Conserved Protein Domain Family
TIGR02680
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TIGR02680: TIGR02680 
TIGR02680 family protein
Members of this protein family belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). Proteins in this family average over 1400 amino acids in length. [Hypothetical proteins, Conserved]
Links
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Statistics
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PSSM-Id: 274256
Aligned: 6 rows
Threshold Bit Score: 1286.29
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Download Cn3D
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
BAC74935        9 RYRLHRAGIRNVWQYDEQEFAFGEGRLLLRGKNGAGKSKALEMLLPYLLDGDAR--ALDATGTGRTTLAWLMLDGf---E 83   Streptomyces ...
CAD17421       16 RWQPLRLGLVELFHYDSEEFWFRDGRLLLRGNNGTGKSKVLSLTLPFLFDAYLKpsRIEPDGDASKKMAWNLLLG----R 91   Ralstonia sol...
CAI09884       24 RWQPLRLGLVELFHYDSEEFWFRDGHLLLRGNNGTGKSKVLSLTLPFLFDAQLKpsRIEPDGDAGKKMAWNLLLG----K 99   Aromatoleum a...
BAD59285       24 RWKPLRAGLADLFYYDNQEFRFRDGRLLLRGNNGAGKSKVLALLLPFLLDGELAphRVEPDADSRKRMEWNLLLGge-hP 102  Nocardia farc...
BAD74604        4 PWVLHRAGLINFWYYDEQYFHFADGKLLLRGSNGAGKSVTMQSLIPVLLDGKKTpdRLDPFGSRARRMEDYLLGEkdvvN 83   Geobacillus k...
WP_009995335   30 RWRPHRAGILNVWRYYDETFTFHQGRLLLRGQNGTGKSKALELLLPFLFDASLRpnRLSTFGGSERTMHWNLLGQg--aS 107  Streptomyces ...

BAC74935       84 QTNRLGYLWLEFVRTDDEENDHHLTIGAAVRASRSTKTAKPIFFTTRLRVGKDV---DLAPAG---RPLPVDQLKSLVGP 157  Streptomyces ...
CAD17421       92 HERRIGYAWVEFGRVDEDGRHHYLTLGSGLSAVAARGQVDTWFFMLDERRINQDf-wLMSPTR---VVLTRDRLREALQD 167  Ralstonia sol...
CAI09884      100 LDRRIGYAWIEFGRIADDGEAHYLTLGCGLSAAAARAQVDAWFFVLEKRRIGEDl-wLTSPAR---NVLTRERLKEALHE 175  Aromatoleum a...
BAD59285      103 HSERVGYTWLEFGRVEADGTELFCTIGCGLKAVASRGIAAHWYFVSSAR-MGVGl-rVLDDQG---YPVSRDRLGEQLVG 177  Nocardia farc...
BAD74604       84 RDERTGYLFLEYKRKESD---QYVTTGIGLRAKRQKSLDFWGFVLFDNRRIGYDlqlYKQEKTgekIPLTKRELATALGA 160  Geobacillus k...
WP_009995335  108 GKTRVGYVWMEFRRVGDDGAEHWFGCGARLHASGHTTTAHADYFTTIARIAHPDgvhLVNDTG---QPLTKAALTEALRD 184  Streptomyces ...

BAC74935      158 E-NVTDRAVEHRARVARELFGlTDSARYRNLLHLLHRLRRPTIGDRIDSGGLVSVLAETLPALDDEVVEQVARSLDDLDS 236  Streptomyces ...
CAD17421      168 CgQFFDTAAPYRRAVDERLFR-LGSTRYAALIDTLIQLRQPQLSKKPDEASLSNALTEALPPISNDLLADVADALNQLEE 246  Ralstonia sol...
CAI09884      176 HgQMFDTATAYRRAVDERLFQ-LGAVRYAALMDTLVQLRQPQLSKKPDEGNLSDALTEALPPLSAELLTDVADALNQLEE 254  Aromatoleum a...
BAD59285      178 NgERYDTAGAYRRAVDEALFG-LGESRYGVLVDLLIRLRQPQLSKKPSEKVLSDALTESLPPIDQAILADVAEAFRSLQE 256  Nocardia farc...
BAD74604      161 GgTVVETQKDYMELVNKHVFRfESLEAFQELIELLIQLRSPKLSKDFKPTVIYEILESSLPPLTDDELRHLSDTIENMDQ 240  Geobacillus k...
WP_009995335  185 RgEVHPSATDYRTTVRRELFAgMGEQRYESLLSALLQLRQPKLSERLDPSLLSTLLSRALPPLGEGEITELAEGFERLDR 264  Streptomyces ...

