Conserved Protein Domain Family
cas_Csd1

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TIGR01863: cas_Csd1 
CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG
CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein that tends to be found near CRISPR repeats of the DVULG subtype of CRISPR/Cas locus. We designate this family Csd1 (CRISPR/Cas Subtype DVULG protein 1). The species range for this subtype, so far, is exclusively bacterial and mesophilic, although CRISPR loci in general are particularly common among archaea and thermophilic bacteria. In a few species (Xanthomonas axonopodis pv. citri str. 306 and Streptococcus mutans UA159), homology to this protein family is split across two tandem genes; the trusted cutoff to this family is set low enough to capture at least the longer of the two.
Statistics
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PSSM-Id: 273839
Aligned: 12 rows
Threshold Bit Score: 568.556
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
tigr:CT1133           22 LQALYDYYQRKAAdpes----------giaPEGFEWKEIPFIIVIDREGNFVSLE-D----------------TREGDGK 74  Chlorob...
tigr:MCA0655           3 LQALYEYYGRKPEl---------------pALGFEEKEIPFLIVVDEQGRFVQLE-D----------------TREGEGK 50  Methylo...
chgcsh:AE010300_4231   3 LQELVKYYERKLEere------------iaREGFETKEIPYLIEIDEEGNFIRFI-S----------------TWQDE-K 52  Leptosp...
AAQ58901               3 LTELLDYYQRQAVldt------------vpRFGFSSEKISYALLLNEAGQLADLPrD----------------IRVAKGK 54  Chromob...
AAS94334               3 LQALHGYYQRMSAdpda----------gmpPYGTSMENISFALVLDAKGTLRGIE-D----------------LREQEGK 55  Desulfo...
AAS82464              27 LRELKEAFHRFRKegv------------llPLAYKRKSVAWFIRLE--GGKARLEgP----------------YGKREGV 76  Thermus...
AAK34352               7 LLKTYEKAELADLvdhqkrnnepvllpiyhTSLKSNGKNIISVKLDKDGQFHKAEf------------------MADKQM 68  Strepto...
WP_013067033           1 MSLLASLVRAYERmpd------------apPYGYSTEKIGFCVVLTAAGEVVEVA-D----------------LRDTDKK 51  Rhodoba...
WP_011715062           4 MQMLHTTYECCKDql--------------gPIYHTTQQAHLEVVLDHSGTFLRAHvP----------------SSKTDST 53  Magneto...
WP_011556937           3 LTALNDFARERGLtdd---------------plYEVKPVDFFIRISAKGKFIKLE-S----------------LAREDG- 49  Myxococ...
WP_015895951           3 VQALAGYADTHLRkq-------------ldDVAFEERPVQYFLQIGKDGSFLGVI-PrftevpvaspkqkkgsADKPPKT 68  Acidoba...
WP_010896519           4 LLHLYETYEANLDqvgktvkkgedreytllPISHTTQNAHIEVTLDEDGDFLRAK-A----------------L--TKES 64  Bacillu...
tigr:CT1133           75 KKKAKPYLLPKSVgRTG-SnsyKTSFLLWDHYGYVLGhsrSES-DKDQAMAEKQMPS-FIEKLRSLpeNVKGDDGVLAVI 151 Chlorob...
tigr:MCA0655          51 KKVPKRFFVPQAVkRTA-G---IAANVLWDNSSYVLG---MDA-KGKPERLKEQTRA-FEQAIRDL--GLEDDAGVSAVL 119 Methylo...
chgcsh:AE010300_4231  53 KKRASSYTIPKAViRSR-G---IEANLLWDNFEYIFG-----------LEKKEKQKD-FIRKIQDLesKSEESSSLTSIL 116 Leptosp...
AAQ58901              55 RYEGRVLNVPQPEkRTA-G---IRANFLWDKTGYVLG---VGA-K-SGGRVADEHAA-FKALHAKWlaDSEDE-GLRALR 123 Chromob...
AAS94334              56 KLRPRKMLVPIAEkKGN-G---IKPNFLWENTSYILG---VDA-KGKQERTDKCHAA-FIA-HIKAycDTADQ-DLAAVL 124 Desulfo...
