Conserved Protein Domain Family
PFK_mixed

?
TIGR02483: PFK_mixed 
phosphofructokinase
Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Statistics
?
PSSM-Id: 274155
Aligned: 12 rows
Threshold Bit Score: 457.534
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
AAD47060   2 RLGVLTGGGDCPGLNALIRGLVKRGTHEFGYEFVGIENGYMGLVE-PGLAHPlTEEDTRGILPKGGTILGTSnKANPFSy 80  Myxococcus xanthus ...
Q9AGC0     2 RVGVLTGGGDCPGLNAVIRAVVRKGIEVHGWDFVGFRNGWNGPLT-GDSRPL-GLNDVEDILTRGGTILRSS-RTNPYK- 77  Amycolatopsis medit...
O08333     2 KVGVLTGGGDCPGLNAVIRAVVRKGVQEYGYDFTGFRDGWRGPLE-GDTVPL-DIPAVRGILPRGGTVLGSS-RTNPLK- 77  Streptomyces coelic...
AAT88673  18 KIGILTSGGDCPGLNAVIRGAVLKGDRVLDAEFAGFRYGWRGVVE-GDIMPL-DRHSVRGLSRQGGTILGSS-RTNPFEg 94  Leifsonia xyli subs...
Q8RQN5     5 RIATLTSGGDCPGLNAVIRGIVRTASNEFGSTVVGYQDGWEGLLA-DRRVQLyDDEDIDRILLRGGTILGTG-RLHPDK- 81  Corynebacterium eff...
Q9FC99     2 RIGVLTSGGDCPGLNAVIRSVVHRAVVDHGDEVIGFRDGWKGLLE-CDYLKL-DLDAVGGILARGGTILGSS-RVRPEH- 77  Streptomyces coelic...
P72830     6 RIGILTSGGDCAGLNAVIRSVVHHAIGTYGWEVIGIQEATQGLMEnPSKAIAlHRDNIDHLLMMGGTFLGTTnKGNPFAf 85  Synechocystis sp. P...
Q8XL57     7 KIAILTGGGDCPGLNAVIRAVTRTAILKYGYEVIGYKFGYRG-LYnNDFVKl-DLDSVSGILHRGGTILHSSnKDNLFDy 84  Clostridium perfrin...
AAR35081   4 KVGILTGGGDCPGLNAVIRGVVKSSIIRRGWEVVGIRDGFDGLLYnNRIVPl-GLNEVRGILPRGGTILGTSnRGNPFSy 82  Geobacter sulfurred...
CAG36638   3 KIAISTGGGDAPGLNAVIYAVVH-ACYRKGWEVYGSRNGYAGFLDlEEMIQl-RPRDVEGIYAIGGTIIGSTnKGNPFAn 80  Desulfotalea psychr...
Q9KH71     5 RIGVLTGGGDCPGLNPAIRGIVMRAL-DYGDEVIGLKYGWAGLLK-ADTMPl-SLEMVEDILEIGGTILGSS-RTNPFKk 80  Dictyoglomus thermo...
CAA74985   2 KIGVLTGGGDAPGLNIAVYTFVK--LAERKHEVYAIYHGWRGLLN--KEVKRvSSRDLLDFAFSGGTYIRTS-RTNPFKd 76  Thermoproteus tenax...
AAD47060  81 A-TREdghwverdvsDQVLLRCEELGLDGLIAVGGDGTLSIAHRLVEKg-LKVVGCPKTIDNDLSGTDQTFGFDTARLIV 158 Myxococcus xanthus ...
Q9AGC0    78 VeGGV----------DKIKQVLADQGVDALIAIGGEDTLGVAKRLTDDg-IGVVGVPKTIDNDLGATDYTFGFDTAVSIA 146 Amycolatopsis medit...
O08333    78 QrDGI----------RRIKDNLAALGVEALITIGGEDTLGVATRLADEygVPCVGVPKTIDNDLSATDYTFGFDTAVGIA 147 Streptomyces coelic...
AAT88673  95 EkGGP----------ENIQRMMDENGIDAIIAIGGEGTLTAARRLTDAg-LRIVGVPKTIDNDLAATDYSFGFDTAVEIA 163 Leifsonia xyli subs...
Q8RQN5    82 FrAGI----------DQVKANLADAGIDALIPIGGEGTLKGAKWLADNg-IPVVGVPKTIDNDVNGTDFTFGFDSAVSVA 150 Corynebacterium eff...
