2AQ9,1J2Z,3R0S


Conserved Protein Domain Family
lipid_A_lpxA

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TIGR01852: lipid_A_lpxA 
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acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
This model describes LpxA, an enzyme for the biosynthesis of lipid A, a component oflipopolysaccharide (LPS) in the outer membrane outer leaflet of most Gram-negative bacteria. Some differences are found between lipid A of different species, but this protein represents the first step (from UDP-N-acetyl-D-glucosamine) and appears to be conserved in function. Proteins from this family contain many copies of the bacterial transferase hexapeptide repeat (pfam00132). [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
Statistics
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PSSM-Id: 188173
Aligned: 17 rows
Threshold Bit Score: 360.423
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2AQ9_A         8 VHPTAIVEEGASIGANAHIGPFCIVGPHVEIGEGTVLKSHVVVNGHTKIGRDNEIYQFASIGEVNQDLKYAGEP-TRVEI 86  Escherichia col...
Q9A715         3 IHPTAIIAPEAKLAPDVEVGPFSIVGPDVTLAAGVRLLSHVVVEGATTIGEGCVVHSFANLGGPPQHLGHKGER-TELII 81  Caulobacter cre...
Q8YHG8         6 IHPTALVEPGVELGQGVSVGPFCHVQSGAIIGNDCELMSHVVITGATTLGAGTKVYPHAILGCDPQNNKHKGGP-TRLNV 84  Brucella melite...
Q92Q45         8 IHPSSAIENGAVIGENVKIGPFCHIGPNVVLADDVEILSHVAVIGHTSVGKGTKIFPGAVIGGDSQSVHHSALN-TKLVI 86  Sinorhizobium m...
Q9ZJL7         4 IAKTAIISPKAEIGKGVEIGEFCVIGDGVKLDEGVKLHNNVTLQGHTFIGKNTEIFPFAVLGTQPQDLKYKGEY-SELMV 82  Helicobacter py...
Q9PIM1         4 IHPSAVIEEGAQLGDDVVIEAYAYVSKDAKIGNNVVIKQGARILSDTTIGDHSRVFSYAIVGDIPQDISYKEEQkSGVVI 83  Campylobacter j...
O84536         4 IHPTAIVEDGARIGNNVTIEPYAIVKKNVTLCDDVVVKSYAYIDGFTTIGRGTTVWPSAMIGNKPQDLKFKGEK-TFVEI 82  Chlamydia trach...
Q9ZED5         6 IHTTAIIAEGAKFGKNVKVGPYCIIGPEVVLHDNVELKSHVVIDGITEIGENTVIYPFASIGQPPQILKYANER-SSTII 84  Rickettsia prow...
1J2Z_A         4 IAKTAIISPKAEINKGVEIGEFCVIGDGVKLDEGVKLHNNVTLQGHTFVGKNTEIFPFAVLGTQPQDLKYKGEY-SELII 82  Helicobacter py...
WP_011058058  15 VHPTAVIEAGARIGEEVEIGPFCYVAATVEIGRGTQLAPHVTLLGYTRLGENCKVHSGAVIGDLPQDVAYQGGI-SYVHI 93  Thermosynechoco...
2AQ9_A        87 GDRNRIRESVTIHRGTVQGGGLTKVGSDNLLMINAHIAHDCTVGNRCILANNATLAGHVSVDDFAIIGGMTAVHQFCIIG 166 Escherichia col...
Q9A715        82 GPRNIIREHVTMHTGTASGKGVTTIGSDGLYMVGSHVAHDCTVGDFVVLAKGATLGGHVAIGDYVFMGGLAAAHQFSRIG 161 Caulobacter cre...
Q8YHG8        85 GVNCIIREGVTMHKGSDNARGYTSIGDNCSFLAYAHVAHDCDIGDYVTFSNNVMIGGHTSIGHHAILGGGAAVHQFVRVG 164 Brucella melite...
Q92Q45        87 GENCTIREGVTMNTGTVEHGGATIVGNNNLFLAYSHVAHDCRLGNNIILSNNVMLAGHVTVEDRAILGGGSAVHQFTRIG 166 Sinorhizobium m...
Q9ZJL7        83 GEDNLIREFCMINPGTEGGIKKTLIGDKNLLMAYVHVAHDCVIGSHCILANGVTLAGHIEIGDYVNIGGLTAIHQFVRIA 162 Helicobacter py...
Q9PIM1        84 GKNATIREFATINSGTAKGDGFTRIGDNAFIMAYCHIAHDCLLGNNIILANNATLAGHVELGDFTVVGGLTPIHQFVKVG 163 Campylobacter j...