AAS82464              77 EPIPAPDRQRSGKaSEA-N---LKPYLLVDDARYVLG---LFE-EGREDEAALLHKG-FKELTEKAwrETQSP-HVKVVL 146 Thermus...
AAK34352              69 IIFPVTADSVARSgSHP-AphpLVDKFAYYSAEMGQIqydSFH-KQLNNWIDYCEEGdVKKFLTFVqqFILKPEFLTLIL 146 Strepto...
WP_013067033          52 RS-PRMLMVPQAVkRTV-G---IAPNFLWDKSAYVLGv-tA----GEGKRTAEEHAK-FRERHLTAlaGAEDP-GLLALA 119 Rhodoba...
WP_011715062          54 TLIPCSEKSAGRT-SGL-MnhpLADKLQYVAGDYLSFa-gALS-EKEQTKMMESHRL-YKEALATWadSPQSHPTVKAIY 128 Magneto...
WP_011556937          50 --RGNAMPIPRLPqRSV-N---IAAGFFADNSKYVLAy-eKDApKAKAGGVEKRLAR-LEAFLKPVreVVAETKDAEARA 121 Myxococ...
WP_015895951          69 RLQPELLSVPRSPaNRNsG---LHPLLGSDDIKYVLGpgpWTK-ASELENHRDRHEA-FVELLRRVakETRDR-ALEICA 142 Acidoba...
WP_010896519          65 TLIPCTEEAASRSgSKV-ApypLHDKLSYVAGDFVKYg-gKIK-NQD----DAPFDT-YIKNLGEWanSPYATEKVKCIY 136 Bacillu...
tigr:CT1133          152 RFYE-KGEYKKVKES----------------------------DNWGECTKIIGCNMSFRLDGEV-----DLVPCRDAVK 197 Chlorob...
tigr:MCA0655         120 AFLDsKEEKAKALEA----------------------------ASSWPEILEKGANLAFRLQSRS-----ELVCQHEMVR 166 Methylo...
chgcsh:AE010300_4231 117 NFFS--KLKMPELKK----------------------------DPLWAEIEEDKHYLTFKLQGQN-----EIICSDKTIV 161 Leptosp...
AAQ58901             124 RFLQdWRPEQFDAFP----------------------------PELQESLR--DANVVFRLDGRR-----EYVHESPTAQ 168 Chromob...
AAS94334             125 QFLEhGEKDLSA-------------------------------FPVSEEVI--GSNIVFRIEGEP-----GFVHERPAAR 166 Desulfo...
AAS82464             147 DLLSsPELGDLR-------------------------------EEFRQKGGKPRDLLAFKVHGVLp-------TELEEVQ 188 Thermus...
AAK34352             147 DSLIgPDYQHNQLKVtfc-----------------------daTGKEKLIDLSACFLEFSIDQFQg------FKNESVST 197 Strepto...
WP_013067033         120 RFLQtWTPEAFG--P----------------------------PLWPEEAK--DQNLVFRLADEF-----GYLHDRPAAR 162 Rhodoba...
WP_011715062         129 AYVAqGRLVGDLVNAgilpcvegsipp-----kwqgpkeetpaIYKAVTGMPLDAFVRWRVEPAPgvceiEPWNDPQLIQ 203 Magneto...
WP_011556937         122 VESFlDSEAERSKAL----------------------------ADRGAEEWTGSEMLAFVVGEAT-----TPVHQNPAIR 168 Myxococ...
WP_015895951         143 QFYDqPEQVERAREA--------------------------------LAKVTPGSNVALFVFGQP-------VTERDEVR 183 Acidoba...
WP_010896519         137 TYLKkGRLIEDLVDAgvlkldenqqliekwekryeellgekpaIFSSGATDQASAFVRFNVFHPEsi--dDVWKDKEMFD 214 Bacillu...
tigr:CT1133          198 RYIET----Q----IGE-SADDAVgLCLVTGKK-AAI-ARIHSDTP--------INKDSKKFVSFQkNSGYDSYGKEQAF 258 Chlorob...
tigr:MCA0655         167 TALTR----R----LTE-ANADPT-VCLVSGEE-DAP-ERLHPPIKgv----wgGQPTGANIVSFN-LDAFNSWGKSQGD 229 Methylo...
chgcsh:AE010300_4231 162 QTISQ----N----ASD-DEVEKG-ICLVSGKT-NPI-ERLHSKISlt-----gANTSGANLVSFN-LDAFESYGKKQGS 223 Leptosp...
