2PHN


Conserved Protein Domain Family
F420_cofE

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TIGR01916: F420_cofE 
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coenzyme F420-0:L-glutamate ligase
This model represents an enzyme of coenzyme F(420) biosynthesis, as catalyzed by MJ0768 of Methanococcus jannaschii and by the N-terminal half of FbiB of Mycobacterium bovis strain BCG. Note that only two glutamates are ligated in M. jannaschii, but five to six in the Mycobacterium lineage. In M. jannaschii, CofE catalyzes the GTP-dependent addition of two L-glutamates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Statistics
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PSSM-Id: 273874
Aligned: 8 rows
Threshold Bit Score: 224.996
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2PHN_A         6 VEVFPVEgLPL---IKEGDD--LAELISSR-----Vr-FEDGDVLVVCSTVISKAEGRIRRLEEFNPSERAKEIAAR--- 71  Archaeoglobus f...
WP_011033367   3 FEAIAVEkIPL---IHEGDN--LPSIICEK-----Ig-LQDRDIMIIASTIVAKAEGEIFRLEDITPGEEALEIAAR--- 68  Methanosarcina ...
Q58178         8 VEVIGLE-LPI---FKGGEQinLSELIAQY-----P--IEDGDIIVIAETLISKLEGGVIDRDKIIPSKEAIELAKK--- 73  Methanocaldococ...
WP_011019339   4 LPTLRIEpVPLerkVRPGDD--LAELIAES-----Ae-LEEGDVLAIAHTVVSKAEGALISLDEIEPSPFAKTLAER--- 72  Methanopyrus ka...
WP_010903932   1 MHAFAVDgLPE---IDAGDD--LAALVAER-----Ad-LTDGDVVCVASTVVSKAEGRTAALAEFTPGPRAEEIAARlad 69  Halobacterium s...
WP_010876650   3 ISLIGVEgMPL---VGAGDD--IAYLIISAlneggEd-LLDGDIIVIAETIVSKAEGNIISLEEIKPSPEALDIAER--- 73  Methanothermoba...
WP_011028727  16 YRVWALPgLPE---VQSGDD--LAKLIAAA-----EpaLADGDVLLVTSKIVSKAEGRVVEAAD---------------- 69  Streptomyces co...
WP_017351528  12 IEILPVIgLPE---FRPGDD--LSAAVAAA-----ApwLRDGDVVVVTSKVVSKCEGRLVPAPEDP-------------- 67  Mycobacterium t...
2PHN_A        72 ---IGKPAEFVQAVLEESEEVL-LDFPFLLVKAKFGNVCVNAGIDASNVEEGSLLlPPLDPDGSAEKLRRRILELTGKRV 147 Archaeoglobus f...
WP_011033367  69 ---TGKDPRFIQAVLSKSREVF-VETPFMLVTTLAGHTCVNAGIDESNIENGFLLyPPENPDASALKIGKELEKLSGKKL 144 Methanosarcina ...
Q58178        74 ---TGKDPKVVQVILDEAKEIVkVGKNFIITETKHGFVCANSGVDESNIYKGIKI-LPKNPDESAEKIRKEIEKLTGKRV 149 Methanocaldococ...
WP_011019339  73 ---TGKDPRVVEVILREAESIVrVGPDFIITEVRGGMVCANAGVDESNAPPGYVIvLPEDPDRSARELRRRLRELVGVDV 149 Methanopyrus ka...
WP_010903932  70 vtgEQKDPRFAQAVIEEATEVIm-DAPFLLTETTCGHVGVNAGIDRSNTGGAELLlLPKRPAESAARIQAGL----AADV 144 Halobacterium s...
WP_010876650  74 ---TGKDPSLVEAILGESSEIIrVGHDFIVSETRHGFVCANAGIDESNVDDGLATpLPRDPDGSAEKILRTLQEATGREL 150 Methanothermoba...
WP_011028727  70 ---------REAAIDAETVRVVaRRGPLRIVENRQGLVMAAAGVDASNTPAGTVLlLPEDPDASARGIREGLRDTLGVDV 140 Streptomyces co...
WP_017351528  68 ---EQRDRLRRKLIEDEAVRVLaRKDRTLITENRLGLVQAAAGVDGSNVGRSELAlLPVDPDASAATLRAGLRERLGVTV 144 Mycobacterium t...
2PHN_A       148 GVIITDTNGRCFRRGVVGFAIGISGVKAMKDWIGRKDLYGRELEVTVECVADEIAAFANLLMGEGGDGIPAVVVRGLN-- 225 Archaeoglobus f...
WP_011033367 145 SIIITDTNGRAFKIGQTGVAIGIYNIKPVKRWIGEKDLFGKVLEITEQAIADELAGAANLLMGEGAGGIPVVIIRGLD-- 222 Methanosarcina ...
Q58178       150 GVIISDSVGRPFRKGAVGIAIGVSGILALWDRKGEKDLFGRELKTTEVAIADELASMANVVMGEADEGIPVVIIRGAN-- 227 Methanocaldococ...
WP_011019339 150 GVIITDTQGRPFREGVVGVAIGASGVPVLADRRGDRDLYGRELKITIVALGDLLASAAELVMGQADEGTPAVIFRGLK-- 227 Methanopyrus ka...
WP_010903932 145 GVVVTDTSGRPFRHGQRGVALGWAGLPAARDWRGETDRDGHELAVTVEAVVDELAATANLVSGEGDDGTPVVVVREFEfg 224 Halobacterium s...
WP_010876650 151 AVIISDTQGRPFREGAVGVAVGVAGLSPIWDRKGERDLYGRSLETTRVAVADELAAAASLVMGQADEGVPAVIIRG---- 226 Methanothermoba...
WP_011028727 141 GVIVTDTFGRPWRAGLTDVAIGAAGVRVLDDLRGGTDAYGNPLGATVVATADELAAAGDLVKGKAA-GLPVAVLRGLPqv 219 Streptomyces co...
WP_017351528 145 AVVITDTMGRAWRNGQTDAAVGAAGLAVLRNYAGVRDPYGNELVVTEVAVADEIAAAADLVKGKLT-ATPVAVVRGFG-- 221 Mycobacterium t...
2PHN_A       226 VAg-----EGSMEEIYRSEEEDVIR 245 Archaeoglobus fulgidus DSM 4304
WP_011033367 223 YYce---gDTSIKESYRPENMDVIK 244 Methanosarcina mazei
Q58178       228 VPf----gNGKGRDLIRPKEEDVFR 248 Methanocaldococcus jannaschii DSM 2661
WP_011019339 228 PElerfegPRKARAIIRSPSRDIFR 252 Methanopyrus kandleri
WP_010903932 225 -------dHDGSEQLFRAVDGDFVR 242 Halobacterium salinarum
WP_010876650 227 YPwghlrsDGGVKPLLRPRELDVFR 251 Methanothermobacter thermautotrophicus
WP_011028727 220 VAed---dGEGARAMVRGARDDMFR 241 Streptomyces coelicolor
WP_017351528 222 Vsd----dGSTARQLLRPGANDLFW 242 Mycobacterium tuberculosis
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