Conserved Protein Domain Family
rSAM_HemZ
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TIGR03994: rSAM_HemZ 
coproporphyrinogen dehydrogenase HemZ
Members of this radical SAM protein family are HemZ, a protein involved in coproporphyrinogen III decarboxylation. Alternative names for this enzyme (EC 1.3.99.22) include coproporphyrinogen dehydrogenase and oxygen-independent coproporphyrinogen III oxidase. The family is related to, but distinct from HemN, and in Bacillus subtilis was shown to be connected to peroxide stress and catalase formation. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Links
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Statistics
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PSSM-Id: 274910
Aligned: 22 rows
Threshold Bit Score: 627.724
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EEG75183  66 KRCVDREIYTGLEQYTGRSLAWGLLTGVRPSKIAMKELEGGAQMEEFLRSFQEQYFVSGEKAQLAWEIAGREKALLEQLD 145 [Clostridium] hylem...
EEG31234  81 RLALCAALYKALCEGLGTELPWGMLTGVRPVKQVHALRGEGKNDEEIRRFFSEQFFVSQTKSDLCLMTADVQEGLEMGIR 160 [Clostridium] methy...
EEG46615  72 EYTLCTLLFELLREKTGQNPPWGMMTGVRPVRIIHDLRAMGATETEIEDRFLRHFACTPEKFTLARGIADLQRPVLAGAD 151 Subdoligranulum var...
EDS10302  78 EHMFGVMLYRLLSRATGVCPPWGVLTGVRPVRLFMTELMRGADDGALRRRFMDGSLVSGEKFDLALQTARIEQPLLSRST 157 Anaerotruncus colih...
EDO60277  85 ERELAVLLFTLLTKLTQITPTWGILTGVRPIKL-MRRLTSELGETGAKAYFRDKLLVSQNKTELAAITMKAEQKLLSLSR 163 [Clostridium] leptu...
EDS01277  78 ENELCRLLCRCMERHGHTPLPWGILTGVRPVKYIRSIYE---TRDNAEEYLRNSLLVSDKKIQLANDVIRIQKPVLDSLD 154 [Eubacterium] sirae...
EDR97717  79 KNSLKAALYRLLSCYFQKELPWGTLNGIRPTKLVFEDCLRGKSRADMQAKLCRDYLVSEEKADLCVSVGIKETELLKNIT 158 Anaerostipes caccae...
EEG37751  90 RNAVCRFLYRLFEKYTGRSLPWGMLTGIRPTKIIMKWMEEEKDSAKLEQRFRETYLADPQKANLCRRVAQREKVLLESRP 169 [Eubacterium] halli...
EDQ96757  84 KETIKRSMFKILEQKFESNVPWGILTGIRPVKIVHALLDEGKDEEYIKIKLGEDYYIKDDKIELALNIAKRERQFIYPID 163 Intestinibacter bar...
EDU35790  67 KEWVKKFLFLYLKSITNKNLPWGTLVGIRPSKIALDLMNKGMEEKEIIDWFSKHRNTREDKTKLCIDIANMEKSIVNKD- 145 Clostridium sporoge...

EEG75183 146 yEDGYSLYVGIPFCPSVCTYCSFSSGALE--AWKDRVEDYLDALMKELAYIGKVSA--GKKLNTVYIGGGTPTTLTACQL 221 [Clostridium] hylem...
EEG31234 161 -PQVASLYVSIPFCPTRCAYCSFVSQAVEkkGTAALIGEYVDKLCGELQATAEVVKqcGLQLETVYFGGGTPTSLSAGQL 239 [Clostridium] methy...
EEG46615 152 -PMDCSVYAGIPFCPTRCSYCSFVSRTVGdkATRALVQPYVDKLCEELTAIRQTADrcGLHIRTFYIGGGTPTSLSAAQL 230 Subdoligranulum var...
EDS10302 158 -PDSFSLYVSVPFCPTRCAYCSFVSQSVE--RDAALIPAYVDRLCEELEYTGCLAKelGLRLRTVYFGGGTPTTLSAEDL 234 Anaerotruncus colih...
EDO60277 164 -KESYSLYVSIPFCPTRCSYCSFVSQTIE--RAHKMIPEYVARLCEELEKTAQIAHelNLRLESVYIGGGTPTTLTWEQM 240 [Clostridium] leptu...
EDS01277 155 -LRKISLYISIPFCPSRCSYCSFISASGE--GALKLIDDYFGLLLKELDIYADIVKrfSLKVDTVYIGGGTPTTLSASQL 231 [Eubacterium] sirae...
EDR97717 159 yESGYSLYVGIPFCPSTCLYCSFTSYPIS--AYREYADHYLDALIREIHYIGEQYR--DREMISLYVGGGTPTTLSPEQL 234 Anaerostipes caccae...
EEG37751 170 fEKEYSLYIGIPFCPTTCLYCSFTSFPVS--RFGDRMRAYLDALYKELAFVAKHHR--DKKLTTIYIGGGTPTALDEECL 245 [Eubacterium] halli...
EDQ96757 164 -ENKVSLYVGIPFCPTRCYYCSFPANPVD--KFGGKKPLYVEKLLQEAKGVAELLRdnNKEIETLYIGGGTPTTLSPEEM 240 Intestinibacter bar...
EDU35790 146 -KNTISVYVGMPFCPTRCLYCSFTSNPIG--KCKNLVEPYLKALYYEMDMLSKYIQhkGLKIQCVYFGGGTPTSVNNAQF 222 Clostridium sporoge...

