Conserved Protein Domain Family
His_Ser_Rich
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TIGR03979: His_Ser_Rich 
His-Xaa-Ser repeat protein HxsA
Members of this protein share two defining regions. One is a histidine/serine-rich cluster, typically H-R-S-H-S-S-H-R-S-H-S-S-H. Members are found always in the context of a pair of radical SAM proteins, HxsB and HxsC, and a fourth protein HxsD. The system is predicted to perform peptide modifications, likely in the His-Xaa-Ser region, to produce some uncharacterized natural product.
Links
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Statistics
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PSSM-Id: 274897
Aligned: 6 rows
Threshold Bit Score: 162.355
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_011427310   4 RKVYLLPSLIAAGFMPSKGDAAPLVGLTQKKPEPTLFER-------LRV-KQAYTLAGhsshssh-----ashsshASH- 69  Rhizobium etli
WP_011106271   6 NLAALLPGFFALNSGANAGTAAPEELDVKDELLLDKVVLa-----pLNE-AIPLYIAA------------------HRS- 60  Vibrio parahaem...
WP_012078872   7 DLSLFLAGVPLL-LAKTSSAAMPPAEMFTDSLEPTAVPLr-----pLNY-DIDNLFAGhrshssh-----rshsshYSG- 73  Janthinobacteri...
WP_011899282   7 TLQRW--GVLGLGVLSGHGVTASEAHLSDDAFNQLNLDNlpnmeasLNM-DVNNLYAGhrshrsh-----sshrshSSHr 78  Aeromonas salmo...
WP_012724415   6 RWKVLISGISLLPMAGTPLAQAGHLPLADANWQPNDKLQppvfadtLNApDTVNIYAAhrshsshrshsshsshysGSG- 84  Pseudomonas flu...
WP_012069950   6 GLAAMLPGFLSL-----NANAIVESYVEPKNIGLLDVIIa-----pLNV-NTPTYLAghrshq--------shsshGSH- 65  Marinomonas sp....

WP_011427310  70 --ASHASGSgggYVVPRGDynnSTTYTQP--D--PTPSYSPNPGPVIRSLPTTpnipattstgsysTGVAPQSSAVNTap 143 Rhizobium etli
WP_011106271  61 --HSSHRSH---SSHRSSA---GSTYSAP--V--KKQKSQPLTQPSTPSYTAP-------------ATKRPVSTAEEL-- 113 Vibrio parahaem...
WP_012078872  74 --SGGGSYS---RSYP-------STPSYA--V--PDKSYQPSSGSSVNNFSSG-------------VGTSDRSKKSNAds 124 Janthinobacteri...
WP_011899282  79 shYSGYG---------------TSTYSAP--VavPSRAYGSSVNSLNQSLQAP-------------LEVTSPARRLTAn- 127 Aeromonas salmo...
WP_012724415  85 --GYSAPRY---YSPPA-----TSTRSYS--A--PSASSSTPSSSLYQSYGTT-------------SGTRSSTSKSRAt- 136 Pseudomonas flu...
WP_012069950  66 --RSSAGGG---YSVPSKP----AKPAFPlsD--PLGRPSSPPTTTPKSSPST-------------TTSKTISGSEML-- 119 Marinomonas sp....

WP_011427310 144 mplktlpgnsDKFRRIVIQVQTALVAFGYFGGPITGQVDAATRVGLNKMQDAYGLKVTGTITPQVLTAFGIST 216 Rhizobium etli
WP_011106271 114 ----------EKRKELIIRVQFALYTSGYYKGIIDGIMGKQTRKALNAYRVDNNIPVSQTLDTVTLNSLGIIA 176 Vibrio parahaemolyticus
WP_012078872 125 insapvlthtEKLKLQITRTQIKLHSLQLYDGQIDGVMNEDTKIALKRFQMIKGLPETGTMGTSTLNALGLPA 197 Janthinobacterium sp. ...
WP_011899282 128 ---------dSAMMDLVMRVQLALFTKGYDVGIIDGKIGPKTRAQIKRYQSDNRlsstgtlttslltslgiqi 191 Aeromonas salmonicida
WP_012724415 137 ---------nEQKSNLVIRVQTALMVRQYYQGTIDGVMGKATRGALMAFQMDSGLTVNGRMDTPSLNALGIKI 200 Pseudomonas fluorescens
WP_012069950 120 ----------EQRELVVRKVQAMLTVHGYYSGKIDGILGEQTRTAISSYRRDTGLSGGSKIDSGLLNSLGILA 182 Marinomonas sp. MWYL1
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