Conserved Protein Domain Family
HpnW_proposed

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TIGR03364: HpnW_proposed 
FAD dependent oxidoreductase TIGR03364
This clade of FAD dependent oxidoreductases (members of the pfam01266 family) is syntenically associated with a family of proposed phosphonatase-like enzymes (TIGR03351) and is also found (less frequently) in association with phosphonate transporter components. A likely role for this enzyme involves the oxidative deamination of an aminophosphonate differring slightly from 2-aminoethylphosphonate, possibly 1-hydroxy-2-aminoethylphosphonate (see the comments for TIGR03351). Many members of the larger FAD dependent oxidoreductase family act as amino acid oxidative deaminases.
Statistics
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PSSM-Id: 132407
View PSSM: TIGR03364
Aligned: 13 rows
Threshold Bit Score: 397.826
Threshold Setting Gi: 499523419
Created: 8-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ZP_00380829    4 TDLIIVGSGILGLATAFRAHRQGRSVRVIDRSARPVGSSIQNFGHACFTGQA-DdaQD-LAMASRDGWLEAAAAT-GIWA 80  Brevibacterium ...
ZP_01548640    6 YDLAIVGAGIVGLAHALAASRRGKSVIVIDRDSYANGASIRNFGFVTVTGQQaGdcWQ-KALRSRQVWAEVADAA-RIPL 83  Labrenzia aggre...
ZP_01619610    7 TEIAIVGAGIVGLAHALAAAKRGFKVTVFERNQQAVGASIRNFGMIWPIGQPqGllFN-RALKSREIWLEIAEKA-KFNT 84  Lyngbya sp. PCC...
ZP_01720816    5 PSAIVIGAGIVGLSITRALQSKGWKVRVIERHPQAQGASVRNFGMIWPIGQTlGpaYD-RALRAKEIWKEMSAKA-EFFA 82  Algoriphagus sp...
ZP_01060164    5 YDLLVVGGGVLGTFHAYHALNKGLRVAVLEQSSRPQGATTRNFGQVVPSGM--NtkWQnFGRESLAIYKAIQKEF-DITI 81  Leeuwenhoekiell...
WP_010052393   7 aDVAVVGAGIVGLAFAWEAARRGHSVVLFDRTPGPQGASVRNFGMVWPIGQLpGpaYD-RALRSRARWLELKERA-GLWV 84  Gemmata obscuri...
WP_011336413  15 NDLLIVGAGILGLSHAYAAARRGLKVTVFERTATPLGASVRNFGQALVTGQPpGpmLE-LAKASREIWGQWAQLA-GLQL 92  Pseudomonas flu...
WP_011120646  18 SDLIVVGAGVLGTFYAYHALRRGLKVTLVERNSKPMDATVRNFGQVVPSGLDrG--WQvHGRESLRIYQELQAQT-ELSV 94  Rhodopirellula ...
WP_010926326   4 YDVVVVGAGMLGIAHAWAAARRGLSVAVIERSQRAHGATIRNFGQVLVTGQApGvmAR-HARQSRELWLELAAGA-GFHV 81  Bordetella bron...
WP_011349428  20 ydvvvvgagivgLAHAYTAALKGLRVCVIERDAACVGASIRNFGFVTVTGQHaEhsWR-RARASREVWADVAPQA-GIDV 97  Burkholderia lata
WP_011596218   7 ydvvvvgagivgLAHAYHARNRGLSVAVIDHADRVAGASVQNFGHACITAQS-GvaRD-YARAGREHWLDLARKA-GFWS 83  Rhodococcus
WP_011773939  31 TDVVIVGAGIVGLAHAAHAVANGLTVTIIERDHHAAGASVRNFGHCCITAQS-GelYE-LAQTSRKYWLEFAERA-GFWA 107 Arthrobacter au...
WP_011210059   1 MRVTIIGGGILGTAHALAAVRRGHEVVQLEREPEARGATVRNFGLVWVSGRA-EheLA-TTLRSRELWEELGGKVpGIGF 78  Nocardia farcinica
ZP_00380829   81 AETGSFIPAMTEPELRVLQEFADHRGPDQ---ATMLSAEEVAAAIG-----------------NPSLGAIGGAHLPLDMR 140 Brevibacterium ...
