3RKO


Conserved Protein Domain Family
NDH_I_M
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TIGR01972: NDH_I_M 
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proton-translocating NADH-quinone oxidoreductase, chain M
This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]
Links
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Statistics
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PSSM-Id: 273903
Aligned: 19 rows
Threshold Bit Score: 448.234
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3RKO_M         3 LPWLILIPFIGGFLCWQTE---RfgVKVP-R-----WIALITMGLTLALSLQLWLqggYSLTQSagipQWQSE--FDMPW 71  Escherichia col...
P31978         3 LPWLILIPFIGGFLCWQTErfgV--KVPR-------WIALITMGLTLALSLQLWLqggYSLTQSagipQWQSE--FDMPW 71  Escherichia coli
P57263         3 LSLLIIIPFLSSFFSFFSPrlhN--NFPR-------WIALSGIIATLLVVIQIFFqenYHIFQIrhypNWNCQ--LIVPW 71  Buchnera aphidi...
P72823         8 LTTMIALPLVAALFIPLIPd----kDGKQv-----rWYALGVGLADFVLMSYVFWt-nYDISST----GFQLQ--EKFSW 71  Synechocystis s...
CAC08260      13 LAFLVVGPLLGAVAALLPAppgL--KGKS-PeqavlRHGVTVTGAVLLAAVVLVLg-fDHDHPS----KMQAS--TDISW 82  Streptomyces co...
WP_017853842   8 LSVFLFLPFIGVPLLFL-----SnkVNWL-R-----FIAGSFTLLPFLIIVGLYFk--YDPTNS----SLQFVdrIWGII 70  Leptospira inte...
WP_010872064   2 LSLLLILPVIGALIIGFFP---GniPAKQlR-----QITEVFAVLTLVWSLLVLFk--FDVTDP----QFQFQ--EYLPW 65  Synechocystis s...
WP_003974372   6 LTVTAALPAVGAIATAAVP---AakRTAA-K-----WLALLVSLATLGLAIAVLVr--FDPDGD----RYQLT--ESHSW 68  Streptomyces
WP_001159928   9 LSVVIFFPMLSALLAFFMS------DQAS-R-----AYAIVIALIELLLILLLWHg--FDIQTA----GMQFE--EMKEL 68  Helicobacter py...
WP_002858136   2 LNYLIFFPLISAFVVLLLN---RggVKVF-S--------VVVSFMILALNLDIFAd--F-LQGV----SFDYN--LSFKI 60  Campylobacter j...

3RKO_M        72 IPR-FGISIHLAIDGLSLLMVVLTGLLGVLAVLCSWKeIE---------K----------YQGFFHLNLMWILGGVIGVF 131 Escherichia col...
P31978        72 IPR-FGISIHLAIDGLSLLMVVLTGLLGVLAVLCSWKeIE---------K----------YQGFFHLNLMWILGGVIGVF 131 Escherichia coli
P57263        72 ISR-FGIEFNIALDGLSIIMLIFSSFLSIIAIICSWNeIK---------K----------NEGFFYFNFMLVFTGIIGVF 131 Buchnera aphidi...
P72823        72 IPQ-FGLSWSVSVDGISMPLVLLAGLVTTLSIFAAWQvDH--------------------KPRLFYFLMLVLYAAQIGVF 130 Synechocystis s...
CAC08260      83 IPA-LDVRIHLGIDGISLPLLVLTALLTFLCALYSYLkQR---------HerltprapgpSPKAFVALLLVLESGTLATF 152 Streptomyces co...
WP_017853842  71 VSGnLKVDYHIGLDGFSLLLCGMSSLLFFLSTLATWTsIT---------N----------RIREFYVYLMIVEMSVHGVF 131 Leptospira inte...
WP_010872064  66 IPQ-LGLNYSLAIDGLSLPLVILNNLLTGVAIYSIGPnV----------N----------RSRLYYGLILLINAGISGAL 124 Synechocystis s...
WP_003974372  69 IAD-FGVRYELGVDGIAVALIALTALLIPFIILAGWHdADpletgssrwR----------PTQGFFALILAVEAMVIISF 137 Streptomyces
WP_001159928  69 VYQ-IGVNYHVGVDGIALFLLLLNAIVVLLSVIYVKE-----------------------RRKDFAICLLLLEGILMGVF 124 Helicobacter py...
WP_002858136  61 LKF-F--SFHVGVDSIALVLILLSSLMIFLSFLFLKLe-----------------------QKALISCIFFLEFAIMGLF 114 Campylobacter j...

