAYCHNPETQVECISCQACVKPCPAHALS-MAN----GKVVWDNSICINC 93  Atopobium parvu...
EDX93957       2 VATVNKIIPFSTVDGPGNRTAIFLQGCNMNCLYCHNPETRCKCMHCGACVNSCPTGALS-FED----EKVRYNCAKCVHC 76  Clostridium the...
EDU38165       4 RGLVNKIIPFSSVDGPGNRTAIFFQGCNFDCKYCHNPETINTCKACGTCAFVCPYGAVE-FLG----DSVKWDENKCKNC 78  Clostridium spo...
EDP24658       4 KGIINKIIDMSVVDGPGNRTSIFLQGCNFNCFYCHNPETIRHCINCMECIPSCPTKSLK-NVN----GKIVWNDKTCINC 78  Parvimonas micr...
EEP37846       2 YAVVNNIIKFSNVDGPGNRMAVFFQGCNFRCIYCHNPETIHLCNNCGECVKVCPVGALT-RED----GIVKWDKKICVDC 76  Sebaldella term...
WP_001088427   5 CALVSKIIPFSCVDGPGSRLALFLQGCNLRCKNCHNPWTMGRCNDCGECVPQCPHQALQ-IVN----GKVVWNAVVCEQC 79  Escherichia
WP_011591720   1 MALINKIIPFSCVDGPGNRMVIFFQGCNFKCFYCHNPETINKCISCGKCVENCEVGALS-ISD----GKVIWDKEECISC 75  Clostridium per...
EDQ02340     100 DACLQACPKQASPKTRQYTVTQLLAVIRKNSPFITGVTVSGGEASLQLMFIVGLFSALKSspelQHLSCMLDTNGSLS-- 177 Shewanella bent...
EDS11747      79 DACIITCPHLASPRVKTMTPRQVMDEVCKNIPFIRGITTSGGECSLRADFLTELFTMAQK----EGLSCLMDSNGIVD-- 152 Anaerotruncus c...
EDN00726      80 DACIRLCPSLASPKVRTMTPEEVMGAVEHNLLFIRGITVSGGECTLYPEFLTGLFTLARA----RGLTCLADSNGTVP-- 153 Pseudoflavonifr...
EEJ21346      94 DNCIKVCQHKSTPKIELLSAREVADRCISNMPFIRGITTSGGECMLRPDFLYELFTYCNA----AGLSCLIDSNGTID-- 167 Atopobium parvu...
EDX93957      77 DSCIKACPHDSSPKTVDMTPEQVWRKVEKQIPFIRGITVSGGECTLYPEFLTELFILAQA----HGLSTLIDSNGTLD-- 150 Clostridium the...
EDU38165      79 GLCLEKCKNNCGPRNKYMSVGEIIKEILRTKPFISGITVSGGECTLQKDFLIDLFEKVKL----LGLTIFVDTNGSLD-- 152 Clostridium spo...
EDP24658      79 DECIRVCKHLSSPKIYNWTVEETVERIKKNMPFIRGITVSGGECTLQHTFLTSLFTEVRK----LGLTCFVDTNGGIP-- 152 Parvimonas micr...
EEP37846      77 DECIKTCRFFSSPKTEKYTVADLLKETEKVKIFIQGVTVSGGEATLNAHFITEFFKEVKK----MNLSVFVDTNGGIDls 152 Sebaldella term...
WP_001088427  80 DTCLKMCPQHATPMAQSMSVDEVLSHIRKAVLFIEGITVSGGEATTQLPFVVALFTAIKNdpqlCHLTCLVDSNGMLS-- 157 Escherichia
WP_011591720  76 DKCIKLCEHMSSPKLKEYSVEELVKKIEKDSFFIRGITVSGGECTLNSEFLIKLFREVKK----LGLTCFADTNGNTK-- 149 Clostridium per...
EDQ02340     178 ESGWHKLLPYLDGAMVDLKAWQTETHKWLTGRDNHRVFRSIELLASRGKLYEVRLLHIPGKSDFDSEITALAGYLQ---R 254 Shewanella bent...
