4GVQ,1QLM


Conserved Protein Domain Family
one_C_mch

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TIGR03120: one_C_mch 
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methenyltetrahydromethanopterin cyclohydrolase
Members of this protein family are the enzyme methenyltetrahydromethanopterin cyclohydrolase, a key enzyme for tetrahydromethanopterin (H4MPT)-linked C1 transfer metabolism. [Central intermediary metabolism, One-carbon metabolism]
Statistics
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PSSM-Id: 274437
Aligned: 12 rows
Threshold Bit Score: 482.223
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4GVQ_A         3 SVNEIAAEIVEDMLDYEEELRIESKKLENGAIVVDCGVNVPGSYDAGIMYTQVCMGGLADV--DIVVDTiNDVPFAF-VT 79  Archaeoglobus f...
WP_011018995   2 SVNENALPLVERMIERAELLNVEVQELENGTTVIDCGVEAAGGFEAGLLFSEVCMGGLATV--ELTEFEhDGLCLPA-VQ 78  Methanopyrus ka...
WP_010962058   6 SVNAHSQPIVKYLITYADKLRLQIDRLPNGCTVIDAGIKVPGSLEAGRLIGEICMGGLGRI--TLTHTD-TFTKWPLtVN 82  Methylococcus c...
WP_011034564   3 SVNEMGSYVIEEMLDWSEDLKTEVIKLENGATIIDCGIKAEGGYEAGMYLARLCLADLADL--KYSTFDlNGIKWPA-IQ 79  Methanosarcina ...
WP_010871160   3 SVNKKALEIVNKMIENKEEINIDVIKLENGATVLDCGVNVPGSWKAGKLFTKICLGGLAHVgiSLSPCEcKGITLPY-VK 81  Methanocaldococ...
WP_011447494   3 SVNELALEIFDNLANYSEDFNVAYHELDNGAKIVDCGVSVPGGYAAGRAFTEICMGGLGEV--NFRMGQiKHVPMPF-IE 79  Methanospirillu...
WP_011449344   3 SVNTNALPVVLDMIRNAEILGIKVHSLENGATLIDCGVMENGCHEAGLQFLKVCAGGLIEP--TIVHQPiAGQIFPF-VH 79  Methanospirillu...
WP_010049337   2 TLNERAQLLADEVERNAARLRVHVAKVA-GARVIDCGGAVSGSLAAGLLMARVCLGDAGEV--EYVPCPiPELGGPA-VQ 77  Gemmata obscuri...
WP_011406814   4 SMNIAAKKIADKMVQDAEKLKVIPSTLSNGTSIIDCGVNAKGSIKGGELFTKVCLGGICDVgiSIPGDLsDIMAMPA-VK 82  Methanosphaera ...
WP_011121084  17 DLSRSASECFESLWNGAIGMRSLPLTIA-GARVLDAGVTCSGSLEAGLGLARLCLGDLANV--RYVPATaDDLVGLS-VT 92  Rhodopirellula ...
WP_003597572   9 SLNALAGPLVESLVADAAKLRLIVAQ-ENGARTVDAGANARGSIEAGRRIAEICLGGLGTV--TIAPIG-PVASWPYtVV 84  Methylobacteriu...
1QLM_A         3 SVNENALPLVERMIERAELLNVEVQELENGTTVIDCGVEAAGGFEAGLLFSEVCMGGLATV--ELTEFEhDGLCLPA-VQ 79  Methanopyrus ka...
4GVQ_A        80 EYTDHPAIACLGSQKAGWQIKVDK----YFAMGSGPARALALK--------PKKTYERIEYE---DDADVAVIALEANQL 144 Archaeoglobus f...
WP_011018995  79 VTTDHPAVSTLAAQKAGWQVQVGD----YFAMGSGPARALALK--------PKETYEEIDYE---DDADVAILCLESSEL 143 Methanopyrus ka...
WP_010962058  83 VHTSNPVIACLGSQYAGWSLSHGEgkdgFYALGSGPARAMATKikdgneepVEELYKELNYR---DKHTETAIVMEVDKV 159 Methylococcus c...
WP_011034564  80 VATDNPVIACMASQYAGWRISVGN----YFGMGSGPARALGLK--------PKELYEEIGYE---DDFEAAVLVMESDKL 144 Methanosarcina ...
