Conserved Protein Domain Family
thiopep_ocin
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TIGR03891: thiopep_ocin 
thiopeptide-type bacteriocin biosynthesis domain
This domain occurs within longer proteins that contain lantibiotic dehydratase domains (see pfam04737 and pfam04738), and as single-domain proteins in bacteriocin biosynthesis genomic contexts. Three named genes in this family, SioK in Streptomyces sioyaensis, TsrD in Streptomyces laurentii, and NosD in Streptomyces actuosus, all occur in regions associated with thiopeptide biosynthesis. [Cellular processes, Toxin production and resistance]
Links
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Statistics
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PSSM-Id: 274836
Aligned: 44 rows
Threshold Bit Score: 110.534
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EEK38862       32 WIYFKLYTGYKTADNILSKTLPAIISQLNTENVLDKWFFIRYSDPK-F-HLRLRFCLKdAKNISSVISLFNREMSPYIDE 109  Pedobacter he...
EEL62620      755 WSYIKLYTSEYKQNELLIKYINPFIERLQKEGIIEKFFFIKYLDPN-P-HIRLRILW--SKSSPNRFDLLNDFLEFLQNK 830  Bacillus cere...
EEL96201      788 WLYVKLYVPQARENEFISKYMTSFANNIVQNGLAQSWFFMRYRDPD-A-HIRLRFYGDpKKLNASVLTHLRDWANNLMNS 865  Bacillus myco...
EEM92724      752 WISLRVNYVDSRVEEFLSCGYKEFYKHNKDINKIEKGFFVRYADPT-P-HLRIRFKLAkNEKYNTFLGNITEWLTNEREK 829  Bacillus thur...
WP_011248397  775 WLYFKLYGPIHKQQKLISTQIPTLVAELENHKLINSWFFIRYYDSE-P-HLRLRFHGDpKTLLAGALPVFQKWYAAQRLA 852  Bacillus clausii
WP_029761609  772 WLYLKLYGVHSRADDFIAFYLSEYCREKLAKGEIEKYFFIRYADPE-Q-HIRLRLN-AsEEKLLQIYPDMKQWLRTLIEK 848  Geobacillus t...
WP_001092607  733 WFALHIHIDKPSQDTFIIDNLYPFVKHLKDKGDIEKYFLMRYIKQG-D-ILKLRLFRNd-ENYAEIYSILKNWLPHVRQT 809  Staphylococcu...
WP_002204591  289 WIYFKLYGINSSTMPELRENLLIFTDELLAEKLVSDFHFVNYNDGG-DgSIRLRFKIMnEDDFEKLRYRIIHWIDFLLNH 367  Streptococcus...
WP_006322107  762 WLYLKIYIINCKQDDFILENIFPLISSLQEDNFKE-FYFIRYNDPE-Q-HFRIRIKGDtE----YFIPKIFKWANKLKNN 834  Anoxybacillus...
WP_011225313  677 WIYFRLYGINSSILPELRERLLLFTDELLVEKLISDFHFVNYRDKDnG-SLRLRFKINnDNNFEDLRFRITHWIDFLLES 755  Streptococcus...

EEK38862      110 DLI--WKVQIDTYQRELERYGT-TTMEHSESMFHFDSEAILSILsilsipEYNESDQQRWLLALKILDALLFDFELGMDQ 186  Pedobacter he...
EEL62620      831 EII--FSTDICSYTPEVIRYGGpNAIEAAETYFYHDSKFISQILd----vTKLQPELDLSIISVITLHHFLSCFNFTLSE 904  Bacillus cere...
EEL96201      866 GFI--HKMTIDTYEREIERYGGpYLIELAENFFHYDSRSVTMLLn----vIGQQAELPVHALASLNIIEIMENFGLTYEQ 939  Bacillus myco...
EEM92724      830 GLV--NDFHFVSYNPEIERYGD-FLIDKAEDIFSIDSLIVADS-------FEGDVPLNRELFCCLNIMSILKGFNLNFAS 899  Bacillus thur...
WP_011248397  853 GNV--KKVVIEPYEREIERYGGlSLMPLMERYFEKDSLLTSNLLgl---sSKQALKEPLELIASMYVVYFLTEYGWHHER 927  Bacillus clausii
WP_029761609  849 RVV--SRFSIDCYEREIERYGGtELIDLAENLFFFDSIVVEDILkl---kRLKHIQFSDEVIGMVSIIHYMEQFGLNYES 923  Geobacillus t...
WP_001092607  810 TEV--SDYEFVSYEPEFFRYGGkNTINEIEAFFEYDTNLAVNII-------ENDFKFDRPYIVAISIMYLFEMFSISNEE 880  Staphylococcu...
WP_002204591  368 YFC--KDVSFNLYEREVERYGGiGFLTVCERIFSIDSYLVLKLF------SKKVLKVDDYLSVLHSIFIYIRLLGISPKQ 439  Streptococcus...
WP_006322107  835 NKI--KKIVLDTYNPEIERYGGpLLIEKAENIFYQDSLVAINWVk-----MKNDFQISKLVFGVLNVIDYLENFNFSLEE 907  Anoxybacillus...
WP_011225313  756 GFCfcNDVSFNLYEREIERYGGdSFTTVCERMFSIDSFLTLKLF------SKKLLNDKDLLSVLHSTFLYVRLLGIPLKR 829  Streptococcus...

