Conserved Protein Domain Family
dapE-lys-deAc

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TIGR01902: dapE-lys-deAc 
N-acetyl-ornithine/N-acetyl-lysine deacetylase
This clade of mainly archaeal and related bacterial species contains two characterized enzymes, an deacetylase with specificity for both N-acetyl-ornithine and N-acetyl-lysine from Thermus, which is found within a lysine biosynthesis operon, and a fusion protein with acetyl-glutamate kinase (an enzyme of ornithine biosynthesis) from Lactobacillus. It is possible that all of the sequences within this clade have dual specificity, or that a mix of specificities have evolved within this clade.
Statistics
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PSSM-Id: 130957
View PSSM: TIGR01902
Aligned: 4 rows
Threshold Bit Score: 506.699
Threshold Setting Gi: 497676202
Created: 8-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAB79614      10 EFLKGALEIPSPSGKERLVAEYLAEGMQKLgLKG-FVDEADNARGQVGEGPVQVVLLGHIDTVPGQIPVRLEGGRLFGRG 88  Thermus thermop...
CAD63113     272 QLFTNIVTIPSVSFDEHVLANYLNDLKMAN-ITS-NIDSAGNIVLKKGSGHKKLLLLGHIDTVRNFWQVKIEAGSLKGRG 349 Lactobacillus p...
WP_010867567  10 KFLKELVEIYSPTGKEEEAAKFIKEKLEEYgVKA-YIDKVGNVIGVKEGEGPLILLAGHVDTVPGYIPVRIEGDILWGRG 88  Pyrococcus abyssi
WP_009990386  14 ELLLDLLSIYTPSKSEANATKFFEKISKDLnLKLeILPDSNSFILGEGD----ILLASHVDTVYGYIEPKIENELIYGRG 89  Sulfolobus solf...
BAB79614      89 AVDAKGPFVAMIFAAAglSeeaRKRLTVHLVGATEEEApSSKGARFVAPRLKPH-YAVIGEPSGWEGITLGYKGRLLVKA 167 Thermus thermop...
CAD63113     350 AVDAKAPFATFLSVLN--KvkvPSDCQLIVIGAVEEESsSSKGAYQVRDNYEKM-PVIIGEPSGIEKLTLGYNGLLKLKL 426 Lactobacillus p...
WP_010867567  89 SVDAKGPLSALLFAMV------ESNANVIFAGLVDEEG-FSKGAR-ALDVPRPE-YVIVGEPSGVNGVTIGYKGSLTVRF 159 Pyrococcus abyssi
WP_009990386  90 AVDAKGPLISMIIATWllN---EKGIKVRVSGLADEES-TSIGAKELIAKNYNFkYIIVGEPSNATDIVVEYRGSIQLDI 165 Sulfolobus solf...
BAB79614     168 RREKDHFHSAHHEPn-AAEELISYFVAIK-AWAEAMNvgqrpFdQVQYTLRDFRVHPAELRQVAEMFFDLRLPPRLPPEE 245 Thermus thermop...
CAD63113     427 NCHMVQGHSAGKGAisSIDALIDYSNKIR-EIMANYD-----P-KGLSSIQDISHSKSDNQTELLLNFRVSRYVKSGYVE 499 Lactobacillus p...
WP_010867567 160 VERVEKFHGSIGGG--AAEKLIERWLSISgNFEDGFN-------GLSGRIVRFVAYERDFEFYGEMIVNLRTPPGYEP-- 228 Pyrococcus abyssi
WP_009990386 166 MCEGTPEHSSSAKN----NLIVDISKKIIeVYKQPENy---dKpSIVPTIIRAGESYNVTPAKLYLHLDIRYAINNKRED 238 Sulfolobus solf...
BAB79614     246 AIRHLTayaPPTIE-LEFFGREVPYQGPKDTPLTRAFRQAIRKAG-GRPVFKLKTGTSDMNVLAPHWPVPMVAYGPGDST 323 Thermus thermop...
CAD63113     500 AIKKQT---DKNIS-LEVLRDTPASTSKRSNQLANAFVSGFKVVQkMIPEYIVKTGTSDMNTLATQWTVPMVAYGPGDST 575 Lactobacillus p...
WP_010867567 229 -PRDWD-----------IIDFVPAYEVNRRSPLVRTFVRSIRELG-MKPKLKKKSGTADMNILAPRFGVDAVAYGPGDSR 295 Pyrococcus abyssi
WP_009990386 239 LIKEITd--KFPECnLKIVDETPPVKVSINNPVVKSLARALLKQN-IKPRLVKKAGTSDMNILQRI-TTNIATYGPGNSM 314 Sulfolobus solf...
BAB79614     324 LDHTPYEHVEVAEFLKGIEVLRGALEALAQT 354 Thermus thermophilus
CAD63113     576 LDHTLQEEVPFADYHLGIQTLQEAIQTYLGK 606 Lactobacillus plantarum WCFS1
WP_010867567 296 LDHTPYERISLMEYLQSIDVLKNVLTKLKGK 326 Pyrococcus abyssi
WP_009990386 315 LEHTTQEKISLDEIYIGVKTYMLAIEELWQK 345 Sulfolobus solfataricus
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