Conserved Protein Domain Family
cas_RAMP_Cmr4
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TIGR02580: cas_RAMP_Cmr4 
CRISPR type III-B/RAMP module RAMP protein Cmr4
This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.
Links
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Statistics
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PSSM-Id: 274210
Aligned: 10 rows
Threshold Bit Score: 245.447
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAM02512       5 LPYFLVCRTPTRAGAGQrATDVIDLPLQREAHTKLPVIYGSTLKGALRHATLRKLSEEldg--etsEGLVDAVF-G-DRP 80  Methanopyrus ka...
AAL81250       4 YLVGLYTLTPTHPGSGT-ELGVVDQPIQRERHTGFPVIWGQSLKGVLRSYLKLVEKVD--------EEKINKIF-G-PPT 72  Pyrococcus furi...
AAS82448       5 ALLFLHALSPLHAGTGQ-GIGAIDLPIAREKATGIPYLPGSSLKGVLRDR-ASAWDRD--------TLF-AVFG-P--DT 70  Thermus thermop...
AAQ66958       4 AAYMIHCLTNMHVGKGDaTYEVVDKCVQRDVTTGMPCIYSSSLKGALRQFFSKQGFAElnyvfgkdQSRDKKNN-G-NEK 81  Porphyromonas g...
BAB67070       9 YPVYIFTVTNSHVGSGSsVSEEVDLPFQRD-HLGYPTIYASSLKGAIKSYLINTISDSe------eRKNVEILF-G---K 77  Sulfolobus toko...
WP_010896511   7 QLFFVHCLSPVHIGTGE-GVGLIDMPIMRERVTKWPLIPGSTTKGVHRDYFVQQ--RDk------eSWIRTAFGaG-KGE 76  Bacillus halodu...
WP_010880200   6 QLLTLYAVTPIHIGSGQs-ISFIDLPIQRERHTGFPILRSNGIKGALRSVAERVWk---------dKAKVETVF-G--PE 72  Aquifex aeolicus
WP_004082339   4 RVFLLYAETQVHAGTGF-EIGVVDLPIQRERTTKFPIIHG--IKGALRAYFRSLIKEDki-----dEKKIEEIF-GsEPK 74  Thermotoga
WP_010923683   4 LFVLAYAITNLHPGAGr-GYGIVDMPVQRD-QMGYPIIYSSAFKGPLKALCAGDAINDhgridckkKGECCCLF-G-SEP 79  Sulfolobus solf...
WP_009990106   5 YLVLAYAITPIHVGAGKsSTGVVDSPLVRD-SIGYPIVYGSSLKGSLKSFLIAk-----------nESLAKCVF-G-GKP 70  Sulfolobus solf...

AAM02512      81 GEGSPSPGVVAFSDAVLLAMPVR------CEPGFLAWVTSPYQLGRLYEVLELTGELEDLREAV-----------EEVl- 142 Methanopyrus ka...
AAL81250      73 EKAHEQAGLISVGDAKILFFPVR------SLKGVYAYVTSPLVLNRFKRDLELAGVKNFQTEIP-----------ELT-- 133 Pyrococcus furi...
AAS82448      71 ENASEHAGAVQVGDAKLLLLPVR------SLYGVFALATSPYLLERFRREALMAGLQPPG----------------VPgl 128 Thermus thermop...
AAQ66958      82 NEEEHSVGNFTFFQANLLAYPVQ------TTQEGATYILK---------------------------------------- 115 Porphyromonas g...
BAB67070      78 DSTPDEVSKVVILDAVLLLIPVRiipiskDFEGVYSYATTEELLETAKSYLDAVSNLLRTQNTE-----------KN--- 143 Sulfolobus toko...
WP_010896511  77 ADAEGNAGSIVMSDARILAFPVA------SYYGTFAYVTCPMVIKRLERDMGAANVSYFSNLIE-----------KVEgw 139 Bacillus halodu...
WP_010880200  73 DDASKFAGCVSITDARILFYPVR------SVRGVFAWITSPIVLRRFQEDLRSIGKEINIKVLKngkevpsnlnlEEN-- 144 Aquifex aeolicus
WP_004082339  75 SDKGTVPGSLSFSEARILLFPVR------NPDRLFVWVTCPLVLIKFAK---SVGDNDVVKELE-----------EANid 134 Thermotoga
WP_010923683  80 EEEESSKGMLNVMDLPLFSVPAP------TFDG-FVQVTTNYLIDRARNIFEAISHINGYLGSL-----------GNE-- 139 Sulfolobus solf...
WP_009990106  71 EEENILTSKYVLTDLIPVFYPVS------SIDEGYIYITTRYLINHIEDLMSRLG--IGSLYKE-----------SKE-- 129 Sulfolobus solf...