ZP_01548640   84 LHEGLTMTAHLPESEAVIDAFLKTEMGAD---CQRLTPSEAALKVPr----------------LRQDKITCALYSPFEIR 144 Labrenzia aggre...
ZP_01619610   85 DSCGSLHTAYHPDELAVLEEFIATTGQQId-sVALLTPKEVTQKSAa----------------VKTEGLLGTLWSSTEVI 147 Lyngbya sp. PCC...
ZP_01720816   83 EETGSLHLAYTDLEMKVVEEYTAAMDGVKs--AKALSPTQVAALSPa----------------TKLEGLKGALWSADEMI 144 Algoriphagus sp...
ZP_01060164   82 RQNGSVYLASNAEEVQLIEELSDINKQNEy-sSTLLTKAQCLEKYPg----------------LRADYVKAGLFFPDEVT 144 Leeuwenhoekiell...
WP_010052393  85 SECGSLHVAHDDDEDALLREFAELARPGGi-rCEYLPRADALGRFPa----------------INPAGFRGALHSPTELA 147 Gemmata obscuri...
WP_011336413  93 KRNGSYLFARTEAEEHLLEAFCAGRAVEHdyrVELLRGAALRDLYG-----------------GQFSHHRAALHGMDDQQ 155 Pseudomonas flu...
WP_011120646  95 RQHGSVYLASDEEECTLIEELHRLNQEAEy-pSELLTPDRCRIKFPn----------------LRSDYCRGGLSFPQEVS 157 Rhodopirellula ...
WP_010926326  82 RANGSLVLARSALEQDVLEEFAAARLQAEgyrAELLSGRELARLFD-----------------GRLGHHCAALRGHDDLQ 144 Bordetella bron...
WP_011349428  98 LHKGLHLIARRPEAMHLIDAFMQTGMADG---CRVLTPGEAAAVAPe----------------LRLDGAQGVLHSPHELR 158 Burkholderia lata
WP_011596218  84 AESGTYCVARHDDELAVITEFAEVREPAE---VELLSRDRILGALP-----------------IVGDRVVGGMYMADDLQ 143 Rhodococcus
WP_011773939 108 SEAGAVVLARTEAEMNVLRELSAVREPGQ---VELLSPAATRARLGssasvteeahdgagtsgAAWPGLVGGAFLRDDLR 184 Arthrobacter au...
WP_011210059  79 RANGSITLVRTPEELAVAEAAAAGASADAr-gFRLLEPEQVRALNPa----------------LR-GTYLAGLHCATDAA 140 Nocardia farcinica
ZP_00380829  141 VDPREAAPALAEWLAGE-GVDFTWNTTVTEG--GDG-----TVSTNRGDV-H-G-EQVVVCPGYQLTSLFPEIAEAHGVR 209 Brevibacterium ...
ZP_01548640  145 VESRDALPRIANWLEEVhAVDFLWQTSVNSV--ETP-----KLETSRGTV-H-A-QTVIVCPGDDGTTLFSDRIAAYEVT 214 Labrenzia aggre...
ZP_01619610  148 VDPREAIAKIPAFLAAEyGVEFEWGTVVTQI--NYP-----QL-IAGGKT-WtA-DQIFVCSGRDFETLYPEVYAQSGIT 217 Lyngbya sp. PCC...
ZP_01720816  145 VDPREAVLKTAKYLNSLeDVEFIWNKAISRI--EGN-----TV-YSGKKS-WsA-DKVFVCSGADFETLYPEVFEATPIT 214 Algoriphagus sp...
ZP_01060164  145 VEPRTMIHRLQQYLVEQkRLDLFTNTKAVHL--ETLgd-qvEVTTAAGTA-FyA-AQVLICNGSDFKTLYPRLFAESDLQ 219 Leeuwenhoekiell...
WP_010052393 148 VNPPDTLARLPRFLAEAhGVQLRLGEAVTSV--DAP-----QVRTAAGDV-WrA-DRVFVCSGADFETLFPETFAASGIR 218 Gemmata obscuri...
WP_011336413 156 LYSREAIPALIEYLRRElKVEFHFSTLVCDV--EPG-----RLHSTAGIF-F-A-EQIIVCSGHDYQTLLAEPIAALDPQ 225 Pseudomonas flu...
