4IZ6,1MDB


Conserved Protein Domain Family
DHB_AMP_lig
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TIGR02275: DHB_AMP_lig 
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2,3-dihydroxybenzoate-AMP ligase
Proteins in this family belong to the AMP-binding enzyme family (pfam00501). Members activate 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate; many are involved in synthesis of siderophores such as enterobactin, vibriobactin, vulnibactin, etc. The most closely related proteine believed to differ in function activates salicylate rather than DHB. [Transport and binding proteins, Cations and iron carrying compounds]
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Statistics
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PSSM-Id: 274063
Aligned: 7 rows
Threshold Bit Score: 984.67
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4IZ6_A        23 IPFTRWPEEFARRYREKGYWQDLPLTDILTRHAAS--DSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQL 100 Escherichia coli
P40871         3 KGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKygDRIAITCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQL 82  Bacillus subtil...
O07899         3 TDFTPWPEALAAQYRQLGYWQDKTLLDYLQQSAERtpNALALVGDNQQWRYQAMLERIEQLAAGFTELGLGCGDNVVLQL 82  Vibrio cholerae...
tigr:BRA0015   3 IEFTHWPPARERLYREKGYWIDKPLTRALEEQAAMrpDAPTILCGERRFTYAELDRLSSNLASRLAAAGIGKGDTALVQL 82  Brucella suis 1330
P10378         3 IPFTRWPEEFARRYREKGYWQDLPLTDILTRHAAS--DSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQL 80  Escherichia col...
CAE15103       3 IEFTPWPVELAERYREKGYWLGKPLTDILYKQCQRqpEAIAIICGNRKFSYHQLDQQSSALASNLTLAGIKRGDTAIVQL 82  Photorhabdus lu...
1MDB_A         3 KGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKygDRIAITCGNTHWSYRELDTRADRLAAGFQKLGIQQKDRVVVQL 82  Bacillus subtilis

4IZ6_A       101 GNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNds-- 178 Escherichia coli
P40871        83 PNIKEFFEVIFALFRLGALPVFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAG---- 158 Bacillus subtil...
O07899        83 GNVAEFYLCFFALLRQGIRPILALPAHRLAEIRYFCQHSQAKAYLIDGAQRPFDYQALAQELLACCPTLQTVIVRGqt-r 161 Vibrio cholerae...
tigr:BRA0015  83 PNIAEFYIVFFALMKAGIAPVNALFSHRKLELGAYASQIEPRLLIGSRQHELFMDDAFARDLGKNLSAPLLTLFAGea-d 161 Brucella suis 1330
P10378        81 GNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNds-- 158 Escherichia col...
CAE15103      83 PNIAEFYITFFALLKMGVVPINALFSHNKLELLAYAQQIDPSLIVLSSEHSLLQNNDFLEQLKIHCPRLRNIVVDGrkiq 162 Photorhabdus lu...
1MDB_A        83 PNIKEFFEVIFALFRLGALPVFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAG---- 158 Bacillus subtilis

4IZ6_A       179 gEHNLQDAINHPA-ED-FTAT-PSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHN 255 Escherichia coli
P40871       159 -EAEEFLPLEDLH-AEpVKLP-EVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVCWLDHSTVYLAALPMAHN 235 Bacillus subtil...
O07899       162 vTDPKFIELASCY-SA-SSCQaNADPNQIAFFQLSGGTTGTPKLIPRTHNDYAYSVTASVEICRFDQHTRYLCVLPAAHN 239 Vibrio cholerae...
tigr:BRA0015 162 pASSLDHWIATPA-DKaVPFS-PTGAGEVAFFQLSGGSTGTPKLIPRTHNDYDYSVRASAEICALTPQTRFLCALPTAHN 239 Brucella suis 1330
P10378       159 gEHNLQDAINHPA-ED-FTAT-PSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHN 235 Escherichia col...
CAE15103     163 yTNELKSWLESTN-LP-LNFE-ATRSDEVAFFQLSGGSTGTPKLIPRTHDDYYYSVRRSVEICELTQQTRYLCALPAQHN 239 Photorhabdus lu...
1MDB_A       159 -EAEEFLPLEDLHtEP-VKLP-EVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVCWLDHSTVYLAALPMAHN 235 Bacillus subtilis

