3KHX,1LFW


Conserved Protein Domain Family
dipeptidaselike
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TIGR01887: dipeptidaselike 
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dipeptidase, putative
This model represents a clade of probable zinc dipeptidases, closely related to the characterized non-specific dipeptidase, PepV. Many enzymes in this clade have been given names including the terms "Xaa-His" and "carnosinase" due to the early mis-characterization of the Lactobacillus delbrueckii PepV enzyme. These names are likely too specific.
Links
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Statistics
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PSSM-Id: 273854
Aligned: 11 rows
Threshold Bit Score: 580.489
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3KHX_A        33 EDQIINDLKGLLAIESVRDDAKASEDAPVGPGPRKALDYMYEIAHRDGFTTH-DVDHIAGRIEAG----KGNDVLGILCH 107 Staphylococcus ...
P45494        13 KDAILKDLEELIAIDSSEDLENATEEYPVGKGPVDAMTKFLSFAKRDGFDTE-NFANYAGRVNFG----AGDKRLGIIGH 87  Lactobacillus d...
CAB82474      10 EDQIINDLKGLLAIESVRDDAKASEDAPVGPGPRKALDYMYEIAHRDGFTTH-DVDHIAGRIEAG----KGNDVLGILCH 84  Staphylococcus ...
BAB06991      17 RDEIVYELREFLQYDSVYDEKTRKAGAPFGTKIEAALLHLLNLGKKANFSVR-NLEGYAGYIEMG----QGEESVGILCH 91  Bacillus halodu...
AAC45369      14 KDALMEDLFSLLRIDSAMDMEHADAENPFGPGPRKALDAFLKIAERDGYTTK-NYDNYVGHFEYEnganADAEVLGIIGH 92  Lactococcus lac...
1LFW_A        13 KDAILKDLEELIAIDSSEDLENATEEYPVGKGPVDAMTKFLSFAKRDGFDTE-NFANYAGRVNFG----AGDKRLGIIGH 87  Lactobacillus d...
WP_010991632  14 KDDFLEDLKGLLRIPSVRDDSKKTEDAPFGPDVKRALDYMIELGKKDGFTAK-EVGNVAGHLEYG----QGEELVGVLGH 88  Listeria innocua
WP_011010327  12 KDDLIESVQNIIRIKSVED--EPKEGMPFGEGVSKSLECALEISKKLGFKVV-NLDGHVGYAEYG----DGEEYVAALGH 84  Clostridium per...
EEU81843      14 KDLFYEDLNKIIAIRSVK--GSPKKEAPFGEGPKRALEETLKLAERYGFQTG-IVNDAVGYAQWG----TAEEYLGIIGH 86  Enterococcus fa...
WP_000686962  10 KDEFLISLKTLISYPSV--LNEGENGTPFGQAIQDVLEKTLEICRDIGFTTYlDPKGYYGYAEIG----QGAELLAILCH 83  Streptococcus p...
WP_029597724  11 KDEVVKEIQNAVRVKSVK--EAPLPGMPFGEGPAKALDHFMDLAKKLGFKAE-KFDNYAMHIDMG----EGKETLGILAH 83  Fusobacterium n...

