1M3S,1JEO


Conserved Protein Domain Family
RuMP_HxlB

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TIGR03127: RuMP_HxlB 
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6-phospho 3-hexuloisomerase
Members of this protein family are 6-phospho 3-hexuloisomerase (PHI), or the PHI domain of a fusion protein. This enzyme is part of the ribulose monophosphate (RuMP) pathway, which in one direction removes the toxic metabolite formaldehyde by assimilation into fructose-6-phosphate. In the other direction, in species lacking a complete pentose phosphate pathway, the RuMP pathway yields ribulose-5-phosphate, necessary for nucleotide biosynthesis, at the cost of also yielding formaldehyde. These latter species tend usually have a formaldehyde-activating enzyme to attach formaldehyde to the C1 carrier tetrahydromethanopterin.
Statistics
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PSSM-Id: 132171
View PSSM: TIGR03127
Aligned: 16 rows
Threshold Bit Score: 201.382
Threshold Setting Gi: 20150408
Created: 8-Oct-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1M3S_A         8 VAEILNELHNSAAYISNEEADQLADHIL------SSHQIFTAGAGRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGD 81  Bacillus subtilis
WP_011249430 219 MFDITDHIRSVAENLKLEQVRGLVDAMI------GANKIFIYGAGRSGLVGKAFAMRLMHLDFNVYVVGETITPAFEAGD 292 Thermococcus ko...
WP_010963719   4 LKDILGEITQVINNVNESEMDGVVDFIT------KNKRVFVCGEGRSGLIGKCFAMRLMHIGYTVYVVGETITPSIKADD 77  Clostridium ace...
WP_011303355   7 YRLILDEIDNTLSHVKDSEAETFLKQII------KAEQVFVSGKGRSGFVANSFAMRLNQLGKGAHVVGESTTPSITEKD 80  Staphylococcus ...
WP_011248193   8 AQACVEEISTVISCTKEEELAAIAQGFK------HARRIFISGDGRSGLMGKAIAMRLMHGGYEVYVVGETITPSIGKGD 81  Bacillus clausii
WP_011308058  16 MKMIAVNLSEIIDKLDREAIKLMIQKIL------EGERIFLMGAGRSGLVAKAFAMRLMHLGFSVYVVGETTTPAVRPED 89  Methanosarcina ...
WP_010962232   3 QKLIIDKISGILAATDAGYDAKLTAMLD------QASRIFVAGAGRSGLVAKFFAMRLMHGGYDVFVVGEIVTPSIRKGD 76  Methylococcus c...
WP_011773249  19 VSLILGEVADTASGIDYSQVSRLADKIN------GAERVFLTGAGRSGLALRMAAMRLMHLGKTVHVAGDTTTPAISAGD 92  Arthrobacter au...
WP_011693534  23 RDLVQDEIRAVSGRVDPVQVAALVTELR------LAGRIFVTGAGRSGLVLKMAAMRLMHLGLTVHVVGETTTPAISAGD 96  Arthrobacter sp...
WP_010978137   1 MFDIAEFVIRAAQMIKPEQVNKMVEVLTnfyynnRNGKVLVMGAGRSGLVGRAFAMRLLHLGYNAYVLGETIVPAIGEKD 80  Sulfolobus toko...
1M3S_A        82 LVIIGSGSGETKSLIHTAAKAKSLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSN----------GS---------Y 142 Bacillus subtilis
WP_011249430 293 LLIAISGSGETKSIVDAAQIAKEQGGKVVGITSYADSTLGKLADVVVEIPGRTKADVP----------TDyiarqmltqY 362 Thermococcus ko...
WP_010963719  78 VLFAISGSGETSMVLNLVRKSKDMGAHIIGITSREGSSLASASFKKIIVPGAVKGDKG----------TD---------K 138 Clostridium ace...
WP_011303355  81 LFVILSGSGSTEHLRLLADKAKAVGAEVVLLSTNPTSKIGELANAVIELPAGTKYDTE----------G----------- 139 Staphylococcus ...
WP_011248193  82 VLLLVSGSASGVAARQVIKKAKQAGAKVMLVTANRETEFGDLCETCLFVPAATKQRKP----------DE---------P 142 Bacillus clausii
WP_011308058  90 IVIAISGSGETHSIADLGKIVKDIGSTLITVTSKKESTLGRISDVTMILPSKTKNDSDtygylernirGG---------Y 160 Methanosarcina ...
WP_010962232  77 LLIVISGSGETETMLAFTKKAKEQGASIALISTRDSSSLGDLADSVFRIGSPELF--------------G---------K 133 Methylococcus c...
WP_011773249  93 LLVVASGSGTTSGVVKAAQTALAAGAQLAAITTNSTSPLAGLADAVVVITAAQKTDHV----------SN---------- 152 Arthrobacter au...
WP_011693534  97 LLLAASGSGTTPGVVKAAETAAGQGARVAAYTTDAGSPLAAVAAAVVLIPAARKTDH-----------GS---------A 156 Arthrobacter sp...
WP_010978137  81 IAIAISGSGRTKLILTAAEAAKEAKATLIAITSYSDSPIAKIADVVVEIPGRTKYSQN----------ED---------Y 141 Sulfolobus toko...
1M3S_A       143 KTIQ---------PMGSLFEQTLLLFYDAVILKLMEKKGLDSETMFTHHANLE 186 Bacillus subtilis
WP_011249430 363 KWIA---------PMGTLFEDSTMVFLDGIIALLMATFQKTEKDMKRKHATLE 406 Thermococcus kodakarensis
WP_010963719 139 KSIQ---------LLSSLFDQSVHIVMDALCLKLSYKDRIDNDAAIKNHSNLE 182 Clostridium acetobutylicum
WP_011303355 140 -SAQ---------PLGSLFEQASQVFLDSIVLDLMTEINVDEETMQQNHANLE 182 Staphylococcus saprophyticus
WP_011248193 143 KTIQ---------PLGNQFDQSIHLLLDAIVVKLTKEK---QAEMKARHANLE 183 Bacillus clausii
WP_011308058 161 KTMP---------PLGTSFEITSLIFLDSIISQLITLTGASEAELKSRHTNIE 204 Methanosarcina barkeri
WP_010962232 134 VVGM---------PMGTVFELSTLLFLEATISHIIHEKGIPEEEMRTRHANLE 177 Methylococcus capsulatus
WP_011773249 153 ISRQ---------YSGSLFEQSLFLVTEAVFHTLWGATDEPAEQLWLRHANLE 196 Arthrobacter aurescens
WP_011693534 157 VSRQ---------YSGSLFEQVLFTTTEAVFQSLWDEDAAAAEELWRRHANLE 200 Arthrobacter sp. FB24
WP_010978137 142 FARQilgiteplaPLGTLFEDTTQIFLDGVVAELMMKLKKTEDDLRVIHANIE 194 Sulfolobus tokodaii
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