WP_010871160  82 IKTSHPAIATLGAQKAGWAVKVGK----YFAMGSGPARALAKK--------PKKTYEEIGYE---DDADVAVLCLEASKL 146 Methanocaldococ...
WP_011447494  80 VSTDYPAISCLGAQKAGWTVKAGN----YFAMGSGPARALALK--------PKHTYEVIGYE---DESDDAVIALESDHL 144 Methanospirillu...
WP_011449344  80 LTVKHPIIACLGSQKAGWVIKRNR----FFAMGSGPARALALK--------PKGTYQAIQYY---DTSDVAIITLEAGML 144 Methanospirillu...
WP_010049337  78 VTTDDPVRACLASQYAGWQVKVGK----FYANGSGPMRALSAR---------EEIFQHIAGK---EESPFAVGVLETDRH 141 Gemmata obscuri...
WP_011406814  83 VKTDFPALTTLGSQKAGWKIDVNG----YYAIGSGPAQTHKFK--------DNNIYKITNYI---EDSDIAVITLEADKL 147 Methanosphaera ...
WP_011121084  93 IQTDHPVLSCLGGQYAGWPVSVAD----YFAMASGPMRCLRGK---------EAMLEQLHLSrqaTDDDFAVGVLESDTL 159 Rhodopirellula ...
WP_003597572  85 VHSADPVLACLGSQYAGWSLADEEgdsgFFALGSGPGRAVAV---------VEELYKELGYR---DNATTTALVLESGSA 152 Methylobacteriu...
1QLM_A        80 VTTDHPAVSTLAAQKAGWQVQVGD----YFAMGSGPARALALK--------PKETYEEIDYE---DDADVAILCLESSEL 144 Methanopyrus ka...
4GVQ_A       145 PDEKVMEFIAKECDVDPENVYALVAPTASIVGSVQISGRIVETAIFK-M-NEIGYDPKLIVSGAGRCPISPI--LENDLK 220 Archaeoglobus f...
WP_011018995 144 PDEDVAEHVADECGVDPENLYLLVAPTASIVGSVQVSARVVETGLYKlL-EVLEYDVTRVKYATGTAPIAPV--ADDDGE 220 Methanopyrus ka...
WP_010962058 160 PPVEVTDKIARACKLDPSHLTVILTPTSSLAGGMQVVARVLEVALHK-A-HALHFPLENIIDGTGCAPVPPP--HPNFIK 235 Methylococcus c...
WP_011034564 145 PDEKVVEYIAKHCSVDPENVMIAVAPTASIAGSVQISARVVETGIHK-F-ESIGFDINCIKSGYGIAPIAPI--VGNDVQ 220 Methanosarcina ...
WP_010871160 147 PNEEVAEYVAKECGVEVENVYLLVAPTASLVGSIQISGRVVENGTYK-MlEVLEFDVNKVKYAAGLAPIAPI--IGDDFA 223 Methanocaldococ...
WP_011447494 145 PNGEVMEKIAKDCGIDVENLCAVVAPTASLVGSIQVCGRCVETAVYK-L-NELGFDTRKITAAMGTAPIPPV--KADATK 220 Methanospirillu...
WP_011449344 145 PDAEVCEYIADKCGVKPSCLYALVASTRSIVGSIQISGRIVTMAMHK-L-EDMGYDLSNIVNAAGRSPVAPV--KRTFEQ 220 Methanospirillu...
WP_010049337 142 PTDEVVANIVAKLPLVAEHLTLLVAPTQSLAGTTQIVARSVETALHK-L-HELKFDVTQVVSGYGVAPLPPT--TPDFVQ 217 Gemmata obscuri...
WP_011406814 148 PDEDIANYIADECGVKPENLTILVAPTSSLVGSIQISGRALETGIYK-MyEIMNFDVTKITYAAGITPITPV--DPDSLK 224 Methanosphaera ...
WP_011121084 160 PGEDVIEAMADECGVDPSRLCLAVAPSTSIAGSAQVVSRSVETALHK-L-HALEFDVTRVVSAHGDAPLPPPakKGDTIG 237 Rhodopirellula ...
WP_003597572 153 PPASVVNKVAAATGLAPENVTFIYAPTQSLAGSTQVVARVLEVALHK-A-HTVGFDLHKILDGIGSAPLSPP--HPDFIQ 228 Methylobacteriu...