AAM02512     143 --------nDCKDPR-----G--NgalapEEGTLLLDRIRVRAEASDAVGDLAGVLSETVFEgapepHFRRYVEERLVVL 207 Methanopyrus ka...
AAL81250     134 ---------DTAIAS-----E--Ei---tVDNKVILEEFAILIQKDDKGILESVVKAIEQAFg---nEMAEKIKGRIAII 191 Pyrococcus furi...
AAS82448     129 r-----dptQVLLAP-----G--SrllgdG-EKVYLEDLDLKAQGEEGVAAWERWLAER---------TEAPVLGRLAVV 186 Thermus thermop...
AAQ66958     116 ------------------------------TNKTLQDPIKELANLFSAPSNIEEMLPKETEK------------------ 147 Porphyromonas g...
BAB67070     144 ------------------------------VDFFLAGNGDKELIVNESYFKFKKDDELKKSYs----ILIPPEIKSVMVF 189 Sulfolobus toko...
WP_010896511 140 ekklstnedKALIGHrcevtD--E-----NNEKIYLDEFELSVVIDGTFGELTNSLAKLVFKdd--hFSQELLASRLVLV 210 Bacillus halodu...
WP_010880200 145 ---------EAILFS-----DglI-----KDGKLFLEEFAFNPILNAP--ENVDWDFFNTIIps--dELVGLLRTHLVIV 201 Aquifex aeolicus
WP_004082339 135 -------ygKAVSFY-----G---------SGEVFLEEVKLEPFVGELPRTRELISKISNCApv--dYLKKKMESDVVVV 191 Thermotoga
WP_010923683 140 -----------------------I-----KALLDAQGNKSVEVYDTEAKVVNFDPSSFKLLS------SLPLFNNRLAIS 185 Sulfolobus solf...
WP_009990106 130 ---------K-------------------SEVRIFLGKISTELSLQLSDEVRSLGNLIKDKN------RVYVLDNSIGLS 175 Sulfolobus solf...

AAM02512     208 GDGAFADLVNSCTERVVRVRLN-EEKTVEQG-PWYEERVPEGTVFFGTLNVR-------Hdtvppkngvdarkvlfgrwe 278 Methanopyrus ka...
AAL81250     192 PDDVFRDLVELSTEIVARIRINaETGTVETGgLWYEEYIPSDTLFYSLILVT-------P-------------------- 244 Pyrococcus furi...
AAS82448     187 HDDLMGFLLETATEVVARIRLDdETKTVAKGaLWYEESLPAESLLYALVRAD-------Rs------------------- 240 Thermus thermop...
AAQ66958     148 ------DLSNETLEQLPVIARNqLDNGKSEN-LWYEEVVPAESRFVFFVSYD-------D-------------------- 193 Porphyromonas g...
BAB67070     190 RGNTGRDIINRSLIRVRRIRIDrEKKTASERgLWSEEYVPRGTYFFTIILVR-------S-------------------- 242 Sulfolobus toko...
WP_010896511 211 SDESFQYFVTQCSEITPRIRLKaEEKVVDDGaLWYEEYLPTETLLYGLIWCE-------K-------------------- 263 Bacillus halodu...
WP_010880200 202 SDNVFRDLVNYAVEVRTRIRINqATGTVERGaLFTEEFIPSESIFYSLLNIS-------E-------------------- 254 Aquifex aeolicus
WP_004082339 192 NDVLFSEIVQAMTEVVPRVRINrEKKTVEEGgLWYEEYLPQDTVMYFVVRKT-------Y-------------------- 244 Thermotoga
WP_010923683 186 DD---KRVIDKSLIIYTRNRLNlLTKVVEEGgLWSEEYIPMGSIFIGGMIIDnvrnkfcD-------------------- 242 Sulfolobus solf...
WP_009990106 176 -------AVESALTRVTRTELDdNTKTSKN--IWSEEYIPQGTILLSGIFEReisnsycE-------------------- 226 Sulfolobus solf...

AAM02512     279 pdgvpdgddrkLEALKEaagELEAGVLGAVADGsgdgyldL--------RFQVGGSETVGFGLVR 335 Methanopyrus kandleri AV19
AAL81250     245 -----------RAKDND---MALIKEVLGKING-------K--------YLQIGGNETVGKGFVK 280 Pyrococcus furiosus DSM 3638
AAS82448     241 -----------FRKGKElrpEGVWGLFRGVLEEg-----gG--------VLQLGGKATVGRGLCR 281 Thermus thermophilus HB27
AAQ66958     194 --------------------EEIFTKFDKIIQEk---------------VIQIGANGSIGYGFCK 223 Porphyromonas gingivalis W83
BAB67070     243 --------------DKEkniNEIFKKFNDKLLN----------------YIIIGGHETIGKGIVR 277 Sulfolobus tokodaii str. 7
WP_010896511 264 -----------MDQVKEs-----WKRLSKg----------R--------VLQVGGNATVGRGRVR 294 Bacillus halodurans
WP_010880200 255 -----------PHNKEVfekAEKVREEVKDLINr-----cK--------IIQVGGDESLGKGFIR 295 Aquifex aeolicus
WP_004082339 245 -----------YGNKEDsgkDSLMEVFENEVNG-------E--------LINIGGKETVGKGMMW 283 Thermotoga
WP_010923683 243 -----------ELSKIScdsRLFLHHFSRIFNAd------KisedvylfYLNIGGKESIGKGLMK 290 Sulfolobus solfataricus
WP_009990106 227 -----------ELNRNNv---nIDNEFLKLIDN-------V--------SVFIGGKESIGKGLTK 262 Sulfolobus solfataricus
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