3KHX_A       108 VDVVPAGD--GWDSNPFEPVVTE-DAIIARGTLDDKGPTIAAYYAIKILEDMNVDWKKRIHMIIGTDEESDWKCTDRYFK 184 Staphylococcus ...
P45494        88 MDVVPAGE--GWTRDPFKMEIDEeGRIYGRGSADDKGPSLTAYYGMLLLKEAGFKPKKKIDFVLGTNEETNWVGIDYYLK 165 Lactobacillus d...
CAB82474      85 VDVVPAGD--GWDSNPFEPVVTE-DAIIARGTLDDKGPTIAAYYAIKILEDMNVDWKKRIHMIIGTDEESDWKCTDRYFK 161 Staphylococcus ...
BAB06991      92 IDVVPPGE--GWSSPPFAAEIQN-DRIVARGALDDKGPTIAAFFAMRIIHELNLSIKRRVRLIIGTDEERNWECVDFYFR 168 Bacillus halodu...
AAC45369      93 LDVVPAGS--GWDSNPFEPEIRN-GNLYARGASDDKGPTVACYYALKILKELNLPLSKKIRFIVGTNEETGWADMDYYFE 169 Lactococcus lac...
1LFW_A        88 MDVVPAGE--GWTRDPFKMEIDEeGRIYGRGSADDKGPSLTAYYGMLLLKEAGFKPKKKIDFVLGTNEETNWVGIDYYLK 165 Lactobacillus d...
WP_010991632  89 VDVVPVGD--GWTNGPFEPTLRD-GKLYARGVADDKGPTIAGYYALKIIKELGLPLSRRVRIIVGSDEESGMSCVERYFE 165 Listeria innocua
WP_011010327  85 LDVVPEGD--DWIYPAYGAEIHD-GKIYGRGTTDDKGPIMASLYGLKAIKELGLSLSKKIRIIFGTNEETGSKDIEYYLE 161 Clostridium per...
EEU81843      87 LDVVPEGS--GWSVPPFQLTKKN-QRLYGRGILDNKGPILACLYGMKLLKELGYQPKKTIRLMFGTDEESGSGDIPLYLE 163 Enterococcus fa...
WP_000686962  84 LDVVPSGDeaDWQTPPFEATIKD-GWVFGRGVQDDKGPSLAALYAVKSLLDQGIQFKKRVRFIFGTDEETLWRCMARYNT 162 Streptococcus p...
WP_029597724  84 VDVVPEGD--NWTYPPYSGTIAD-GKIFGRGTLDDKGPAIISLFAMKAIADSGVKLNKKIRMILGADEESGSACLKYYFG 160 Fusobacterium n...

3KHX_A       185 --T--EEMPTLGFAPDAEFPCIHGEKGITTFDLvqnK--LT-EDq--DEPDYELITFKSGERYNMVPDHAEA-RVLV-Ke 253 Staphylococcus ...
P45494       166 --H--EPTPDIVFSPDAEYPIINGEQGIFTLEF---S--FK-NDd--TKGDYVLDKFKAGIATNVTPQVTRA-TISG-P- 230 Lactobacillus d...
CAB82474     162 --T--EEMPTLGFAPDAEFPCIHGEKGITTFDLvqnK--LT-EDq--DEPDYELITFKSGERYNMVPDHAEA-RVLV-Ke 230 Staphylococcus ...
BAB06991     169 --H--EEMPTVGIVPDADFPIIVAEKGVLDVEV---SipFH-DT---SEHPVRLQTFYAGERLNMVPDRAIAsLICS-He 236 Bacillus halodu...
AAC45369     170 --HceLPLPDFGFSPDAEFPIINGEKGNITEYL---H--FS-GK---NAGQVVLHSFKAGLAENMVPESATA-VISG-Ak 236 Lactococcus lac...
1LFW_A       166 --H--EPTPDIVFSPDAEYPIINGEQGIFTLEF---S--FKnDD---TKGDYVLDKFKAGIATNVTPQVTRA-TISG-Pd 231 Lactobacillus d...
WP_010991632 166 --T--EEQPTLGFVPDAEFPIIHAEKGISELDV---S--FK-DGeasGEAAFRLLSVESGERYNMVPDHATA-IIEDvKd 234 Listeria innocua
WP_011010327 162 --H--EKAPVAGFTPDAEFPIINGEKGITIFDIv-kT--FE-EKt--TDGDVLVESIKGGIASNVV-----A-SLCE-Tk 224 Clostridium per...
EEU81843     164 --K--ENAPVFGFTPDCKYPVVYGERGIVNYEI---T--TT-IP---DDSSEQIGQIIGDQAKDHVPDQLSV-VIAG-K- 227 Enterococcus fa...
WP_000686962 163 --I--EEQASMGFAPDSSFPLTYAEKG--LLQV---K--LH-GP---GSDQLELE---VGGAFNVVPD--KA-NYQG-L- 219 Streptococcus p...
WP_029597724 161 elK--MPYPDIAFTPDSSFPVTYAEKGSVRVKI---K--KK-FN---TLQDLVI---KGGNAFNSVPNEANG-VI----- 220 Fusobacterium n...