BAC74935      237 VRAYLGRLERTDRALRTFLADYRGYLHGTLRRRTGRANGALEQLMEYRTFAGDATRNAEGLRERERELDARTEALEGEAS 316  Streptomyces ...
CAD17421      247 YRRELEEYEALERAVGQFNQRYQRYAATQARRQARNLRTAQTGFDNASRELNAAREALETTQAEEQHADQAWRQADTVLT 326  Ralstonia sol...
CAI09884      255 YRCELQDYEALAKAVGQFNQRYQRYAAINARRQARGLRSAQSGYDTASRSLNEARTDLQAAQHAEAQAQSRLDAAEAALL 334  Aromatoleum a...
BAD59285      257 DRDELADMQSALDGTRNFLTHYREYARTASRRRTTRLRQAHSRYERVGKDLGGAKDALATADDELRRLRADTRDAEDQRE 336  Nocardia farc...
BAD74604      241 AKQQLEQLERDERALKRLCDQYRLYNEYMIAEKATEYVKAVKQAEQLAAAQHRLHDEEEQARKTLDELDESITRLRREED 320  Geobacillus k...
WP_009995335  265 QRDHLDRLDAEVTAAENVASRQRAYARRVLRAGAAALISATTEMDDLTRDARVSAQEYEKACEERGSTLALREELDLRAH 344  Streptomyces ...

BAC74935      317 AAETDLAALHAGAGYRGVKELAEKRATVTALHSAAAAAFKAVRQAHSNQEEAGRRLTDESGRFGEELVELSTLQGELVRE 396  Streptomyces ...
CAD17421      327 TNRTRLEELQNDPAMADAKTLEKADADSRQRRKEANTARQTCYDMQTRLERERQATRTRAQRAEHAGRALAESREDAAQA 406  Ralstonia sol...
CAI09884      335 AGRTRLDQLQSDPAMKDANRLNQAERDAVARTADLADATRMSAEATARLEREQRALDERGARRTQAEESLATAREGVAAA 414  Aromatoleum a...
BAD59285      337 RLAEQRQALYDSSAAGAARELERARDQARDAQKLAADRAGDHTEAQQHYDAFRTRADEEQETLATTDTEFRAARQQAAHT 416  Nocardia farc...
BAD74604      321 VLRSREIDLAGHEVFQQAEKYEQLKSERERLQERWERHEQTIAEKERLERQHRRRLDESEARLDDLERKLEDELAQLRAD 400  Geobacillus k...
WP_009995335  345 ALDEIIEGLRESDAYQKGEELDRLRRGTEEQVAAAAELRTAARSAESDAEEDRKHADDVAGHARSCVEHARATADETNRS 424  Streptomyces ...

BAC74935      397 AERSGVDPVHLGEPVGTPAAPVAPARtaeltapegdfhlvrhsevlavdietcatalyAWDARLDAAQPVIRNRSRFVTE 476  Streptomyces ...
CAD17421      407 AERAGLSPAYSANPLACAGAHTLQPL--------------------------------ALDTARQDLRRASIERREQVAL 454  Ralstonia sol...
CAI09884      415 ALASGIGEPWRVNPLAALPAAELATLgd-----------------------------lPLDTARQDLRQVTQVRREQLAL 465  Aromatoleum a...
BAD59285      417 AAQALLTTAHTADIDAALDRQPLGET----------------------------------APLRRAADRIAALQSAAIKK 462  Nocardia farc...
BAD74604      401 AEEGAFSLHETNEDDFHRHRQKQQEFs--------------------------------FAAWKQEADRHIEQLEELARL 448  Geobacillus k...
WP_009995335  425 ARAAGMESIHHEVKTILDAEGEVKSLgngta-----------------------stpvRTGSRRSDAPGAAARRLLRGAV 481  Streptomyces ...

