Conserved Protein Domain Family
CoB_CoM_SS_C
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TIGR03290: CoB_CoM_SS_C 
CoB--CoM heterodisulfide reductase, subunit C
The last step in methanogenesis leaves two coenzymes of methanogenesis, CoM and CoB, linked by a disulfide bond. Members of this protein family are the C subunit of the enzyme that reduces the heterodisulfide to CoB-SH and CoM-SH. Similar enzyme complex subunits are found in various other species, but likely act on a different substrate.
Links
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Statistics
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PSSM-Id: 132333
Aligned: 7 rows
Threshold Bit Score: 237.733
Threshold Setting Gi: 499343390
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_011018943  38 VQACYQCGTCTGSCPSGRRTSYRTRLIMRKLQLGLVDEVIKSDELWMCTTCYTCYERCPRGVKIVDAVKAARNLAAKKGY 117 Methanopyrus ka...
O27906        32 LEYCFQCGTCTGSCPSGRRTPYRVRQIIRKANVGLKDEIISDPALWMCTTCYSCQERCPRKVKIVDVVKLARNEAAKAGF 111 Methanothermoba...
WP_011406601  32 LAICYQCGTCSGACPSGRRTPYMIRRLVRKALAGLKDQVISDDAIWMCTTCYECQERCPRDIKIVEIVKAIRNVAAHEGY 111 Methanosphaera ...
WP_010870249  32 FKACYQCGTCTGSCPSGRITAFRTRKLIRYAQFGMKSAIIDSEDLWMCTTCYECYERCPRTVKITDIIKVLRNIAAREGK 111 Methanocaldococ...
WP_010870379  33 IKACYQCGTCTGSCPSGRRTAYRTRKVLRKVLLGL-DDVLDSDDIWYCTTCYTCYERCPRDVKITEIIKTLRNIAAQKGN 111 Methanocaldococ...
WP_011448820  41 ANMCYQCGTCTGSCPSAPRSSYRIRLFMRRCVLGLENEALTDPDLWLCTTCYSCTDRCPRDIAPTDVIMAMRNLAFKRDI 120 Methanospirillu...
WP_011032929  16 VLSCMHCGTCTGSCPSGRHTGLNTRRIIRDARKN-RATVLSDDALWLCTTCYTCQERCPRGIPITDALLELRRLAVRKGF 94  Methanosarcina ...
O27906        32 LEYCFQCGTCTGSCPSGRRTPYRVRQIIRKANVGLKDEIISDPALWMCTTCYSCQERCPRKVKIVDVVKLARNEAAKAGF 111 Methanothermoba...
WP_011406601  32 LAICYQCGTCSGACPSGRRTPYMIRRLVRKALAGLKDQVISDDAIWMCTTCYECQERCPRDIKIVEIVKAIRNVAAHEGY 111 Methanosphaera ...
WP_010870249  32 FKACYQCGTCTGSCPSGRITAFRTRKLIRYAQFGMKSAIIDSEDLWMCTTCYECYERCPRTVKITDIIKVLRNIAAREGK 111 Methanocaldococ...
WP_010870379  33 IKACYQCGTCTGSCPSGRRTAYRTRKVLRKVLLGL-DDVLDSDDIWYCTTCYTCYERCPRDVKITEIIKTLRNIAAQKGN 111 Methanocaldococ...
WP_011448820  41 ANMCYQCGTCTGSCPSAPRSSYRIRLFMRRCVLGLENEALTDPDLWLCTTCYSCTDRCPRDIAPTDVIMAMRNLAFKRDI 120 Methanospirillu...
WP_011032929  16 VLSCMHCGTCTGSCPSGRHTGLNTRRIIRDARKN-RATVLSDDALWLCTTCYTCQERCPRGIPITDALLELRRLAVRKGF 94  Methanosarcina ...

WP_011018943 118 MAKAHRMVAMFVIKTGHAVPINDEIREVRKNIGLDEVPPTTHRYEEALEEVQKLVKINEFDKLI 181 Methanopyrus kandleri
O27906       112 MAPAHKAVGSFVIKTGHGVPINDATMELRKAVGLGELPPTTHQFPEALEEVQKIIKATGFDQLI 175 Methanothermobacter thermautotr...
WP_011406601 112 MALSHKKTGSFVAKTGHAVPINDKVKTLRKEIGLDEVPATTHKFPEALEEVQTLIKATGFDELI 175 Methanosphaera stadtmanae
WP_010870249 112 MAEAHKKTALYVFKTGHAVPINDQIKKARKEIGLTEIPPTTHKYPDALEVVRGIMKDLRFCDMV 175 Methanocaldococcus jannaschii
WP_010870379 112 MALAHRKTASYVLRFGHAVPANNQIVELRGKLGLPAKSPTAQFSEKDLEEVRTLIKELKFDKLI 175 Methanocaldococcus jannaschii
WP_011448820 121 VPKNFLQTVQLIYNSGHGVPNNDVNRAARTKLGLPADPPTTHSYPEFVKGIQKIIDHYELKENA 184 Methanospirillum hungatei
WP_011032929  95 MRPEHRRVSELVLECGHAVPLDEETKKKREELGLDPIPETVQKYPEALEELKALLKTCKFDELA 158 Methanosarcina mazei
O27906       112 MAPAHKAVGSFVIKTGHGVPINDATMELRKAVGLGELPPTTHQFPEALEEVQKIIKATGFDQLI 175 Methanothermobacter thermautotr...
WP_011406601 112 MALSHKKTGSFVAKTGHAVPINDKVKTLRKEIGLDEVPATTHKFPEALEEVQTLIKATGFDELI 175 Methanosphaera stadtmanae
WP_010870249 112 MAEAHKKTALYVFKTGHAVPINDQIKKARKEIGLTEIPPTTHKYPDALEVVRGIMKDLRFCDMV 175 Methanocaldococcus jannaschii
WP_010870379 112 MALAHRKTASYVLRFGHAVPANNQIVELRGKLGLPAKSPTAQFSEKDLEEVRTLIKELKFDKLI 175 Methanocaldococcus jannaschii
WP_011448820 121 VPKNFLQTVQLIYNSGHGVPNNDVNRAARTKLGLPADPPTTHSYPEFVKGIQKIIDHYELKENA 184 Methanospirillum hungatei
WP_011032929  95 MRPEHRRVSELVLECGHAVPLDEETKKKREELGLDPIPETVQKYPEALEELKALLKTCKFDELA 158 Methanosarcina mazei
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