Conserved Protein Domain Family
OrgA_MxiK

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TIGR02555: OrgA_MxiK 
type III secretion apparatus protein OrgA/MxiK
This gene is found in type III secretion operons and has been shown to be essential for the invasion phenotype in Salmonella and a component of the secretion apparatus. The protein is known as OrgA in Salmonella due to its oxygen-dependent expression pattern in which low-oxygen levels up-regulate the gene. In Shigella the ghene is called MxiK and has been shown to be sessential for the proper assembly of the secretion needle complex.
Statistics
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PSSM-Id: 131606
View PSSM: TIGR02555
Aligned: 6 rows
Threshold Bit Score: 192.697
Threshold Setting Gi: 45504741
Created: 8-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
tigr:BMAA1551   6 LMRVMYGPLGYAHPDHRTIAGVDLArMPAD-VANQWLIDHHRLDtAIDFDWRDAPrAAPCVDHWARLPRIAYLIGVQRLR 84  Burkholderia m...
AAS66873        6 LDSVMFDPLTWIHPSRFALPASLDG-IAQRsIVNDMLISLYGLS-LERPALPTHSlPRQFVEAWHLLPQIALLMACQRHR 83  Sodalis glossi...
Q06082         11 YLSIIFDPAFYINRNRLNLPSELLEnGVIRsEINNLIINKYDLNcDIEP-LSGV--TAMFVANWNLLPAVAYFIGSQESR 87  Shigella flexneri
AAS66832        9 vMRVMYHPVSYLHASRFP-SGWHREdQAAHpLLNHWILRHYHCP-SDDGADRGDPfYRFLLDNWQRLGDAALLIGAHLLR 86  Sodalis glossi...
WP_001303643    5 LRKIIYAPISYIHPQRVSLNNTPINnPVLRsITNEMILLQYNLS-VEHFNLNSSL--IYYINNWNLLPLICLLSGCHFYR 81  Escherichia coli
WP_001081596   10 WQRIIFDPLSYIHPQRLQIAPEMIVrPAARaAANELILATWRLKnGEKECIQNSL-TQLWLRQWRRLPQVAYLLGCHKLR 88  Salmonella ent...
tigr:BMAA1551  85 AALVERGRYVRLDASSQRFL----------CMPLAAVPKAA-CAGMPDDDAIVAAGTACLTAALHDAPRALRQRLPLLF- 152 Burkholderia m...
AAS66873       84 ASLAKGGYGASLPDWLRQFA----------ALSLVSSRSSP-GETIPPPAQLLAWGKYELLAFAGSLPRGLRQRLDLLF- 151 Sodalis glossi...
Q06082         88 --------LINHSEMVISYY----------GGKISKQGEAA-----------IRSGFWHLIAWKENISVGIYERINLLFn 138 Shigella flexneri
AAS66832       87 NRLLSEGRFILLSAPVQSFLalplppltpgALPQEQEEPATtLLQDPDPAA---WGAYCLLSMLKRLSPAVYRRACLLF- 162 Sodalis glossi...
WP_001303643   82 ERFAERGFFYKVPDVLRDYLs---------AIPLEINEKARyKPGIANYHNIITCGFSTLLPYIRQQPLAMQQRFNLLF- 151 Escherichia coli
WP_001081596   89 ADLARQGALLGLPDWAQAFL----------AMHQGTSLSV--CNKAPNHRFLLSVGYAQLNALNEFLPESLAQRFPLLF- 155 Salmonella ent...
tigr:BMAA1551 153 PrahaaRLASGLDGAHDDAraAWSSSLFSFAVNHALlEPAPVS 195 Burkholderia mallei ATCC 23344
AAS66873      152 PpeegrDDLSRLSLPPPCR--LLLKLAFQHAKRHPA-TPDTAD 191 Sodalis glossinidius
Q06082        139 P-----IALEGNYTPVERNlsRLN-EGMQYAKRHFTgIQTSCL 175 Shigella flexneri
AAS66832      163 P----------VEQPLPQQatSLSPSSINLIKMALHhAQYFTR 195 Sodalis glossinidius
WP_001303643  152 P-----DFVDHILSPLPLAstLLERITFYAKKNRDElDKISCK 189 Escherichia coli
WP_001081596  156 P-----PFIEEALKQDAVEmsILL-LALQYAQKYPNsVPAFAC 192 Salmonella enterica
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