4H4K


Conserved Protein Domain Family
cas_TM1794_Cmr2

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TIGR02577: cas_TM1794_Cmr2 
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CRISPR-associated protein Cas10/Cmr2, subtype III-B
This model represent a Crm2 family of the CRISPR-associated RAMP module, a set of six genes recurring found together in prokaryotic genomes. This gene cluster is found only in species with CRISPR repeats, usually near the repeats themselves. Because most of the six (but not this family) contain RAMP domains, and because its appearance in a genome appears to depend on other CRISPR-associated Cas genes, the set is designated the CRISPR RAMP module. This protein, typified by TM1794 from Thermotoga maritima, is designated Crm2, for CRISPR RAMP Module protein 2.
Statistics
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PSSM-Id: 274208
Aligned: 14 rows
Threshold Bit Score: 314.387
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4H4K_C        45 TLLRIKIVPVQPFIANSRKQLDLWASSHLLSMLMYKALEVIVDKFGPEHVIYPSLRDQPFFLKFYLGENIGd-------- 116  Pyrococcus fur...
AAM25759     196 AFLLFTIGPVQSFIATARKTSDLWAGSYMLSYFIWKIMKFVVERYGADVIVYPNLLGQPLVDLWLSSEVFGnslthlsqk 275  Caldanaerobact...
AAS82445       3 HLLAIALGPVQEFIATARRTRDLYAGSRLLSEAAARAAEALAREVGAKNLIFPAPEDEAGLERLAGAGIPNvllv----- 77   Thermus thermo...
AAM02510     136 VTVRLRPSGGIKTWLRGRKLADSLAASWLLGYLVYRVYERLCRRLDVERVLRPVLPGNHPFEKKPDNLEPWetrgcvmpd 215  Methanopyrus k...
AAQ66960       5 IYTAITIGPICKTLDKARSVKSFWTASYLFSWIMRELLERLPKEERPEGSFEVLSPHRDGKDVP---------------- 68   Porphyromonas ...
BAB67074     222 LLLGLDIVGVADYINKSRKLRDLWASSYLVSALIWYVLISFVEKFGADSVLFPSLRFNPFFATYIYHKYLKnkekdel-- 299  Sulfolobus tok...
WP_010896509   9 TLMLFSIGPVQEFIAQARKTRDLWFGSHLLSELG-KAAAFKLSKL-EAHVIFPYVENLEKLDAKEKEKINSpnr------ 80   Bacillus halod...
WP_010865405 191 SLVAVAIGPVQEVIAQARKVKDLWAGSYLLSYLIYGAIEVVGKKYGFDSIISPYLRGNYFVKETLESMGVDledlc---- 266  Thermotoga mar...
WP_010923686 232 FYVVIDIPGVQEIINSARKASDYWAGSWMLSMIIWLTVWQLIKEYGPDVLLAPTTRFNPIYYAMTLNYLEKefgmddglk 311  Sulfolobus sol...
WP_010880206   2 KLLVFTFSPVQGFIEKSRKLRDFFNSSLILSYITKKLIEKLKEDPDVE-IIYPAIKEHDSEKLLMNYPNRLvakf----- 75   Aquifex aeolicus
4H4K_C       117 --------------------EILVANLPNKALAIVSGkeaEKIE---EEIKKRIRDFLLQLYREAV-------------- 159  Pyrococcus fur...
AAM25759     276 efdewfkewnniprskgleeKLTIANMPNRFLAIAPIn-eGEALklgEECEKNFKEQLKSLAKKTV-------------- 340  Caldanaerobact...
AAS82445      78 -------------------rvpEGKDPRGLGEQALGAardYLREraeEVLGPRRDLLFWREALAQV-------------- 124  Thermus thermo...
AAM02510     216 ------------avelvvdgDVSAEEVARIARETVEDvleDVLKrgrETPWRCHNVSLYEPLEDWW-------------- 269  Methanopyrus k...