EEG75183 222 ERLLDCIDSNFSREH-LLEYTVEAGRPDSITKEKLSVLYRHRITRISINPQSMQQKTLDLIGRRHTVEDIVRTYALARET 300 [Clostridium] hylem...
EEG31234 240 SILLDCIERSFDLSH-LKEYTVEAGRADTITADKLEVLHDHGVGRISINPQSFNDRVLEQVGRRHTARQVVDAYHLARSV 318 [Clostridium] methy...
EEG46615 231 EQLMGHIARTFDLST-LDEYTVEAGRPDCTNAEKLRIIKQYGATRISINPQTFSDEVLRNIGRRHTAQDIIDCFAAARAA 309 Subdoligranulum var...
EDS10302 235 TRVMGTVADRFDLSG-LWEYTVEAGRPDTVTPQKLRAIYAGGARRVSINPQTLSDTVLCAIGRRHTSAQFFEAFAMARAA 313 Anaerotruncus colih...
EDO60277 241 ELLLRTIRRNFDFSC-CREFTVEAGRPDTITPEKLKAMKRYGVDRISINPQTLNDGVLELIGRKHSARQTIDAFKLARKE 319 [Clostridium] leptu...
EDS01277 232 DSLIEKLGE-FDIAN-IREFTAEAGRPDTITEDKLRALKNGGVRRISINPQSMNDSVLEAVGRRHTVKQVCEAFDIARKV 309 [Eubacterium] sirae...
EDR97717 235 ERLFGELKRCFDFGR-VREITVEAGRPDSITAEKLSVLSENGVTRISINPQTMNNDTLRKIGRNHTAEDVADSFHAARKA 313 Anaerostipes caccae...
EEG37751 246 SKLMNMIHELFPVEE-SEEFTVESGRPDSITKEKFRILKEAGVTRISINPQTMHQETLDLIGRAHTVEQTKEAFLLAREC 324 [Eubacterium] halli...
EDQ96757 241 DTLIKGLFKEFDLSN-IKEFTVEAGRPDTINREILEVLKKHGVSRISINPQTMNDETLQKVGRKHSVNDIIECFQLAREL 319 Intestinibacter bar...
EDU35790 223 EKTLNKIYYNFVHNKeVEEFTVECGRPDSITEEKLLSMKKYNVHRISINPQTMNNSTLKNIGRTHSVEDIERIYHLAKSI 302 Clostridium sporoge...

EEG75183 301 GFDNINMDLIAGLPGESAADMRDTLRQAEALAPDSLTVHSLAIKRAAQMGQEQsar-gyvEALERDTGtmaqvmtEMIRA 379 [Clostridium] hylem...
EEG31234 319 GFESINMDLIAGLPGDTLESFERTVEQAVVLAPENITVHALTIKRSSALHEQG-------RAGGGDAP-------AMVAY 384 [Clostridium] methy...
EEG46615 310 GHQNINMDLIAGLPGDTVEGFTHSLEQAIALDPENITVHTLTLKRASNLVVEHr------AADYDDVA-------AMLAR 376 Subdoligranulum var...
EDS10302 314 GFDCINTDLIAGLPADTPEGFAASVDGVLALHPENVTVHTLTVKRASRLTFDEa------RSELELVG-------GMVGY 380 Anaerotruncus colih...
EDO60277 320 GFHHINMDLIAGLPGDSLTSFQNTIQGICQLDPESVTIHTLAMKKSSKLTMEGkk---lyRDECLEAA-------QMLDY 389 [Clostridium] leptu...
EDS01277 310 GFDCINSDIIAGLPAETERSFEDSLQQLCKLSPENITVHTLSLKRSSALFCRFg------DDIGKGAK-------YMTDT 376 [Eubacterium] sirae...
EDR97717 314 GFDNINMDTICGLPGEGIRELETTFKALGELEPDSITVHALAIKRSAPLNQMRd------qFSCGADD-------EMIRF 380 Anaerostipes caccae...
EEG37751 325 GFDNINMDIITGLPGESLSYVHETLDEIFKLRPESLTVHSLAIKRAAHLNIEMek---yqGMVKGSTN-------EMLRL 394 [Eubacterium] halli...
EDQ96757 320 GFDNINMDIILGLVDENLAMVENTLKEIEKLSPESLTVHTLAVKRTSKLKENIdn---yeLTQFDEMT-------KMIDL 389 Intestinibacter bar...
EDU35790 303 GFKNINMDLIVGLPGEGIEEIKNTCRRIKKLNPDNITVHGMSIKRGSILHEKLvnkmefnIPKQEELN-------RMYEE 375 Clostridium sporoge...