WP_011120646 158 VNPRRMIHHLHDFLRTQsNFESRFETLIQHI--DPVrsdliHLQTSNGETlS-A-NKVVVCCGTEFQALFPENFRASEMK 233 Rhodopirellula ...
WP_010926326 145 IYSREALPAITAYLADRfGVEFLTATLASAV--REG-----VVQTSAGAL-R-G-RHAFVCPGHDYLTLAPELFAPLGLQ 214 Bordetella bron...
WP_011349428 159 IEPRTAIPQLAAWLAERfDVRFRYGEMVHEV--RTP-----TVRTSRGVV-H-A-ERVIVCGNADSRHLYGDWFARHKVR 228 Burkholderia lata
WP_011596218 144 VNPREAAPAIARWLGAs-GVDFFWRTAATGF--DTG-----VVHTSRGDL-H-A-ATVFVTVNYDIDRLFPEPAERGGLL 212 Rhodococcus
WP_011773939 185 ADPRTTVATLAEWLSQQpGVELHWNTAALGF--SQSpa-gvTVRTSRGEL-S-A-KQVFVCVGHDVDYLFPDLAEEHRIQ 258 Arthrobacter au...
WP_011210059 141 VESRQALPALRAYLTRTgRYTFHPATEARSVagSSA-----TVLDDHGRV-H-AgDLVLVCPGATHSGLVRELVGEIPVR 213 Nocardia farcinica
ZP_00380829  210 ICTLAMSLIERPQR-IPSGFAMLTGTSLARYDGFAAMPGASALREDlTEREPELVDVIANLMVTDIP-GGLLIGDSHAYD 287 Brevibacterium ...
ZP_01548640  215 RCKLQMLRVAPRQR-LDLGTAVMSDLGLARYLGYAELPEAAPLKARlDREMTDQRDNGIHLIVVQSEdGSLVVGDSHHYS 293 Labrenzia aggre...
ZP_01619610  218 KVKLQMMRTIPQPNqFKIGASLCGGLTLTHYAAFYQLQSLRALKDRiQAETPYFPEWGIHVMVSQNShGELIIGDSHEYG 297 Lyngbya sp. PCC...
ZP_01720816  215 KCKLQMMRLVQQPQdWRIGPPLCAGLSFIHYKGFEVAKSLPELKSIyQEQYPELLELGIHVMVSQNGlGELTIGDSHEYG 294 Algoriphagus sp...
ZP_01060164  220 LSKLQMMQTKPQHN-FELPGSILTGLSIRRYEAFYECPSFQAIKAQ-EDPKGLEKKWGVHMLFKQAAdGSVILGDSHEYA 297 Leeuwenhoekiell...
WP_010052393 219 RCKLQMMKTRPQPNgWRAGTHIAGGLTLCHYKAFELCSTLPALKARiAATMPEYVKYGIHVMAAQNDrGEVVIGDSHEYD 298 Gemmata obscuri...
WP_011336413 226 ICRLQMLRVRPQID-LNLQHALLTGLSCVHYGAFADLPEAAEVQAQiLREQPHLQANGIHLLISPTPyGELIIGDSHHYG 304 Pseudomonas flu...
WP_011120646 234 LCKLQMLRLSPQPQ-SVLPGNLLTGLSIRRYESFAECPSWNAIKAN-EPKDTFAHAWGLHILFKQESdGGIILGDSHEYT 311 Rhodopirellula ...
WP_010926326 215 VSCLQMLRVAFETRpFALDRPLLTGLSCVHYGAFSDLPTARTLRESlQRHEPDLLDNGIHLLVSPTPhGELIIGDSHRYG 294 Bordetella bron...
WP_011349428 229 LCQLQMLRVRPRRP-LALHAAVMSDLSLLRYSGFAALPAADALRTRlKAEEPVCLGYGIHLIAVQSAdGSLVVGDSHEYG 307 Burkholderia lata
WP_011596218 213 RCRLHMMRARIPLS-APLSAPLFTGWSLVRYSGFENLPATAAVAARlRDEYPDYVDLDLHQMYTPQPdGSILLGDTHIRE 291 Rhodococcus
WP_011773939 259 RCALQMSLAAKPAG-VEFAPAVLTATSMLRYPAFTDMPAAAALHSEvLENQPELLEIGANVMFTQRPdGTVILGDSHHYH 337 Arthrobacter au...
