3C90


Conserved Protein Domain Family
histidine_hisI
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TIGR03188: histidine_hisI 
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phosphoribosyl-ATP pyrophosphohydrolase
This enzyme, phosphoribosyl-ATP pyrophosphohydrolase, catalyses the second step in the histidine biosynthesis pathway. It often occurs as a fusion protein. This model a somewhat narrower scope than pfam01503, as some paralogs that appear to be functionally distinct are excluded from this model. [Amino acid biosynthesis, Histidine family]
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Statistics
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PSSM-Id: 274477
Aligned: 86 rows
Threshold Bit Score: 41.7039
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3C90_X         9 FEDLFAELGDRAR-----TRPADSTTVAALDGGVHALGKKLLEEAGEVWLAAeheSNDA-LAEEISQLLYWTQVLMISRG 82  Mycobacterium t...
Q6A7U7         5 FEELFAELAIKSQ-----TRPAGSGTVEELDRGVHAIGKKIVEEASEVWMAAeheGNER-LAEEICQEIYHLQVMMIKQG 78  Propionibacteri...
Q8FTD4         8 FDSLYEELLDRAQ-----NRPEGSGTVAALDKGVHHIGKKVIEEAGEVWIAAeyqSDEE-LAEEISQLMYWTQVMMVARG 81  Corynebacterium...
BAD81115     200 LYSLEDTISRRKEeivteGSGKPSWTKKLILD-NRLLCSKISEEAGELNQTLlenEDESrTISEMGDLLYHAMVLLRVKG 278 Japanese rice
P00815       245 LVGLESLLKQRLQ-----DAPEESYTRRLFND-SALLDAKIKEEAEELTEAKg----kKeLSWEAADLFYFALAKLVAND 314 Saccharomyces c...
XP_500110    288 ISCLEKTLQQRLQ-----NAPAGSYTKRLFDD-SDLLRAKIMEEAEELVEAKd----aEeVSWEAADLIYFAMVKVVKEG 357 Yarrowia lipoly...
O74712       293 LPKLDSTLQDRLE-----NAPEGSYTKRLFDD-EKLLIAKLKEELDELIEAKs----kEeIAWECADLVYFAMVWCIKHG 362 Candida albicans
P07685       300 LPKLEQTLISRKQ-----SAPEGSYTARLFSD-EKLVRAKIMEEAEELCTAQt----pQeIAFEAADLFYFALTRAVAAG 369 Neurospora cras...
XP_760121    307 LAKLEATLKHRLQ-----TAPAGSYTARLFND-ASLLGAKLREEAAELADANnn--dKKhVAFEAADLIYFALTKCVSAG 378 Ustilago maydis...
WP_011554225 109 LSALDDTLARRAApaerpDDAPPSYTRRLLED-RNLRLKKLGEEAAEL-VTAcadVDPSrAAEEAADVLYHVLVAVRPLG 186 Myxococcus xanthus

3C90_X        83 LSLDDVYRKL 92  Mycobacterium tuberculosis H37Rv
Q6A7U7        79 LSLDDVYKHL 88  Propionibacterium acnes KPA171202
Q8FTD4        82 IKPEDVYKNL 91  Corynebacterium efficiens YS-314
BAD81115     279 VRMEQVLEVL 288 Japanese rice
P00815       315 VSLKDVENNL 324 Saccharomyces cerevisiae S288c
XP_500110    358 VSWAQVMNNL 367 Yarrowia lipolytica CLIB122
O74712       363 VRLADIEKNL 372 Candida albicans
P07685       370 VTLADIERSL 379 Neurospora crassa OR74A
XP_760121    379 IGLEEIEASL 388 Ustilago maydis 521
WP_011554225 187 LSLDDVKAVL 196 Myxococcus xanthus
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