2HZP


Conserved Protein Domain Family
kynureninase

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TIGR01814: kynureninase 
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kynureninase
This model describes kynureninase, a pyridoxal-phosphate enzyme. Kynurinine is a Trp breakdown product and a precursor for NAD. In Chlamydia psittaci, an obligate intracellular pathogen, kynureninase makes anthranilate, a Trp precursor, from kynurenine. This counters the tryptophan hydrolysis that occurs in the host cell in response to the pathogen. [Energy metabolism, Amino acids and amines]
Statistics
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PSSM-Id: 130873
View PSSM: TIGR01814
Aligned: 8 rows
Threshold Bit Score: 552.032
Threshold Setting Gi: 499309938
Created: 8-Oct-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2HZP_A        66 ALHLDEEDKLRHFREXFYIPKIQ------------DlppvdlslvnkdENAIYFLG-NSLG-LQ-PKMVKTYLEEELDKW 130 human
Q16719        30 ALHLDEEDKLRHFRECFYIPKIQdlppvdlslvnkD------------ENAIYFLG-NSLG-LQ-PKMVKTYLEEELDKW 94  human
NP_509023     43 AEFLSDSDALKEIRDLFHYPKAGtlpdad-pslvdP------------ESDSIYLCgNSLG-LM-PKATGEVMKDHLDKW 107 Caenorhabditis ...
WP_011036737  10 aaaldaadplRALRDAFVFPQHG------------G------------QDQTYFVG-NSLG-LQ-PRQARAMVSEVLDQW 62  Xanthomonas cam...
NP_013332      4 ALELD-GEYPESLRDEFNIPTFKsmg------lssD------------DKPVTYLCgNSLG-LM-PKSTRNSINAELDAW 62  Saccharomyces c...
WP_011065164  10 AQEMDEQDELKQFRSEFHLK-----------------------------NESIYMDgNSLG-LM-SKRAENALHNIIDSW 58  Oceanobacillus ...
WP_011000713   8 CLERDAADPIAPLRDAFALP-----------------------------DGVIYLDgNSLGaRP-HAALARAQQVIADEW 57  Ralstonia solan...
WP_010909531  10 VEALDAADPLRAMRDRFILPEG-----------------------------VIYLDgNSLG-AAaPAVFNELQKAATQEW 59  Mesorhizobium loti
2HZP_A       131 AKIAAYGHEV------GKRPWITGDESI-VG--L--MKdiVG-A-NEKEIALMNALTVNLHLLMLSFFKP----TPKRYK 193 human
Q16719        95 AKIAAYGHEV------GKRPWITGDESI-VG--L--MKdiVG-A-NEKEIALMNALTVNLHLLMLSFFKP----TPKRYK 157 human
NP_509023    108 AKMGVFGHMS------GEVPWAHCDEYC-LE--GvgRL--VG-A-KKEEVSVCNSLTVNIHVLLTSFYKP----TETRHK 170 Caenorhabditis ...
WP_011036737  63 GALAVEGHFT------GPTQWLTYHQLV-RD--G--LArvVG-A-QPDEVVAMNTLTVNLHLMMASFYRP----SAERAA 125 Xanthomonas cam...
NP_013332     63 SDCAVESHFKhpeearGKVPWVSIDLPI-LP--L--LApiVG-A-QENEVAVMNSLTANLNSLLITFYKP----TEKRFK 131 Saccharomyces c...
WP_011065164  59 KKYGIDGWME------GDHPWYYLSEHLgEK--M--SV--LV-GgKKDEVIATGSTTINLHQLVSTFFQP----EGKRTK 121 Oceanobacillus ...
WP_011000713  58 GEGLIRSWN--------QAGWFELPRRLgNK--L--AP--LIgA-RADEVVITDTTSINLFKVLAAALRVqredAPERRI 122 Ralstonia solan...
