Conserved Protein Domain Family

TIGR02595: PEP_exosort 
PEP-CTERM protein-sorting domain
This model describes a 25-residue domain that includes a near-invariant Pro-Glu-Pro (PEP) motif, a thirteen residue strongly hydrophobic sequence likely to span the membrane, and a five-residue strongly basic motif that often contains four Arg residues. In nearly every case, this motif is found within nine residues, and usually within five residues, of the extreme C-terminus of the protein. Proteins with this motif typically have signal sequences at the N-terminus. This region appears many times per genome or not at all, and co-occurs in genomes with a proposed protein-sorting integral membrane protein we designate exosortase (see TIGR02602). PEP-CTERM proteins frequently are poorly conserved, Ser/Thr-rich proteins and may become extensively modified proteinaceous constituents of extracellular material in bacterial biofilms. [Cell envelope, Surface structures]
PSSM-Id: 131644
Aligned: 65 rows
Threshold Bit Score: 27.153
Created: 8-Oct-2014
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
BAB75517     221 IPEPSQVPGLVTLGglgLMVIGKKLKL 247 Nostoc sp. PCC 7120
BAB72879     239 TPEPTTVLGLGAVA---TLAFLRRRQF 262 Nostoc sp. PCC 7120
BAB77655     180 IPEPGVIFGLLAVG---SLARVLKKKP 203 Nostoc sp. PCC 7120
jgi:Ava_1684 326 VPEPSGLFGLFTVG---SLIIASRSKC 349 Anabaena variabilis ATCC 29413
BAB75333     315 TPESSTTIGVLFLGvlgAMSNIKRLQR 341 Nostoc sp. PCC 7120
jgi:Ava_2299 239 TPEPATLIGLFGLGafgITSNLKRNRK 265 Anabaena variabilis ATCC 29413
jgi:Ava_4737 298 VPEPSITIGFLGLGllaFGSRLKNKNR 324 Anabaena variabilis ATCC 29413
jgi:Ava_0835 165 VPEPNSILSLIALGtlgAGSVLKHNQR 191 Anabaena variabilis ATCC 29413
BAB73140     494 VPEPTTIFGLFGIAimgIATKLKRRCE 520 Nostoc sp. PCC 7120
BAB72381     416 VPEPTTVLGSLTAAalgASSMLKKRKR 442 Nostoc sp. PCC 7120
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