Q9FC99    78 LrDGV----------ERARGHVEELGLDAIIPIGGEGTLKAARLLSDNg-LPIVGVPKTIDNDIAVTDVTFGFDTAVTVA 146 Streptomyces coelic...
P72830    86 P-MADgtvr---drtEDIIAGYRQLGLDALIGIGGDGSLAILRRIAQQggINLVGIPKTIDNDVGATEISIGFDTATNIA 161 Synechocystis sp. P...
Q8XL57    85 QvEDEngkivkkdvsDVGVENLKKEGVDALVVIGGDGTLTSARDFSRKg-VNVIGVPKTIDNDLLATDVTFGFNTATEIA 163 Clostridium perfrin...
AAR35081  83 PvEADgktvl-tdvsDEVVANIKKQGIDALVAVGGDGSLKIALELMNKg-IPVVGVPKTIDNDLMETDVTFGYNTALETA 160 Geobacter sulfurred...
CAG36638  81 PvKNLagetqvidisDKILRNFKRMNFDCHIAIGGDGSMEIAHQFAEKg-MPVIGVPKTIDNDLEETDRTFGFDTAVSTA 159 Desulfotalea psychr...
Q9KH71    81 EeDVQ-----------KCVENFKKLNLDALIAIGGEDTLGVASKFSKLg-LPMIGVPKTIDKDLEETDYTLGFDTAVEVV 148 Dictyoglomus thermo...
CAA74985  77 EeRAR-----------LLESNVKELGLDVVVAIGGDDTLGAAGEAQRRgiLDAVGIPKTIDNDVYGTDYTIGFDSAVNAA 145 Thermoproteus tenax...
AAD47060 159 TEALDRLHSTAEAHDRVMVVEIMGRHAGFLTLESGIAGGADVILIPEIPYSVESVVEKIRRRSTRrRSFSIIAISEGAFP 238 Myxococcus xanthus ...
Q9AGC0   147 TEAIDRLHTTAESHHRALVVEVMGRHAGWIALHSGLAGGASVILVPERHFNVDQVVSWVERRFEK-EFAPIIVVAEGALP 225 Amycolatopsis medit...
O08333   148 TEAIDRLHTTAESHMRVLVVEVMGRHAGWIALHSGLAGGANVILIPEQRFDVEQVCSWVTSRFRA-SYAPIVVVAEGAMP 226 Streptomyces coelic...
AAT88673 164 TEAIDRLRTTAESHQRCMVLEVMGRHVGWIALHSGMAGGAHAILIPELPQSVDRICEWVESVRDR-GRAPVIVVSEGFHL 242 Leifsonia xyli subs...
Q8RQN5   151 TDAIDRLHTTAESHNRVMIVEVMGRHVGWIALHAGMAGGAHYTVIPEVPFDISEICKRMERRFQMgEKYGIIVVAEGALP 230 Corynebacterium eff...
Q9FC99   147 TEALDRLKTTAESHQRVLIVEVMGRHTGWIALHSGMAAGAHAVVVPERPFDIDELTAKVGERFSAgKRFAIVVAAEGAKP 226 Streptomyces coelic...
P72830   162 TEALDRLHFTAASHNRVMVLEVMGRDAGHIALAAGIGGGADIILIPEIPYRIQSVCNKIRQRQAEgKNFCLVMVSEAVRT 241 Synechocystis sp. P...
Q8XL57   164 TEALDRLHTTAESHHRIMLLEVMGRNAGWIALESGIAGSADVILLPEIPYDINKIVEKVKEREEAgKQFTIIVVAEGAKP 243 Clostridium perfrin...
AAR35081 161 TDALDKLHSTAESHHRVMIMEVMGRYAGWIALESGISGGADVILIPEIPYDISAVCRAVDERRRRgSSFSIIVVAEGAFP 240 Geobacter sulfurred...
CAG36638 160 TEALDKLHSTAKSHDRVMVVEVMGRDSGWIALYSGISGGADIILIPEVPFDMDKVCEKITDNDLRgKDYSIVVVAEGAQA 239 Desulfotalea psychr...
Q9KH71   149 VDAIKRLRDTARSHARVIVVEIMGRHAGWLALYGGLAGGADYILIPEVEPNLEDLYNHIRKLYARgRNHAVVAIAEGVQL 228 Dictyoglomus thermo...
CAA74985 146 IEATESFKTTLISHERIGVVEVMGREAGWIALFTGLSTMADAVLIPERPASWDSVAKRVKEAYNE-RRWALVVVSEGIKE 224 Thermoproteus tenax...
