4H4K


Conserved Protein Domain Family
cas_cmr3
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TIGR01888: cas_cmr3 
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CRISPR type III-B/RAMP module-associated protein Cmr3
CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This highly divergent family is found in at least ten different archaeal and bacterial species as part of the CRISPR RAMP modulue but is not a member of the RAMP superfamily itself. A typical example is TM1793 from Thermotoga maritima.
Links
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Statistics
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PSSM-Id: 273855
Aligned: 11 rows
Threshold Bit Score: 195.334
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4H4K_A         4 VTFTPYD--VLLFRESRPFDAGSE----SVARSIIPLPQTVAGAIRTLLFYKG---LKNCVGv------gEe-eP----- 62  Pyrococcus furi...
AAK42182       5 VLIKPLE--PLMFRSQGEFEPLITgshtAAQSLIIPRPSTIAGMLGYILFNKSsgtGDWLSDl------tN---L----- 68  Sulfolobus solf...
AAK41929       4 MRIKPLEeyRIGLRQSSGIVIENVd-----VISAFPSPTTILGIIG---AMKNa-kPSQLSGi------dDlreA----- 63  Sulfolobus solf...
WP_010879359   3 LVMKPYD--SLLFREPRPFDVNN-----HVARTILPLPQTLAGAVRSAIYVKYgskVKDLIGf------gKe-eP----- 63  Archaeoglobus f...
BAB04048       8 IRIRPLD--PLMVRDGRPFKDSPGa---RAYSMMDVVPGVIAGTVRTMLAEQAa-kSSRVVD--------YhtfS----- 68  Bacillus halodu...
WP_004082340   6 IYFEPED--WVGFRETRRFSFSDR------VESVFPSSFPFYGAVRTALLMKNq--kFDPGDv------eRa--G----- 62  Thermotoga
WP_011026629   4 FKITPYD--VFFFGSGRPFNVGD------VVYSIFPHPHTLAGAICTKIHAHTkidTSRILKnvygpfieRngkL----- 70  Caldanaerobacte...
WP_010880205   4 YLFKPYD--VIGFGGLKNFSAGET----HIQKSIFPPP------IMRFFHIFNs-------------------------- 45  Aquifex aeolicus
WP_005874912   6 IKLTPLD--KFFFGQKKTFGDDNAn--yFVYSSLFPQQTTLLGLLRYQLLQIAgeeIFKDNKi------qDehkA----- 70  Porphyromonas g...
WP_011019666  10 FLVLPQD--RAFFRRPEPFRAAAE----SVAESEGPKPWTVAGCVRNALLEVTdgdLGEVLEypr--klvRsapPgsige 81  Methanopyrus ka...
BAK54700       6 LVIKPLE--PLMLRSSGEFDIETKgpasYAKSLLVPRPSTIAGMLASLLY-KGsnkDYWLDDi------kQnikP----- 71  Sulfolobus toko...

4H4K_A        63 ----E----FTLVGIAIGTE----K--------G----RIYPLPFNiik--------------------seKFYKVVNPg 98  Pyrococcus furi...
AAK42182      69 ----L----DTIYGTFIETN----G--------E----YLFPLRMG-------------------------NHLALVDQ- 98  Sulfolobus solf...
AAK41929      64 ----Y----TSLTGNNTLSG----D-----------------CDSS-------------------------------DNp 83  Sulfolobus solf...
WP_010879359  64 ----E----FEILGHFFYRY----D--------G----KFELLVESphd--------------------vtQNLGLVKPh 99  Archaeoglobus f...
BAB04048      69 ----K----VPVYGPLYVWK----G--------K----PFFPLPSDigfyedengalqmnyrqpqplvngqGYLGIGDKg 124 Bacillus halodu...
WP_004082340  63 ----D----VRMFGPFVFENtpegR--------K----HYFPLPRNiyk--------------------tdSGYRVTPIv 102 Thermotoga
WP_011026629  71 ----Y----FPKPSNILGER----K--------KeeieNIFHARHYel---------------------ntKLFKKENTn 109 Caldanaerobacte...
WP_010880205  46 -----------VYGVFLYKD----G--------N----LFLPVPSDcl----------------------vKRKEESGKa 76  Aquifex aeolicus
WP_005874912  71 ----GeligKQSFSPFVKDK----LqfgiiqslS----PVFIIDKKknde------------------gkeEYFLPVGRr 120 Porphyromonas g...
WP_011019666  82 algeT----ALFLGTWVVEV----RpgapdrleR----VWWPCPAHlaryepesggeavdllrveevgdaaIAFSGHDEa 149 Methanopyrus ka...
BAK54700      72 ----I----SDICGPLIVKD----N--------Y----GYVPLRIG-------------------------SVFTFLKAp 102 Sulfolobus toko...

