4ELS


Conserved Protein Domain Family
menB

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TIGR01929: menB 
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naphthoate synthase (dihydroxynaphthoic acid synthetase)
This model represents an enzyme, naphthoate synthase (dihydroxynaphthoic acid synthetase), which is involved in the fifth step of the menaquinone biosynthesis pathway. Together with o-succinylbenzoate-CoA ligase (menE: TIGR01923), this enzyme takes 2-succinylbenzoate and converts it into 1,4-di-hydroxy-2-naphthoate. Included above the trusted cutoff are two enzymes from Arabadopsis thaliana and one from Staphylococcus aureus which are identified as putative enoyl-CoA hydratase/isomerases. These enzymes group with the naphthoate synthases when building a tree and when doing BLAST searches. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Statistics
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PSSM-Id: 200143
Aligned: 5 rows
Threshold Bit Score: 472.801
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4ELS_A        22 FEDIRYEKs-TDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAG------DKAFCSGGDQKVRGDY 94  Escherichia col...
Q9TM10         9 FIDIKYIK--QDQISEIIISRPQVLNAFRPRTINEIIAAFYDSREDSSIGVVILSGHG------SRAFCVGGDQKIRSKT 80  Cyanidium calda...
P27290        22 FEDIRYEKs-TDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAG------DKAFCSGGDQKVRGDY 94  Escherichia coli
WP_005874673  10 YEDILFEY--FEGIAKITINRPKVYNAFRPQTNAEILDAMDICRERPDIGVVVLTGAG------DKAFCSGGDQHVKGMG 81  Porphyromonas g...
ETB55690      20 LTDITYHRhvDDATVRVAFDRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGpspkdgGWAFCSGGDQRIRGRS 99  Mycobacterium a...
4ELS_A        95 GgYKDDSGV----------HHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAA-DNAIFGQTGPKVGSFD 163 Escherichia col...
Q9TM10        81 G-YIDEKGR----------SSLNVLELQRIIRTFPKPVIAKVSGYAVGGGQILNMMCDLTIAS-ENAVLGQSGPKVGSFD 148 Cyanidium calda...
P27290        95 GgYKDDSGV----------HHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAA-DNAIFGQTGPKVGSFD 163 Escherichia coli
WP_005874673  82 G-YIDGGGV----------PRLNVLDVHKAIRSLPKPVIAMVNGYAIGGGHVLHVVCDLTIAA-EHARFGQTGPKVGSFD 149 Porphyromonas g...
ETB55690     100 G-YQYASGEtadtvdparaGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASrEHARFKQTDADVGSFD 178 Mycobacterium a...
4ELS_A       164 GGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQ 243 Escherichia col...
Q9TM10       149 AGYGSAYMARIIGQKKARELWFTCYQYDAFEAYKMGLVNWVVKIEDLDSYAIKLATDILNKSPLAIRFLKSSLNADCDGQ 228 Cyanidium calda...
P27290       164 GGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQ 243 Escherichia coli
WP_005874673 150 GGFGSSYLARCVGQKKTREIWFLCRQYTAAEAEAMGMVNKVVPAARLEDETVDWCKTILSRSPMAIRMIKRALNAELDGQ 229 Porphyromonas g...
ETB55690     179 GGYGSAYLARQVGQKFAREIFFLGREYTAEQMHRMGAVNAVVEHAELERAGIEWAREINAKSPQAQRMLKFAFNLLDDGL 258 Mycobacterium a...
4ELS_A       244 AGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKF 281 Escherichia coli K-12
Q9TM10       229 SGLQELAGYSTMLFYMSAEGQEGHRAFLENREPDFSKF 266 Cyanidium caldarium
P27290       244 AGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKF 281 Escherichia coli
WP_005874673 230 RGLMEFAGDATLMYYLMEEAQEGKNAFLEKRTPDFDKF 267 Porphyromonas gingivalis
ETB55690     259 VGQQLFAGEATRLAYMTDEAVEGRDAFLEKRPPDYSRF 296 Mycobacterium avium 10-5560
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