Conserved Protein Domain Family
carnitine_TMLD
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TIGR02410: carnitine_TMLD 
trimethyllysine dioxygenase
Members of this family with known function act as trimethyllysine dioxygenase, an enzyme in the pathway for carnitine biosynthesis from lysine. This enzyme is homologous to gamma-butyrobetaine,2-oxoglutarate dioxygenase, which catalyzes the last step in carnitine biosynthesis. Members of this family appear to be eukaryotic only.
Links
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Statistics
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PSSM-Id: 274119
Aligned: 6 rows
Threshold Bit Score: 556.7
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAS52650   27 VFHWIYLRDNCTCTECFHDATVQRtldTFDELPwkvcrqsySAEAPKEAEFEIREGK--LRVRWP-DEHVSEFSEDWLRR 103 Ashbya gossypii AT...
Q9NVH6     70 RFDYVWLRDHCRSASCYNSKTHQR---SLDTAS--------VDLCIKPKTIRLDETT--LFFTWP-DGHVTKYDLNWLVK 135 human
CAH03064   28 LFHLVYLRDNCTGKESFHGETHQRlidIFNDI---------DLEKDLNGTVVVEGDE--LVVKWF-DGHISRFTERWLLN 95  Kluyveromyces lactis
CAG81994   15 SFHNIWLRDNCRCQEHYHPLTKQRlqnTFAIP-----------EDVQPSKVALNGDN--WDVTWKhDGHVSSYPVDWLNR 81  Yarrowia lipolytic...
CAG89285   31 KYHNIWLRDNCHCEECYYIATKQRllnSCSIK-----------SDIKAASVDSDSKN--LRIEWNqDSHKSEYESSWLAL 97  Debaryomyces hanse...
NP_495793  43 IMPFVWLRDHCTSQKLYHLPTNQRksnCCDITS--------LSKIKHSNQVIIDEATnsLQIVWI-DGHQSKFKIGNIIR 113 Caenorhabditis ele...

AAS52650  104 HSYQPPLSTKPka---lSLPAKSHWDRAEFNkLLGDGAHFCTRYDnlp-----seLPTVLREIYEFGFTFVRNVPVSIEA 175 Ashbya gossypii AT...
Q9NVH6    136 NSYEGQKQKVIqp---rILWNAEIYQQAQVP-SVDCQSFLETNEG----------LKKFLQNFLLYGIAFVENVPPTQEH 201 human
CAH03064   96 HAYYPEKNVINnk--avKLPNRITWCKQEFNeLKQASDHFKNDYNhind---dstKKIIFNEIYQYGFTLIDNVPVSLDA 170 Kluyveromyces lactis
CAG81994   82 HNYSKPKTQTKtgpaqlDTQVRKKYWLAADIeADKPTVKFEDVMktd------kgLAEWSKKIYADGFCFVSGVPATPED 155 Yarrowia lipolytic...
CAG89285   98 HSYNPKLVPNQfkikgeQEVLKQSYWKVKDIkDNMPSVEFRAIMDssdrtdkedaIKDWCLKIWKYGFCMIDNVPISPGE 177 Debaryomyces hanse...
NP_495793 114 ---EGKVEKNVs-------nDNKIYELWNSKsLKDVPRISKSTLS----------LQSFSKNLVKYGVIIVDGVEGTSEA 173 Caenorhabditis ele...

AAS52650  176 TKTVSELISIIRPTHYDtGVWEFTSDLAKH-----DTAYTTVGISMHTDGNYWHELPGLQLFHLLEHSGgEGGETQIVDV 250 Ashbya gossypii AT...
Q9NVH6    202 TEKLAERISLIRETIYG-RMWYFTSDFSRG-----DTAYTKLALDRHTDTTYFQEPCGIQVFHCLKHEG-TGGRTLLVDG 274 human
CAH03064  171 TKEVSELISIIRPTHYDtGVWDFTSDLSKK-----DTAYTSLAIDMHTDGNYWYETPGLQLFHLLLHDG-QGGETRICDV 244 Kluyveromyces lactis
CAG81994  156 TEKLCERLAHIKHTHYG-GFWDFTADLAMN-----DTAYTNFHLASHTDGTYWTDTPGLQLFHCLHHDG-KGGENMLVDG 228 Yarrowia lipolytic...
CAG89285  178 TEKLCEKITYIRPTHYG-GFWDFTSDLSKN-----DTAYTNFDISSHTDGTYWNDTPGLQLFHLLYHDG-TGGTTSLVDA 250 Debaryomyces hanse...
NP_495793 174 TEKLCQSLVPVHDTFFG-QFWVFSNSATNDepayeDTAYGSDEIGPHTDGTYFDQTPGIQVFHCLTPAK-TGGDTVLVDS 251 Caenorhabditis ele...

AAS52650  251 AKVVDQLRELAAQDeswrttYKVLTEHPLAFHQSGELD-SVFYQADY--PTLTLD-ATGELEQCRWNTSDRISQAPLApg 326 Ashbya gossypii AT...
Q9NVH6    275 FYAAEQVLQKAPEE------FELLSKVPLKHEYIEDVG-ECHNHMIGigPVLNIYpWNKELYLIRYNNYDRAVINTVP-- 345 human
CAH03064  245 AHILKLIKDKANEDeswqetLEILTKQPIEFHQSGESE-NVFIENRY--PILQVD-KDGELIQCRWNTSDRTS---MLkg 317 Kluyveromyces lactis
CAG81994  229 FRAAQEFKKLNPEG------YELLSRVRIPAHSAGE-D-SVCITPEVpqPVFTHDpITGELQQVRWNNDDRSVMD--Twd 298 Yarrowia lipolytic...
CAG89285  251 FQCAKILQKEHPED------FDLLTKIPVPAHSAGE-E-KVCIQPDIpqPIFKLD-NQGELVQVRWNQSDRSTMD--Nws 319 Debaryomyces hanse...
NP_495793 252 FYCAEKLRNESPED------FEILCNTKISHHYLEGSPpGSSIHSVSleKPVIERnSFGNITQIRFNPYDRAPFSCLNss 325 Caenorhabditis ele...

AAS52650  327 --sPYTVPQVYQALFRLDSLIKDEKNYVQFKMQPGTIFIFDNWRVLHARTSFTGCRRLCGSYLTRDDFLARFRSIVF 401 Ashbya gossypii ATCC ...
Q9NVH6    346 ---YDVVHRWYTAHRTLTIELRRPENEFWVKLKPGRVLFIDNWRVLHGRECFTGYRQLCGCYLTRDDVLNTARLLGL 419 human
CAH03064  318 --tKYPVNEIYRAMARFNDLINDTDNYVRFPLAPGTILVFDNWRVLHARTAFNGKRRLCGSYLTRDDFLARYRSLLF 392 Kluyveromyces lactis
CAG81994  299 --sPEDVPKFYKAIRQWNGILTDPKFEYVCKLVAGECLIFDNWRVLHGRKGFVGNRRMCGAYHARDDFLSTFRLTNF 373 Yarrowia lipolytica C...
CAG89285  320 --nPEDVPRFYKAIGNWYKIITDPENEIFYQLRPGQCLIFDNWRCFHSRTEFTGKRRMCGAYINRDDFMSRLKLLNL 394 Debaryomyces hansenii...
NP_495793 326 easAAETIKFYEAYEKFSKICHNPDNSIEISLRPGSVIFIDNFRILHSRTSFQGYRQMCGCYLSRDNFMAKAIPFLS 402 Caenorhabditis elegans
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