3KHX_A       254 nMTDVIQDFEYFLE---Q-NHLQGDSTVDSGILVLTVE--GKAVHGMDPSIGVNAGLYLLKFLASLNL-DNNA-QAFVAF 325 Staphylococcus ...
P45494       231 -DLEAVKLAYESFL---AdKELDGSFEINDESADIVLI--GQGAHASAPQVGKNSATFLALFLDQYAF-AGRD-KNFLHF 302 Lactobacillus d...
CAB82474     231 -NMTDVIQDFEYFL---EqNHLQGDSTVDSGILVLTVE--GKAVHGMDPSIGVNAGLYLLKFLASLNL-DNNA-QAFVAF 302 Staphylococcus ...
BAB06991     237 -STEAIKASFDHFI---EeHQLEGKAKAENGLLMLTLE--GKSAHGSTPEKGINAAVKLAQFLHHVN---GLS-DPFIQF 306 Bacillus halodu...
AAC45369     237 -DLEAALEKFVAEH---AsKNLRFDLEEADGKATITLY--GKSAHGAMPEKGINGATYLTLFLNQFDF-ADGA-AAFIKV 308 Lactococcus lac...
1LFW_A       232 -LEAVKLAYESFLA---D-KELDGSFEINDESADIVLI--GQGAHASAPQVGKNSATFLALFLDQYAF-AGRD-KNFLHF 302 Lactobacillus d...
WP_010991632 235 -FDKVASEFKAFLA---N-HPVEGSLEENGKTVKINIV--GKSAHAMEPNNGINAGLHLVAFLGKFKL-TGAA-NDFVTF 305 Listeria innocua
WP_011010327 225 -LKAKEVNKVCEEIskfA-KENNIKFEVSHKNDEIELKvfGVSAHGSTPEKGINAIMQTIKILAELNL-AQEDiKAFIKF 301 Clostridium per...
EEU81843     228 ---------------------------------TTAIT--GKRAPSNAPELGKNAITLLAQKISEEQL-VKG---NLLQY 268 Enterococcus fa...
WP_000686962 220 ---LYEQVCNGLKE---A-G-----YDYQTTEQTVTVL--GVPKHAKDASQGINAVIRLATILAPLQ-----E-HPALSF 279 Streptococcus p...
WP_029597724 221 ---PVDMLGEVRNK---N-K---VEFEREGNTYKVFSA--GIPAHGAYPSKGYNAVSALFEVLKDIEVkNEEL-KGLVTF 287 Fusobacterium n...

3KHX_A       326 SN---RYLFNSDFGEKMGMKFHTDVMGDVTTNIG--VITYDNENAGLFG-INLRYPE---GfefEKAMdRFANEI---QQ 393 Staphylococcus ...
P45494       303 LA---EVEHEDFYGKKLGIFHHDDLMGDLASSPS--MFDYEHAGKASLL-NNVRYPQ---G---TDPDtMIKQVL---DK 367 Lactobacillus d...
CAB82474     303 SN---RYLFNSDFGEKMGMKFHTDVMGDVTTNIG--VITYDNENAGLFG-INLRYPE---GfefEKAMdRFANEI---QQ 370 Staphylococcus ...
BAB06991     307 IS---EHLR-ETNGAGLSIACSDDVSGPLTMNAG--RFAYTYGEAGTIG-VNIRYPV---T---VDIEtFLAGLQ---AH 370 Bacillus halodu...
AAC45369     309 GA---EKLLEDHEGEKLGTAFVDELMENTSMNAG--VWSFDENGEGKIA-LNFRFPQ---G---NSPE-RMQEIL---AK 372 Lactococcus lac...
1LFW_A       303 LA---EVEHEDFYGKKLGIFHHDDLMGDLASSPS--MFDYEHAGKASLL-NNVRYPQ---G---TDPDtMIKQVL---DK 367 Lactobacillus d...
WP_010991632 306 GR---DYLFGDSRAVKLGISYEDVESGELTMNVG--VIRYDVAEGGKYG-LNFRYPV---T---ANMD-KLKN------K 366 Listeria innocua
WP_011010327 302 LN---DNIGEDVYGEKFGILLQDEVSGKLSFNVG--VIDLNDKV-GRLT-LNLRYPV---T---KTLDdMMTPFN---ER 365 Clostridium per...
EEU81843     269 FDwltASFHEKHYGEGVALDFKDQDSGQLILTP----YALEKRGQQLVLsLAVRYPVsitE---NEVTtQLTKAL---FP 338 Enterococcus fa...
WP_000686962 280 LA---TQAGQDGTGRQIFGDIADEPSGHLSFNVAglMINHERSE---IR-IDIRTPV---L---ADKE-ELVELLtrcAQ 345 Streptococcus p...
WP_029597724 288 FD---KFVKMETDGKSFGVKCTDGETGELTLNLG--KINLENNEL-EIW-IDMRIPV------------KVKNEQ---II 345 Fusobacterium n...