WP_010909531  60 AQDLIRAWNT--------ASWFDMPVAL-GDqlG--RL--IG-A-VSGQTVVCDTTSINIYKVLHAALGM----RPNRSV 120 Mesorhizobium loti
2HZP_A       194 ILLEAKAFPSDHYAIE-SQLQLHg-LNIEESMRMIKPR-EgEETLRIE--DILEVIEKE-GDSIAVILFSGVHFYTgQHF 267 human
Q16719       158 ILLEAKAFPSDHYAIE-SQLQLHg-LNIEESMRMIKPR-EgEETLRIE--DILEVIEKE-GDSIAVILFSGVHFYTgQHF 231 human
NP_509023    171 ILLESKAFPSDHYAIE-SQIRLKg-RTVQDSMVCLEPR-EgEETLRTE--DILDYIEKN-GDEIAIVFFSGIQYYTgQLF 244 Caenorhabditis ...
WP_011036737 126 ILIEAGAFPSDRHAVE-SQLRLHg-LDPDTHLIEVEPDaA-DGTLSMD--AIAATIAQH-GPRLALVLWPGIQYRTgQAF 199 Xanthomonas cam...
NP_013332    132 ILFEKGSFPSDYYAFY-NQCKIHgiSEPENVFIQIEPR-EgETYIRTQ--DILDTIEVN-QDELALVCLSGVQYYTgQYF 206 Saccharomyces c...
WP_011065164 122 ILADALTFPSDIYALK-AQLQLK--GYDESHLVQVQSE-D-G---NLL--NEEHLIEAM-TDDIALIVLPSVLYRSgQIL 190 Oceanobacillus ...
WP_011000713 123 IVSEAHNFPTDLYIAEgLADLL---------------R-D-GYKLRLI--DAPDALETAlGDDVAVTMLTHVNYKSgHMY 183 Ralstonia solan...
WP_010909531 121 IVAEGDSFPTDLYMAEgVASTRP--GTV----------------LRLEgvDAPTIEELI-DERVAVILVNHVNYKTgQLR 181 Mesorhizobium loti
2HZP_A       268 NIPAIT-KAGQAKGCYVGFDLAHAV-GnVELYLHDWGVDFACWCSYKY--LNagAGG--I--AGAFIHEKH-----AHTI 334 human
Q16719       232 NIPAIT-KAGQAKGCYVGFDLAHAV-GnVELYLHDWGVDFACWCSYKY--LN--AGAg-Gi-AGAFIHEKH-----AHTI 298 human
NP_509023    245 DMRAIT-EAGHRKGCFVGFDLAHAF-AnVPLHLHWWDVDFACWCSYKYgcTG--AGS--I--GGLFVHERF-----LNDQ 311 Caenorhabditis ...
WP_011036737 200 ALGEIA-RLARAQGAAVGFDLAHAV-GnIPLSLHDDGVDFAVWCHYKY--LN--AGP--GavGGCFVHARH-----AHSN 266 Xanthomonas cam...
NP_013332    207 DIGRITsFAHQFPDILVGWDLAHAV-GnVPLQLHDWGVDFACWCSYKY--LN--AGPggI--GGLFVHSKHtkpdpAKES 279 Saccharomyces c...
WP_011065164 191 DMERLT-REAHKRNIKIGFDLCHSI-GsIPHDLHKWGVDFAFWCTYKH--LN--GGP--GsvAGLFLHEKH-----F-GV 256 Oceanobacillus ...
WP_011000713 184 DMAAVS-ALAHRHGALAVWDLAHSAgA-VPVDLHTGGADYAIGCTYKY--LN--GGP--G--SPAFVWASP-----ALRE 248 Ralstonia solan...
WP_010909531 182 DMAALT-CKAHQVGALIVWDLCHTAgA-LPVELDAANADFAIGCTYKY--LN--GGP--G--APAFIYAAK-----RHHE 246 Mesorhizobium loti
2HZP_A       335 KPALV--GWFGHELSTRFKMDNKLQ--LIPgvC--GFRIS-NPPILLVCSLHaS-LEIFKQAT-MKALRKKSVLLTGYLE 405 human
Q16719       299 KPALV--GWFGHELSTRFKMDNKLQ--LIPgvC--GFRIS-NPPILLVCSLH-AsLEIFKQAT-MKALRKKSVLLTGYLE 369 human
NP_509023    312 RERML--GWWSHKMSSRFVMDNVLD--LDEgaA--GYRIS-NPPIHTVAAMLgS-LKVFDQVS-LENLRSRSCYLTGYLE 382 Caenorhabditis ...
