2ICJ


Conserved Protein Domain Family
IPP_isom_1

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TIGR02150: IPP_isom_1 
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isopentenyl-diphosphate delta-isomerase, type 1
This model represents type 1 of two non-homologous families of the enzyme isopentenyl-diphosphate delta-isomerase (IPP isomerase). IPP is an essential building block for many compounds, including enzyme cofactors, sterols, and prenyl groups. This inzyme interconverts isopentenyl diphosphate and dimethylallyl diphosphate. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Statistics
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PSSM-Id: 273998
Aligned: 13 rows
Threshold Bit Score: 172.14
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2ICJ_A        27 CILIDENDNKIGAETKKNC--HLNENIek-glLHRAFSVFLFNTENKLLLQQRSDA-KITFPGCFTNTCCSHPLSnpael 102 human
P58044        21 CILIDENDNKIGADTKKNC--HLNENIdk-glLHRAFSVFLFNTENKLLLQQRSDA-KITFPGCFTNSCCSHPLSn---- 92  house mouse
Q39471        75 CILVDEVDRVVGHESKYNC--HMWEKIesgnmLHRAFSVFLFNSKFELLLQQRSAT-KVTFPLVWTNTCCSHPLYr---- 147 Clarkia breweri
Q10132        24 CIVVDENDVPLRYGTKKEC--HLMENInk-glLHRAFSMFIFDEQNRLLLQQRAEE-KITFPSLWTNTCCSHPLDv---- 95  Schizosaccharom...
WP_025687065  14 VVLLNDRGDATGVADKATV--HTGDTP-----LHLAFSSYVFDLHDQLLITRRAAT-KRTWPAVWTNSCCGHPLP----- 80  Mycobacterium t...
WP_012475940   2 VILCNELGEATGTAPKSEI--HHSDTP-----LHLAFSVYIFNGDNKLLVTRRASD-KITWPGVLSNSCCGHPQP----- 68  Agrobacterium r...
BAA33978      67 CILVDADDNITGHVSKLEC--HKFLPHqpaglLHRAFSVFLFDDQGRLLLQQRARS-KITFPSVWTNTCCSHPLHgq--- 140 Haematococcus p...
Q9KK75         4 VVLVDHAGDPIGVQSKADV--HGQSTP-----RHLAFSCHVVDEQGRLLVTRRALK-KRTWPGVWTNSFCGHPAP----- 70  Brevibacterium ...
WP_011015025  14 VVLADSEGNPIGTAPKATV--HTKDTP-----LHFAFSTYILNPRGELLVTRRALS-KKTWPGVWTNSMCGHPGP----- 80  Corynebacterium...
WP_023258155   6 VVLLDEQDKPSGTLEKYAA--HTLNTP-----LHLAFSCWLFNEDGQLLVTRRSLS-KKAWPGVWTNSVCGHPQQ----- 72  Salmonella ente...
AAM48607      15 LMLVDSNDVVIGYEEKASA--HQGEGQ-----LHRAFSIFLLNDHGEVLLQQRSSL-KPLWPMYWSNTCCSHPRK----- 81  uncultured mari...
WP_015920849   1 -mtemvpawveGRLMPVEKleAHQRGL-----RHMAISVFVMAGE-AVLIQRRAAG-KYHTPGLWANTCCTHPRW----- 67  Rhodobacter sph...
AAL76360      15 LILVDSLDQVIGNASKKQV--HLPGGQ-----LHRAFSIFLYANNQ-QVMLHKRSLeKPLWPNFWTNSCCSHPRT----- 81  uncultured mari...
2ICJ_A       103 eesdalG-V--R--R---------------A--AQRRL-K--A-EL-GI-PLEEVPpeeIN-YLTRIH-YKAQsd----- 147 human
P58044        93 -----pG-E--L--Eennai------gvkrA--AKRRL-K--A-EL-GI-PLEEVDlneMD-YLTRIY-YKAQsd----- 141 house mouse
Q39471       148 -----eS-E--L--Idennl------gvrnA--AQRKL-L--D-EL-GI-PAEDVPvdeFT-PLSRML-YKAPsd----- 196 Clarkia breweri
Q10132        96 -----aG-E--R--Gntlpea---vegvknA--AQRKL-F--H-EL-GI-QAKYIPkdkFQ-FLTRIH-YLAPst----- 147 Schizosaccharom...
WP_025687065  81 ------G-Es-L--P---------------G--AIRRR-La-A-EL-GL-TPDRVD---L--ILPGFR-YRAAm------ 116 Mycobacterium t...
WP_012475940  69 ------G-Ep-L--T---------------E--AIERR-G--HeEL-RI-RADDIR---L--VLPEFS-YRASm------ 104 Agrobacterium r...
BAA33978     141 ----tpD-E--V--DqlsqvadgtvpgakaA--AIRKL-E--H-EL-GI-PAHQLPasaFR-FLTRLH-YCAAdvqpaat 201 Haematococcus p...
