Conserved Protein Domain Family
dnaX_nterm

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TIGR02397: dnaX_nterm 
DNA polymerase III, subunit gamma and tau
This model represents the well-conserved first ~ 365 amino acids of the translation of the dnaX gene. The full-length product of the dnaX gene in the model bacterium E. coli is the DNA polymerase III tau subunit. A translational frameshift leads to early termination and a truncated protein subunit gamma, about 1/3 shorter than tau and present in roughly equal amounts. This frameshift mechanism is not necessarily universal for species with DNA polymerase III but appears conserved in the exterme thermophile Thermus thermophilis. [DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 274111
Aligned: 35 rows
Threshold Bit Score: 423.516
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAT88359        4 VTALYRRYRPDTFAEMIGQSQVTDPLTTALRTNRVNHAYLFSGPRGCGKTTSARILARCLNCA----EGPTDIPCGVCPS 79   Leifsonia xyl...
AAQ00862        5 YQPLHQKYRPKRFDDLVGQDSIVATLKQALISNRIAPAYLFCGPRGTGKTSSARILARSLNCQq--sEKPTIAPCCQCNL 82   Prochlorococc...
AAS13103        3 YQVTATRRRPQRFEDLLGQEFVAATLQKSIEAGKIAHAYLFSGPRGCGKTSSARILAKVLNCA----EGPRPTPCGHCTS 78   Treponema den...
AAS14717        1 -MNIALKHRPSSFKDLVGQDILVRVLENAFILNKIPQSILLSGSSGVGKTTTARIIALCLNCS----LGPIFEPCGSCEN 75   Wolbachia end...
CAE11094        2 SQALALKYRPTRFEDLIGQDPISQTLSLALDSGRLSHAYLFSGLRGSGKTSSARIFSKALNCAq----GPSSTPCDVCEN 77   Wolinella suc...
AAS72345      353 HQSLTQKYSPKTFKDMIGQSLVVQALSNAILKRKIGLVYVFYGPHGTGKTSCARVFAKALNCHs----PEHPRPCDSCAS 428  Japanese rice
WP_011120949   37 YVVVARRYRPRDFTQLVGQDHVARALQGAIETSRVGHAYLFTGARGVGKTSTARIFAKALNHP----DGPTANPDSESDV 112  Rhodopirellul...
WP_002657945    4 srgtALKKRPRDFNSLEGQDFVVETLKHSIEKNKIANAYIFSGPRGVGKTSSARAFARCLNCR----NGPTVMPCGECSN 79   Lyme disease ...
WP_010993898    2 YRPLHLKYRPQILSEVIGQEHIVRTLINAIAFQKIAPAYLFSGPKGTGKTSTARIIAKSLNCQs--sNEPTTKPCGECNS 79   Nostoc sp. PC...
WP_026054924   10 YIPFARKYRPSNFAELQGQEVLVKVLSYTILNDRLAGGYLLTGIRGVGKTTSARIIAKAVNCSalitENTTIKTCEQCTN 89   spotted fever...
AAT88359       80 CVELSrgGGGSLDVVEIDAASHNGVDDARDIRERAIFAPARDRYKIFILDEAHMVTPQGFNALLKIIEEPPDHVKFIFAT 159  Leifsonia xyl...
AAQ00862       83 CKEIG--KGTALDIIEIDAASNTGVDNIRELIERSQFAPVQARWKVYVIDECHMLSTAAFNALLKTLEEPPSQTVFVLAT 160  Prochlorococc...
AAS13103       79 CEEIT--AGSCLDVIEIDGASNTSVNDVRQIKDEILFPPNSNRYKIYIIDEVHMLSTSAFNALLKTIEEPPPYVVFIFAT 156  Treponema den...
AAS14717       76 CLAIK--NSSHPDVIEIDAASHTSIDDIKVILGDICYSPISSKFKVYIIDEVHMLSSSAFNALLKTLEEPPSSVKFILAT 153  Wolbachia end...