AAQ66960      69 ---------------------EETSKKVGLFPDRLFAkgeLEEEklqEIKG-KIFIELAEKFKNAF-------------- 112  Porphyromonas ...
BAB67074     300 -------------ikeivnyITTYIFNGDETYKKLGIppyPIIParaTLILLGVKYVSRELGLKKS-------------- 352  Sulfolobus tok...
WP_010896509  81 -----------------vmaLVDTSEPKAVALEVKAAvieKWMSyanGARRLLGRDINPALWKRQV-------------- 129  Bacillus halod...
WP_010865405 267 ----------------pvppRREVASLPNLFVAIVPSsdeEILKeceEAIRNRWKTIVDETKEKLS-------------- 316  Thermotoga mar...
WP_010923686 312 kei------eeilntilgklSGIYDYTQFLKEAIIPAtasLILPkeqNTCSIKLEQEIFEYYKNAYncivkeiptgnvqs 385  Sulfolobus sol...
WP_010880206  76 -----------------ekdKNYCEELKNQFSKIWEEiytYIADkikIPESVKATFKSHNKHYFTY-------------- 124  Aquifex aeolicus
4H4K_C       160 ---DWAVENGVVKVDRSEKDSMLKEAYLKIVREYFTVSITWVSLS------EKE-DIYQVTENa--gLSDED------VK 221  Pyrococcus fur...
AAM25759     341 ---KRLESILNLEGDLEKIQLQIENQLLNYFQVYWAVMPWFEEKE------SPK-EVLDDYKEiigeTELYKt----iSE 406  Caldanaerobact...
AAS82445     125 ---EDLLEGYYAYLPLEGDYPRARERLMALLAARKNTRDFAPVSWg-------S-PAYKSSLDg---------------- 177  Thermus thermo...
AAM02510     270 ---ERTSGRSAARVELPPGLIQVSAAVVDLEEPDDEEAYREAVRRvaslvgTRA-EVMDARGSggqpCSVCG------TY 339  Methanopyrus k...
AAQ66960     113 ---QDEKDGITRKIDTESDPKRKRE------------------------------------------------------- 134  Porphyromonas ...
BAB67074     353 ---DISCIEKYVITRFNEGWGRLIDHLITYALSHTDNPFWALFNKviekesVKN-AVKIPPVQlrviTLKKEn----eVS 424  Sulfolobus tok...
WP_010896509 130 ---KDLIEFHAVWMDCKEEAHYAEVRQKAEELLAARKTLRDFKPN------QPS-HMYGEVKS----------------- 182  Bacillus halod...
WP_010865405 317 ---KSEFLFNEHSFDYQSSLFP-------------DIQTSKVSFD------EPE-RIVETVRNlftgSGIED-------- 365  Thermotoga mar...
WP_010923686 386 dicKEFVEAFNIIYQSNSTLDNLMNVIINEAEKYADKILIRPAIYivdiddIRD-EVESDLRNknvnAILNNkqfnqlVP 464  Sulfolobus sol...
WP_010880206 125 ---FCEIQEEVDREEWMTELKVNEETLKKFKINQENPYGFTYDLL------ERKlGARKTFRPyygrVDENKk----vHG 191  Aquifex aeolicus
4H4K_C       222 KWLKFAEKk----ENSRVLERIAIYPLLVKI-----LDSLGERKVTEERFEKSEQLKGWKCHVCGENLAIFGd---MYDh 289  Pyrococcus fur...
AAM25759     407 FIESVPKIwsknkEKDEEYRDFSIAYSLLLE-----LTEKLLGARKSIREFEQLEQKGRKCSLCGEFEVLPLdwekLRS- 480  Caldanaerobact...
AAS82445     178 ----ARESvlrlpEREADHLRVRLGLRPGEY-----LAGPDLLKRWWKAGHGFLSTTHMAALPFWEGVRRAGleavLKEa 248  Thermus thermo...