AAQ58901             169 QLRAR----M----LAE--GGGDTgMCLVSGET-APL-ARLHPAIKgv----ngAQSSGASIVSFN-LESFASYGKSQGA 231 Chromob...
AAS94334             167 QAWAN----C----LNR-REQGLCgQCLITGERqKPI-AQLHPSIKggrdgvrgAQAV-ASIVSFN-NTAFESYGKEQSI 234 Desulfo...
AAS82464             189 AFWAR----H----LAE-EIQGGKgYCALCGTLgPVL-RIFPREVV--------VLGQKCQLVSFN-QKAFESFGKEQAA 249 Thermus...
AAK34352             198 FKALHqsyiS----FVE-ANRENLgICNISGRE-EQL-TDKHRGLMg-----------NAKIISVS-NKREAYKGRFRER 258 Strepto...
WP_013067033         163 ALWAR----L----GAE-AASE-AqVCLVTGAS-APV-ARLHPSLKgv----wgAQSSGASLISFN-LDAFNSYGHEQGD 225 Rhodoba...
WP_011715062         204 AWIDH----Y----LALlEESAPRgTCMVTGQT-DVLlAQSHPAKLr-------HAADKAKLISANdSSGYTYRGRFLSA 267 Magneto...
WP_011556937         169 ACWER----Ra---GAQ-RALGRRaLCLVTGRE-GVV-AVTHPKLKnv----peAQPSGASLVSFN-APAFSSHGLEQGE 233 Myxococ...
WP_015895951         184 AWWRQ----HyeasTAE-RGAGQTaECLISGVV-GPI-PSTHAKIKgts--algGQPAGVSLMSFD-KPAFRSYGWEQNA 253 Acidoba...
WP_010896519         215 SFISFy---N----DKL-GEED---ICFVTGNR-LPS-TERHANKIr-------HAADKAKLISANdNSGFTFRGRFKTS 274 Bacillu...
tigr:CT1133          259 N--APISESAVFAYTTALNMLLGKns----kNKVQVGD---ATTVFWSEKQ-------------------------DVFE 304 Chlorob...
tigr:MCA0655         230 N--APVGKRAAFAYTTALNHLLAKds----kQRLQVGD---ASTVFWAAQA-------------------------NPLE 275 Methylo...
chgcsh:AE010300_4231 224 N--APTSKYANFAYGTSISSLTSKds----rQKILIGN---TTMMFWSETK-------------------------NELE 269 Leptosp...
AAQ58901             232 N--APISEFAAFAYTAALNHLLRReed--nrQRLQIGD---ATVVFWARAAsa---------------------egAVAA 283 Chromob...
AAS94334             235 N--APVSQEAAFSYVTALNYLLNPsn----rQKVTIAD---ATVVFWAERSspaedifagmfdppsttakpessngTPPE 305 Desulfo...
AAS82464             250 N--APLCFTCASQVVDTLDYLIRSerhsrplYREEEGGlrnQLAVFWLSEKvevp-----------------letpVDLE 310 Thermus...
AAK34352             259 EdvFSVGYETSEKIHLMLKYLLENk-----nTSTWLGSs--QYLINWFSDDltnd------------------srlDIVS 313 Strepto...
WP_013067033         226 N--APVSEGAAFAYTTALNRFLEKds----gHRLQIGD---ASTVFWADASea----------------------eAAQA 274 Rhodoba...
WP_011715062         268 DevCGVGLETTQQVHNTLRWLIEK-------QGYRQGD---LRIVAWAVDGrttp------------------gilISTQ 319 Magneto...
WP_011556937         234 N--APISQEASLGYVLALNDMLRRteqrrfrQGIQLADg--SVMVFWTRAS--------------------------PSE 283 Myxococ...