1QLM_A       145 PDEDVAEHVADECGVDPENLYLLVAPTASIVGSVQVSARVVETGLYKlL-EVLEYDVTRVKYATGTAPIAPV--ADDDGE 221 Methanopyrus ka...
4GVQ_A       221 AMGSTNDSMMYYGSVFLTVKk------YDEILKNVPSCTSRDYGKPFYEIFKAANYDFYKIDPNL-FAPAQIAVNDLETG 293 Archaeoglobus f...
WP_011018995 221 AMGRTNDCILYGGTVYLYVEgd---deLPEVVEELPSEASEDYGKPFMKIFEEADYDFYKIDPGV-FAPARVVVNDLSTG 296 Methanopyrus ka...
WP_010962058 236 AMGRTNDAILFGGRVHLFVKgsd--eaAETLANELPSSVSRDYGKPFAEVFKEYKYDFFKVDAML-FSPASVIVTTVDSG 312 Methylococcus c...
WP_011034564 221 CMGSTNDCVIYCGETNYTVSfegelakLEDFVRKVPSTTSDDFGKPFYQTFKAANFDFFKVDAGM-FAPARVTVNDLKNK 299 Methanosarcina ...
WP_010871160 224 MMGATNDMVLYGGITYYYIKsde-nddIESLCKALPSCASKDYGKPFMEVFKAADYDFYKIDKGM-FAPAVVVINDMTTG 301 Methanocaldococ...
WP_011447494 221 AMGTTNDATIYHGQISLTMKap----dIVDFLEKIPSNKSKGYGKPFYEIFKEANFDFYQIDTSL-FSPAEVTINELTEG 295 Methanospirillu...
WP_011449344 221 AMGVTNDCNIYYGSVIISTRfys--ddFSR----ITSDNSEMYGRPFYELFRNANYDIVNIGSYLgFSPAELTVNDCTTG 294 Methanospirillu...
WP_010049337 218 AMGRTNDAILYGAKVVLWVRadd--evLERMGPKVPSSSSKDHGKPFADVFTHYKGDFYQIDPLL-FSPAEVEFRNLKTG 294 Gemmata obscuri...
WP_011406814 225 AMGKTNDAIMFGGRAYYYIEpde-gedLEELAANLPSSASDNYGQSFIELFKEANQDFYKMPKDI-FAPAQVIVNDMITG 302 Methanosphaera ...
WP_011121084 238 GIGRTNDAMLYGARVTLWVDaed--daIDSVASKVPSQSSDDHGRPFAEIFKQYEYDFYQVDPML-FSPAVVTIHSLQSG 314 Rhodopirellula ...
WP_003597572 229 AMGRTNDAIIYGGRVQLFVDadd--adAKQLAEQIPSTTSADHGAPFAEIFSRVNGDFYKIDGAL-FSPAEAIVTSVKTG 305 Methylobacteriu...
1QLM_A       222 AMGRTNDCILYGGTVYLYVEgd---deLPEVVEELPSEASEDYGKPFMKIFEEADYDFYKIDPGV-FAPARVVVNDLSTG 297 Methanopyrus ka...
4GVQ_A       294 KTYVHGKLNAEVLFQSYQ 311 Archaeoglobus fulgidus DSM 4304
WP_011018995 297 KTYTAGEINVDVLKESFG 314 Methanopyrus kandleri
WP_010962058 313 RSFHAGEVDVELLERSFG 330 Methylococcus capsulatus
WP_011034564 300 KTISSGGLYPEILLESFG 317 Methanosarcina mazei
WP_010871160 302 KVYRAGKVNAEVLKKSLG 319 Methanocaldococcus jannaschii
WP_011447494 296 KVYHVGEVNPDVTLKSFG 313 Methanospirillum hungatei
WP_011449344 295 KIYHFGRLNEEVLLESFQ 312 Methanospirillum hungatei
WP_010049337 295 RCHQFGGVEPGLLRRSFG 312 Gemmata obscuriglobus
WP_011406814 303 QMFHTGFIDLKRLKKSFE 320 Methanosphaera stadtmanae
WP_011121084 315 RTWRHGQISIDVMRKSFG 332 Rhodopirellula baltica
WP_003597572 306 KSFRGGRLEPQLVDASFv 323 Methylobacterium extorquens
1QLM_A       298 KTYTAGEINVDVLKESFs 315 Methanopyrus kandleri
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