BAC74935      477 LRALMGRSDEAQREAQAADAARERLEEQADHARSGAEQrRQETVHEGEAYAAaaRAWTEQLRSLTGVPVDTAVSALAGHD 556  Streptomyces ...
CAD17421      455 LLRRCDEADHAEQTHARAQTQHDERADEAETAAARREE-ADTAVDRQGHTLL--DAWQRYLDGLRQLHCPDSADALEALA 531  Ralstonia sol...
CAI09884      466 VQRRVSEVAQAEATHAGRQQARDERLDEAEAAAARRSA-ADAAIETEGSRVV--DAWQAHFANLQVLQVAEPP--LPALA 540  Aromatoleum a...
BAD59285      463 LRTLIAAVDTAEQRLTATRARIDKLDTDAAGLAEAARL-AEQAVDAEAARLT--DSTSTYLRAATELALDDLPAVLDDLT 539  Nocardia farc...
BAD74604      449 WRRHDDVKRRYEEASTEAGERRREMDEWRHQQQKWEELlEQEKERFEQAVLAwvEQGGIDVSEADIQAFLRQMGALYELY 528  Geobacillus k...
WP_009995335  482 TARREQVADITDAIDAHDRAVRDRGTAEGLLDEARTRL-ADAIAHRDTAATAgdNALAAQAERLLAWARNWTEMRIADLD 560  Streptomyces ...

BAC74935      557 PADGPLSAHAPdeVADAARSAVDPWLAELGEERDTLTLAARELQTERDRLRHRREEWERRTDPEPPPPSHRAAPR-APGT 635  Streptomyces ...
CAD17421      532 PWTVSLQGDNP--ARTALHRAQQAASLRLARRQAALQNDRHVLEQERDTLRDERARLEQGEDTMPQPPHWRAPDIrAVRA 609  Ralstonia sol...
CAI09884      541 SWVAGLQGDNP--ARVALSSAQQRAADHLAQQRAGHLVAQKILHDEQAALHTEHERLAQGEDAAPPPPYTRTAEArKQRA 618  Aromatoleum a...
BAD59285      540 AWARILTGESP--VRVAVAARASALADELTRAESSLEHEESVLEEQCRAHRTELNRLREGGIEYPPTRHTRSALSdSDRD 617  Nocardia farc...
BAD74604      529 SLDDLKRPFVQ-----AYYDAVGKKKDEKWRLEHDIRLLEEKRAEREAELRQWREQRDPEPERDEQTTAARLALErEGIP 603  Geobacillus k...
WP_009995335  561 ELAARAAVEAD--VRELVETVARPLEEEITTERAAFRTAQQGLEQERDLLDARRSKLSGETDLQPVAPPTRTTVR-TAAA 637  Streptomyces ...

BAC74935      636 GAPLYRLVDFAHDLEPDARAGLEAALEASGLLDAWVRADGTVLDPATr-DTLLVPAAPVPGETLARVLRPVDAPDSGVTA 714  Streptomyces ...
CAD17421      610 GAPLWQLVDFRPGTSAADCAGLEAALQASGLLDAWVTPNGMLQDSDGshAQLPHDAQWLTRERQPQSLAAWLRPAEAASD 689  Ralstonia sol...
CAI09884      619 GAPLWQLVDFREHVDAAQRAGLEAALEAAGLLDAWVTADGRLQAAEG--APPLHDTQWTERPHQGASLAAWLAPSAVAa- 695  Aromatoleum a...
BAD59285      618 GTAFWQLTAFADRVPETDRAGLEAALEAAGILDARIGADGTLRAVTG--EVILSPETVAPGRSLTGVLEPALDPADSR-- 693  Nocardia farc...
BAD74604      604 FVPFYAAVEFVDDVPDDVRERIESALSHAGLLDALIAARDVDVDCDR----VLIPKPVHMVHTLADYLRPDADAPVSAER 679  Geobacillus k...
WP_009995335  638 GAPLWRLIAFHENVPLPVQAGVEAALEASGLLDAWVSASEGFTLPGHdtRVEVGLATTAPGSSLLDVLRPEEHIPVLAG- 716  Streptomyces ...

