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5,10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdB Members of this archaeal protein family are HmdB, a partially characterized radical SAM protein with an unusual CX5CX2C motif. Its gene flanks the H2-forming methylene-H4-methanopterin dehydrogenase gene hmdA, found in hydrogenotrophic methanogens. HmdB appears to act in in biosynthesis of the novel cofactor of HmdA. [Protein fate, Protein modification and repair, Energy metabolism, Methanogenesis] |
Jiyao W et al.(2023). "The conserved domain database in 2023.",