WP_015895951         254 N--SPVSSDRAMAYVLALNDLLKPgs----qNRKDFDG---VAFLFWLKRD---------------------------VD 297 Acidoba...
WP_010896519         275 ReaVGISYEVSQKAHNALKWLIHr-------QSKSIDD---RVFLVWSNDNsl----------------------vPNPD 322 Bacillu...
tigr:CT1133          305 EDFPAFFG-YSKDDPDADVR--------AVKALYEGIKSG-HAQMDS-KTRFYVLGL-APNSARISVRFWHTGTIAEFAG 372 Chlorob...
tigr:MCA0655         276 DLLADLFSePPKDDPDRNTR--------AVESLYKAPHTG-ASVFDDdGTQFYVLGL-APNAARIAVRYWHVATVRELAR 345 Methylo...
chgcsh:AE010300_4231 270 DEFLSLLKpSDEDQKKDSKRkqearsnqTIKEHFVSPFTGkLQHLLNdGTKFFILGL-APNAARISVRFWYPSTVGEISK 348 Leptosp...
AAQ58901             284 EAAFADWLdPPADDASEAQRvl-----aALQDIADGRPAAeLGLRLEpDTRLFVLGL-APNASRLSIRFWECGRLESFAT 357 Chromob...
AAS94334             306 DSEEGSQPdTARDDPHAAARmh-----dLLVAIRSGKRATdIMPDMDeSVRFHVLGL-SPNAARLSVRFWEVDTVGHMLD 379 Desulfo...
AAS82464             311 TILGAVLSgALVHSPTPPADl------tQLQELLATPWTGkAWPLNLdETRFHLAVL-SANKGRLVVREWLAVSLSRLKE 383 Thermus...
AAK34352             314 PIFDDGLEeDDDDDTPPVITl------aTEDNKRIGKSFIkGQKLFAnDATYYVAILnKTSNGRIALKYFRQLQASQLLT 387 Strepto...
WP_013067033         275 EGFFAAFFdTAATEKIEALNig-----aQLARIRACEPLAeVAPQLAsGVRFCVLGL-APNAARLSVRFWWEDDFGTLTA 348 Rhodoba...
WP_011715062         320 ELLGDNVPaETEEEDELLPTssmghsvdQSFGLRLGKKISgYYSQLGdLTDIVVMGIdSATPGRMSIIYYRELQQTEFLQ 399 Magneto...
WP_011556937         284 ESFLLSLLdPTEDDLKRFVEs----------------PRKgVEPGELdDRAFYAVTL-AGNAGRVAVRDWFESRVGEVKQ 346 Myxococ...
WP_015895951         298 IDYNSLLEePPSDVLLDKAR-------------AIIGLKNgAWMRQEeRNELYMAAV-SATGSRLVLRSWSSMPLEDALE 363 Acidoba...
WP_010896519         323 E---DAVDiMKHANRELERDpd----tgQIFAGEVKKAIGgYRSDLNyQPEVHILVLdSATTGRMAVLYYRSLNKELYLN 395 Bacillu...
tigr:CT1133          373 NIRQHFDDLEIIRSPKDS--------G----HFSMFWLLSAMAHE-------GKVDNVPPNLSGQIFQSVITG--GLYPA 431 Chlorob...
tigr:MCA0655         346 HIKQHFRDLEIIHAPSEK--------P----YLSLFRLLVCTATQ-------GKSENIPPNLAGEFMKSILAG--IPYPH 404 Methylo...
chgcsh:AE010300_4231 349 NINQHFTDLKLEIYNIES--------G----FISLNRILSSTAIQ-------GKMENVSPLLSGKLVTSIISG--SEYPR 407 Leptosp...
AAQ58901             358 RLAAHYRDLELAPLPWKR-------------PPGVWRLLYAVAAQ-------GKAENVPPQLAGELARSILGG--GRYPR 415 Chromob...
AAS94334             380 KVGRHYRELEIIPQFNNE--------Qe---FPSLSTLLRQTAVL-------NKTENISPVLAGGLFRAMLTG--GPYPQ 439 Desulfo...
AAS82464             384 TLGRFLEGTRLVRPWGEA--------P---------QPVPVGALV-------QALGDGNPGLVRGLLRTAYLG--TPPPH 437 Thermus...
