3CMN


Conserved Protein Domain Family
DUF2342_F420
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TIGR03883: DUF2342_F420 
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uncharacterized protein, coenzyme F420 biosynthesis associated
A phylogenetic tree of the DUF2342 family (TIGR03624) consists of two major branches. One of these branches, modeled here, is observed almost entirely to be found in coenzyme F420 biosynthesizing species of the Actinobacterial, Chloroflexi and Archaeal lineages. The few organisms having genes within this family and lacking F420 biosynthesis may either have an undiscovered F420 transporter, or may represent F420-to-FMN revertants. This family includes a Chloroflexus Aurantiacus protein whose crystal structure has been determined (PDB:3CMN_A). This has been annotated as a putative hydrolase, but the support for that assertion is untraceable. There is no cofactor present in the structure.
Links
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Statistics
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PSSM-Id: 274833
Aligned: 20 rows
Threshold Bit Score: 353.591
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3CMN_A        18 IDWEQARQAALRLSQW-E-QAPVDNRAFRREQYARMVALSEPLIADYLGVRLPEPVS---RIFVFDRREWLEANIVSFSQ 92  Chloroflexus au...
WP_012120773  43 IDWLQARNIGVAVSQSy--LAPVVDRAARQEQYRRMVQRSEPLISAYMGVRLPQPID---RIYVFDRAEWIEANLAAFQS 117 Roseiflexus cas...
WP_011562154  14 VDWRFAATVGAKLVRPgP-PATDYTRRQAVEQLATASREAELPVREVTGLTEGNAVT---EARIIDRPGWIQAAAQSMRT 89  Mycobacterium
WP_011206916  27 VDWRLAARTGAALVPAgP-RTSRYSAEQVVAELAASSIRAEGPVREVSGLLDDQPVP---EARIVDRPGWISAAADSMST 102 Nocardia farcinica
WP_003419571  13 VDWEFAASVGERLARPaP-PSTEYTRRQVIDELTVAAEKAEPPVRDVTGLIADGVVP---PARVVDRPAWIRSAAESMRA 88  Mycobacterium t...
WP_009477472  13 VDWKLAARTGVKLARSgP-VTSRYTAETVVAELADASMRAELPVREVTGLADGLPVP---TAQILDRAGWIHAAAHSMSQ 88  Rhodococcus sp....
WP_012642250  38 VDWERAREIALRLSGg-V-RLSPLEREEATDRYRRLVTELAPAIADFVGSPVPSGIH---RVYAFDRIDWIDANLEGFAE 112 Thermomicrobium...
WP_011564948   2 ISWGAARTIAVAVA------ARSETPPAPGFDYPAAVEEAAGALSGFTGIELPQGPPggrQLRVTGRAEWIDFNIEGFGA 75  Rubrobacter xyl...
WP_011572147  21 IDWRATAEAAKQARDQgAlTLDDAERRAYATDVRDARSR----LRTVGGLEFD-IPQ---TIEVQNRHHWIDANIKTFER 92  Haloquadratum w...
WP_011323858  19 IDWSAVGNAARSATDSgElSLSTAERQGYADDVADARDG----IRAAAGVDFDLP-D---TVQVQTRHHWIDANVDTFQR 90  Natronomonas ph...

