Conserved Protein Domain Family
FGAM_synth_II

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TIGR01736: FGAM_synth_II 
phosphoribosylformylglycinamidine synthase II
Phosphoribosylformylglycinamidine synthase is a single, long polypeptide in most Proteobacteria and eukarotes. Three proteins are required in Bacillus subtilis and many other species. This is the longest of the three and is designated PurL, phosphoribosylformylglycinamidine synthase II, or FGAM synthase II. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Statistics
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PSSM-Id: 273781
Aligned: 15 rows
Threshold Bit Score: 930.174
Created: 8-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9HJA4  27 LSLDEMKAVRsyfERLGRDPIDAEIHAVAQSWSEHCSYKSSKYYLKKY-LGSlk--tDYTILAME--DDAGVVDFDGE-Y 100 Thermoplasma acidophi...
Q9UX24   5 LLPIEMDEIR---KRLGREPNETEWRVIDAVWSEHCSYKSSKIFLKSFsIDS-----PNVIMGIKdwQDAGAVDIGDG-W 75  Sulfolobus solfataric...
Q8U491   1 MFPHEEKLIR---EKLGREPNDLEKAMLEVMWSEHVSYKSSRKWLKLLpTKN-----EHVILGPG--EDAGIIKFDDK-T 69  Pyrococcus furiosus D...
Q58660   1 MDENDLKYIE---KVLGRKPNHIELAMFENLWSEHCAYRTSKKLLRMFaKTVnektsKNIVVGIG--DDAAVIRLKND-I 74  Methanocaldococcus ja...
O27427   3 LTDSEMEFIR---KELGRDPNPLEYGMLDVMFSEHCSYKSSRPVLGLFpTEG-----EDVIIGPG--DDAGVVEITDE-L 71  Methanothermobacter t...
Q8TY09   3 LDERDLELIR---EELGRDPNATERAMFENMWSEHCAYRSTRHLLRQLpSEA-----DHVIVGPG--DDAAVVAIDDE-W 71  Methanopyrus kandleri...
Q8TIT6   2 LPEEDLKIIR---KELGREPTLVEQGCFLNLWSEHCSYRSSAPLLKTFtSTG-----ENVLIGPG--DDAAIIKFEDG-Y 70  Methanosarcina acetiv...
Q9HR49   3 LGDSDRERVV---AALGRDPTPAEAALFENLWSEHCAYRSSRSLLSAFdSDS-----EAVVVGPG--DDAAVVRVPGTdQ 72  Halobacterium sp. NRC-1
O28339  35 LSVDEMKRIQdyfRQKGRNPYDIELQSLAQAWSEHCCYKSSKYYLRQYlLEAsk--aDYVISAIE--EDAGVVEFDDE-Y 109 Archaeoglobus fulgidu...
Q9RXT4  15 LTTEEYDLFV---SQLGREPNALEAAIVGAMWSEHCGYKNSRPLFRAFpTTG-----PQVLQGPG--ENAGVVDIGDG-W 83  Deinococcus radiodura...
Q9HJA4 101 AYVLKMESHNHPSAVEPYGGAATGIGGIVRDVLCMGAQPVALIDSLFLG---DVSSDryeg---llsPRYIFGGVVGGIR 174 Thermoplasma acidophi...
Q9UX24  76 AVVIKVESHNHPSAIDPFNGAATGVGGIIRDIISKGAKPIALMDMIRVG---NLKIKk---------NVWLLKNIIAGIA 143 Sulfolobus solfataric...
Q8U491  70 WIVIGIESHNHPSAVEPYGGAATGVGGIVRDILCMGARPIALLDPIRFG---PLEKEk---------NRYLFEYVVKGIA 137 Pyrococcus furiosus D...
Q58660  75 CLAIAMESHNHPSYIDPYNGAATGVGGIVRDVLSMGAKPIALLDPLRFGdifGKEGDk---------VRWLIEGVVKGIG 145 Methanocaldococcus ja...
O27427  72 ALVIGIESHNHPSAIEPYGGAGTGIGGILRDIISMGAMPVALLDSLRFG---YLEDQk---------SRYLFEHVVRGIS 139 Methanothermobacter t...
Q8TY09  72 AVVVGIESHNHPSYVDPYNGAATGVGGIVRDVLSMGAFPIALLDPLRFG---PLDGEr---------VPYLVDGVVRGIS 139 Methanopyrus kandleri...
Q8TIT6  71 VLAIGMESHNHPSYVDPYNGAATGIGGIVRDIISMGARPIALMDPLYFG---PLDTPk---------NLFLFEQIIKGIA 138 Methanosarcina acetiv...
Q9HR49  73 LVTVGVESHNHPSYVDPYDGAATGVGGIVRDTLSMGAYPIALADALYFG---DFDDEh---------ARYLLDGVVEGIS 140 Halobacterium sp. NRC-1
O28339 110 AYVTAFESHNHPSAIEPYGGAATGIGGILRDVLCMGAQPIALIDPLFFG---NLDTPyeklprgtkhPLYLLKGVVAGIR 186 Archaeoglobus fulgidu...
Q9RXT4  84 GVAFKMESHNHPSAVEPVQGAATGVGGILRDIFAMGARPFAVLDSLRFG---NPDSPr---------tRFLVNGVVDGIA 151 Deinococcus radiodura...
Q9HJA4 175 DYGNRIGIPNVAGSLYFDKLYNSNPLVNAGCVGIVRRDRIVRSKSYKPGDVLVLMGgKTGRDGIHGVNFASTTLGk-VTK 253 Thermoplasma acidophi...
Q9UX24 144 AYGNSIGVPVVGGELSFDDTYNDNPLVDVAAIGIVRKDKIKPSIVDKAGLKLVLAG-LTGVDGLGGASFASRKLS--GED 220 Sulfolobus solfataric...
Q8U491 138 DYGNRIGVPTVGGETEFDESLDNYTLVNVACIGIMRPEHLVHSYVTEPGLKLVIVGnRTGRDGIHGVTFASEELGenAEE 217 Pyrococcus furiosus D...
Q58660 146 DYGNRIGVPTVGGECEFDSSFDYNNLVNVVCVGLVKENEIITGKAKEPGLSLILIG-STGRDGIGGASFASKDLTeeSEE 224 Methanocaldococcus ja...
O27427 140 DYGNRVGVPTVAGEVEFDENFQLNPLVNVMCAGLVPKNDIKRGIAPRPGDVFLLMGgRTGRDGIHGVTFASEELTssSEL 219 Methanothermobacter t...
Q8TY09 140 DYGNRIGVPTVGGELEFDPSYERNPLVNVMCVGIVRRSEIVRGRADRPGDVLVLVGaRTGRDGIGGAAFASEELGeeSEE 219 Methanopyrus kandleri...
Q8TIT6 139 GYGNCIGVPVVNGETFFDRRYSGNPLVNVVAVGLCKEENVTTSRSQKAENKLILAGsSTGKDGLGGASFASRDLSesAEA 218 Methanosarcina acetiv...
Q9HR49 141 DYGNAIGVPTVAGATQFHDGYTGNPLVNVACVGLVTEDRLVTAAAKSPGNKLVLVGnATGRDGLGGASFASEDLAedAET 220 Halobacterium sp. NRC-1
O28339 187 DYGNRVGIPTVAGMVFFDNSYLTNCLVNVGCVGIVRKDRIIHSRAGGAGDLFVLAGgKTGRDGIHGVTFASAELDekSEE 266 Archaeoglobus fulgidu...
Q9RXT4 152 HYGNAIGVPTVGGEVTFHPSYQENPLVNVMALGLLRHEDLATGTMGEVGNQIVYVGsKTGRDGLGGAVFSSADLSa-aSQ 230 Deinococcus radiodura...
Q9HJA4 254 SsRLAIQLGNPIVEQPMIKAVLEANDAglIRAMKDLGGGGLSSAATEMVYagGFGAEITLDDIKLKESNMSGWEIWISES 333 Thermoplasma acidophi...
Q9UX24 221 E-IGAVQIADPFAGKIILDVTLEIADK--VEAIKDLGGGGLAVAVTEITN--GLGATVDIEKIPLRVKNMNPSDVIISET 295 Sulfolobus solfataric...
Q8U491 218 EdRSAVQIPDPFTEKLLIEATLEAVYTgkVKALKDLGGGGLTCAASEMVGkrGFGAIIYADKVPLREPGMTPLEVMISES 297 Pyrococcus furiosus D...
Q58660 225 E-RPSVQVGDAFSEKCLIDAVLEAVKTgkVKAMKDLGAAGLSGASSEMCYggGVGCELYLENVVLREP-LTPYEIMVSES 302 Methanocaldococcus ja...
O27427 220 EdRPAVQVGDPFTKKMVMEASFEIMDEieVSGVKDLGGGGLTCCISELVAkcDNGARVSLEAIPLREEGMTPYEIMLSES 299 Methanothermobacter t...
Q8TY09 220 EdRPAVQIGDPFTERQLIIAIREAVERglVKGCKDLGAAGLTCAATEMAAdgGTGVEIDVFKVPLREEGMEPWEIMLSES 299 Methanopyrus kandleri...
Q8TIT6 219 EdRPSVQVGDPYTEKLVMEMTLEAIEKgyVKSCKDLGAAGLGGASSELAAkgGLGARIIADAVPQREPNMNAYEILLAES 298 Methanosarcina acetiv...
Q9HR49 221 AdRPAVQVGDPYTEKLLIEANETLLDRdlVVAARDLGAAGLGGASSEMVAqgELGARITLDAVHQREPEMNAMEILLAES 300 Halobacterium sp. NRC-1
O28339 267 EaRGAVQLGNPIMKEPLIHACLEVVEKglLTGMKDLGGGGLSCVIGEMALaaGFGAEVYLDKVPLKEEGMAPWEIWISES 346 Archaeoglobus fulgidu...
Q9RXT4 231 AdRPAVQVGDPFMEKLLLEATLEAIQAglVAGVQDMGAAGLVSSTCEMAYraSLGITMDLDKVPTREEGMVPMELCLSES 310 Deinococcus radiodura...
Q9HJA4 334 QERMLMECYPEDVEKIRQIAEKWNLDFSVIGQVTADRRIRVYYKKRKIIDMDIEFLDD-SPVYQRPYRIKEVEKSVTV-- 410 Thermoplasma acidophi...
Q9UX24 296 QERMLYAVEEKNVKEVCEAFEEYEYPCSVIGEITNEPVIKFRYIGKDLVSLPTNVLLN-PPRFLWPIKNTKKNVEEKI-- 372 Sulfolobus solfataric...
Q8U491 298 QERMLFAIKPEDVEELGKIFEKYELEWSVVGEVIEEPKFIVYWKGRKVAELPIELLTN-VPTIEWPM-KEYRIEEDVE-- 373 Pyrococcus furiosus D...
Q58660 303 QERMLLAVEPGSEEEIIEIFKKYELPASVIGKTIPEKRIIAKYKGEVVVDLPLDLLCE-APLYDREG-KEDLKEKEDD-- 378 Methanocaldococcus ja...
O27427 300 QERMIFVMAPDDVEAAMEICRKYELPAAVIGEVTDTGRMIVESEGEVIADLPAKLLAD-PPVVEREARKPQLPEGQVE-- 376 Methanothermobacter t...
Q8TY09 300 QERMLLVVAPEDVDEVIEICRKYGLEASVVGRVTDDGYLTVKDGDDVIARVPAEFLADgAPEVEWEEEPYSYPENVDV-- 377 Methanopyrus kandleri...
Q8TIT6 299 QERMLFEVAPEDVDAVLALVQKYDLNGAVVGYLTKEPTYTVEFGGEIVADIPIAFLTGgAPTCEKPSEAPTLREEGKK-- 376 Methanosarcina acetiv...
Q9HR49 301 QERMCYEVAPADVDAVREVATRYDLGCSVIGEVTTG-NYVCEFDGETVVDAPATVLADgAPATDQPSTVPQAPATDR--- 376 Halobacterium sp. NRC-1
O28339 347 QERMMLTVRPEHIDEVLYIFQKWDVPATVVGKVIPEKITRIYYKGYKIYEMDTEFVTS-GPEYCRPYVARKPEKELHE-- 423 Archaeoglobus fulgidu...
Q9RXT4 311 QERMILVPVPGKEQALHDLLAKWELDVVTIGEVEAHDRYRLTWKGEVVCDLPVALLNe-APKYTREGVESADIRAARErd 389 Deinococcus radiodura...
Q9HJA4 411 --PQEp-eDLNSFVRDFMA----RLNT--CARFNVVRQYDHTVRGSTIVTPFVgrpnkethaDATVIKPLEnSMRg--LV 479 Thermoplasma acidophi...
Q9UX24 373 --VDL---PLESAIYTVLT----HPDL--VSKGWAYSQFDYEVNTSTVVKPGDa--------DSAVVSLPN-GKL---LA 429 Sulfolobus solfataric...
Q8U491 374 --TPQi--SLEEAFEKVWR----SPNV--ISKRWVWEQYDHEVQGRTVIKPGF---------DSAVLKINEeYg----LA 430 Pyrococcus furiosus D...
Q58660 379 --KEKi--KMPEDLNAVLLklleSPNI--CSKEWIYQQYDHEVQIRTVVKPGK---------DAAVLRINEvYPMg--IA 441 Methanocaldococcus ja...
O27427 377 --VKHp--PLKDTLLKLIS----SPNI--ASKRWVYRQYDHEVQIRTVVKPGD---------DAAVLRVDGtTg----VA 433 Methanothermobacter t...
Q8TY09 378 --PEP---DPEDLVRSVLS----SPNVspALREWVYRQYDHEVQGRTVVKPGH---------DAAVMWLQHeGLEdvaLA 439 Methanopyrus kandleri...
Q8TIT6 377 --PETp-eDLKVAFLKVLS----SYNI--ASKEWIYRQYDHEVQLRTVVKPGE---------DSGVLRITGtKG----IA 434 Methanosarcina acetiv...
Q9HR49 377 --PDP---ALGTAIDAVLS----APNT--ASNEWVYRQYDHEVGARTVQRPGE---------DAAGLALHEaDDGt-tVA 435 Halobacterium sp. NRC-1
O28339 424 --EVEppaDYVKTFMKMLS----HPNA--AFKEWIVRQYDHEVRASTVLKPLQgkmnfethgDAAVIKPTR-SFRg--LA 492 Archaeoglobus fulgidu...
Q9RXT4 390 lsGVPlpgDLGAVLLELLS----HPTI--ASKRPIFERYDHQVMTNTVVVPGAa--------DAAVLRVKGsPm---gVA 452 Deinococcus radiodura...
Q9HJA4 480 LTSGSRPNMVSVDPYAGTLLTLAEAYKNILSTGGRPHSVVDALNFGNPEREEIMGQFVESVRAIGDFCRKMGLPVVAGNV 559 Thermoplasma acidophi...
Q9UX24 430 IKADANPDMCAEDGYECGKGIVAEAYRNLATVGARGMVAVDHLQFGDPKKAEVYYTFVEAIRGIGEATRFFNIPIVGGKV 509 Sulfolobus solfataric...
Q8U491 431 ITADGNPTHCYLNPYHGAMGVVVEVVRNLVSVGAKPLALVDNLNFASPERPEVYWSFVETIKGLADAAKAFGLAYVSGNV 510 Pyrococcus furiosus D...
Q58660 442 LTTDCNSRYCKLNPYVGAVNAVAEAVRNLATVGAEPIAMLDNLNFGNPERPERFWQLAECIKGLADAAEFFEIPVVGGNV 521 Methanocaldococcus ja...
O27427 434 LTVDCNSIHTKLDPYGGGAASVGEAIRNVVSMGAWPVCIVDCLNFGNPEKPEVFWQFRECVRGMADMAETFSTPVISGNV 513 Methanothermobacter t...
Q8TY09 440 LTTDSNPRHVLIDPKTGTEGCVAEALRNLATVGAEPLCLVDCLNFGSPENPRVYYQLRRSIEGLGKAAREFEVPVVGGNV 519 Methanopyrus kandleri...
Q8TIT6 435 LTCGCQPRATLLDPYNGGKTAIIENSMNLAVKGAEPLAIVNCLNFGNPERPETYWQFENAVLGLGDEARKLSIPVVGGNV 514 Methanosarcina acetiv...
Q9HR49 436 LSAGANPGWTACQPYAGAYATAVENATNLAAAGAEPLAAVDCLNGGNPEDPDVYGGFEAMVAGLADGCRAIDTPVVGGNV 515 Halobacterium sp. NRC-1
O28339 493 ITADVNPWMCKVDPYWGAASSFDEMVRNLVAVNAVPHSFNDCLNFGNPEKPERMGEFVEAVKALGWMAKGVGVPCVSGNV 572 Archaeoglobus fulgidu...
Q9RXT4 453 ATSDCNPRFVQLDPYAGAAAAVAEAARNLACVGATPLAITDNLNFGNPHRPEVYYQLQQAVQGIADACRALNTPVTGGNV 532 Deinococcus radiodura...
Q9HJA4 560 SFYNEYR----KTDIMPTPTIMMVGLIDDvrRSRTt--YMKGSGNAIYLIGEPC-----DNLTGSeYSRMHG-YTDgFLP 627 Thermoplasma acidophi...
Q9UX24 510 SFYNENNq---GRPIKPTPLIVMAGLVQD--KLLK---NRVEDNLYVVSVGYTR-----KELGGS-LLSKIFkIPS-QAP 574 Sulfolobus solfataric...
Q8U491 511 SFYNEVVn----KPVKPTPVVAGVGKVKl-eKIP----RGPREGDLIGLIGETR-----KELGGSeLYRVLG-VSKgIAP 575 Pyrococcus furiosus D...
Q58660 522 SLYNETViegkEHPINPTPAIFVLGKVEDveKVPGvldNKIKEGDILIITNETK-----DEMGGSeYYKVIHnTEEgRVP 596 Methanocaldococcus ja...
O27427 514 SFYNETEg----VTVNPSPVVGVAGKLSl-dSIKTl--DFKDEGEEIVVIGETG-----PELGASeYLRTVHgIVDgKPP 581 Methanothermobacter t...
Q8TY09 520 SLYNEHe---vDGPVNPTPVIGAVGVIRGldYLEDf-pREPEEGEAVIVLGETR-----EELGGSlYLIEYHgIKGgKVP 590 Methanopyrus kandleri...
Q8TIT6 515 SLYNESDe--fKTAIPPTPSIGMIG-KVDleIPLPs-gFFAKDGDSIILVGETT-----PEMGGSeYYACMDsGNAgMVP 585 Methanosarcina acetiv...
Q9HR49 516 SLYNDSa----TGPIAPTPTLAVVG-YRDq-HPVPg-sGLAGDGD-LVLVGGHA-----DGLGGSvYLQAL--GGTdQFP 580 Halobacterium sp. NRC-1
O28339 573 SFYNETP----YGAVAPTPSLLGVGIVEDvrKAITs--EFKGRG-AVILVGETH-----NEFGGSlYSAVMG-QRChKVP 639 Archaeoglobus fulgidu...
Q9RXT4 533 SLYNQYTegdhKVAIHPTPTIGMVGVLPDvtVRASl--NLKAAGQTLLLLGHRAekgwsDSIGASqYLETVHgLEAgQVP 610 Deinococcus radiodura...
Q9HJA4 628 APDLDELTRIRDFLSS--KAD--MILSSHDVSSGGLFAALSEMSFGsGIGFHVDISNVSA--ARPTVKLFSECGNGLVLE 701 Thermoplasma acidophi...
Q9UX24 575 KVRLQEDLLSSEVVIDsiNEG--KITFAKDVSRGGLAASLFSILVH-GYGVEISTKSILSdtDNVIENLFSESSGRFIVL 651 Sulfolobus solfataric...
Q8U491 576 RVDLEVEKRNAESVLKliEEG--LVSFVHDVSRGGVAVALAELSTWfNVGIKSEITTS----LLPLDFAFSESHGRYIVT 649 Pyrococcus furiosus D...
Q58660 597 RVDLEKEKKIYEEVREvvKEG--LVSEAVDCSRGGLAVALAKMAVLnNIGLEVDLTEYNKnnLRDDILLFSETSGRIILA 674 Methanocaldococcus ja...
O27427 582 ETDLKAEFEAAKAVKEiiDGSgnKVTAVHDCSAGGIAVAVAEMAIKsGIGARIDPMKIPGrfRNIHEALFSESNGRYIMT 661 Methanothermobacter t...
Q8TY09 591 RVRYREERALHDLLRRiaRKN--MVSSVTDVSTGGLLAAVAELLGP--VGASLSLSEVPNsvSRWDFLLLSESHGRAIVT 666 Methanopyrus kandleri...
Q8TIT6 586 AVPENAP-ELIKAIIEavKSG--KLSSAHDLSLGGIGAGLARMCRS--MGAKVDLSELAGetQ-ADELLFSEAPARALLA 659 Methanosarcina acetiv...
Q9HR49 581 AADAAG----VDAVREaaTRA--DTLAVHDISDGGLAVTLAEMVTAd-AGATVTVPGLA--------ALFSECPGRAVVE 645 Halobacterium sp. NRC-1
O28339 640 RTSPERLKTYSDAMLEsfRKF--EVKACHDVSMGGLAVCIAEMSFGrGLGFEAAR-------ELSFVELFSESNTRWVVE 710 Archaeoglobus fulgidu...
Q9RXT4 611 PVDLDLAQKVVDGTLAliRAG--LTDTAHDCAEGGLAVALAEMAIAgGLGLNVSLDAPASv--RADALLFGEAHSRVIVA 686 Deinococcus radiodura...
Q9HJA4 702 IAKDKE-EQFVDg--SNGLAIKRLGe-TGGDRIIVDEAGl-nIIDVAVDDLRGAWEHGLDRYI 759 Thermoplasma acidophilum DSM 1728
Q9UX24 652 TNEPEWiVEKSK---SKGIVASIIG--RVNKKTNILTID---NIDYNLKNIVDNYFNFLEEVM 706 Sulfolobus solfataricus P2
Q8U491 650 FPEEN--LEAVK----KIAPITLLGr-IGGEKFELKINGe--KVSKTVKWLSDVHWNELYRIM 703 Pyrococcus furiosus DSM 3638
Q58660 675 VRDEN--KDKVL---SKLSSAYIIGk-VGGSRLKIKINEk-dVVNLDVEEMKKRYYEAFPKMM 730 Methanocaldococcus jannaschii DSM 2661
O27427 662 VRGSA--RDILG---GLDVPWAVIGt-TGGR--TLEFG----DVALDISELDDAYHGVIEAYM 712 Methanothermobacter thermautotrophicus...
Q8TY09 667 TDRPDDvLGAAE---EAGVPAQVVGevTGDGVLRISVGPv--DVSLDREELEELWRSPLHYLe 724 Methanopyrus kandleri AV19
Q8TIT6 660 ISEPEAvREILK-----DVPHAVIGk-VGGETLEIKGKNf--ELSVSLKEIAEAYGSLTRFMm 714 Methanosarcina acetivorans C2A
Q9HR49 646 TRDADAlQAAL------DVPVVRLGsaTTDGTLSVTVDDe--TVTRDAATIRDHRGVIARELd 700 Halobacterium sp. NRC-1
O28339 711 VPESVA-EGYAEffrAKELKAEVIGy-SGGER-----LDf-gAFSVELGEADKSWREGLTKFL 765 Archaeoglobus fulgidus DSM 4304
Q9RXT4 687 VEDAAA-AGAKLd--ELGLPYAVLGetVEAPKVTIAAPaqhvHLSVNLESLKTAWEEPLKGIL 746 Deinococcus radiodurans R1
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