AAK34352             388 NLNKWQETYSWESRSKFG--------KsrlrTPTFHDILNVSYGVdrdrfleLDNDNFKSDQIQKLVASLIDG--KPMPQ 457 Strepto...
WP_013067033         349 HYQRYLDDMRLDPPPRDD--------W----P-PLWRYLSELAPQ-------GKRENVPPLIAGDWMRAILTG--TAYPL 406 Rhodoba...
WP_011715062         400 RLEKWHSQMAWPQNFGKDsq----ftG----APAPRDIAEAAYGR-------RLDDKLKSTTLQRILPCIIDE--QPFPE 462 Magneto...
WP_011556937         347 NIRRYFDDLRMGDAP--A--------G----PIPVYRLLKAVEAP-------SGRG-LTPDIAARMLGAALRG--QPFPR 402 Myxococ...
WP_015895951         364 SLLGFWEQLKMQPLEKDK--------P-----PRAEPFWKLLHAL-------DREGRPPASRTVALRRRALEGrcSPLGY 423 Acidoba...
WP_010896519         396 RLEAWHDSCAWEHRYRRDekefisfyG----APATKDIAFAAYGP-------RASEKVIKDLMERMLPCIVDG--RRVPK 462 Bacillu...
tigr:CT1133          432 TMLQQAIRRIRATQ------------EVTRIQASILKACLNRFSRIYNt-KAKEITVALDPT--NNNPGYRLGRLFAVLE 496 Chlorob...
tigr:MCA0655         405 SLLQAAIRRIRADR------------EITYPRAALVKACLNRQTRYSNpdNVKELTVALDDT--QTNIGYRLGRLFAVLE 470 Methylo...
chgcsh:AE010300_4231 408 TLLSSILIRLKAEK------------EISFVRVSVLKAILNRKGRFEKfkNYKELTTSMDEE--NINVAYRLGRLFAVME 473 Leptosp...
AAQ58901             416 SLLVNAIMRMRADG------------ELSGTRVALCKAVLGRDQRLGVagINLELPVSLDIA--NRDPGYLLGRLFAELE 481 Chromob...
AAS94334             440 SLLPAVLGRIRAEHarpedksryrleVVTYYRAALIKAYLIRNRKL-------EVPVSLDPA--RTDRPYLLGRLFAVLE 510 Desulfo...
AAS82464             438 ALSLAIHLLRNPKTltp-------eeREGWGRLHALVAALKLWLFYGK--EEAKRMAELDKE--RKNPAYLSGRLLAVLE 506 Thermus...
AAK34352             458 SIVKKLGNNVKERHry---------rKHWYQVEQVCLAILHKQNG-------EEFSPMLDHT--NQNRSYLFGRLLAIFE 519 Strepto...
WP_013067033         407 TLLSTVLMRIRADG------------EINALRAAMLKSVLIRNFQS------KEAPVALDPA--SKDTGYVLGRLFAAYE 466 Rhodoba...
WP_011715062         463 DLIHAVVHRTSNRVafdrs--ktgfqWEWEKCLGIACALVRGSNLRAH--IKKEYAMALEPD--YTSRDYLYGRLLALAD 536 Magneto...
WP_011556937         403 QLLVAALDRLRLPPadgg-----verEQLRLRVALIKAYLLRDRNRGS--TPLEVTVSLDKD--NPSQPYVLGRLFAVLE 473 Myxococ...
WP_015895951         424 RIVSDVLARMRADKe----------kRRDIAALGLLRLCLNDLHATTG--KGEPMPAALDETepPQHPAYVCGRLLALHD 491 Acidoba...
WP_010896519         463 DIVRSAFQRASNPVsm--------erWEWEKTLSITCALIRK--MHIE--QKEEWGVPLDKS--STDRSYLFGRLLAVAD 528 Bacillu...
tigr:CT1133          497 KIQEEAS-PGL----NATIRDRFYGAASSTPVTVFPQLLKL-KNHHLSKLDNAg------RRVNFERMLAGVFEGIGn-- 562 Chlorob...
tigr:MCA0655         471 KIQEEAN-PGI----NATIRDRYYGAASSTPVAVFQTLMRL-KNHHLAKLENRg------RAVNLERLIGEIVDGIDa-- 536 Methylo...
chgcsh:AE010300_4231 474 RLQERAN-PGI----NATIRDRYFSSASSRPATVFPVLFNL-SMHHASKSGS----------VWFEKLKGEILAPLSg-- 535 Leptosp...
