Conserved Protein Domain Family
amidohydrolases

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TIGR01891: amidohydrolases 
amidohydrolase
This model represents a subfamily of amidohydrolases which are a subset of those sequences detected by pfam01546. Included within this group are hydrolases of hippurate (N-benzylglycine), indoleacetic acid (IAA) N-conjugates of amino acids, N-acetyl-L-amino acids and aminobenzoylglutamate. These hydrolases are of the carboxypeptidase-type, most likely utilizing a zinc ion in the active site. [Protein fate, Degradation of proteins, peptides, and glycopeptides]
Statistics
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PSSM-Id: 273857
Aligned: 14 rows
Threshold Bit Score: 359.351
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O50173        15 MTQWRRDLHHYAESGWVEFRTASKVAEQLHQLgydltlgrdavdadsrmglpdEITLANAFQRAreqgapepwlsafegg 94  Pantoea agglome...
P54968        52 MRGIRRKIHENPETGFQEFKTSQLVRDELDSL---------------------GVKYKYPVAKT---------------- 94  thale cress
P58156        18 IIQIRRKIHENPELSYKEYSTSKLVAETLRKL---------------------GIEVEEGVGLP---------------- 60  Sulfolobus solf...
O34980        41 LIGIRRHLHQYPELSKEEFETTAFIKKCLKEK---------------------GIQIRP-TALK---------------- 82  Bacillus subtil...
CAC60050      43 LIATRRHIHSHPELSGEEFETAALIARELSLA---------------------GLRPRL-LPKG---------------- 84  Micromonospora ...
P54983        12 IMDIFEHLHANPEVSWKEYETTSFLKQKLEDL---------------------GCRTRT-FSDC---------------- 53  Bacillus subtil...
BAB97495      46 LRTLAFTLHDHPEEAFEEVFATEEITKLLQNH---------------------GFEVQSGVYGVkt-------------a 91  Corynebacterium...
WP_011067345  14 LIEWRREFHRFPELSFEEFHTSKRIVEILQTMn--------------------HIQIEKGLGTP---------------- 57  Oceanobacillus ...
WP_000523148   7 aVTWRRYFHQFPELSDKEFKTTQKIKDILTEH---------------------HIRILD-LPLA---------------- 48  Staphylococcus ...
WP_010973047  26 LVSIRHDLHQHPEIGFEEVRTSGIVAEKLTSW---------------------GIEVHRGYGKT---------------- 68  Agrobacterium f...
O50173        95 fTGIVATLDTGRPg-pTLAFRVDMDALDLNEDTDghhrpfrEDFASCNPGMMHACGHDGHTAIGLGLAHVLKQYADr--L 171 Pantoea agglome...
P54968        95 -GVVAWIGSCSKP---VFGLRADMDALPLQELVE-------WESKSKVDGKMHACGHDTHVAMLLGAAKLLQTTKHl--I 161 thale cress
P58156        61 -TAVVGKIRGNKPg-kTVALRADMDALPVEETSD-------VEFKSKVKGVMHACGHDTHVAMLLGGAYLLVKNKDl--I 129 Sulfolobus solf...
O34980        83 -TGVFADIAGESEg-pAIALRADIDALPIEEKTG-------LPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDs--L 151 Bacillus subtil...
CAC60050      85 -NGVICDIDGRPDg-pVVALRADIDALPLTDVKD-------VPYRSTKDGVCHACGHDVHTTVLLGVGVLLAQLANlgeL 155 Micromonospora ...
P54983        54 -TGVVGEIGSGSP---VVAVRADIDALWQEVNGT-------FRAN-------HSCGHDSHMTMALGTLMLLKKQPEl--P 113 Bacillus subtil...
BAB97495      92 lETSFETPGYDPAqhpSIAILAEYDALPEIGHACg--------HN-----IIAAAGVGAFLAVTNMIKTAEVKGVDhldF 158 Corynebacterium...
WP_011067345  58 -TSVIATITTG-Eg-pVVALRADMDALPIQEQTH-------TPYESQNPGVMHACGHDAHTAILLGAAKVISVLAQskaW 127 Oceanobacillus ...
WP_000523148  49 -TGLVAEVGQGl---sCIAVRADIDALPIQELVE-------QDFKSENEGVMHACGHDIHMASILATAVKLKEIEGt--L 115 Staphylococcus ...
