Conserved Protein Domain Family
B12_SAM_MJ_1487
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TIGR04013: B12_SAM_MJ_1487 
B12-binding domain/radical SAM domain protein, MJ_1487 family
Members of this family have both a B12 binding homology domain (pfam02310) and a radical SAM domain (pfam04055), and occur only once per genome. Some species with members of this family have a related protein with similar domain architecture. This protein is occurs largely in archaeal methanogens but also in a few bacteria, including Thermotoga maritima and Myxococcus xanthus. [Unknown function, Enzymes of unknown specificity]
Links
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Statistics
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PSSM-Id: 274917
Aligned: 25 rows
Threshold Bit Score: 483.687
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EEB53442       3 LVFVLSKTNRYSIAALFGAIEDL--------E------V------DV------E---VIGESEFINA-NYI---GsddA- 48  Thermotogales b...
EEJ95750       6 IIIRYRKAVSYGHHVLLGALETLsadvsyevR------F------AT------S---AAAVVEEIKK-ALP---TahrV- 59  Thermomonospora...
WP_011994197   6 ILFRTNKHNRYSITALVGAILSR--------I------D------ID------Vi-eSKSISDILQY-PVE---G---T- 50  Fervidobacteriu...
WP_012002593   3 IIFRFHKHNRYSLIPLIAAIHDK--------F------P------SI------Em-aFVGSLNEIMN-ISP---P---A- 47  Thermotoga
WP_011998403   5 YVHLLRKDTKYSAYSVVAIVESS--------G------F------EA------TlvkDPAQALELAK-KRP-------V- 49  Ignicoccus hosp...
WP_004082817   3 ILFREMKNNWYSLAALLSTIYSR--------H-------------LD------Ve-aRPVKFEEIKKfPPE---K---T- 47  Thermotoga mari...
WP_012583117   5 IVFYDVKENKYSINALLGALEKD--------FknfeigF------VE------Ks-qVDFWLENIEK-DVF-------Y- 54  Dictyoglomus tu...
WP_011838826   7 VIIYYDQRAKYSIHALTAVIDSL--------N------I------ADvyliekTs-gFLEFVKNISE-KYR---K---C- 57  Staphylothermus...
WP_011556381   9 LVLSYQYPGKYAFTVLAGAVESD--------P------AladvtlHF------Pr-sRETLLDTIRE-RVDagdT---V- 62  Myxococcus xanthus
WP_012097198  81 LVLHYRRTARHALNVLLGAVEAH--------P------AtaeipaVV------At-sPEAVIDAAAA-ALA---S---Gr 132 Anaeromyxobacte...

EEB53442      49 --IIALSFMSPEA--KK--NEKLIRKLSSAGN----RVIVGGPHASAKPEEILG-MGAYAVFVGEGERTLRKFLL----- 112 Thermotogales b...
EEJ95750      60 --LVLWSFYSPDA--LE--MAAELQRIRAEIDdpavTHIAGGVHATAEPVQVLD-AGWDIAAVGEGETTFLRLVAag--- 129 Thermomonospora...
WP_011994197  51 --VVAYSFMSFDI--DI--VKVEVQELKKHGY----IIIAGGPHATALPQETLK-IGFDYVFTGDGEENIVRFLLg---- 115 Fervidobacteriu...
WP_012002593  48 --VVAYSFMSFDV--DW--VSQEVNILKKKGY----ALIAGGPHATAKPEDVIR-MGFDHVFKGDGEENILLFLKge--- 113 Thermotoga
WP_011998403  50 --VFGVSLMTTDLldEN--LLRWIKALKGKA-----FLVAGGPHATGDPWGTLN-LGFDAAVHGEAEETLPELLRaleeg 119 Ignicoccus hosp...
WP_004082817  48 --IVAYSFMSFDL--DT--VREEVKTLKERGY----TLIAGGPHVTADPEGCLR-MGFDHVFTGDGEENILKFLMg---- 112 Thermotoga mari...
WP_012583117  55 --IFCVSFFTTQF--FE--TEALLKRIKEKIEn--vKIIAGGPHASGDPYSTLK-IGADIVVVGEGEKIFPEIIKriisg 125 Dictyoglomus tu...
WP_011838826  58 --IIGLSIQTTML--ADdsYLDFVIKLNKHKGk--cISIAGGPHPSGDPIGTIKsLGFDYAFIGESEKTIQDFIYafvnd 131 Staphylothermus...
WP_011556381  63 --VAAWSFYSASF--AP--AAEELAWVRERLEgrdvLCIAGGVHATAETLQTLQ-AGFDLVAVGEGEYSLRALLGrvlrg 135 Myxococcus xanthus
WP_012097198 133 cpVVAWSFYTASF--DE--VAAELARVRAALPdgrvLHVAGGPHASAEPAATLG-AGFDLVAVGEGEETLPALLArlsvg 207 Anaeromyxobacte...

