Conserved Protein Domain Family
MDP-1
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TIGR01685: MDP-1 
magnesium-dependent phosphatase-1
This model represents two closely related clades of sequences from eukaryotes and archaea. The mouse enzyme has been characterized as a phosphatase and has been positively identified as a member of the haloacid dehalogenase (HAD) superfamily by site-directed mutagenesis of the active site residues.
Links
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Statistics
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PSSM-Id: 273756
Aligned: 4 rows
Threshold Bit Score: 210.088
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CAC14608  16 LPRVIVFDLDGTLWTPEMYQLWGGsPFKPHKQNPS---IMIDKSGTEVRLIGESRDVLQTLATnpkwANTYLAISSTCDV 92  Leishmania major
P40081     4 YPDVAAFDLDYTIWPCYCDTHLHG-PFKPVKSSNGevlTIICRDGYELTIYKDIPRILGDLKD----NGVKLMTASRTWA 78  Saccharomyces cerev...
BAB66517   2 MIKIVVFDADKTLWDHYNISIFKK-PYKLIN-EN----SIEDSEGNRLTLFPEVRDTLKSLKD----MGLFIGLATWN-L 70  Sulfolobus tokodaii...
AAL63167   1 --MLIALDLDGTVWDHHDISSLYP-PFKRVSPLK-----IQDNRGAEVTLRKHVRDFLQWARN----SGHIITTLSWN-D 67  Pyrobaculum aerophi...

CAC14608  93 PSWARELLGTFEFTdYAGKTVPMHSLFSDRIEIYKaNKAKQHEMILQKVNKVDpsVSEYAQMLFFDNQTDNVrHVSGIGV 172 Leishmania major
P40081    79 PEIAQEILKIFKVK-YAGVVTPLANLFDEFQWGER-SKIGHLRDGLKDLYNTS--DLKSKKICLFDDESRNK-EVEKYGV 153 Saccharomyces cerev...
BAB66517  71 PEKTYEILDLLKIR----------EYFDIITSKDYpFKFIFIAEIIDKMREKGi-YLKPDEIMFIDDRRVHFgNTWLYLG 139 Sulfolobus tokodaii...
AAL63167  68 FQVAYQALRAFEID----------AYFHYLVIEPHpRKDKMLYYLLRRIKAERgvEIKPQDIVYIDDRDIHIrEIWENIG 137 Pyrobaculum aerophi...

CAC14608 173 TSCYCPSGMTKGTFEKgLEMWRR 195 Leishmania major
P40081   154 KFVYVRDPENGPSWKL-YQDYLS 175 Saccharomyces cerevisiae S288c
BAB66517 140 NIKCLEMWSDIIHHKQiLEKIKS 162 Sulfolobus tokodaii str. 7
AAL63167 138 PVRFIQFGIDVKCFLEiIPLLSA 160 Pyrobaculum aerophilum str. IM2
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