3RKO_M       132 LAIDMFLFFFFWEMMLVPMYFLIALWGhka------sdGKTRITAATKFFIYTQASGLVMLIAILALVFVHyna-tgvW- 203 Escherichia col...
P31978       132 LAIDMFLFFFFWEMMLVPMYFLIALWGhka-----sdgK-TRITAATKFFIYTQASGLVMLIAILALVFVH-------Yn 198 Escherichia coli
P57263       132 ISCDLFLFFCFWEIMLIPMYFLIALWSdkt------ekK-KNFLAANKFFLYSQTSGLILLSSILLLVFSH-------Yy 197 Buchnera aphidi...
P72823       131 VAQDMLLLFIMWELELVPVYLLVCIWG-----------GQKRQYAAMKFLLYTAAASVFILVAALGLAFYG-------Dv 192 Synechocystis s...
CAC08260     153 AVLDLILFFLAFEMVLIPMYFLIARWG-----------GEGRAGAAWKFILFTLLGSVVMLLGLLLIGITA-------Gt 214 Streptomyces co...
WP_017853842 132 LSGNLVLFYIFWEAMVSPMVLMVGIWG-----------EDQRVKAAIKYLIFSFTGSVLMLAGILILYFKTgtivieeL- 199 Leptospira inte...
WP_010872064 125 LAQNLLLFIVFYELELIPFYLMIAIWG-----------GEKRGYASMKFLLYTAFSGLLVLAAFLGMSLLSg-----sH- 187 Synechocystis s...
WP_003974372 138 EATDVFLFYIFFEAMLIPLYFLIGGFGdrahehgektaATQRSYAAVKFLLYNLAGGLIMLAAVIGLYVVAg-------- 209 Streptomyces
WP_001159928 125 SSLNMIFFYAFWEISLLPVLYLIGRFG-----------RNNKIYSGMKFFLYTFLASLCMLLGILYIGYDYann-ygmM- 191 Helicobacter py...
WP_002858136 115 SAKDGLLFYVFWEFSLLPLLYIMGVYG-----------KD--FRAGVKFFIYAFAGSILMLVALIYQAYLNyql-lniF- 179 Campylobacter j...

3RKO_M       204 -----TFNYEELLN------TP--MSSGVEYLLMLGFFIAFAVKMPVVPLHGWLPDAHSQAPTAGSVDLAGILLKTAAYG 270 Escherichia col...
P31978       199 atgvwTFNYEELLN------TPmsSG--VEYLLMLGFFIAFAVKMPVVPLHGWLPDAHSQAPTAGSVDLAGILLKTAAYG 270 Escherichia coli
P57263       198 stnilTFNYNLLIN------KPinIY--VEYIVMIGFFLSFAIKMPIVPFHGWLPDIHSRSLSCGSVEIIGVLLKTAPYA 269 Buchnera aphidi...
P72823       193 ----tTFDIAELGL------KD--YPIALELFLYAGLLIAFGVKLAIFPFHTWLPDAHGEASAPVSMILAGVLLKMGGYG 260 Synechocystis s...
CAC08260     215 f---dMVALATDNG------RS--LTTSVQVIAVLAIGLGLAVKTPMWPLHSWLPDAHTAAPTVGSVLLAGVLLKMGTYG 283 Streptomyces co...
WP_017853842 200 -----STGLLPEIP------KN--I----RLFMFFAFVLAFAIKVPLFPLHTWMPDVHSQAPTVGSVDLSGILLKIGLYG 262 Leptospira inte...
WP_010872064 188 -----SFDYNPEIT------QT--FTESAQTILLILILLGFGIKIPLVPLHTWLPDAYTEASPATAILLGGILAKLGTYG 254 Synechocystis s...
WP_003974372 210 -----nFSLTEIAEarangsLD--MATSTERWLFLGFFFAFAVKAPLFPLHTWLPNAMGESTAPVAVLITAVVDKVGTFA 282 Streptomyces
WP_001159928 192 -----SFDILDWYQ------LN--FSSGVKTWLFVAFLIGIAVKIPLFPLHTWLPYAYSNAPTLGSVMLSALLSKMGTYA 258 Helicobacter py...
WP_002858136 180 -----TFDLEIWKN------NAsaVNFTEQLLLFGAFFIAFAIKAPLFPLHTWAPKVYANSPILVSVML--VVFKMAPFG 246 Campylobacter j...