BAC74935      715 eQVERVLRAVALARGGIGAGEADtAGAAHTAIGVDGSWRLGVARGRHAKQV-AEYVGAEVRAETRRRALAELDLRLTRVQ 793  Streptomyces ...
CAD17421      690 aPPRVDPTVVQRLLEGVACGAED-NPAAEAWIAPTGRFRLGALAGVWHKPG-AEFIGYAARCAARERRQHEIDARLEAID 767  Ralstonia sol...
CAI09884      696 -VPVVDAALLTRLLEGIACSAHD-DGRAEGWLAPDGRFRLGALAGAWAKPQ-ATYIGYAARTAARARRLAEIDLRLGEIA 772  Aromatoleum a...
BAD59285      694 -TATLTPAAVTAVLTSIGLGTG---STHHTWVDVSGDFQIGVLHGAWTKTD-AQYIGAVARERFRLARITALEANLDTLA 768  Nocardia farc...
BAD74604      680 ---------IDEVLRSIVITDAE--QEGGMTIDETGRYSLGLVRGHAPRRArAMFIGRAARERWRLENIAALEAEIAAVG 748  Geobacillus k...
WP_009995335  717 --------TVTRILAGIAYGTPL-PGGHPVAVSSDGTWRLAPATGSWSKPE-PAHIGALARQRAKQRESTELAELIAEKD 786  Streptomyces ...

BAC74935      794 DELAERQRSLRMLTQHRDQVGDLLRRPPSARGLTDAWARTAEAERTAESFAGQAATAAREAEQARAGAVVARREAEATAS 873  Streptomyces ...
CAD17421      768 AALTLLAQNFAQLDADQREAADEWQCAPSDDSLRAAHVEAVSRAREFDMARQRLEHTDRLLRAAAEQWEQARTILERDAE 847  Ralstonia sol...
CAI09884      773 DASRRTDDALAELARQQERAAAEWQGAPSDESLRAAHADAAAREREFQTAKNRLDEADRQLRAASDALQSRRDALAADAA 852  Aromatoleum a...
BAD59285      769 RQLAELAAQRRALTERKRALRAEAAGLPDEEALRGAHRRITEVATQRRRLTAELADAAADAAREEAAVHTASTERDRYAG 848  Nocardia farc...
BAD74604      749 QEIDRLRREHQAVGAAIQALADWLASFPADRDVRTAFEEGQEARRQAESKEREWKRQEEKAALLAREWKQIKQQLRDESA 828  Geobacillus k...
WP_009995335  787 ASLATLADRLRELGARAARLADDRSARPDHRELDACRRDWDQAEEKVAARDDAVRYATEHLAAREGDVAGALRTLSRRAA 866  Streptomyces ...

BAC74935      874 AQDLPADPAALETVRLALDRLGQGAQRLRRRVRAVLSAADGHRGSRTDYGRAESARREAESDYAEPLGRLEAARRTVRAL 953  Streptomyces ...
CAD17421      848 DLTLPPARDALRAIDQALQMFGDCLHTLAVVVRELRDAQTEHAEQLQREQQAESDARHALEQSAEREALADEAGIRLETL 927  Ralstonia sol...
CAI09884      853 DLRLPTDAAALEAVGAALLHFGETLHGLFQAVQELRLAATELARQQERTRETEADALRRAEHLTERRRQADEAQVRLATL 932  Aromatoleum a...
BAD59285      849 DAGLPVTPDALDDIAEALTDYRVHTAALWIATTRRTEAAGRAETARADAEQAHNRLLLRAEAAEAARIDALKADERHRTL 928  Nocardia farc...
BAD74604      829 ELDLAFTLDGCEQAQLAMKSYVRHLHELEVLYRETRHTEAMIAQQRERLAALETEIDEAKGERNRIRDEKERISLEIVEM 908  Geobacillus k...
WP_009995335  867 ENGLPTDRDRLRELGRDMERFRDLADTWTDARIDAIAAAERAEETAARADRSRLLAEKQAADAAAAEAKAAGMTARLKAV 946  Streptomyces ...