O84536        83 GEHCEIREFAMITSSTFEG-TTVSIGNNCLIMPWAHIAHNCSVGNNVVFSTHVQLAGHVQVGDCVTIGSMVGVHQFVRIG 161 Chlamydia trach...
Q9ZED5        85 GSNNTIREYVTVQAGSKSGGMITRVGNNNLFMVGVHIGHDCKIGNNLVFANYVSLAGHIKVGDYAIIGGLSAVHQYTRIG 164 Rickettsia prow...
1J2Z_A        83 GEDNLIREFCMINPGTEGGIKKTLIGDKNLLMAYVHVAHDCVIGSHCILANGVTLAGHIEIGDYVNIGGLTAIHQFVRIA 162 Helicobacter py...
WP_011058058  94 GDRCTLREGVTIHRGTQPE-TVTHVGHDCLLMAHSHLGHNVYVGNHVTIANNTLIAGYAQVGDRAFISGNCLVHQFTRIG 172 Thermosynechoco...
2AQ9_A       167 AHVMVGGCSGVAQDVPPYVIAQGN-HATPFGVNIEGLKRRGFSREAITAIRNAYKLIYRSGKTLDEVKPEIAELAETYPE 245 Escherichia col...
Q9A715       162 RYSFIGGLAAVTKDVIPYGSVWGN-HAHLEGLNLVGLKRRGFPRETINALRAAYRLMFADEGTFQERLDDVAEIHAGNAE 240 Caulobacter cre...
Q8YHG8       165 HHAFIGGLAAVVSDLIPYGMAIGV-HAHLGGLNIIGMKRSGMERKEIHNLRHAVRMLFDRTKPIRQRAQDVLAAIPDSPT 243 Brucella melite...
Q92Q45       167 RQAFIGGLSAVSYDVIPYGMLNGN-PGVLSGLNVVGMTRAGIDRPAIHRVRRCYKQIFEGDGSIRANAAAIRNEYLDCAP 245 Sinorhizobium m...
Q9ZJL7       163 KGCMIAGKSALGKDVPPYCTVEGN-RAFIRGLNRHRMRQL-LESKDIDFIHALYKRLFRPIPSLRESAKLELEEHANNPF 240 Helicobacter py...
Q9PIM1       164 EGCMIAGASALSQDIVPFCLAEGN-RASIRSLNLVGIRRR-FDKDEVDRLSRAFKTLFR-QGDLKENAKNLLENQES-EN 239 Campylobacter j...
O84536       162 SYSMVGAMSGIRRDIPPFTIGTGN-PYALGGINKVGLQRRQVSFETRLALIKTFKRVFRSDESFQASLESVLEDFGEVPE 240 Chlamydia trach...
Q9ZED5       165 EYSMIGGLSPVGADVIPFGLVSSK-RAVLEGLNLIGMNRKGFDKADSLTALNAVEEIFLGEGNFVDRIKQVAEKYKNNSI 243 Rickettsia prow...
1J2Z_A       163 KGCMIAGKSALGKDVPPYCTVEGN-RAFIRGLNRHRMRQL-LESKDIDFIYALYKRLFRPIPSLRESAKLELEEHANNPF 240 Helicobacter py...
WP_011058058 173 RLAMLSGGTAIQKDVPPFCMTRSLsTNTIMGLNVVGLRRAGFSAQDRQLLKKALDILYRSQLTTSQALQHLREQFVH-PL 251 Thermosynechoco...
2AQ9_A       246 VKAFTDFFAR-STRGLI 261 Escherichia coli K-12
Q9A715       241 VMEIVDFIRTdANRPLC 257 Caulobacter crescentus CB15
Q8YHG8       244 VSDMISFINVdTKRAYC 260 Brucella melitensis
Q92Q45       246 AIEILDFIAAeSDRALS 262 Sinorhizobium meliloti 1021
Q9ZJL7       241 VKEICSFILE-SSRGVA 256 Helicobacter pylori J99
Q9PIM1       240 VKKMCHFILE-TKRGIP 255 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
O84536       241 VRHFVEFCRQpSKRGIE 257 Chlamydia trachomatis D/UW-3/CX
Q9ZED5       244 VTQIIDFLNQdSSRAFC 260 Rickettsia prowazekii str. Madrid E
1J2Z_A       241 VKEICSFILE-SSRGVA 256 Helicobacter pylori
WP_011058058 252 IQEFCDFISA-SQRGIC 267 Thermosynechococcus elongatus
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