Q9KK75        71 ------GeT--L--E---------------D--AVSRRaE--F-EL-GL-SIDHIT----C-AIPNFS-YVARd------ 106 Brevibacterium ...
WP_011015025  81 ------DeT--N--A---------------D--AIRRR-G--VdEL-GLeVDSFLD---IQeILPDYQ-YRAVd------ 119 Corynebacterium...
WP_023258155  73 ------G-E--TteE---------------A--IIRRC-R--F-EL-GV-EITDLT----P-VYPHFS-YRATd------ 108 Salmonella ente...
AAM48607      82 ------G-EtlA--Q---------------S--TTRRL-R--E-EL-NL-EA---P---LK-YLYKFQ-YHARy------ 115 uncultured mari...
WP_015920849  68 ------G-E--E--A---------------AdcAVRRL-R--E-EL-GI-TGLVT-------VFADRVeYRADv------ 102 Rhodobacter sph...
AAL76360      82 ------G-EsyEd-----------------A--VHRRL-KeeL-GIeTP----------LT-RIYQFe-YQAHf------ 115 uncultured mari...
2ICJ_A       148 --gIWG--E--H--EIDYIL-LVRKn--V--T-LNP-D-PnE-IKSYCYV-SK-EEL-KE-LLKKaASGei--kITPWFK 204 human
P58044       142 --gIWG--E--H--EVDYIL-FLRKn--V--T-LNP-DpN-E-IKSYCYV-SK-EEV-RE-ILKKaASGei--kLTPWFK 198 house mouse
Q39471       197 --gKWG--E--H--ELDYLL-FIVRd--V--A-VHP-NpD-E-VAEIKYV-NR-EQL-KE-LLKKaDAGeeglkLSPWFR 255 Clarkia breweri
Q10132       148 --gAWG--E--H--EIDYIL-FFKGkveL--D-INP---N-E-VQAYKYV-TM-EEL-KE-MFSDpQYG-----FTPWFK 201 Schizosaccharom...
WP_025687065 117 ---ADGtvE--N--EICPVY-RVQVd--Q--Q-PRP-NsD-E-VDAIRWL-SW-EQFvRD-VTAGvIAP-----VSPWCR 172 Mycobacterium t...
WP_012475940 105 ---TNG--I--TenELCPVF-AAHCk-tS--G-VNP-DlN-E-VSAWEWV-HW-QWF-FE-SVQAeRLL-----VSPWCR 160 Agrobacterium r...
BAA33978     202 qsaLWG--E--H--EMDYIL-FIRAn--V--T-LAP-NpD-E-VDEVRYV-TQ-EEL-RQ-MMQP-DNGl---qWSPWFR 258 Haematococcus p...
Q9KK75       107 ---ASG--IeeN--EHCPVF-IARAv--S--S-LTP-N-PaE-VAEAQWT-SS-SEL-KSaIDAApWA------FSPWLV 161 Brevibacterium ...
WP_011015025 120 ---ASG--I--VewELCPVH-LVRLa--VgeF-VEPlD-D-E-VEEFEWAePQ-KLF-DA-VDATpFV------FSPWLV 176 Corynebacterium...
WP_023258155 109 ---PNG--I--VenEVCPVF-AARAt--S--V-LQV-N-SeE-VMDYQWSeFK-SVW-QS-LLATpWA------FSPWMV 163 Salmonella ente...
AAM48607     116 --eAFGs-E--H--ELCSVFvGHVQg--R--PePFF-N-NtE-IANTVWL-PI-AEV-NE-WLSNdQIS-----TTPWFA 172 uncultured mari...
WP_015920849 103 ---GNGliE--H--EVVDIF-VAEAp--SdlP-VNP-D-PeE-VWETRWV-DL-TDL-AR-EVKEhPER-----FTPWLR 159 Rhodobacter sph...
AAL76360     116 --gSIG--SehE--LCSVYV-GHLKe-pV--D-ITP-H-P-NeISQWGWF-DLeDVD-DW-IT---KAPe---eFTPWFL 172 uncultured mari...
2ICJ_A       205 I-IA 207 human
P58044       199 I-IA 201 house mouse
Q39471       256 L-VV 258 Clarkia breweri
Q10132       202 L-IC 204 Schizosaccharomyces pombe 972h-
WP_025687065 173 S-QL 175 Mycobacterium tuberculosis
WP_012475940 161 A-QV 163 Agrobacterium rhizogenes
BAA33978     259 I-IA 261 Haematococcus pluvialis
Q9KK75       162 ehft 165 Brevibacterium linens
WP_011015025 177 D-QL 179 Corynebacterium glutamicum
WP_023258155 164 M-QA 166 Salmonella enterica
AAM48607     173 Lewe 176 uncultured marine proteobacterium
WP_015920849 160 I-YL 162 Rhodobacter sphaeroides
AAL76360     173 MeWR 176 uncultured marine proteobacterium
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