4IZ6_A       256 YAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIegESRAQLASLKLLQVGGARLSAT 335 Escherichia coli
P40871       236 YPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTITALVPPLAMVWMDAAS--SRRDDLSSLQVLQVGGAKFSAE 313 Bacillus subtil...
O07899       240 FPLSSPGALGVFWAGGCVVLSQDASPQHAFKLIEQHKITVTALVPPLALLWMDHAE--KSTYDLSSLHFVQVGGAKFSEA 317 Vibrio cholerae...
tigr:BRA0015 240 YPMSSPGALGVFHAGGCVVMASNPEPLNCFSIIERHGVNMVALVPPAVALWLQATP--DHLAALSSLKLVQVGGASFAEA 317 Brucella suis 1330
P10378       236 YAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIegESRAQLASLKLLQVGGARLSAT 315 Escherichia col...
CAE15103     240 YPLSSPGALGVFYAGGCLILATDPGPTTCFPLIREHKVTMTSLVPSAVALWIQTMR--KYQYSLESLRLLQVGGAKLSES 317 Photorhabdus lu...
1MDB_A       236 YPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTITALVPPLAMVWMDAAS--SRRDDLSSLQVLQVGGAKFSAE 313 Bacillus subtilis

4IZ6_A       336 LAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYY 415 Escherichia coli
P40871       314 AARRVKAVFGCTLQQVFGMAEGLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGYY 393 Bacillus subtil...
O07899       318 AARRLPKALGCQLQQVFGMAEGLVNYTRLDDSAELIATTQGRPISAHDQLLVVDEQGQPVASGEEGYLLTQGPYTIRGYY 397 Vibrio cholerae...
tigr:BRA0015 318 LARQVPQVLGCKLQQVFGMAEGLVNYTRLDDPDEIVFTTQGRPISPDDEIRIVDEDGEPVAEGQPGMLATRGPYTFCGYY 397 Brucella suis 1330
P10378       316 LAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYY 395 Escherichia col...
CAE15103     318 VARVIPKLFSCKLQQVFGMAEGLVCYTRLNDDDERIFTTQGCPMSGDDEVRIVDDNGNIQAPGSAGMLIIRGPYTFRGYY 397 Photorhabdus lu...
1MDB_A       314 AARRVKAVFGCTLQQVFGMAEGLVNYTRLDDPEEIIVNTQGKPMSPYDESRVWDDHDRDVKPGETGHLLTRGPYTIRGYY 393 Bacillus subtilis

4IZ6_A       416 KSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSC 495 Escherichia coli
P40871       394 KAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLLAHPAVHDAAMVSMPDQFLGERSC 473 Bacillus subtil...
O07899       398 RADQHNQRAFNAQGFYITGDKVKLSSEGYVIVTGRAKDQINRGGEKIAAEEVENQLLHHPAVHDAALIAISDEYLGERSC 477 Vibrio cholerae...
tigr:BRA0015 398 RNPEHNAQVFDSEGFYYSGDVVQRTPEGYLRVVGRVKDQINRGGEKVAAEEIENLILLHPDVTHAALVAMQDELLGEKSC 477 Brucella suis 1330
P10378       396 KSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSC 475 Escherichia col...
CAE15103     398 KSPAHNAKVFDKEGFYYTGDLAYMTKEGYICIVGREKDQINRGGEKIASEEIESLLLKHEDVIHSALVSMPDPLMGEKSC 477 Photorhabdus lu...
1MDB_A       394 KAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLLAHPAVHDAAMVSMPDQFLGERSC 473 Bacillus subtilis

4IZ6_A       496 AYLVVKEP--LRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLR 547 Escherichia coli
P40871       474 VFIIPRDEa-PKAAELKAFLRERGLAAYKIPDRVEFVESFPQTGVGKVSKKALR 526 Bacillus subtilis subsp. subtilis str. 168
O07899       478 AVIVLKPEqsVNTIQLKRFLHQAGLADYKIPDQIQFIDQLPKTSVGKIDKNALR 531 Vibrio cholerae O1 biovar El Tor str. N16961
tigr:BRA0015 478 AFIVSRNPd-LKPPVLRRHLLALGVAEYKLPDRIRLIETMPLTAVGKIDKKHLR 530 Brucella suis 1330
P10378       476 AYLVVKEP--LRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLR 527 Escherichia coli K-12
CAE15103     478 AFIVVADPn-INTLQLRKYLRGMGIAEYKLPDRFEIIDVMPVTPVGKIDKLLLR 530 Photorhabdus luminescens subsp. laumondii...
1MDB_A       474 VFIIPRDEa-PKAAELKAFLRERGLAAYKIPDRVEFVESFPQTGVGKVSKKALR 526 Bacillus subtilis
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