EEB53442     113 -NP--TPGIWYGE-----------KLQQLDTFPPFSLKHEFFSPMEISRGCPFGCNYCQTPRIFGRRVRHRSVENILHFA 178 Thermotogales b...
EEJ95750     130 gEPagIPGLVYRDeagglvrtgraERRELDAYPAFSVRWRRFNPIEITRGCVYACRFCQTPFMFSAKFRHRSVENVKRHV 209 Thermomonospora...
WP_011994197 116 ----eRPENRIFDgi--------sKRINLDEYPAICEKKKLFMPLEISRGCPFNCGYCQTPRLAGKIVRHRSIEQIVEYE 183 Fervidobacteriu...
WP_012002593 114 ------rsTVFDgl---------vKRINIDEYPPFCSDLDLFMPIEITRGCPFGCAYCEVSLIGGKKPRHRSVESIVHHC 178 Thermotoga
WP_011998403 120 sDWrrVKGVYSDEgfs-----gprGLADLDRYPPWPHWRGLVGPIEITRGCPFACSYCQTTFMFKAFVRHRSIENVIKYA 194 Ignicoccus hosp...
WP_004082817 113 ----eRKKIFdg----------isKRVNLNHYPPFLPSKGIYMPIEITRGCPFSCAYCQTPIIAGRRVRHRDVDVVVHYA 178 Thermotoga mari...
WP_012583117 126 eD---VKGIFKGE-----------SFVKLDDYFPFSLRFKRFGPIEISRGCPYGCYFCQTPRIFGGVMRHRSTEKILDIV 191 Dictyoglomus tu...
WP_011838826 132 dDLlnVKGLFTIVddkpi-ytgkqEPIKLDDYPPFPYWRLLFNPIEISRGCPYGCKYCQVSYMHGFYMRHRSIDNIVEYT 210 Staphylothermus...
WP_011556381 136 eVPreTHGVAYLKdgklv-qhgrgEGVQLDDFPPFAARNGQYGAIEITRGCIYACRFCQTPFMSKARFRHRSVANVAHWA 214 Myxococcus xanthus
WP_012097198 208 dDPraGPGLAWLDgggvr-tsgraAPVDLDALPPFAPRAARIGPLEVTRGCAWACRFCQTPFLFRARFRHRSLESIRRWA 286 Anaeromyxobacte...

EEB53442     179 RESVERGRKVARFITPNAFGYGSKN-GvTPNTKVIYELLSGMRK--I----GM--REVYFGSFPSDVRPESVSDDVLAIV 249 Thermotogales b...
EEJ95750     210 EQMVAHGRRDVRFITPTSLSYGSGD-E-NVNLEAVEELLAACKSvvG----KQ--GRVFFGSFPSEVRPEHVSVRALRLI 281 Thermomonospora...
WP_011994197 184 KISVKYGKTIARFITPNAFGYGSKN-GvTPNLEAIDELLYKVKA--T----GV--TEIYFGTFPSDVRPESVTDEVLKII 254 Fervidobacteriu...
WP_012002593 179 KSGINKSRYIARFITPNAFGYGS-D-GmKVNVEAIDNLLYNLKK--V----GM--KEIYFGSFPSDVRPEFVTDEVLKTI 248 Thermotoga
WP_011998403 195 SIMRDMGLKDMRFITPNALSYGG-D-GrRPNLEAVEELLARLKK-------LG--VRTFFGSFPSEVRPEFVNEESIKIL 263 Ignicoccus hosp...
WP_004082817 179 KLGVKHGRKLARFIAPNSFGYGSKN-GvTPNVEKIEELLYGLKK--V----GI--EEIYFGTFPSEVRPESVTDEVLKVV 249 Thermotoga mari...
WP_012583117 192 KIMNKLNLKDIRFITPNAFAYGSLT-GkDVNLRRLEELLYGIRN--I----IGdkGRIFFGSFPSEVRPEHVREEILELL 264 Dictyoglomus tu...
WP_011838826 211 GYMIRKNVRDIRFISPDSLAYGLKTiSrKPRLDLIEELLFRLYK--KyvekKN--ARIFYGSFPSEVRPEHLTRDAARIL 286 Staphylothermus...
WP_011556381 215 RELRRSGRRDIRFITPTSMSYGTAD-E-SVNLDAVEALLAAVKE--Am--aPD--GRVYYGTFPSEVRPEHVTPEALELL 286 Myxococcus xanthus
WP_012097198 287 RHLAALETRDLRVLTPSALSWGSPD-Gg-CDLAAIEALLATLREaiG----PD--RRLFVGSFPSELRPEHVSAEALALL 358 Anaeromyxobacte...