4H4K_A        99 rflgk-------lilppkGKYKSGYV--TESILEKYLKGEL--KEVEE---NKV------IRIE-KEKRI---------- 147 Pyrococcus furi...
AAK42182      99 ------------------QHLINLPI--LLEKEYEQREKGI--YELFYd-kNKL------FQIInHQDRI---------- 139 Sulfolobus solf...
AAK41929      84 liwgpl------ikekdnKIYTPLFFnkLILDPIEYVKTSL--NENVK---VQS------ESLVk---EI---------- 133 Sulfolobus solf...
WP_010879359 100 ridklgit-ilmdsegikFRPFNGFL--KFSGLIDYLQGRI--AEDSV---VER------QKIFkKERRV---------- 155 Archaeoglobus f...
BAB04048     125 dheslwpa-kvipqmgkvSSIVPAYL--SLDWMSRWLRGDL--SPKSWtspLAE------WQQLvRDNKLdstdkdvhfl 193 Bacillus halodu...
WP_004082340 103 eidgvylp-wkpeykmdsKESTSGGL--IELSDLELLRSNT--QGVCKfdlVSA------EKIFkKETHI---------- 161 Thermotoga
WP_011026629 110 adsniktf--plymgkedIGTFPAFI--SIEGLRKWLKGEK--IEIHEi--LQY------KEIFtKEERL---------- 165 Caldanaerobacte...
WP_010880205  77 kisplefp-plirgdleaYERANGFI--SFSDLMNKYAKNI--DGFKIy--L-L------EEFLkKESRV---------- 132 Aquifex aeolicus
WP_005874912 121 fqkeneka-pynllhlscQAGCPPIF--GEYKPKKGLASCWlsSKSHTl--LNE------EDFFtKDERI---------- 179 Porphyromonas g...
WP_011019666 150 lrrrygfmtpkpprpgsdVETPGRYV--DTGTISKILAGRT--PARRTp--DLEdnvagpGELLrPELHV---------- 213 Methanopyrus ka...
BAK54700     103 lkelsk------cisdkiSDIISFYE--DKGEDYDKIDTKI--SKLMS---QDW------TDIIaIQPRL---------- 153 Sulfolobus toko...

4H4K_A       148 -GIKLSREKKVVe----------EGMLYTVEFLRI----------EKIYAWIEDpg----cGIKDI-------------- 188 Pyrococcus furi...
AAK42182     140 -GISIDKSTRTVk----------EHYLYSARYLAFkk-------eVNYVIFIDNd------AISDK-------------- 181 Sulfolobus solf...
AAK41929     134 -GIQIRRMNQMNrgs------rntIHLFYQKFFGSny-------eLEYCINIDD--------LKKL-------------- 177 Sulfolobus solf...
WP_010879359 156 -GIALTKAK-VTk----------EEHFYQVEMLRFsd-------dCGIAVWVEDg--------VDF-------------- 194 Archaeoglobus f...
BAB04048     194 pPFALDERDHIAveagt--rmakDQALFTTQSIVFpp-------dLDMHARVEIpq----eAAWPM-------------- 246 Bacillus halodu...
WP_004082340 162 -GVAFEENRKKVk----------ERMIYSISYYRFyd--------gGFFMFTDDe------RTVEL-------------- 202 Thermotoga
WP_011026629 166 -GIKMDSTVNAVgg--------eEDALYRIEFMRLke-------dVNLIVWVEFd-----fEAEEIkkagfsdesklrgf 224 Caldanaerobacte...
WP_010880205 133 -GITLDKERRVVrsikeinrkeeKGLLYSQDFFRFnd-------gVKLAVLGEIn------KDIVI-------------- 184 Aquifex aeolicus
WP_005874912 180 -GIRKDYEGATN-----------DDAFFCQRYYRFknfk--evegEKTKVCKQPpvrehdfCFAVL-------------- 231 Porphyromonas g...
WP_011019666 214 -GVKLVGLKTAD-----------EGYLYAARFLRPgrspvdggslVGFLTVLAVp-----eDAWDDgvle---------d 267 Methanopyrus ka...
BAK54700     154 -GIGLDRSRKVTk----------EGMLYVANYVSIna-------sIYVIVNGDSk------EIKSA-------------- 195 Sulfolobus toko...