WP_011036737 267 LPRMA--GWWGHEQPTRFRMEPQFV--PSPgaE--GWQLS-NPPVLALAPLRaS-LELFDQAG-MPALRAKSEQLTGHLE 337 Xanthomonas cam...
NP_013332    280 LPRLA--GWWGNDPAKRFQMLEVFE--PIP--GalGFRQS-NPSVIDTVALRsS-LELFAKFNgINEVRKRSLLLTNYMT 351 Saccharomyces c...
WP_011065164 257 APGLA--GWFSSAKDKQFDMEHTLT--HAN--NagAFQIG-TPHLFSVAPLIgS-LDLFHEAG-IEKVRKKSLALTDYLM 327 Oceanobacillus ...
WP_011000713 249 RFWQPlsGWWGHARPFAMASHYDAG---AG--I--GRFLCgTQPITSMAMVE-CgLDIFAQTS-MTALRAKSLALTDLFI 319 Ralstonia solan...
WP_010909531 247 DVHQPlsGWWGHARPFAFEQSYTAGsgIRR-------FLCgTQPVLSMRALKgA-LDIWDDVD-MAAVRKKSIGLTDLFI 317 Mesorhizobium loti
2HZP_A       406 YLIKHNYGK---------DkaatkkPVVNIITPSHVEERg-CQLTITFS----VPNKD--VFQELEKRGVVCDKRNPNGI 469 human
Q16719       370 YLIKHNYGKdka---atkK------PVVNIITPSHVEERg-CQLTITFS----VPNKD--VFQELEKRGVVCDKRNPNGI 433 human
NP_509023    383 YLVKTLFGEnseq--rttK------LSISIITPEEFHQRg-CQLSLKFS----SPIDI--IYPELVKRGCAVDKRYPNVI 447 Caenorhabditis ...
WP_011036737 338 QLIHTRV-----------P------QVLQIVTPADPAQRg-CQLSLRVAgg-rTQGRA--LFEYLQSVGVLGDWREPDVI 396 Xanthomonas cam...
NP_013332    352 ELLEASKYYkhplrieklP------CFFTILTPTSTDEEhgAQLSLYFDsdtgKEDIMpkVFQYLHDHGVIGDARRPNVI 425 Saccharomyces c...
WP_011065164 328 ELIKHELDG---------H------GVV-ICNPENHIQRg-GHVYVEHP-----EAAR--ICKALKMKKVIPDFRTPSGI 383 Oceanobacillus ...
WP_011000713 320 ELVEARCAG---------Y------P-LTLATPRDHAVRg-SHVSYAHP-----DGFA--VMQALIARGVIGDYREPSIM 375 Ralstonia solan...
WP_010909531 318 QLVEARCG----------A------YGLELEGPRDGNARg-SQVSFLHP-----HGYQ--VMRALIERGVIGDFRAPSTI 373 Mesorhizobium loti
2HZP_A       470 RVAPVPLYNSFHDVYKFTNLLTSILD 495 human
Q16719       434 RVAPVPLYNSFHDVYKFTNLLTSILD 459 human
NP_509023    448 RVAPVHLYNNYVDIRRFISVLQEVAH 473 Caenorhabditis elegans
WP_011036737 397 RIAPVPLYNRFCDLHQLVEHVETWAA 422 Xanthomonas campestris
NP_013332    426 RLAPAPLYNTFSDVYIAVNALNEAMD 451 Saccharomyces cerevisiae S288c
WP_011065164 384 RLAPVALYNTFEDVYDCVQIFKTIME 409 Oceanobacillus iheyensis
WP_011000713 376 RFGFTPLYTRFVDVWDAVDVLREVLE 401 Ralstonia solanacearum
WP_010909531 374 RFGFTPLYVGYKDVWQAVEVLEDILR 399 Mesorhizobium loti
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