EEK38862      187 KIALLTELSEDFKKEmgftiKGYKLQlDKKFRTHRklIEEIMGTPEQASw-AIPLMEIIRQRSLKVKPIAGTLLQMEMNQ 265  Pedobacter he...
EEL62620      905 QNKLLSNNTSHKLFR-----KDYRNS-RKLLMHLSndNNNWMNLRENKK--YCFLYELLIQREEGIINYRKTLDLLINNG 976  Bacillus cere...
EEL96201      940 QLETIERNTDKYEF------MDEFRPmRKLLNNIGnpEGDWNNLRNYNSsiGLEIYKSLLVRRESLKEYFSSIQKYKNED 1013 Bacillus myco...
EEM92724      900 QLEILNMAIDP---------KIYKEAyRENKANLDpiITNIYDYIEIPMseKLIIPTTFNDRDNVIRKYAELIDA--NED 968  Bacillus thur...
WP_011248397  928 QLEWISKWSEDPAYS-----KEFRPYrNDVLKWLd-qEENWKALKEQKG----FLFKLFSKNEAIIHELSHNMEITPM-- 995  Bacillus clausii
WP_029761609  924 QLDFLQQQVNKQDYR-----EDFQKN-RSVYMKVCntDNDWQGLRDTDE--GMLLLNVLNQRNRSIKEYASKIQDGLEAS 995  Geobacillus t...
WP_001092607  881 RMEIVNNYVPTSFKS-----KDIRPf-KNELVTICnpANNFEYMAKHYS----GIYRILKDGNQILSKLNEGLKKt---- 946  Staphylococcu...
WP_002204591  440 LLKLMKDTFTQNIYR-----KSFKKVfPNNAKVIK-------------------EFKQYFEDQSKFDIFNEVFKSFSPIE 495  Streptococcus...
WP_006322107  908 QLEFIEGFELQDNFT-----DDFRKEkNTIFd----lIKNKNSKKPSSK--KEMANQLFCSRKKSIYSYNQAYNSNCNVY 976  Anoxybacillus...
WP_011225313  830 LLELLKGNLTQNRYR-----KSFKKLfPNNTIVVK-------------------EFKEYFDYKNQFEIFNEVFREFPPID 885  Streptococcus...

EEK38862      266 klEVSLHSLLRSYIHMTINRLFrSKQRVYELVIYDMLERYY 306  Pedobacter heparinus DSM 2366
EEL62620      977 tlSNNLENIVFSCIHMYCNRLY-GTNRESEQKVVTLTSHTI 1016 Bacillus cereus F65185
EEL96201     1014 klWNKQQTIMGAIIHMHCNRLL-GANRELEKKALAFTRHIL 1053 Bacillus mycoides DSM 2048
EEM92724      969 vlTNVKSDIIASILHMHCNRLN-GINRDLENKILGMCYHTI 1008 Bacillus thuringiensis IBL 200
WP_011248397  996 --TNTEERVVGSLIHMHCNRLL-GTDRDREKKAMAFVRQII 1033 Bacillus clausii
WP_029761609  996 ----SELSILDSVVHLHCNRLF-GIDREFEKKIRTLVAHTL 1031 Geobacillus thermodenitrificans
WP_001092607  947 -lTTKRSRIIGSLIHMRCNRIF-GIDKDQETFVLSIVKEIV 985  Staphylococcus aureus
WP_002204591  496 khFEYKNDMIHSLLHMHMNRI--GIFSLNEKEYLYFVRYIL 534  Streptococcus pneumoniae
WP_006322107  977 t---TKERIVKSFIHLSLNRL--GFNKLEEMKVYALTKHTV 1012 Anoxybacillus flavithermus
WP_011225313  886 gyFEGKNDIVYSLLHMHMNRV--GIFPYREKEYLYFIMYIA 924  Streptococcus thermophilus
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