AAM02510     340 PTVGDREFweelsERLPPQLLKRWEGGFERL-----CAACLLKRYFGTHVIRSWYLEKISWIPSTAEVAITPvkvgILNr 414  Methanopyrus k...
AAQ66960     135 ----LEEIqsrysNAALKGEDIRKYLENYLS-----ISCITVELSSDCNILEQLNSYLDTQELFN--------------- 190  Porphyromonas ...
BAB67074     425 NYEEFDNRyrelvSNFKRKKLSKVSPHTQLSnynyyIDSIGETKRGFEYCSICGVLPAMLILPKDENEYKKFveehTGKq 504  Sulfolobus tok...
WP_010896509 183 ---SLDPGrecvlEKHQYKRYAPYGIKKDES-----LDAISLVKRLSFHLSPNTRHFPSVCDVAFSQLRRKIekdnLLT- 253  Bacillus halod...
WP_010865405 366 ----FKEVlkkvsEHAGYKENPGTFYRYLHR-----LLTSKLAARKMARLFPGYEEDVYPDHFTDADDFGAGvracAVFk 436  Thermotoga mar...
WP_010923686 465 QYIFHYIStklfrEKVKEKYKREILPKPNWFtsfnkEFDYINGGKNWEYCTVCGNEPAIINFGKENDDYSAStkceILRl 544  Sulfolobus sol...
WP_010880206 192 CTLCGERPaldlnWEELRKNLPPYHLDDSER-----LCGVCLTKRFFHFYLKEKEGIKDLAKFHSTRHFALAplikKVE- 265  Aquifex aeolicus
4H4K_C       290 -------------dNLKSLWLDEEPLCPMCLIKRYYPVWIR------------SKTGQKirfesvvdvally-------- 336  Pyrococcus fur...
AAM25759     481 --------------KEKGLVKEKEQLCGVCLAKRLFPKVMKee--------lnLSEEMKfpstsematigekrriadnke 538  Caldanaerobact...
AAS82445     249 l------------eELGGLVGEEARAEVRHPVLRDTPFGEWd-------------------------------------- 278  Thermus thermo...
AAM02510     415 we----------elKDDGGFREAALGFLREVLPEQLRQIAHylr-------cvKEVDRAgeleeaakdlkrdrlepeglp 477  Methanopyrus k...
AAQ66960     191 ----------------KASIQTDEDYMELFIEAPNNPFLKAys------------------------------------- 217  Porphyromonas ...
BAB67074     505 fnd-------dqieALKAILSPGEKLCPWCLIKRAIGVRPEflr-------vlITSEDLrsf------------------ 552  Sulfolobus tok...
WP_010896509 254 --------------DLAKNYQEWVWNKYPKLKKRLFSDLF-----------------DSr-------------------- 282  Bacillus halod...
WP_010865405 437 d------------kDIEKDIEKEDRLGTLNTVKRFLPEILN------------I-------------------------- 466  Thermotoga mar...
WP_010923686 545 ayqnrykvtdddlkDLKVWFKPGEKLGPLCIIKRGLYFRLRknlekvfkstddIAYSYYk-------------------- 604  Sulfolobus sol...
WP_010880206 266 ----------------KDKLSEEEKEILREILSMYTNNQIN------------DGN--Lk-------------------- 295  Aquifex aeolicus
4H4K_C       337 --knwrkifdekygKDLVSKAREVSEDFVKDNMLVDSDLYysstWESGLSKklknkkeideek--------vkevvdfln 406  Pyrococcus fur...
AAM25759     539 fiaefkelfgefkqKLLLPNTVSVPKLKDNQLFEIDGQWLmresYREEYIKsehtenfkveef--------qkmsqkitk 610  Caldanaerobact...
AAS82445     279 -------------vRLLYESRLEEFPSLAEDPGLLEKARDrlraLWRRLSP----------------------------- 316  Thermus thermo...