EEB53442     250 QEFCDNKVIVVGLQSGSDRILKQLNRGHDVQTAINTIRKISRYGFTPYVDMIFGFPFEEDSDIEKSFEVAYYLYeKYGAV 329 Thermotogales b...
EEJ95750     282 KRYCANDNLIIGAQSGSARVLEAAKRGHGVQEVRDAVRIGVQEGFRINVDMIFGMPGETPADAAASLALARELA-DLGAR 360 Thermomonospora...
WP_011994197 255 KKYVNHDYIVIGAQSGSNRILEKIQRGHTVEKVEEALEILAQNGFYAKVDFIFGFPFETKEDVEETFKFIEKIVkKYNAK 334 Fervidobacteriu...
WP_012002593 249 KKYVNNRYIILGAQSGSDRVLRLIKRFHTVEHVVRSAEIVLNNGFVPRVDIIFGFPFENEDDLAKTFDLIKKLV-KMGCK 327 Thermotoga
WP_011998403 264 KKYVSNKRLVIGAQSASDAVLKRIHRGHAWEDVVNAVEVSVKHGFVPEVDFILGLPGESEEDMMETLRGMRKLA-SMGAR 342 Ignicoccus hosp...
WP_004082817 250 KKYVNNRSIVIGAQSGSDRILKIIKRGHTVEQVEEAIEKISLHGFIPHVDFIFGFPFETEEDVEKTFSFIVKIVeRYGAK 329 Thermotoga mari...
WP_012583117 265 KTYADNDNLVIGAQSGSQRILDLAHRGHTVEDVYRAVSLTLRYGLKANVDFIFGLPYEEERDIEETLKFIEELV-KMGAR 343 Dictyoglomus tu...
WP_011838826 287 RKYVANKNIILGAQTGSNRLLRLIGRKHSIEDVYSAVENAVKYGFIPNVDYIIGLPGETREDLYETLRSIKKLV-SIGAR 365 Staphylothermus...
WP_011556381 287 KRYVHNDNLIIGGQSGSERILQSTRRGHDVETVVRATRIAVECGFVPNVDFILGLPGEEPEDVDATVALMEKLA-GLGAR 365 Myxococcus xanthus
WP_012097198 359 RRYCDNRTLVIGGQSGSDRLLVSMRRGHDAESVTRAARLALEAGFTPSVDFIFGLPGETEDDRIATRGQMQGLA-AMGAR 437 Anaeromyxobacte...

EEB53442     330 IHGHTFMPLPGTPFENLK-SKLSSKTLRELGRLSAKGIMKGQW 371 Thermotogales bacterium TBF 19.5.1
EEJ95750     361 IHAHTFMPLPGTPWREATpGRVDPETLRAIGELTGRGALYGHW 403 Thermomonospora curvata DSM 43183
WP_011994197 335 IHAHTFMPLPGTPLWNVGpGILKNYHYKFLGTLASQGILDGYW 377 Fervidobacterium nodosum
WP_012002593 328 IHAHTFMPLPGTELESSGhAVLPEWVRRELSRFAQEGNLDGYW 370 Thermotoga
WP_011998403 343 AHLHYFMPLPGTPLAYADpTPLPERVRKEVAKLVGEGKGWGQW 385 Ignicoccus hospitalis
WP_004082817 330 IHAHTFMPLPGTELFNAGpGRLTEVHYKFLGRLASKGILDGYW 372 Thermotoga maritima
WP_012583117 344 VHAHTFMPLPGTPFAKFPpGKLEGMYKKIINRLLPKGVIFGNF 386 Dictyoglomus turgidum
WP_011838826 366 IHLHVFLPLPGSPYAWMPpGKVPSWVKKELMKLIGAGKAYGQW 408 Staphylothermus marinus
WP_011556381 366 VHGHTFMPLPGTPFRDAPpGSVDEATQRKLDRLASQGRLYGHW 408 Myxococcus xanthus
WP_012097198 438 VHAHAFMPLPGTPWGGAApGRIDGTTRALLGRLAASGAAHGQW 480 Anaeromyxobacter sp. Fw109-5
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