WP_010973047  69 -GVVGVLRGRHAGn-rSIGLRADMDALPMPEETG-------LPYTSVYPGKFHGCGHDVHTTILLGTARYLAETRDf--A 137 Agrobacterium f...
O50173       172 HGVIKLIFQPAEEg-----TRGARAMVAAGVVDD--VDYFTAIHIGTGVPAGTVVCGSDNFMATT-KFDALFTGVAAHAg 243 Pantoea agglome...
P54968       162 KGTVKLVFQPGEEg-----YAGAYEMLKDEILDD--LDGILSVHVFPSIPSGGIGSRPGTVLAGAgLFTVTVHGQGSHA- 233 thale cress
P58156       130 SGEIRLIFQPAEEdg---gLGGAKPMIEAGVMNG--VDYVFGIHISSSYPSGVFATRKGPIMATPdAFKIVVHGKGGHG- 203 Sulfolobus solf...
O34980       152 KGKIRLLFQPAEEa-----gAGATKVIEDGQLDG--IDAVIGLHNKPDIAVGTVGLKTGPLMAAVdRFKVEIEGKGAHA- 223 Bacillus subtil...
CAC60050     156 DGRVRLIFQPAEEil----pCGSLEVIEAGGLDD--VVQIFALHCDPNQPVGKVGLRVGPITAAAdNVTVRLTGPGGHT- 228 Micromonospora ...
P54983       114 KGTIRFIFQPAEEk-----gGGALKMIEEGVLDD--IDYLYGVHVRPIQETQNGRCAPSILHGSSqHIEGTIIGEEAHG- 185 Bacillus subtil...
BAB97495     159 EGRIVLLGTPAEEg-----HSGKEYMIRNGAFDG--IDASIMMHPFGFDLAEHVWVGRRTMTAT-------FHGVSAHAs 224 Corynebacterium...
WP_011067345 128 EGTIKLIFQPAEEaqdehgLSGSPYLLQAGVYDQ--VEAAFALHMCPWKKTGQLLINDGFSMASVdEFEATIYATGGHG- 204 Oceanobacillus ...
WP_000523148 116 TGRVKFIFQPAEEl-----GHGAFKIIETHALKD--VQAVLGFHNDPSRSVGTFAIKTGAITSAVdRFEFHIKGVGGHA- 187 Staphylococcus ...
WP_010973047 138 -GTVVFIFQPAEEg-----LGGARAMIADGLFKDfpVDEIYGLHNSTHAAPNYLKVSPGTILAGAdFFDIRLKGRGAHA- 210 Agrobacterium f...
O50173       244 GKPEDGRNALLAAAQAAIALHAIAPHSAGASR--VN-VGVMQAGT-GRNVVPSGALLKVETRGETEDINRYVFERAREVI 319 Pantoea agglome...
P54968       234 ATPHFSKDPVLAASSAVVALQQIVSRELDPLEagVVtVGYIEGGH-AQNVIPQSAKFGGTFRSLSNDGLLFIQRRIKEIS 312 thale cress
P58156       204 SAPHETIDPIFISLQIANAIYGITARQIDPVQpfVIsITTIHSGT-KDNIIPDDAEMQGTIRSLDENVRSKAKDYMRRIV 282 Sulfolobus solf...
O34980       224 ALPHNGFDPIIGASQLIVALQTIVSRNVNPLQsaILtVGKINGGS-TWNVIPDTVVIEGTVRTFDSEVRNQVKQRFFAVT 302 Bacillus subtil...
CAC60050     229 ARPHLTVDLVDALGRLVTEVPALVSRRVPANSglLLvFGHASAGT-RYNVIPSEASASGTLRVMDRDTWDQAPKIVAQVV 307 Micromonospora ...
P54983       186 ARPHLGKNSIEIAAFLVHKLG---LIHIDPQIphTVkMTKLQAGGeSSNIIPGKASFSLDLRAQTNEAMEALIAETERAC 262 Bacillus subtil...
BAB97495     225 SQPFMGKNALDAASLAYQGFG-VLRQQMPPSDr--LhAIITEGGN-RPSIIPDTATMSLYVRSLLPEALKDISKRVDDVL 300 Corynebacterium...