EEG75183 380 AAESARRMGLLPYYLYRQKNIAGNFENVGYAKVDKAGIYNILIMEEKQSIIAAGAGASTKIVLKeaaelpgskngKKtnL 459 [Clostridium] hylem...
EEG31234 385 AGQRLLREGYRPYYLYRQKNMVDNLENVGYAKPGHESPYNIYIMEENQTILACGAGGSTKLVAP-----------GR--I 451 [Clostridium] methy...
EEG46615 377 CDR-LQQAGYRPYYLYRQKGTLQNLENIGWAKPGKECLYNIYIMEEIHTILSAGAGGSTKLVIPgk-------rhGK--I 446 Subdoligranulum var...
EDS10302 381 ARNACEAAGLHPYYLYRQTGTLASLENVGYAAVGTEGLYNTYIMDETHTILAVGAGASTKLRHPk---------tGR--I 449 Anaerotruncus colih...
EDO60277 390 AGEVLLSRQYAPYYLYRQSKMVGNLENVGWAKPGFESFYNVYVMDETHTILACGAGAVTKLKQPq---------gDY--L 458 [Clostridium] leptu...
EDS01277 377 AYDMLFEKGYFPYYLYRQKNIADNLENIGYCKDGCESIYNICIMEDVQTILAAGCGASTKLYDg-----------KN--V 443 [Eubacterium] sirae...
EDR97717 381 AQRACFDLGMEPYYMYRQKNIPGNFENTGFSLEEKECLYNILIMEELHDIIAAGAGASSKIVg------------GRrnI 448 Anaerostipes caccae...
EEG37751 395 VDEYASNMGMEAYYMYRQKNIPGNLENIGYCVPDKECLYNILIMEEKQDIISCGAGASSKYVFEq----------GR--I 462 [Eubacterium] halli...
EDQ96757 390 SMKYAKKMGLNPYYMYRQKHMLGNLENIGYAKEGYECIYNIQIMEERQSNIALGAGSITKFVYAd---------eNR--I 458 Intestinibacter bar...
EDU35790 376 TEVLAKDLGMKPYYMYRQKNMLGNMENVGYSKENKIGIYNIQMIEERQTIIALGADAVSKIIFMd---------eNR--I 444 Clostridium sporoge...

EEG75183 460 VRIENVKAIDAYIARIGEMIERKGEWL 486 [Clostridium] hylemonae DSM 15053
EEG31234 452 ERIFNYKYPYEYCNGFEEILRRKQEVV 478 [Clostridium] methylpentosum DSM 5476
EEG46615 447 ERIFNFKYPTEYIDRFAEILARKQGVE 473 Subdoligranulum variabile DSM 15176
EDS10302 450 ERVYNYKHPTEYIGRFDEALRRKQRVR 476 Anaerotruncus colihominis DSM 17241
EDO60277 459 ERVFNFKYPYEYLSRFQEMLERKNQVR 485 [Clostridium] leptum DSM 753
EDS01277 444 SRVINYKYPYEYISRFALMNERKRDIE 470 [Eubacterium] siraeum DSM 15702
EDR97717 449 QRVENLKDVRQYTERIEEMILRKDKLL 475 Anaerostipes caccae DSM 14662
EEG37751 463 ERTENVKNLDHYINRIDEMIDRKRKYL 489 [Eubacterium] hallii DSM 3353
EDQ96757 459 ERVENVKNLEQYIDRVDEMINRKYKEV 485 Intestinibacter bartlettii DSM 16795
EDU35790 445 ERSPNVKDVIEYTKRVEEMVQRKKKIL 471 Clostridium sporogenes ATCC 15579
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