WP_011210059 214 RVRLQMMQTAPLGE--PLTTSIADGDSFRYYPGFAG-PAVEALERE-QSQAATAAEHKMQLLCVQRLhGGLTIGDTHEY- 288 Nocardia farcinica
ZP_00380829  288 LSPEP----FI---DARVGDLLLNRATSILGIDEPMVRQRWLGQYADS-T-ETNLILE-RPDARTTVAVVTSGIGMTLSF 357 Brevibacterium ...
ZP_01548640  294 ATPDP----FI---DKTVNDLILGEMETILDLGPYDISETWIGTYASA-P-DRWRFTD-APDDATRIVVVTAGCGASTAF 363 Labrenzia aggre...
ZP_01619610  298 LTPDP----FN---KAEINQYILDYLQTFVQVPSLEITETWNGVYAKI-P-GKTELIA-PVEKGVTLVNALSGAGMTLSF 367 Lyngbya sp. PCC...
ZP_01720816  295 LNLDP----FD---QNHINQLIIDFLKTFAQFKDWSIGSSWHGIYPKM-TnGAIDFVK-DIDDSVTIVNGMGGAGMTLSF 365 Algoriphagus sp...
ZP_01060164  298 DADKIedlgYDl--NMDIDNFMIAEAKKIFDLPTYEIQDRWYGIYSQC-K-TQDIFLK-DIDARIHVATGIGGKGMTGSA 372 Leeuwenhoekiell...
WP_010052393 299 ADISV----FD---KTEIDELILKEIRTMIDVPDWTIGARWHGIYAKH-P-EKHFVTH-EPHPGCVIAVAPGGLGMTMSF 368 Gemmata obscuri...
WP_011336413 305 SDPSP----FN---AEQVDNWMLELAEQTLGCK-VQVVERWQGVYGSR-G-PGPFSFL-RPAPGLSVALMHSGVGMSVGP 373 Pseudomonas flu...
WP_011120646 312 SADQPaelnFDi--RSDINNAILIEAKRIMDLPSWDVEASWHGVYSQT-ShPSGIHLE-TIFPNVHVTTGIGGKGMTSSA 387 Rhodopirellula ...
WP_010926326 295 VDALP----FN---DEQVDCAMLDLAQQALGCR-LRVIERWQGVYGAH-G-PAPFSVL-PVDDQTTVAVMHSGVGMTVGL 363 Bordetella bron...
WP_011349428 308 AAPLP----FA---TQEIDAQIVRLLHETLEMPELDIVERWTGSYPSA-A-DADCVIE-VPDDATRVVVVTSGAGMSTGF 377 Burkholderia lata
WP_011596218 292 ISAEP----FQ---SEKGFEVLIREAAALFGVSDVTVTERWQGVYSSA-P-DSEFLIE-EPIDGVHIVTVTTGIGMTTSM 361 Rhodococcus
WP_011773939 338 RTADP----FL---DEAVTTTLNAEITDRIGEP-LEIIQRWQGVYASS-D-VAPILVR-AIQPGVTVVSVTSGVGMTLSF 406 Arthrobacter au...
WP_011210059 289 --TEP----FAfdvDEAPYEHLTAVTEELLGRTLPPVVRRWAGVYSQSvD-PAAIVTRaRADEHVWVITGPGGRGMTLGP 361 Nocardia farcinica
ZP_00380829  358 GIADR 362 Brevibacterium linens BL2
ZP_01548640  364 AIGEE 368 Labrenzia aggregata IAM 12614
ZP_01619610  368 GLAEE 372 Lyngbya sp. PCC 8106
ZP_01720816  366 GLGEE 370 Algoriphagus sp. PR1
ZP_01060164  373 GFAKH 377 Leeuwenhoekiella blandensis MED217
WP_010052393 369 ALAED 373 Gemmata obscuriglobus
WP_011336413 374 AMAER 378 Pseudomonas fluorescens
WP_011120646 388 GFTQH 392 Rhodopirellula baltica
WP_010926326 364 AVGEN 368 Bordetella bronchiseptica
WP_011349428 378 GIAQD 382 Burkholderia lata
WP_011596218 362 GLAKD 366 Rhodococcus
WP_011773939 407 GLAHR 411 Arthrobacter aurescens
WP_011210059 362 ALGEE 366 Nocardia farcinica
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