AAQ58901             482 SIQRGALgEKI----NATIRDRYYGAASATPANVFPLLLRN-AQHHLSRLRKDkp----gLWKTLERDLADIIHGLDa-- 550 Chromob...
AAS94334             511 KAQEDAV-PGA----NATIKDRYLASASANPGQVFHMLLKN-ASNHTAKLRKDper--kgSAIHYEIMMQEIIDNISd-- 580 Desulfo...
AAS82464             507 EAQKRASsYTL----RRTLVDRFYGAASTTPAATFGVLLRLsTTAHLPKVGQ-----------ELNQAVEEILSRLDea- 570 Thermus...
AAK34352             520 LIETLRYgLDGnnndRITNAERYWTAYTGQPTKLMMLLENK-IKPYEEPLKLNrr----gsWMKLEKEKEEILELLNpl- 593 Strepto...
WP_013067033         467 NIQKAALgKGV----NATIRDKFYGSASATPARVFGSLAAN-AFNHLAKIRKEkp----aFAHYLQDELQQIANLLEvsa 537 Rhodoba...
WP_011715062         537 YLEEQALhAANe--hRATNAARLMQRFSQRPNATWLTIYDA-LLPYKNRLQVNkp----gLYINMMRELDNVMNLFAi-- 607 Magneto...
WP_011556937         474 RLQGVAL-KDL----NATIRDRYFGAASRNPVTVFPRLIQL-SVHHASKAGENg--------rWLERTKGEVMALLPsk- 538 Myxococ...
WP_015895951         492 SLQWRTFdAAEeaqpNATVADRYYTLMMNSPAIGVAKVFDL-GRKHLSKLRKLdaksgtsYCDYFTRRICELEEHLGg-- 568 Acidoba...
WP_010896519         529 VLERGALgKDEt---RATNAIRYMNSYSKNPGRTWKTIQES-LQPYQAKLGTK--------ATYLSKLVDEIGDQFEp-- 594 Bacillu...
tigr:CT1133          563 -eMPSHLSMEDQARFAIGYYHQRQDFFKKKDSE 594 Chlorobium tepidum TLS
tigr:MCA0655         537 --FPPILSLADQGHFTIGYYHQRQALFTKTDRS 567 Methylococcus capsulatus str. Bath
chgcsh:AE010300_4231 536 -rIPNTFSLEEQGLFAVGYYHQRNELFKKKEEL 567 Leptospira interrogans serovar Lai str. 56601
AAQ58901             551 -pLPRNLGIAAQGQFAIGYYHQAHAYYHNKGGD 582 Chromobacterium violaceum ATCC 12472
AAS94334             581 --FPVTMSSDEQGLFMIGYYHQRKALFTKKNKE 611 Desulfovibrio vulgaris str. Hildenborough
AAS82464             571 ggFPRTLNLVGQAEFALGFYHQRAHFRANRAGK 603 Thermus thermophilus HB27
AAK34352             594 -lETETMEKPLDYRFIFGYYAEKNYYYTKQNTE 625 Streptococcus pyogenes M1 GAS
WP_013067033         538 epFPSSLSQESQAKFALGYYHQASFRKPADTEQ 570 Rhodobacter capsulatus
WP_011715062         608 --aDYQNDAPLKGEYLLGYHCQRAVLWAKKGDK 638 Magnetococcus marinus
WP_011556937         539 dpFPPVFQPEQQGLFAVGYYHQREAFFTKREaa 571 Myxococcus xanthus
WP_015895951         569 -ePPVQFDLHDKARFALGFYHEKAPRFRARKAE 600 Acidobacterium capsulatum
WP_010896519         595 --GDFNNN-PLTEQYLLGFYSQRRELYKKKEEE 624 Bacillus halodurans
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