2Q7E,3DSQ


Conserved Protein Domain Family
PylS_Cterm
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TIGR02367: PylS_Cterm 
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pyrrolysyl-tRNA synthetase, C-terminal region
PylS is the enzyme responsible for charging the pyrrolysine tRNA, PylT, by ligating a free molecule of pyrrolysine. Pyrrolysine is encoded at an in-frame UAG (amber) at least in several corrinoid-dependent methyltransferases of the archaeal genera Methanosarcina and Methanococcoides, such as trimethylamine methyltransferase. This protein occurs as a fusion protein in Methanosarcina but as split genes in Desulfitobacterium hafniense and other bacteria. [Protein synthesis, tRNA aminoacylation]
Links
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Statistics
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PSSM-Id: 188213
Aligned: 6 rows
Threshold Bit Score: 438.081
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2Q7E_A        53 FRELESELLSRRKKDLQQIYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDTELSKQIFRVDKNF 132 Methanosarcina ...
WP_011033391 216 FRELESELLSRRKKDLQQIYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDTELSKQIFRVDKNF 295 Methanosarcina ...
WP_011462270  70 FQGIEHQLMSQGKRHLEQLRTVKHRPALLELEEGLAKALHQQGFVQVVTPTIITKSALAKMTIGEDHPLFSQVFWLDGKK 149 Desulfitobacter...
WP_011500100 178 FKVLEKELIQRRRDDLKKMYEEDREDRLGKLERDITEFFVDRGFLEIKSPIMIPFEYIERMGIDKDDHLNKQIFRVDESM 257 Methanococcoide...
EEN15948      37 YKRVEMRLINESKQRLNKLRHETKRPAICALENRLAAALRGAGFVQVATPVILSKKLLGKMTITDEHALFSQVFWIEENK 116 Desulfotomaculu...
3DSQ_A        46 FQGIEHQLMSQGKRHLEQLRTVKHRPALLELEEKLAKALHQQGFVQVVTPTIITKSALAKMTIGEDHPLFSQVFWLDGKK 125 Desulfitobacter...

2Q7E_A       133 CLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLNFCQMGS--GCTRENLESIITDFLNHLGI- 209 Methanosarcina ...
WP_011033391 296 CLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLNFCQMGS--GCTRENLESIITDFLNHLGI- 372 Methanosarcina ...
WP_011462270 150 CLRPMLAPNLYTLWRELERLWDKPIRIFEIGTCYRKESQGAQHLNEFTMLNLTELGTplEERHQRLEDMARWVLEAAGIr 229 Desulfitobacter...
WP_011500100 258 CLRPMLAPCLYNYLRKLDKVLPDPIRIFEIGPCYRKESDGSSHLEEFTMVNFCQMGS--GCTRENMEALIDEFLEHLGI- 334 Methanococcoide...
EEN15948     117 CLRPMLAPNLYYILKDLLRLWEKPVRIFEIGSCFRKESQGSNHLNEFTMLNLVEWGLpeEQRQKRISELAKLVMDETGId 196 Desulfotomaculu...
3DSQ_A       126 CLRPMLAPNLYTLWRELERLWDKPIRIFEIGTCYRKESQGAQHLNEFTMLNLTELGTplEERHQRLEDMARWVLEAAGIr 205 Desulfitobacter...

2Q7E_A       210 DFKIVGDSCMVYGDTLDVMHGDLELSSAVVGPIPLDREWGIDKPWIGAGFGLERLLKVKHDFKNIKRAARSESYYNGIST 289 Methanosarcina ...
WP_011033391 373 DFKIVGDSCMVYGDTLDVMHGDLELSSAVVGPIPLDREWGIDKPWIGAGFGLERLLKVKHDFKNIKRAARSESYYNGIST 452 Methanosarcina ...
WP_011462270 230 EFELVTESSVVYGDTVDVMKGDLELASGAMGPHFLDEKWEIVDPWVGLGFGLERLLMIREGTQHVQSMARSLSYLDGVRL 309 Desulfitobacter...
WP_011500100 335 EYEIEADNCMVYGDTIDIMHGDLELSSAVVGPIPLDREWGVNKPWMGAGFGLERLLKVRHNYTNIRRASRSELYYNGINT 414 Methanococcoide...
EEN15948     197 EYHLEHAESVVYGETVDVMHRDIELGSGALGPHFLDGRWGVVGPWVGIGFGLERLLMVEQGGQNVRSMGKSLTYLDGVRL 276 Desulfotomaculu...
3DSQ_A       206 EFELVTESSVVYGDTVDVMKGDLELASGAMGPHFLDEKWEIFDPWVGLGFGLERLLMIREGTQHVQSMARSLSYLDGVRL 285 Desulfitobacter...

2Q7E_A       290 NL 291 Methanosarcina mazei
WP_011033391 453 NL 454 Methanosarcina mazei
WP_011462270 310 NI 311 Desulfitobacterium hafniense
WP_011500100 415 NL 416 Methanococcoides burtonii
EEN15948     277 NI 278 Desulfotomaculum acetoxidans DSM 771
3DSQ_A       286 NI 287 Desulfitobacterium hafniense
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