3RKO_M       271 LLRFSLPLFPNASAEFAPIAMWLGVIGIFYGAWMAFAQT------DIKRLIAYTSVSHMGFVLIAIYTGSQLAYQGAVIQ 344 Escherichia col...
P31978       271 LLRFSLPLFPNASAEFAPIAMWLGVIGIFYGAWMAFAQT------DIKRLIAYTSVSHMGFVLIAIYTGSQLAYQGAVIQ 344 Escherichia coli
P57263       270 LLRYNLVLFPDSTKSFSLIAVFWGIISIFYGAWIAFSQT------NIKRLIAYSSVSHMGLILIGIYSNNERALQGVVIQ 343 Buchnera aphidi...
P72823       261 LIRLNLGLLEDAHVYFAPILVILGVVNIIYGGFSSFAQD------NMKRRLAYSSVSHMGFVLLGIASFTDLGISGAMLQ 334 Synechocystis s...
CAC08260     284 FIRILLPVAPEGFRIFAPYLAAFAVVGIIYGSLACLALArrgakgDLKRLIAYSSVGHMGFVLLGVATMTPTGVNGALFA 363 Streptomyces co...
WP_017853842 263 FIRLAIPLFPEEMLEYRELLGALCIAGIIYGAVIAMAQE------NSKRVVAFSSLSHMSFCMLGILSFTEEGMAGGMLQ 336 Leptospira inte...
WP_010872064 255 IIRFGLQLFPQTWAQFAPVLAIIGTVTVLYGALSAIAQK------DIKRMVAYSSIGHMGYILVAAAAGTELSVLGAVAQ 328 Synechocystis s...
WP_003974372 283 MLRFCLQLFPEASKWATPVILVLAVISIIYGALLAVGQR------DIKRLIAYASISHFGFIIMGIFAMTSQGQSGATLY 356 Streptomyces
WP_001159928 259 LLRFLLPLFPDLSEIYLTPIAIAALCMIIYGGFLAYAQK------DLKTLIAYSSFSHMGVVVLGVFSFNVEGISGAVFM 332 Helicobacter py...
WP_002858136 247 FLLFCLPLFPDASVYFMPLIVALCIVSIVYNALIAYRAE------NIKELIAYSSISHLGVMILGIFSLNALGISGAVFY 320 Campylobacter j...

3RKO_M       345 MIAHGLSAAGLFILCGQLYERIHTRDMRMMGGLWS-----KMKWLPALSLFFAVATLGMPGTGNFVGEFMILFGSFQ--- 416 Escherichia col...
P31978       345 MIAHGLSAAGLFILCGQLYERIHTRDMRMMGGLWS-----KMKWLPALSLFFAVATLGMPGTGNFVGEFMILFGSFQ--- 416 Escherichia coli
P57263       344 MLSNSLTVAALCILSGQIYKRFKTQDMSKMGGLWS-----CIYWIPGFSLFFSLANLGVPGTGNFIGEFLILSGVFE--- 415 Buchnera aphidi...
P72823       335 MLSHGLIAAVLFFLAGVTYDRTHTLSLAQMGNIGk-----VMPTVFALFTMGAMASLALPGMSGFVSELAVFVGVSSsdi 409 Synechocystis s...
CAC08260     364 NIAHGLITGLLFFVVGALKDRTGTTDLDTLAEESGhalygKAPRLGGLLAFAAVASLGLPGLAGFWGEMLALFGAFDphd 443 Streptomyces co...
WP_017853842 337 MLNHGFTAGMLFFMLGMLHERIGNNDISKAGGLSK-----LLPVFSVFFAIAIFSSLGVPGTNSFIGEFLIILGSIK--- 408 Leptospira inte...
WP_010872064 329 MVSHGLILALLFHLVGIVERKAGTRDLDVLNGLMNpi--rGLPLTSALLITGGMASAGIPGLVGFAAEFIVFQGSFP--- 403 Synechocystis s...
WP_003974372 357 MVNHGISTAVLMLIAGFLISRRGSRLIADFGGVQK-----VAPILAGTFLIGGLATLSLPGLAPFVSEFLVLVGTFT--- 428 Streptomyces
WP_001159928 333 MFAHGIIVMGLFLLAGILEERASSLEIARFGSIAK-----SAPIFAAFFMIVLMANVGMPLSIGFVGEFLSLLGFFA--- 404 Helicobacter py...
WP_002858136 321 MFAHGIVTGALFLMVELLYQRYHTYDISFYHSLAK-----KAPLFSIFFMLILLASVSLPLTVSFVGEFLILLGIAK--- 392 Campylobacter j...