CAE11094       78 CLAAK--EGRHMDIIEMDAASSRKIDDIRDLIEQTKYHPAMGRFKIFIIDEVHMLTKEAFNALLKTLEEPPPYVKFILAT 155  Wolinella suc...
AAS72345      429 CIAHN--LGKSRSLVEIGPVGNIDLDSIVDILDNVMLSPVPTQHRVFIVDDCNTLPPDTWSVISKVIERAPRRVVFILIS 506  Japanese rice
WP_011120949  113 AQAID--SGEDVDVIEIDGASNRGIDEIRSLRANVGVRPSRSRYKIYIIDEVHMLTGAAFNALLKTLEEPPEHVKFIFCT 190  Rhodopirellul...
WP_002657945   80 CKSIE--NDSSLDVVEIDGASNTSVQDIRQIKEEIMFPPAISKYRIYIIDEVHMLSNSAFNALLKTIEEPPNYIVFIFAT 157  Lyme disease ...
WP_010993898   80 CKGIT--ASSSVDVTELDAASNSGVELIRELISTTQFAPVESRFKIFIIDECHALSSQSWQALLKTIESPPRHVVFIFCT 157  Nostoc sp. PC...
WP_026054924   90 CISFN--NHNHPDIIEIDAASKTSVDDIRRIIESAEYKPLQGKHKIFIIDEVHMLSKGAFNALLKTLEEPPPHIIFIFAT 167  spotted fever...
AAT88359      160 TEPEKVIGTIRSRTHHYPFRLVPPALMLEYVQTLCDSEGITVAPGVLPLVVRAGGGSPRDTLSLLDQLMAG---SEGssI 236  Leifsonia xyl...
AAQ00862      161 TDPQRLLQTILSRCQRFDFRRIPITSLTSHLTTIASKEKIEIDQESINLIAQRSEGGLRDAESLLDQLSLL---KPP--I 235  Prochlorococc...
AAS13103      157 TEIHKVPATIKSRCQQFNFKLVSIEILKQALADAAAELGISADDEALYWIAREATGSVRDAYTLFDQVAAF---SDGh-I 232  Treponema den...
AAS14717      154 TEIKKIPITIIARCQRFDLHNIPVAKIVERLNDVAQKESYSIEKGALELIARHSGNSMRNALFLMNQAVLY---SKdgaI 230  Wolbachia end...
CAE11094      156 TDPLKLPATILSRTQHFRFKKIAHRDVIAHIQKILHLENVPFEPEALEMIARSGGGSLRDTLTLLDQSIIF---CKg-nL 231  Wolinella suc...
AAS72345      507 PNLD-LPHIIVSRCQKFFFPKLKECDIVNTLQWISTSEGLDVDRDALKLIASRSDGSLRDAEMTLDQLSLL---GQR--I 580  Japanese rice
WP_011120949  191 TDPEKIPITVLSRCQRFDFAPVESDKIVQRLREIVEAEDNTVEDEALELLARRAAGSMRDSQSLLEQVLSF---SDGh-L 266  Rhodopirellul...
WP_002657945  158 TESHKLPETIKSRCQHFNFKLLSLDKIYNMLKKVCLEDDIKYEDEALKWIAYKSSGSVRDAYTLFDQIVSF---TDSn-I 233  Lyme disease ...
WP_010993898  158 TELHKVPETIVSRCQKFDFKRVPVSLVASYLEKISHQESINIAPSAVTAVAKANKGHLRDSLKLLDQLTLL---GEEe-I 233  Nostoc sp. PC...
WP_026054924  168 TEVQKIPATIISRCQRYDLRRLSFEEIFKLLEYITKQENLKTDIEALRIIAYKSEGSARDAVSILDQAASMsvkSDNi-I 246  spotted fever...
AAT88359      237 EYERAVALLGYTHAALLDEVVDAIAARDAAGAFAAVDRVIQTGQDPRRFVDDLLERLRDLIVVAAT--SvegaaA--VLR 312  Leifsonia xyl...