WP_011067345 205 GYPEKSTDPIWMLSLVLPGLYGIISRRIAAAEkgVIsVGEIQAGN-ATNIIPAKASIRGTIRSYTPTIRDQLERELHQVF 283 Oceanobacillus ...
WP_000523148 188 AKPEQCNDPVIVLAQLINSIQSIVSRNLSAFDeaVVtIGQISCGN-TWNVIADHAYVQGTVRSFDPVVRKLVETRLQDIA 266 Staphylococcus ...
WP_010973047 211 AHPDVSRDPVPATGELIQALQTIVSRNVSPTDpaVLsITRIEAGS-AYNVIPETASIAGTVRAFSDSVRETIRGRIRTIS 289 Agrobacterium f...
O50173       320 HGAAAMYGASVELRLMG----AATSSAPSPGWVHYLREQAARVPGvEQAIDRIAAPAGSEDATLMMARVQQHNGLASYMV 395 Pantoea agglome...
P54968       313 EAQASVYRCKAEVNFEEkkpsLHPVMNNDEGLYEHGKKVAEAMIG-KNNFHDFPVTMGGEDFSFFTQKTKAAIFVLGVKN 391 thale cress
P58156       283 SSICGIYGATCEVKFMEd---VYPITVNNP---EVTDEVMKILSS-ISTVVETEPVLGAEDFSRFLQKAPGMYFFLGTRN 355 Sulfolobus solf...
O34980       303 EQISAAFSLKANVKWHSg----PPPLCNDEAITG-LVRDAAHKAKlQVIDPAP-STAG-EDFAYYLEHIPGSFAFFG--- 372 Bacillus subtil...
CAC60050     308 RDVIAPTGATVDLEYLRg----RPPVTNDARAIQVLTAATHAALGpEGVAETP-QSMGGEDFSWYLEYVPGALARLGVGR 382 Micromonospora ...
P54983       263 EAAAAAFGAKIELHKEHs----LPAATQNKEAEAIMAEAITEIIG-AERLDDPLVTTGGEDFHFYAVKVPNLKTTMLG-- 335 Bacillus subtil...
BAB97495     301 DGAALMAGVGVEKQWDVhp-aSLPVRNNHVLARRWAKTQNLRGRTaLSEGILPDTLAASTDFGNVSHLVPGIHPMVKIS- 378 Corynebacterium...
WP_011067345 284 QMV-HSLGGEYRLNVSR----GEPALYNDPYLNQIVRHSVRKIQThIDLFED-NFGMGGEDFGYVSQKLPATMFFLGCAL 357 Oceanobacillus ...
WP_000523148 267 DGLAQAYNMKINLNYTH----LPGAVMNDEALTHKAIAVAQHVGYkVEMMEQPLTI--GEDFSGYSQHFPSVFALIGSHS 340 Staphylococcus ...
WP_010973047 290 DHIAAAHGLTAEVDIRD----IFSVLTNDDASVEIVASVAREVLGdERVSTEPGRFMGSEDFADLLKHAPGAFFTLGHSG 365 Agrobacterium f...
O50173       396 FGTELSAGHHNEQFDFDENVMAIA 419 Pantoea agglomerans
P54968       392 ETLGAGKPLHSPYFFVDEEALPVG 415 thale cress
P58156       356 EKKGCIYPNHSSKFCVDEDVLKLG 379 Sulfolobus solfataricus P2
O34980       373 -TDG-DHDWHHPAFTIDETAIIKA 394 Bacillus subtilis subsp. subtilis str. 168
CAC60050     383 SGP--NVDLHRASFDVDEGAIAVG 404 Micromonospora carbonacea
P54983       336 LGCGLQPGLHHPHMTFDRNAMFTG 359 Bacillus subtilis subsp. subtilis str. 168
BAB97495     379 PENVALHTKEFAAYARTEEAIDAA 402 Corynebacterium glutamicum ATCC 13032
WP_011067345 358 EEDY-SRDLHTPVFDIDESSLVLG 380 Oceanobacillus iheyensis
WP_000523148 341 E-----YDLHHPQYKPDERILEKv 359 Staphylococcus aureus
WP_010973047 366 -----TVPAHNPGFIVDDAILPVG 384 Agrobacterium fabrum
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