BAC74935      954 EEAIGAT-EQEILDREAETMRRLDAVGRQLPRIRRDLADVHDLRVRAEEEErARREALADQEAEALACGRGLRKALALPG 1032 Streptomyces ...
CAD17421      928 RASVGAR-VEELQQRLSDARGAVTSGETELRQRNDARRLAGEARARAEQKA-EAADATLVERTTARQHAVGQLQGFSATG 1005 Ralstonia sol...
CAI09884      933 RESIGAQ-VDELQKRLREARAAVSDGDRHVKAAGESLRTAGEARARGEQKV-LDADATLQERADARQRAITQLQSFAATG 1010 Aromatoleum a...
BAD59285      929 DASVGAE-VAELRAELARVATAIEDNKRRRGELATALETAVHAHGIAEGKL-AELTEQLDIERADRDHEITAVHRFAETG 1006 Nocardia farc...
BAD74604      909 ERTLAQMgADDIRAEIARIQERLASLRREIPRLVNERARTEQQLMRLAEEReKEARREAFARELAAMWEKSFAREAALGL 988  Geobacillus k...
WP_009995335  947 EETVGAD-YRQIVARVAETRAERVRCGKEARQAAELLLGLEGRIGELRATS-GQDADRQEKAVEARDGAARRFRHLCLVG 1024 Streptomyces ...

BAC74935     1033 VLRGAGLDTDGDEVALKSPDPLHLDVRERIAALRLLVDAVRRGLDAERHDISDTTLLNRhtdlRDQLSGGYDATIEEHDG 1112 Streptomyces ...
CAD17421     1006 LLVTALPDAELPSMHAPWTIEPALALARRTEQALLHVKDDDEAWNRVQNQVSQDYTELG----RALAALSHQAQAETNDF 1081 Ralstonia sol...
CAI09884     1011 LLSAALPEVELPDLRAPWTIEPALTLARRTEQALAQVADDDEAWTRIQNQISHDYGELG----RTLTALGQQAQADTSDY 1086 Aromatoleum a...
BAD59285     1007 LFEIALTDTAVPTADT-WSAAAAISFARAAESELAEVAEDDKTLDRAARRIAEEHKTLT----DLLSAQGNTTSMTPRDD 1081 Nocardia farc...
BAD74604      989 VDLDRSRSLLEQAKEAKQRYEAVLKETRSSLLARLNTVFFQESSNLTEYRASFEPLEEQtkpeWTAAAPDDEMAMKAADW 1068 Geobacillus k...
WP_009995335 1025 LAEDAG---VVPELDAGDGTKATLEVARAMAARWPQVPHAPRHLGDAATRLSEAVHEAR----RHLGVR-ADLELEPDDD 1096 Streptomyces ...

BAC74935     1113 I-----KLCRLVDDHGLHDIAVVGERIAAEAAEARDRLTEREREVFQRFLAGELGDHLSSQVLAAGALVAALNTTLATVR 1187 Streptomyces ...
CAD17421     1082 G-----LVVSIIYQNRPERPDQLSARLAGEIAQRRELLTAGERQVLENHLQAEIASAVQKLLRDAERQVKAINDELDKRP 1156 Ralstonia sol...
CAI09884     1087 G-----MVVSVIYQNRPERPDQLTARLDTEIAQRRELLTARERTLLENHLQAEIAAEVQRLLQAAERQVDAINKELSKRP 1161 Aromatoleum a...
BAD59285     1082 G-----LVVDIVFRGRPVTVAGLAETLEQEVGDRNRLLTAREREVLENHLVDEVAAALQELILAAEDQVLRMNTELASRP 1156 Nocardia farc...
BAD74604     1069 RekqerHVIYLDYKGERATPFAVLAEVERDIVLQHEYMKEQDRELYEDVILKSVGRILRSRIQRAERWVNDMNKLMGGLD 1148 Geobacillus k...
WP_009995335 1097 I-----QLFTATLEGVRVGATGLLAVLTQERDRSGDDISTAERRLFDQILTGDIRRHLAARIRRAGELVAHMNGHLERVR 1171 Streptomyces ...