AAD47060 239 QGGELAV-LDTAEAIPGrgVVRLGGSGKALADLLARHIE-AEIRVTVLGHLQRGGSPSAADRVLATRYGCKVLDLVSAGQ 316 Myxococcus xanthus ...
Q9AGC0   226 EGGEEKL-LTGEKDAFG--HVRLGGIGTWLADEIAHRTG-KESRAVVLGHVQRGGTPTAYDRVLATRFGLNAVDAVADGD 301 Amycolatopsis medit...
O08333   227 RDGDMVL-KDESLDSYG--HVRLSGVGEWLAKQIEKRTG-NEARTTVLGHVQRGGTPSAFDRWLATRFGLHAVDCVHDGD 302 Streptomyces coelic...
AAT88673 243 DTMEEAH-SHKGLDAFN--RPRLGGIGEMLAPLIQERTG-IESRATVLGHMQRGGVPSAYDRVLATRLGMAAVDAAYEGR 318 Leifsonia xyli subs...
Q8RQN5   231 KEGTMEL-REGEVDQFG--HKTFTGIGQQIADEVHRRLG-HDVRTTVLGHIQRGGTPTAFDRVLATRYGVRAARACHEGQ 306 Corynebacterium eff...
Q9FC99   227 KAGTMDF-DEGGKDVYG--HERFAGIARQLSIELEERLG-KEARPVILGHVQRGGTPTAYDRVLATRFGWHAVEAVHRGE 302 Streptomyces coelic...
P72830   242 ELG------DQVKQIQQfgEDRYGGIGKYIAEQIAQRTG-AETRVTVLGHIQRGGIPSPFDRLLGSVFGVAAVDLIAEGK 314 Synechocystis sp. P...
Q8XL57   244 KDGEVVV-SKIVDDSPD--PIRLGGIANKLAIDLEGLIKnHEIRSTVLGHIQRGGNTSTYDRILSTKYGVKAVELINSNL 320 Clostridium perfrin...
AAR35081 241 RGGNRVV-QKRADETNT--IERLGGIGQYVARQLGDCLD-MDVRVMVLGHLQRGGSPSTFDRCLGSRFGVAAIDLIEQEQ 316 Geobacter sulfurred...
CAG36638 240 LNGQRFI-KGGLEPGRQ--EVILGGVGEWVATEIQRRTD-KDTRSLVLGHLQRGGSPTTFDRLLALRFGAAAVRLVEQET 315 Desulfotalea psychr...
Q9KH71   229 PGFTYQKgQEGMVDAFG--HIRLGGVGNVLAEEIQKNLG-IETRAVILSHLQRGGSPSIRDRIMGLLLGKKAVDLVHEGK 305 Dictyoglomus thermo...
CAA74985 225 YGG--------PKDEYG--HSRLGGVGNELAEYIERSTG-IEARAVVLGHTIRGVPPTAFDRILAVRYATAAYEAVENGR 293 Thermoproteus tenax...
AAD47060 317 WDHMVALRAGEIIAVPLSESR 337 Myxococcus xanthus DZF1
Q9AGC0   302 FGVMVALKGTDIVRVKLSEAT 322 Amycolatopsis mediterranei S699
O08333   303 FGKMVALRGTDIVRVPIAEAT 323 Streptomyces coelicolor A3(2)
AAT88673 319 WGSMVALRGTDVVNVSIADAT 339 Leifsonia xyli subsp. xyli str. CTCB07
Q8RQN5   307 FNTVVALKGERIRMISFDEAV 327 Corynebacterium efficiens YS-314
Q9FC99   303 FGKMTALRGTDIEMVSLADAV 323 Streptomyces coelicolor A3(2)
P72830   315 FDHMVAWRNRQTISVPIEEAI 335 Synechocystis sp. PCC 6803 substr. Kazusa
Q8XL57   321 FGNMVALKGNKVSYESLENVI 341 Clostridium perfringens str. 13
AAR35081 317 YGRMVCLRGRDIKSVSIERAV 337 Geobacter sulfurreducens PCA
CAG36638 316 FDHMVALKNSEMKAVPIADAI 336 Desulfotalea psychrophila LSv54
Q9KH71   306 SGLFVAVKGNELVPVDITLIE 326 Dictyoglomus thermophilum
CAA74985 294 YGVMVAYSNGDIAYVPIVDVV 314 Thermoproteus tenax Kra 1
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap