4ETW


Conserved Protein Domain Family
bioH
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TIGR01738: bioH 
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pimelyl-[acyl-carrier protein] methyl ester esterase
This CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. Its exact function is unknown, but is proposed in ref 2. This enzyme belongs to the alpha/beta hydrolase fold family (pfam00561). Members of this family are restricted to the Proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]
Links
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Statistics
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PSSM-Id: 273783
Aligned: 5 rows
Threshold Bit Score: 354.508
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4ETW_A        10 GQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGR-SRGFGALSLADMAEAVLQQAPDKAIWLGWALGGLVA 88  Shigella flexneri
P13001        10 GQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGR-SRGFGALSLADMAEAVLQQAPDKAIWLGWSLGGLVA 88  Escherichia col...
EET25375      20 GQG-QDLVLVHGWGMNGAVWQQTAQALSDHFRVHVVDLPGYGH-SAEQHAASLEEIAQALLEHAPRNAIWVGWSLGGLVA 97  Vibrio cholerae...
Q9K197        11 PDAVKKVYLIHGWGANRHMFDDLMPRLPATWPVSAVDLPGHGD-APFVRPFDIAAAADGIAAQIDAPADILGWSLGGLVA 89  Neisseria menin...
WP_010893860   7 GYG-PALVLIHGWAMHSGVFAPLVEQLRAHHTLYLVDLPGHGYnHTTLTPLALPHVVHAIAAATP-PAVWLGWSLGGLFA 84  Xylella fastidiosa

4ETW_A        89 SQIALTHPERVQALVTVASSPCFSARDEWP-GIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLA 167 Shigella flexneri
P13001        89 SQIALTHPERVQALVTVASSPCFSARDEWP-GIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLA 167 Escherichia col...
EET25375      98 THMALHHSDYVSKLVTVASSPKFAAQGSWR-GIQPDVLTAFTDQLVADFQLTIERFMALQAMGSPSARQDVKVLKQAVLS 176 Vibrio cholerae...
Q9K197        90 LYLAARHPDKVRSLCLTASFARLTADEDYPeGLAAPALGKMVGAFRSDYAKHIKQFLQLQLLHTPDADGIIGRILPDLAR 169 Neisseria menin...
WP_010893860  85 LHAAATLPQ-VRGLIMLAATPCFVRREDWPhAVEVSIFTQFAEDLKQNYTETINRFLALDTLGSTYAQSELRQLRQILNA 163 Xylella fastidiosa

4ETW_A       168 LPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWP--HSESYIFAKAAHAPFISHPAEF 245 Shigella flexneri
P13001       168 LPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWP--HSESYIFAKAAHAPFISHPAEF 245 Escherichia col...
EET25375     177 RPMPNPQSLLAGLTMLAEVDLRDELQHISVPMLRLYGRLDGLVPAKVARDLNHLAP--YSEAFMFDQSSHAPFMTEAEAF 254 Vibrio cholerae...
Q9K197       170 CGTP--QALQEALDAAERADARHLLDKIDVPVLLVFGGKDAITPPRMGEYLHRRLK--GSRLVVMEKAAHAPFLSHAEAF 245 Neisseria menin...
WP_010893860 164 RHTPNTATLQAGLELLAHTDLRRAVIDLTPPSLWIAGQRDRLVPAASIHAATALAPsgQTELLTITGGGHAPFLSHANQM 243 Xylella fastidiosa

4ETW_A       246 CHLLVALK 253 Shigella flexneri
P13001       246 CHLLVALK 253 Escherichia coli K-12
EET25375     255 CQQLIEFA 262 Vibrio cholerae MO10
Q9K197       246 AALYRDFV 253 Neisseria meningitidis MC58
WP_010893860 244 TAALQHFI 251 Xylella fastidiosa
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