3KHX_A       394 YG--FEVKLGk-V-----Q-------PPHYVDKNDPFVQKLVTAYRNQTND-MTEPYTIGGGTYARNLDKGVAFGAMFSD 457 Staphylococcus ...
P45494       368 FSgiLDVTYNg-F-----E-------EPHYVPGSDPMVQTLLKVYEKQTGK-PGHEVVIGGGTYGRLFERGVAFGAQPEN 433 Lactobacillus d...
CAB82474     371 YG--FEVKLGk-V-----Q-------PPHYVDKNDPFVQKLVTAYRNQTND-MTEPYTIGGGTYARNLDKGVAFGAMFSD 434 Staphylococcus ...
BAB06991     371 NH---RIMNH--------L-------KPSYVEKDHPLIRTLQTVYKRQTGE-EATLLAIGGGTYARALKTGVAFGPLFPD 431 Bacillus halodu...
AAC45369     373 LDgvVEVELSkhL-----H-------TPHYVPMSDPLVSTLIDVYEKHTGL-KGYETIIGGGTFGRLLERGVAYGAMFEG 439 Lactococcus lac...
1LFW_A       368 FSgiLDVTYNg-F-----E-------EPHYVPGSDPMVQTLLKVYEKQTGK-PGHEVVIGGGTYGRLFERGVAFGAQPEN 433 Lactobacillus d...
WP_010991632 367 MQtvVYEYNAq-YthyddS-------KPLFVPKDHPLIQTLQEVYTKQTGE-EATLLAIGGGTYARHMETGVAFGALFPG 437 Listeria innocua
WP_011010327 366 IKgtGIEIENfeH-----Q-------KPLYFSPDHPLIKTLKNVYKEETGK-EGELMSIGGGTYAKEMPNIVAFGPIFPG 432 Clostridium per...
EEU81843     339 ESe-VTVIRR--------L-------PSTLFPKDERNVQKLTKVYEQITGL-DGTPVTTTGATYARFMPNIVAFGPSFPG 401 Enterococcus fa...
WP_000686962 346 NYqlRYEEFD--Y-----L-------APLYVAKDSKLVSTLMQIYQEKTGD-NSPAISSGGATFARTMPNCVAFGALFPG 410 Streptococcus p...
WP_029597724 346 ETi-KENTEDygY-----EfllhsntQPLYVAKDSFLVSTLMNIYKELTGDnDAEPVAIGGGTYAKYAKNAVAFGALLPD 419 Fusobacterium n...

3KHX_A       458 SEDLMHQKNEYITKKQLFNATSIYLEAI 485 Staphylococcus aureus subsp. aureus COL
P45494       434 GPMVMHAANEFMMLDDLILSIAIYAEAI 461 Lactobacillus delbrueckii subsp. lactis
CAB82474     435 SEDLMHQKNEYITKKQLFNATSIYLEAI 462 Staphylococcus aureus subsp. aureus COL
BAB06991     432 EEDTAHQKDESISIDQLLRATALYAEAI 459 Bacillus halodurans C-125
AAC45369     440 EPDSMHQANEMKPVENIYKAAVIYAEAI 467 Lactococcus lactis subsp. cremoris MG1363
1LFW_A       434 GPMVMHAANEFMMLDDLILSIAIYAEAI 461 Lactobacillus delbrueckii subsp. lactis
WP_010991632 438 REDTMHQKDEFSYFDDLLKATAIYAEAL 465 Listeria innocua
WP_011010327 433 EPDVIHKPNEYIKIDDLILISKIYAKAL 460 Clostridium perfringens
EEU81843     402 QKGIAHNQDEYMDEKDLLLNLEIYMQAM 429 Enterococcus faecalis D6
WP_000686962 411 AKQTEHQANECAVLEDLYRAMDIYAEAV 438 Streptococcus pneumoniae
WP_029597724 420 QEDRMHQRDEYLEISKIDKLLQIYVEAI 447 Fusobacterium nucleatum
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