3CMN_A        93 LFRPIEEMYEKnggGR-GA---LGVLMNDVSSK-LLGVQIGGLLGYLAQRVLGQYDLS--------L------LSA--EA 151 Chloroflexus au...
WP_012120773 118 LFAPLEELYDEvsaRQ-GM---VGILIGQLNSQ-LIGMQVGALIGFLARRVLGQYDLGl-------L------SPD--PD 177 Roseiflexus cas...
WP_011562154  90 MTG-----------GT-DR---PSNF---LTGR-VTGAQTGAVLAFVSSGILGQYDPFataggqerS------DPG--NG 142 Mycobacterium
WP_011206916 103 LTGT----------GA-QA---DTGFKGRLAGK-PAGVQAGAMLAFLSTAILGQYDPF--------------------TG 147 Nocardia farcinica
WP_003419571  89 MTH-----------GS-AK---PRGF---LTGR-ITGAQTGAVLAFVASGILGQYDPF-----------------G--AA 130 Mycobacterium t...
WP_009477472  89 LTG-----------GD-AA---PGTLV----GK-PAGIQAGAMLAYLSSAILGQYDPF--------------------TG 128 Rhodococcus sp....
WP_012642250 113 VLRPLEVVIQL---PE-QPlarAAAVLWAHAGRsAATMEVGMALGFLSRRVLGQYDIAv-------L------GGE--PT 173 Thermomicrobium...
WP_011564948  76 LMEPVLRK------AA-RN---AGNLTWALGGV-TLTAQMGLLLGFLSARVLGQYDTGp-------L------LARkrAG 131 Rubrobacter xyl...
WP_011572147  93 MLDPIDIATLI---DDtNA---LNGPSGYATRM-VNTGSMAAALAFLSGNVLGQYDPQl-------LsqttdtIET--NE 156 Haloquadratum w...
WP_011323858  91 LLGPLEAQV---------------SATPSLART-ANTGSMAVTLGFLARNVLGQYDPLl-------L------G-----D 136 Natronomonas ph...

3CMN_A       152 TGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFALVSGQMLSSGNSLVDMLMRL 231 Chloroflexus au...
WP_012120773 178 LRGALYFVEPNIARICAQLGLNGDDFRMWIALHETTHVFEFEAFPWVRAYFQDLLRQFIGRVNDQAAMLSVGIVRLIERL 257 Roseiflexus cas...
WP_011562154 143 PSGELLLVWPNVIAVERQLRVSPTDFRLWVCLHEVTHRVQFGANPWLADHMSSALAVLTKDAGEDVTEVAGRLADYVRNR 222 Mycobacterium
WP_011206916 148 PDGTLLLVAPNIMAVERALGVSPTDFRFWVCLHEVTHRVQFSSAPWLADYMRSNVDVLGEVGEEPLAEMLSRLVAEVRER 227 Nocardia farcinica
WP_003419571 131 GEGCLLLVYPNVIAVERQLRVEPSDFRLWVCLHEVTHRVQFTANPWLSGYMSQALNLLTFEPVDDIGRVVSRLADFIRSR 210 Mycobacterium t...
WP_009477472 129 DNGTLLLVAPNVVSVERTLRVRPSDFRLWVCLHEVTHRVQFSSSPWLTGYMQESVETLGSAEDESVTDMVGRLSSALRAR 208 Rhodococcus sp....
WP_012642250 174 AAGKLYFVEPNIRWLIRNWRLPEHDFYRWLVLHEVTHAFEFESSPWLRDHVNGLLRQWVEALRHE-GKLFHRVIEILRTA 252 Thermomicrobium...
WP_011564948 132 RPGKVFFLDGNIAAAAARLGVPPDGLRLWIVLHEMTHALQFEGYPWLRVHLGGLLERLLAPLAERVG-AVETVRRVVENL 210 Rubrobacter xyl...
WP_011572147 157 NNHELYFVHPNIVDVAAELDVEYPRFRRWIAFHEVAHAAEFGAAPWLRTHIEDRIE------------------------ 212 Haloquadratum w...
WP_011323858 137 DDHELYFVHPNIEAVADALEVDRDRFRRWIAFHEVAHAAEFGSAPWLADHLESQMEA----------------------- 193 Natronomonas ph...