3RKO_M       417 -----VVPVITVISTFGLVFASVYSLAMLHRAYFGKa-----------KSQ---------------IASQELPGMSLREL 465 Escherichia col...
P31978       417 -----VVPVITVISTFGLVFASVYSLAMLHRAYFGKa-----------KSQia---------------sQELPGMSLREL 465 Escherichia coli
P57263       416 -----VFPLVSILATIGIVFSSIYSLNVIQKIFYGPc-----------KQNi------------------kVFFINKQEV 461 Buchnera aphidi...
P72823       410 y-stpFKTVTVFLAAVGLVLTPIYLLSMLRQLFYGNnippscnleqdnLSAnsdqeavcfgtscvlPGNAIYDDARPREV 488 Synechocystis s...
CAC08260     444 nlsrpAFLTFMAIAAFGTLLTAAYMLIVVRRVCMGAvp---------qEAP-----------------QPKFADVRTYEF 497 Streptomyces co...
WP_017853842 409 -----SNIVYGALAATGVVFAAGYLLLFAKRMIFGE------------PTK---------------N-LIEHNDLNLKEW 455 Leptospira inte...
WP_010872064 404 -----TFPIPTLLCILASGLTAVYFVILLNRTCFGK------------LDN---------------Q-RAYYPKVLASEM 450 Synechocystis s...
WP_003974372 429 -----RYPVIGIIATLGIVLAALYTLVLYQRTMTGP------------VKA----------------EVNGMPDLRVREL 475 Streptomyces
WP_001159928 405 -----TYPLLAIIAGTSIILSAIYMLTSYKDVFFGN------------LKAg-------------sNQISVFEDLNAREV 454 Helicobacter py...
WP_002858136 393 -----INLFYALLAGLVIILGAIYMFAVFRKIFFMQ------------KQ----------------SFIEGFS-LLFREI 438 Campylobacter j...

3RKO_M       466 FMILLLVVLLVLLGFYPQPILDTSHSAIGNIQQWF 500 Escherichia coli BL21(DE3)
P31978       466 FMILLLVVLLVLLGFYPQPILDTSHSAIGNIQQWF 500 Escherichia coli
P57263       462 WTIIALVFTLVFLGLNPQKIIDVSYNSIHNIQKEF 496 Buchnera aphidicola str. APS (Acyrthosiphon pisum)
P72823       489 FIAACFLLPIIAVGLYPKLATQTYDATTVAVNSQV 523 Synechocystis sp. PCC 6803 substr. Kazusa
CAC08260     498 AAWTPLVALTVVAGLWPRTLLGLTDPAVQQLLSGG 532 Streptomyces coelicolor A3(2)
WP_017853842 456 VILVPTVIMIFWIGIYPKPFLKVLEPSVKVALNsa 490 Leptospira interrogans
WP_010872064 451 IPALVLTAIIFFLGVQPNYLVHWTQTTTNEMIAQL 485 Synechocystis sp. PCC 6803
WP_003974372 476 VVVAPLVALLIFLGVFPKPVTDIVNPAVEQTMSDV 510 Streptomyces
WP_001159928 455 GVLSVILALILILGIYPKVLLKPIEQGSKQLLEVI 489 Helicobacter pylori
WP_002858136 439 VALVCIVVMIFGLGLMPNILLKPIQKDVDNLIKTM 473 Campylobacter jejuni
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