BAC74935     1188 TSHGLGVALDWKLADGVEADVKA-----AVDLLRSPSGLRTREQSEQLRDVLQRRIEDARRADPA----AGYAAHLRTAL 1258 Streptomyces ...
CAD17421     1157 TSTGVRFRLQWETLPEGADGAPVgleaaRRRLLNTSTDLWSAEDRRVVGEMLQQRVAAERSRADAdq-gGSLLDQLARAL 1235 Ralstonia sol...
CAI09884     1162 TSTGVKFRLLWQPLPEGGEGAPVgleaaRKRLLNTSTDLWSAEDRRVVGEMLHQRIAAERLKADAv--gGSLLDQLAQAL 1239 Aromatoleum a...
BAD59285     1157 TSTGMRLRLNWVLG----DEAPTgaraaLRQLRQT-ADLWNETDRAAVGEFLQQEIERVRAEHGV----GTWLEHLTAAF 1227 Nocardia farc...
BAD74604     1149 TSSGLVLSIQWKPKTAETEAELDtk--eLVRLLRLDPRLLREEDLQRVTNHFRSKIARARELLEErgqgSTLHQIIKEVL 1226 Geobacillus k...
WP_009995335 1172 TASNVAVQLVWDVRPDLPDSTRT-----ARQLLLKDPGRVTESDREALHAFFRARIEETKGSDTA----ASWEEHLGEVL 1242 Streptomyces ...

BAC74935     1259 DYRDWFAFTPwvVNDaAPGSRRRLsg-rTGLSQGEQRVLSYLVLFAAAAAHFTslADAAPHAPRLILLDDAFAKVDEPTH 1337 Streptomyces ...
CAD17421     1236 DYRRWHRFRV--QRW-DGQWRPLS----GPASSGERALGLTVPLFAAVSSYYT--QESYAHAPRLVLLDEVFAGIDDAAR 1306 Ralstonia sol...
CAI09884     1240 DYRRWHRFRV--QRWqDGQWRPLS----GPASSGERALGLTVPLFAAVSSFYS--QASYVFAPRLVLLDEAFAGIDDAAR 1311 Aromatoleum a...
BAD59285     1228 DYRRWHKFVI--ELQqRGQWRPAT----GPASGGERVLAASVPLFAAASSHYS--SAGNPHAPRLVMLDEAFAGVDDNAR 1299 Nocardia farc...
BAD74604     1227 DYRKWFSFTLyyEKTnEPKRELTNhr-fYQFSGGEKAMAMYIPLFAAAYSRYQ---EAGDDAPYIISLDEAFAGVDENNI 1302 Geobacillus k...
WP_009995335 1243 DYTAWHTFTVrlDRAdGSGWQPLTkrlhGALSGGEKAIALHLPLFAAVAAHYE--DVP--LAPRPILLDEVFVGVDTVNR 1318 Streptomyces ...

BAC74935     1338 ARLGRILVDLDLDFVLTSERLIGNWPDVPSLHIYECLRDPHVRGVATLHYTWNGRQRR 1395 Streptomyces avermitilis MA-4680 = ...
CAD17421     1307 AHCWALIREFDLDFVVTSEREWACSAELPGVAIAQLQRHEGIDAVHVSRWTWDGRNRR 1364 Ralstonia solanacearum GMI1000
CAI09884     1312 AHCMGLIREFDLDFVITSEREWACYAELPGVAICQLQRREGIDAVHVSRWTWDGRARR 1369 Aromatoleum aromaticum EbN1
BAD59285     1300 AKYFGLLAAFDLDVVMTSEREWGCYPEVPGLAIAQLARTDEVAAVLVTPWEWDGSDRH 1357 Nocardia farcinica IFM 10152
BAD74604     1303 RNLFGLVEQLGFNYIMNSQALWGDYDTVPALSICELVRPRNASFVTVIHYRWNGRVKQ 1360 Geobacillus kaustophilus HTA426
WP_009995335 1319 GQVFALLTALDLDLMITSDHEWGNYRELPGIAVHQLLT-DGDDAVTSARFVWNGTGME 1375 Streptomyces clavuligerus
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