4H4K_A       189 --LS-----------SyEFLTLGGESRVAFVEVDDKTPDIFnrel---------gstKKALFYFSTPTIGKVGE----IV 242 Pyrococcus furi...
AAK42182     182 --IN-----------G-KIVNFGGENRIAKLEVDDYKVDTS----------------IEEEYYLTLSPILIPDE----AL 227 Sulfolobus solf...
AAK41929     178 --VK-----------E-NVVALGGENRYARVRIDNGNCNFGng----------------nYAILLQPLLFESDSeyfvRL 227 Sulfolobus solf...
WP_010879359 195 --DD-----------E-GILGVGGERRFVKFEKREEPECITnlrskwkkirdkinetGRLKIYLATPAILGAKG----YS 256 Archaeoglobus f...
BAB04048     247 --QL-----------S-TLHSLGGKRRLAHFSESQDDQFWQcpeale----qsldesQYVRLVLATPAYFAKGW----KP 304 Bacillus halodu...
WP_004082340 203 --VS-----------KlDGVFLGMKSKWSAVEVEELNTTAFdpp-----------dyKNVAVALITPAVFDGGG----MP 254 Thermotoga
WP_011026629 225 fnQP-----------P-RALKIGGEMKNAFYEVEEENFVEFlrenl------gvsqmVEVKCGDIVKVLFLTPG----VF 282 Caldanaerobacte...
WP_010880205 185 --SG-----------K-QYFRLGGEGKIVSFKHTEHINSFLegkik-------ikngNYYKFYCLTHAYINNGI----IE 239 Aquifex aeolicus
WP_005874912 232 --LEthrdikheelnK-RIVYLGGERQPFLMDLMEVSEETFklnies----stltsdEKHYTVVLLSDAMIEPK----LL 300 Porphyromonas g...
WP_011019666 268 lpSP-----------G-GRLGRGRHAWVIPLRAGDWSDDVFpeve--------epegDLPGLYLETPTPFPEGD----VR 323 Methanopyrus ka...
BAK54700     196 --LD-----------G-KISTFGGEGRLVKLHILDDEAFS------------------CDKFEDSKPGVLLSPL----PV 239 Sulfolobus toko...

4H4K_A       243 QELEKRLNak-----idD-------YLLVSSRPT----------------------AISGWDMHEKK---PKGTKFAIPP 285 Pyrococcus furi...
AAK42182     228 DDLLDNIS---------D-------YVTMGKVDK----------------------ISLGFDIANTK---RKEMLTAILE 266 Sulfolobus solf...
AAK41929     228 DNVKGLGCideiygvlvEkgn-kidFNNFK---------------------------VKVVYYALGYgneRRPMLQALPP 279 Sulfolobus solf...
WP_010879359 257 SKLDYDLLgdigiervrS-------VNFIGGKPV----------------------IFSGWDFVTRK---PKPTRYAVPA 304 Archaeoglobus f...
BAB04048     305 RWLDDELCtneifakeiSrevklqlVWACISRWQ----------------------PVSGWSYSLKQ---PKAVRRMVPA 359 Bacillus halodu...
WP_004082340 255 KDKTILGKr--------V-------LTTAGIRKQ----------------------VVSGWDLRENK---PKKIYHAVSP 294 Thermotoga
WP_011026629 283 PDFKFSVEg-------fE-------VFSLALDKY----------------------TIVGRYSPKLK---ITKTVRAFPS 323 Caldanaerobacte...
WP_010880205 240 SKIQTICIe----------------gINFEVEWL----------------------YNGGVEYVSGY---NKPFLEMLRP 278 Aquifex aeolicus
WP_005874912 301 EGVKFASTevkdfacllThvg--trRFYNKKKKR----------------------EEQNIEEVETA---LSHQHELYAR 353 Porphyromonas g...
WP_011019666 324 SSSPGDRLkae----avL-------VRPGSPRDRvlqvelevsevesevladrvieTRRVSTWSGKR---ASPDHLAAAE 389 Methanopyrus ka...
BAK54700     240 ESATRFIGefs----iiG----------------------------------------MGFDLKNNR---RKEIVKAILE 272 Sulfolobus toko...

4H4K_A       286 GSVLFVEFKEEVE--VPPy-------------IKLGKLKKLGYGLALGGIW 321 Pyrococcus furiosus DSM 3638
AAK42182     267 GSIVKRSIIDFIK--KEInnn---------llDRFTKYEKIGYNTLMNLCK 306 Sulfolobus solfataricus P2
AAK41929     280 GTVIKV--KETCnn-----------------aKALGLLSELGFGAIYRVDP 311 Sulfolobus solfataricus P2
WP_010879359 305 GSVYFVEFEGEVK--LDMp------------yLKLGKLTKLGYGLCFMGVW 341 Archaeoglobus fulgidus
BAB04048     360 GSVYFFKVTEGNP--RELarrgwlntvsdanrRKGAFDKEDGFGLALWGTW 408 Bacillus halodurans C-125
WP_004082340 295 GAVYYLEGKVNGH--V----------------LNESKFTDFGFGRCIFMKY 327 Thermotoga
WP_011026629 324 GTVMWFKAKEDML--LMNpafivpegnyhsfkIPSGEQEFIGSNLILIGKE 372 Caldanaerobacter subterraneus
WP_010880205 279 GSVLILKAKNEGE--IQRlnqis----tnvpiSNIKNFLNRGWNSGIIVEG 323 Aquifex aeolicus
WP_005874912 354 GSVFYFDTKEQANqfc-------------edlEKVPNFHTIGYNHAIIIEP 391 Porphyromonas gingivalis
WP_011019666 390 GTVLALGKLDVDPgtPLLlfprmgd-edrellASRLAFHLSGVGTAYALSl 439 Methanopyrus kandleri
BAK54700     273 GSIVINs-------------------------IPINEYYSIGYGSYVRIFT 298 Sulfolobus tokodaii str. 7
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