AAQ00862      236 NLQSIWELLGEVPENDLIILTSSLISQDPISLLKTCRKLFDNGKEPISILQGLTATLRDLVLIKSL--Pd---qP--SLC 308  Prochlorococc...
AAS13103      233 TFEKIHEKLGLTGVDSINKLVSACVAKNGQEALSILDGILQGGISVEQVVSDCADYFRSLLLVKHGit-----kE--ALI 305  Treponema den...
AAS14717      231 STKNVTDILGLVDKDIIFDLLGAILEGDLQKALSVFDKAVKTANPLSIF-EGLLQTIQLVCRFLIT--K-----E--IDN 300  Wolbachia end...
CAE11094      232 TPALVAQMLGLVDPELLERLFDAIFSHDEPTLSELLKELELHETEMVLEEIAIFLKEKLSQNHPQY--Pl----G--MLD 303  Wolinella suc...
AAS72345      581 SMSLVQELVGLVSDDKLVDLLDLALSADTVNTVKTLRDITETGVEPLALMSQLATIITDILAGTYA-------------F 647  Japanese rice
WP_011120949  267 TADHVHTMLGTADDQRLHRLAEAMADRDASAALSQIDEAIAAGVDAGRLAEQMLGYFRDLMAVAVGceA-----S--LMR 339  Rhodopirellul...
WP_002657945  234 KLDQIRSKMGLTNDEFLEKLSVSILGEDVKELICVLDSIFSSGVSYEQFLLDSIEFFREALFLKIGikN-----F--EFI 306  Lyme disease ...
WP_010993898  234 TYNWVWELSGTIPEYDLLTVCENIIKGEITGNLGILQDWIESGKQPTAIHTSLVNFLKDLLVCKTN--P-----NgrHLT 306  Nostoc sp. PC...
WP_026054924  247 SPQVINQMLGLVDSSVIIEFVECIIYRETEKAINLINKLYGSSVNLEIFIESASDFIAYLNKVKML--P-----N--YSL 317  spotted fever...
AAT88359      313 GVPADVLDTMGRQAMMFGAA-ELSRCADIVNAALTEMTGATSPRLHLELMVARVL 366  Leifsonia xyli subsp. xyli str. CTCB07
AAQ00862      309 SLSKQSQETLTKISSELELD-RILYWQKYLKGSESQIRFSLQPRLWLEVLLLGLL 362  Prochlorococcus marinus subsp. marinus...
AAS13103      306 GQRADRFP--QDILQGWEAV-QIERALSIMLQLFKDLRFSIDQRYELELAVSRLS 357  Treponema denticola ATCC 35405
AAS14717      301 AVTEHEKNRIKDLSIKRSLI-FFSRLWKMLLKGIQDIKTSTCNDVAAEMMLISLC 354  Wolbachia endosymbiont of Drosophila m...
CAE11094      304 RFFRIIADSQTLLSLGSHNA-FVLTLTILKMKEALKIKEIDGMIEELEQELFSKN 357  Wolinella succinogenes
AAS72345      648 TQERVRRKFFKCPTLSKDDMeKLRQALKTLSEAEKQLRVSNDKMTWLTAALLQLA 702  Japanese rice
WP_011120949  340 YAAASMHGSLGELAGRWGLQ-TVLAIVGLVDETLVRIRHSVHARVLLEATVIQVC 393  Rhodopirellula baltica
WP_002657945  307 GIKSED---LRKKLIEFDLN-YLERIIVVLLETYRDLQFSVNPRYELEINFIKIL 357  Lyme disease spirochete
WP_010993898  307 QLEQDTWEELVSISQLWNID-QIRNAIAILMARQSLMR-DEDAHLWLEATLIEIv 359  Nostoc sp. PCC 7120
WP_026054924  318 PIYESFNDRTKNILDKTSLP-HLSILWQIYNKGVGEIKISYNQLTETEMLVIKSI 371  spotted fever group
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