AAM02510     478 edvrkelhrltpkaPRLDEELGDVEDSLIEVLLCVEGRFWydpeAPGGLRElle-------------------------- 531  Methanopyrus k...
AAQ66960     218 -------------qDRAFPSTSEIAVSGWEQDPPKDENGEveytQLTSKPG----------------------------- 255  Porphyromonas ...
BAB67074     553 -----------eekDVFIPSVSHVAFYKKFEKLKEDNIINpdkeNTISLWKyyetypiekr-------------gllren 608  Sulfolobus tok...
WP_010896509 283 --------------LFYVTHIKEMVEGAYPNKNEQEQIIKliaqKLESFYK----------------------------- 319  Bacillus halod...
WP_010865405 467 --------------RIKFDSTTDVARNNQANKEIEDPE------------------------------------------ 490  Thermotoga mar...
WP_010923686 605 --------------NVIQPRIKDLDECEKLKNFLNAEELDvyetFGNPVIArrlfskctevedkklpciqkeygvsdvnn 670  Sulfolobus sol...
WP_010880206 296 --------------ELIYNNIDELTYKRVKALVRKRLDKIpdkdKEVRLKE----------------------------- 332  Aquifex aeolicus
4H4K_C       407 aayKEIGNPPKYYAILVMDGDDMGKVISGEVLGEISTRIHPN-------------------------------------- 448  Pyrococcus fur...
AAM25759     611 lleKHRVNPSRYYAILQMDGDHMGKWLKGENNPPIMETLHPKvgehikqha----------------------------- 661  Caldanaerobact...
AAS82445     317 ---KVRVPPGAYYALLHADGDRMGETLDG--------------------------------------------------- 342  Thermus thermo...
AAM02510     532 -agDLENLYTPYYALLKLDGDRMGELFSR--------------------------------------------------- 559  Methanopyrus k...
AAQ66960     256 -----FRNCYKYLAVIKADGDGFGTYIKELKVDEEKE------------------------------------------- 287  Porphyromonas ...
BAB67074     609 peeKGWKDVSPYYALVRADTDYLGDLLEGKVTPYLAGIIDSSfyggereneskvknaitrylrnaakglyqevindvlke 688  Sulfolobus tok...
WP_010896509 320 ---ETKLNSTPYYAFLVCDGDQMGKALR---------------------------------------------------- 344  Bacillus halod...
WP_010865405 491 ------KFKNGYIAVLLMDGDRMGDWMLGENAPFLEKVINPKviemfqetd----------------------------- 535  Thermotoga mar...
WP_010923686 671 afiDALKGYREFYAIVKADADDMTELARGEIDAEKYFEVLPRlikegefeekesknpknra------------------- 731  Sulfolobus sol...
WP_010880206 333 ---FEKKFKNSYFSILMADGDEMGKWLGLK----------PE-------------------------------------- 361  Aquifex aeolicus
4H4K_C       449 -----------------------------------------IRdyveipeaKYYSTPQVHVAISQALANFSIREVRSVVK 487  Pyrococcus fur...
AAM25759     662 ---------------------------------kdnlssilCK--------KHPTTPSLHQTLSRKISTFALQEVRRIVE 700  Caldanaerobact...
AAS82445     343 -----------------------------------------------------LPSPEAHRRFSNALALGFAAQVKDIVE 369  Thermus thermo...
AAM02510     560 -------------------------------------------------------DPETTRGASRATIEFGLKAMRIVHG 584  Methanopyrus k...
AAQ66960     288 -----------------------------------------IK--------ENGEKENELSRFTKSFFEFSVEVANELIQ 318  Porphyromonas ...
BAB67074     689 dinqakeliknaavtaeieindndieriisdlkdflnknvdRD--------RLLLFPSWHVSISSMLNRILLKEIQLVNA 760  Sulfolobus tok...
WP_010896509 345 ----------------------------------------------------NLKNIEDHQAFSKKLSEFAAKARKIVTT 372  Bacillus halod...
