3QN0


Conserved Protein Domain Family
queuosine_QueD
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TIGR03367: queuosine_QueD 
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queuosine biosynthesis protein QueD
Members of this protein family, closely related to eukaryotic 6-pyruvoyl tetrahydrobiopterin synthase enzymes, are the QueD protein of queuosine biosynthesis. Queuosine is a hypermodified base in the wobble position of tRNAs for Tyr, His, Asp, and Asn in many species. This modification, although widespread, appears not to be important for viability. The queuosine precursor made by this enzyme may be converted instead to archeaosine as in some Archaea. [Protein synthesis, tRNA and rRNA base modification]
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Statistics
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PSSM-Id: 274547
Aligned: 36 rows
Threshold Bit Score: 94.1893
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3QN0_A        26 LFKDFTFEAAHRLPHV-P-EghKCGRLHGHSFMVRLEITGEVD---PHTG--WIIDFAELKAAFKP-TYERLDHHYLND- 96  Escherichia col...
WP_010877947   7 IGISTSFSAAHSIPGH-K----KCGKVHGHNFKVEVEISGKV----KENG--MVMDFFDLKRIVNE-VVAKFDHTLLNE- 73  Archaeoglobus f...
WP_010898399  17 LNKDMHLAAAHFIPAK-DaG--KCQDVHGHTYFINVTIAGDEL---DKTG--FLVDFKQLKTI----VHKRYDHTLLND- 83  Bacillus halodu...
WP_014113589  17 LNKDMHISAAHFIPREsA-G--ACSRVHGHTYTVNITVAGDEL---DDSG--FLVNFSVLKKL----VHGNYDHTLLND- 83  Bacillus subtilis
WP_011499336   6 LGIIEYIDSAHYLPEH-E----TCGIVHGHTYKIEVVLEGEK----QENG--MVMDFYIIKKIVKE-ILKTYDHKLLND- 72  Methanococcoide...
KDE48567      17 LNKDMHIAAAHFIPHE-AaG--SCANVHGHTYIVNVTVAGDEL---DESG--FLVNFQTLKQL----VHRKLDHTLLNDh 84  Geobacillus sp....
WP_015411330   6 LGVIDYIDSAHYLPGH---G--KCGRVHGHTYKIEVVVE-GEV---RENG--MVIDFYDLKKGIKE-TLQEYDHTLLND- 72  Methanosarcina ...
WP_011224065  24 gdRPLRISAGHRLLHH-D-G--KCSRPHGHNYEVTVRVTGELT---DE-G--WVVDKGEITD-----VIDEWDHRFLLEa 88  Haloarcula mari...
WP_011312696   3 ITRRLEFDAGHRIPNH-G-S--QCRHLHGHRYALEITLAGAIVateGAREqgMVMDFSDVKAIAREvLVDRWDHAFLVYe 78  Thiobacillus de...
WP_004189793   3 ITRKLEFDAGHRIPDH-R-S--QCRNLHGHRYVLEITLRGDLVeteGAPDrgMVMDFADVKALAMEhLVSKWDHAFLVYa 78  pseudomallei group

3QN0_A        97 ------------------IPGL------E--NPTSEVLAKWIWDQV 116 Escherichia coli BL21(DE3)
WP_010877947  74 --------------------QI------E--IPTSENICLRIFSEL 91  Archaeoglobus fulgidus
WP_010898399  84 ------------------HDEF------KgtFPTTEMVAKTIYERI 105 Bacillus halodurans
WP_014113589  84 ------------------HEDFsqddryS--LPTTEVVAKTIYDNV 109 Bacillus subtilis
WP_011499336  73 ------------------VLPF----------PSAENICEHMHGQL 90  Methanococcoides burtonii
KDE48567      85 sdw------------fdgHDPN------R--FPTSEVVARTIYETI 110 Geobacillus sp. CAMR12739
WP_015411330  73 ------------------ILDF----------PSSEHLCQHIHSRL 90  Methanosarcina mazei
WP_011224065  89 gdplveafdssgdgdavvVLDH------P---PTAEVMAAILEQRL 125 Haloarcula marismortui
WP_011312696  79 gdrvvvdllaalpehktvVLPV---------VPTAEHLAEEAFRVL 115 Thiobacillus denitrificans
WP_004189793  79 rdeivrsflekmadhktvVLDR---------IPTVENLAAIAFDIL 115 pseudomallei group
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