Conserved Protein Domain Family
thy_syn_methano

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TIGR03283: thy_syn_methano 
thymidylate synthase, methanogen type
Thymidylate synthase makes dTMP for DNA synthesis, and is among the most widely distributed of all enzymes. Members of this protein family are encoded within a completed genome sequence if and only if that species is one of the methanogenenic archaea. In these species, tetrahydromethanopterin replaces tetrahydrofolate, The member from Methanobacterium thermoautotrophicum was shown to behave as a thymidylate synthase based on similar side reactions (the exchange of a characteristic proton with water), although the full reaction was not reconstituted. Partial sequence data showed no similarity to known thymidylate synthases simply because the region sequenced was from a distinctive N-terminal region not found in other thymidylate synthases. Members of this protein family appear, therefore, to a novel, tetrahydromethanopterin-dependent thymidylate synthase. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Statistics
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PSSM-Id: 132326
View PSSM: TIGR03283
Aligned: 6 rows
Threshold Bit Score: 277.393
Threshold Setting Gi: 499768046
Created: 8-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011448780   2 ILIRKRSIGQAHEEVIREIARrcEGQVRVTEDGEYTWDPEEPIcIHVEEPFAE---------------PMRSGASLFGEK 66  Methanospirillu...
WP_011406813   3 KFIRTNSISQAWLTCVKKIMQ--EGHEVTDERGSLTKELQNVI-LEITNPNDN---------------TIPECSPWHDDR 64  Methanosphaera ...
WP_010876412   8 YSIEVNEIADGWKKLVEKIMH--DGREIRDERGSLTREVMNTV-VTIKKPLGKsddfyhirrgsllniKVPEGYFWSGEK 84  Methanothermoba...
WP_015411679   9 RIIRAKNISDAWYRGLNIIWN--HGRVITDERGSQIKEFMDLM-VVIENPYTD---------------RIPADTAWNEER 70  Methanosarcina ...
WP_010870012   2 LCIKKPSVASAFNELIPKILK--DGEVVETEFEERTKEIRNTI-IEITNPKLK---------------KVPEKYPLGEKA 63  Methanocaldococ...
WP_011019738   8 LVVRGRTVEQVWRQAVTGIKV--HGEKVERERGP-VKEVRGLI-AHLEPSGPEs-------------fDIPDDYPLDEHS 70  Methanopyrus ka...
WP_011448780  67 FsEQYQASLytITPRR-DDgtdAVYTYGNRLRDYpkaevgivskhggavkkaidalfrklgyvpadacgeliwkgdgryG 145 Methanospirillu...
WP_011406813  65 L-ETYKKEL--LDPDNeQG---FVYTYGNRLRQY---------------------------------------------F 93  Methanosphaera ...
WP_010876412  85 L-EKYSEQF--LSGDR-KG---FVYTYGNRLRAH---------------------------------------------F 112 Methanothermoba...
WP_015411679  71 L-EEYAKQL--ISGENiQD---FEYTYGQRLRNW---------------------------------------------N 99  Methanosarcina ...
WP_010870012  64 V-EEYTKNL--LYGSK-NV---FSYDYHQRLFEYpy-----------------------------------------adE 95  Methanocaldococ...
WP_011019738  71 V-RAYEDQL--LDPEL-RG---FEYTYGHRLRRY---------------------------------------------F 98  Methanopyrus ka...
WP_011448780 146 G-IDQIqESIINRLIQNPESRRAISITWFPVQDITAD-----EPPCLQLVQCVIdKNNHLNLICVFRSNDMLSAWGQNAY 219 Methanospirillu...
WP_011406813  94 K-IDQI-DTCIEKLNNCPQSRRAIAITIDPIQDNKVD-----EIPCLQEIAFLI-RDNQLYMTDFFRSNDCGGATFPNLF 165 Methanosphaera ...
WP_010876412 113 G-VDQL-DEAIRRLKNCTESRRATMVTWDPPEDTASD-----EVPCMILVDFKI-RDGRLFTTALWRSHDIYGAWFPNAV 184 Methanothermoba...
WP_015411679 100 GeVDQI-EYVIEKLKESPTSRRATAVTWIPPVDTKVN-----EVPCMILDDFKI-RDEKVHLTTLFRSHDFGGAYPANLY 172 Methanosarcina ...
WP_010870012  96 K-INQI-DYIIEKLNQQKNSRRAVAITWNPKIDIEVSrdergSVPCLQLVQFLI-RNGKLYQTVIFRSNDALLAFVSNAI 172 Methanocaldococ...
WP_011019738  99 G-LDQV-TKIVERLSESNNTRRAIAVTWDPRRDLDEE-----EVPCLTALQLQSdGGSGLELHAFYRSWDVGKALVANMI 171 Methanopyrus ka...
WP_011448780 220 GLAHLQKFICEQINlkrknaeekVSQGWLETISISAHMYfHRDQLEL 266 Methanospirillum hungatei
WP_011406813 166 GIREVGYYVAKNTD---------TELVNMVHHAMSLHIY-EHDWDKC 202 Methanosphaera stadtmanae
WP_010876412 185 GLAYLADHVAAEVG---------VEVGHITIHSISAHIY-EVNFKEA 221 Methanothermobacter thermautotrophicus
WP_015411679 173 GLSKLLEYVAEKVG---------VEPGVITTVSISAHVY-DHDWDMV 209 Methanosarcina mazei
WP_010870012 173 GLITLGEYIAKKVG---------VGYGTYTHHAISMHIYvDRDFDYI 210 Methanocaldococcus jannaschii
WP_011019738 172 ALRRLQEHVAERAG---------LEPTTLTVYAANAHVY-EEDLPDL 208 Methanopyrus kandleri
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