WP_010865405 536 --------------------------------dlkyaweklKE--------FKTIQPAYHRGVSRTLGIFSQLVGKIVDR 575  Thermotoga mar...
WP_010923686 732 ----------------------ckfliytysnmtsiakvinDG--------NILMSPTYRVALSLAMMITLLRDIKTVEV 781  Sulfolobus sol...
WP_010880206 362 -----------------------------------------KR--------KVELTENFHKKFSEALFKFAQKITKIEDN 392  Aquifex aeolicus
4H4K_C       488 De---GLLIYAGGDDVLAILPVDK--ALEVAYKIRKEFGKSFENgsl----------------------------lpG-W 533  Pyrococcus fur...
AAM25759     701 Eth-yGKLVYAGGDDVLALLPVEE--VLECAYELQNAFKEVLSS---------------------------------E-A 743  Caldanaerobact...
AAS82445     370 Ah--gGGLVYSGGDDVLALLPLHT--ALMAARALADRFREAMAPfgr---------------------------egrA-P 417  Thermus thermo...
AAM02510     585 Hy---gVLLYCGGDDVFAALPLHT--ALDCAFELEETFRESLKKwk---------------------------------g 626  Methanopyrus k...
AAQ66960     319 Kt--kAIPVYIGGDDLFLFAPVLEgnVEKDVFNLIKEIDDLFIQkei-----------------------------gegL 367  Porphyromonas ...
BAB67074     761 Lg---gFVVYAGGDDLLAILPVEN--ALQFVENSRKIVAGIEDAssykgfiki---------------nnsyfsqlpL-V 819  Sulfolobus tok...
WP_010896509 373 DkrdeGELVYAGGDDVMAYLPLHR--CLDVAAKLQQLFGELMNEalp---------------------------keaVrP 423  Bacillus halod...
WP_010865405 576 Hn---GMLVYSGGDDVLALLPADS--VLECANDIRKFFSGHLEYeieiesgsdverfrsengvlyhndkpfaplmgrA-A 649  Thermotoga mar...
WP_010923686 782 En--yGQIIYAGGDDVVALVPIDR--LIDTLIGLERNFVGENGFfkvrqw---------------------yiptfyP-H 835  Sulfolobus sol...
WP_010880206 393 Ic---LKFVYLGGDDVLAVAHPSV--ILKAAKIIRKRFSEILKKelkps------------------------nikeD-P 442  Aquifex aeolicus
4H4K_C       534 KLSAGILIVHYKHPLYDALEKARDLLnNKAKN 565  Pyrococcus furiosus DSM 3638
AAM25759     744 SMSAGIVIVHHKYPLYLALKEVQLAQ-KKAKD 774  Caldanaerobacter subterraneus subsp. tengcongensis MB4
AAS82445     418 SLSVGLAVVHHLEPLQDALDLARRAE-KWAKE 448  Thermus thermophilus HB27
AAM02510     627 TCSAGLAVVHHLHPLRDAIDLAYRLE-KRAKE 657  Methanopyrus kandleri AV19
AAQ66960     368 SMSYGVSIFYYKSPMSEAIDIADSML-RKAKE 398  Porphyromonas gingivalis W83
BAB67074     820 GRSYILYFSHVKYPLQLALEESYNLL-EEGKE 850  Sulfolobus tokodaii str. 7
WP_010896509 424 TLSVGIVIAHMMEPMSEVRKLAMAAE-KQAKR 454  Bacillus halodurans
WP_010865405 650 TMSAGIAIVHHKFPLQVALKIAREAE-KRAKN 680  Thermotoga maritima
WP_010923686 836 GRSFSVRIANIADFMTNEIQMATELL-NRVKK 866  Sulfolobus solfataricus
WP_010880206 443 TMSAGLVIAHEKENLAFVLEHLRTAE-RRAKN 473  Aquifex aeolicus
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