EDS11747     153 LAAYPALMEVCDGVMLDVKAWDSEMHRALTGADNANVKKNLGFLSEHGKLEEIRIVCIDELVDTRAAIDGIARTIG---S 229 Anaerotruncus c...
EDN00726     154 LAPLSGLMAVCDGVMLDVKSWDPDVHKALTGSGNETVKENLAFLSRCGKLEELRIVCVPGAVDVEAVLEGAARVLG---D 230 Pseudoflavonifr...
EEJ21346     168 FTEYRDLLALSDGVMLDVKAWDDQWYEHLTGENGVIVRKNLAFLAEQNKLEEVRVIVTEGWNDAEAAVDGIALTLG---E 244 Atopobium parvu...
EDX93957     151 FEHYPDLLAVTDGVMLDIKAFDCEEHKRVTGWSNQVVLKNARFLASKGKLFEVRTVVSPGLFDAEQTITQTSDMLSsylP 230 Clostridium the...
EDU38165     153 FSKNPKLTELMDMAMVDVKSFDNQEHKMLTKRDNDIVLKNVRYLASIDKLYEIRTVIVPDLLDNENNVFEISKIIA---S 229 Clostridium spo...
EDP24658     153 LKRLPDFVEVSDAFMLDIKAFDNEEHLFITKSKVDVVLENADYLASINKLFEIRTVTIAG-MDNRTTIDNITRMLSkyiK 231 Parvimonas micr...
EEP37846     153 LEEYKEFVEVTDKFMLDIKAWDSTEHKELTGADNEIVLKNLRFLLEKNKMYEVRTV-VNSMINAKETIMKTAEILK---D 228 Sebaldella term...
WP_001088427 158 ETGWEKLLPVCDGAMLDLKAWGSECHQQLTGRDNQQIKRSICLLAERGKLAELRLLVIPGQVDYLQHIDELAAFIK---G 234 Escherichia
WP_011591720 150 LD--DELINLTDKFMLDVKSIDEKENIWLTKSSNKLVLENFKKLLELDKMYEVRTVIAKGL-NNEKTVDEVSKIIG---D 223 Clostridium per...
EDQ02340     255 LPSSTKIRLNAFRHHGVKGEALEW---QTCSETDMTVLAEGLTKLGIT-LVLP 303 Shewanella benthica KT99
EDS11747     230 RRTQTRLKLITFRKNGVRGRLSET---PSPSPETMQAHADYARAAGFNnIVLT 279 Anaerotruncus colihominis DSM 17241
EDN00726     231 RASAARLKLIAFRPNGVRGAFADR---AVPTAEQMSAYEAAARRMGFReILLR 280 Pseudoflavonifractor capillosus ATCC 29799
EEJ21346     245 KVGQTRIRLMKFRHFGVRGPMENS---PSPSDERMREIESQARSLGFGeVVVS 294 Atopobium parvulum DSM 20469
EDX93957     231 IRP-IRYKLISYRPMGVRPQYKETl--QIPTRNQMEYYAGLLAAKGFKdIIII 280 Clostridium thermocellum JW20
EDU38165     230 LNPNIRYKLIKYRPIGVRKEKIDP---KTPTDKYMENLKNIALKNGCKdIIIL 279 Clostridium sporogenes ATCC 15579
EDP24658     232 MGHKIRYKIIKYRKYGVREEYSMF---SAPTDDEMEELKEIAIRNGFEdVIIV 281 Parvimonas micra ATCC 33270
EEP37846     229 YP-DVRYKIIAYRHFGVKEEFKEKf-hPLPNIKDLEKLKSEAEKIMKNeIILL 279 Sebaldella termitidis ATCC 33386
WP_001088427 235 LG-DVPVRLNAFHAHGVYGEAQSW---PSATPEDVEPLADALKVRGVSrLIFP 283 Escherichia
WP_011591720 224 ---KCRYKLIKYRPFGVREEGIKVhgtISPEDSYMNELKEKSIANGCIdTIIT 273 Clostridium perfringens
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