3CMN_A       232 LQ------GIGSG-------Q------HW---IETVLTPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQI-EQ 288 Chloroflexus au...
WP_012120773 258 LQ------GQPId-------H------HW---IELMLTPEQREIFTRMQALMSVVEGYSNHIMNAIGAQLLPSYPSI-EA 314 Roseiflexus cas...
WP_011562154 223 RA------HTDAHs------T------GVlglMRAMQAEPQRRALDQLLVLGTLLEGHADHVMDAVGPAVVPSVATI-RA 283 Mycobacterium
WP_011206916 228 RR------GGVPDd------PanrgviGL---LRATQAPPQREALDRLLMLGTLLEGHADHVMDAVGPAVIPTVAQI-RA 291 Nocardia farcinica
WP_003419571 211 GH------GTDDSevnpsgiL------GL---VRAVQSEPQRKALDQLLVLGTLLEGHAEHVMDAVGPMVVPSVATIrRR 275 Mycobacterium t...
WP_009477472 209 GRtepdesGAPGGi------V------GL---LRAAQAEPQREALDRLLVLGTLLEGHADHVMDAVGPAVVPSVAAI-RA 272 Rhodococcus sp....
WP_012642250 253 RR------GDWTAd------T------TW---MELLMSTEQRRLFRQLQAIMAVIEGYSNYVMREVGREIVESYPLI-ER 310 Thermomicrobium...
WP_011564948 211 RT------GGRS--------------------LELVMSREQREAFDRMQAAMSVVEGYSDYVMHRVGSRMVPGYGHL-TR 263 Rubrobacter xyl...
WP_011572147 213 --------------------S------GL---EALTGGRLDRSAFSDVDIVMTAVEGYAELLMD---RAFDKEYADL-RA 259 Haloquadratum w...
WP_011323858 194 ---------------------------AV---SDLASGSLDRDALGELNVTMTAVEGYAELVMD---RAFDDEYADL-RA 239 Natronomonas ph...

3CMN_A       289 QIAQRQ-R-Q-RTMLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMD 363 Chloroflexus aura...
WP_012120773 315 RVRQRQ-L-R-RPLIEEAFNRITGMDLKLAQYQQGEAFINAVVAACGADFANRIWERPENLPTMDEIRAPHRWIARMS 389 Roseiflexus caste...
WP_011562154 284 RFNQRReR-K-QPPVQRILRALLGVDAKISQYTRGKAFVDHVVAKVGMERFNTVWSGPETLPLPTEVDEPQRWIDRVL 359 Mycobacterium
WP_011206916 292 AFDKRR-Q-RpANPIQRILRALLGVDAKVAQYVRGKAFVDHVVGRVGMASFNTVWTDAETLPRTDEIEDPDRWIARVL 367 Nocardia farcinica
WP_003419571 276 FDDRRH-H-K-QPPLQRLVRALLGFDAKLSQYTRGKAFVDHVVDRAGMKLFNTIWSGPETLPLPAEIENPQRWIDRVL 350 Mycobacterium tub...
WP_009477472 273 AFDQRR-RrK-SNPVQRLIRALLGMDAKMAQYVRGKAFVDAVVDRVGMDRFNVVWTGPDTLPRLAEIDAPDAWVSRVL 348 Rhodococcus sp. JVH1
WP_012642250 311 RFEERE-R-A-RTPAERLLLRLTGLDMKLEQYRRGEGFCRAIADRMGREAFAVLWRGPEWLPTYEELAEPDSWISRVT 385 Thermomicrobium r...
WP_011564948 264 RMALSR-L-H-RPPLESAVFRITGLDMKLEQYRLGESFAAAVARRQGMEGLNRVWERPENLPSLRELRDPGLWMLRME 338 Rubrobacter xylan...
WP_011572147 260 KLDARR-G-G-GGPVAQLFRRLLGLGVKERQYERGAQFFETIADQRGVKAAATVWEDPRYLPDESELDNPQYWIDRVN 334 Haloquadratum wal...
WP_011323858 240 KLDARR-Q-E-AGPVSRLVRRLLGFGMKRRQYERGKAFFDAIADERGVAGAAAVWEHPENLPTDDELDAPEAWLARVD 314 Natronomonas phar...
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