Conserved Protein Domain Family
half-pint

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TIGR01645: half-pint 
poly-U binding splicing factor, half-pint family
The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.
Statistics
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PSSM-Id: 130706
View PSSM: TIGR01645
Aligned: 3 rows
Threshold Bit Score: 822.779
Threshold Setting Gi: 6684440
Created: 8-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAF23589    7 ALQVNGQQGGGSEPAAAAAVVAAG---DKWKP--------PQGTDSIKMENG-QSTAAK--LGL--PPLTPEQQEALQKA 70  human
NP_525123  10 SPRSDDQREISDMPATKRTRSDSGkstDSKIPylsqplydLKQTGDVKFGPG-TRSALLglLGGalPKLSSEQHDLVSKA 88  fruit fly
NP_491176   5 SADIENRPVAAFRPAVSVPMPVLP------------------QDGEVFVGPGgKKDAQKigLGL--SKLSSKRKDDIQMA 64  Caenorhabditis ele...
AAF23589   71 KKyAMEQSIKSVLVKQTIAHQQQQLTNLQMAavtmgfgdplsplqsmaAQRQRALAIMCRVyVGSIYYELGEDTIRQAFA 150 human
NP_525123  89 KKyAMEQSIKMVLMKQTLAHQQQQLATQRTQ-----------------VQRQQALALMCRVyVGSISFELKEDTIRVAFT 151 fruit fly
NP_491176  65 KKyAMDISIKQILLRQQKQ----QQENQQRQ-----------------QMYSQALSIMSRIyVGSISFEIREDMLRRAFD 123 Caenorhabditis ele...
AAF23589  151 PFGPIKSIDMSWDSVTMKHKGFAFVEyEVPEAAQLALEQMNSVMLGGRNIKVG--------RPSNIGQAQPIIDQLAEEA 222 human
NP_525123 152 PFGPIKSINMSWDPITQKHKGFAFVEyEIPEGAQLALEQMNGALMGGRNIKVG--------RPSNMPQAQQVIDEVQEEA 223 fruit fly
NP_491176 124 PFGPIKSINMSWDPATGHHKTFAFVEyEVPEAALLAQESMNGQMLGGRNLKVNsmmfqemrLPQNMPQAQPIIDMVQKDA 203 Caenorhabditis ele...
AAF23589  223 RAFNRIyVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKA 302 human
NP_525123 224 KSFNRIyVASIHPDLSEEDIKSVFEAFGPILYCKLAQGTSLHTHKGYGFIEYANKQAMDEAIASMNLFDLGGQLLRVGRS 303 fruit fly
NP_491176 204 KKYFRVyVSSVHPDLSETDLKSVFEAFGEIVKCQLARAPTGRGHRGFGYLEFNNLTSQSEAIAGMNMFDLGGQYLRVGKC 283 Caenorhabditis ele...
AAF23589  303 VTPPMPL--LTPATPGGLPPAAAVAAAAATAKITAQEAVAG-------------AAVLG---------------TLGTPG 352 human
NP_525123 304 ITPPNAL--ACPTTNSTMPTAAAVAAAAATAKIQALDAVAS-------------NAVLGlsqntpvmaagavvtKVGAMP 368 fruit fly
NP_491176 284 VTPPDALtyLQPASVSAIPASVSVACAAITAKVMAAEAAAGsspktpsesggsrAASPApraqspatpssslptDIENKA 363 Caenorhabditis ele...
AAF23589  353 LVSPALTLAQ--PLGTLPQAVMAAQAPGVITG------------VTP---ARP---PIPVTIPSVGVVNP---------- 402 human
NP_525123 369 VVSAATSAAA--LHPALAQAAPALLPPGIFQA------------PTP---VAPsllGVPAGLQPLQAVVPtlp-----pp 426 fruit fly
NP_491176 364 VISSPKKEPEeiEVPPLPPSAPDVVKDEPMEIeeeeeytipeekPKPvaiVPPpglAIPSLVAPPGLIAPteigivvpnp 443 Caenorhabditis ele...
AAF23589  403 -ILA-------------------------SP-------------------------------------------PTLGLL 413 human
NP_525123 427 aLLA-------------------------TPtlpmtvggv--------------------------gvglvptvATLAGA 455 fruit fly
NP_491176 444 sFLAqqqqkieekieeeeeartervklstSQrkkmkreklnqmtfeekmaqvlgqqkavqnqrmadpvtfgaldDTVAWK 523 Caenorhabditis ele...
AAF23589  414 EPKK-------------------------------------------------------------EKEEEELFP------ 426 human
NP_525123 456 EASKgaaaaaalsaaanna-------------------------------avtaanlsenikkahEKQQEELQKkl---- 500 fruit fly
NP_491176 524 DPSNedqtsedgkmlaimgpgrggdnvasmalalmdggsslmlannakakeaaaalalepkkkkkVKEGKKIQPklntaq 603 Caenorhabditis ele...
AAF23589  427 -------------------ESERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEEC 487 human
NP_525123 501 ------------------mDEGDVQTLQQQENMSIKGQSARQLVMQRLMRPVDSRVIILRNMVGPEDVDETLQEEIQEEC 562 fruit fly
NP_491176 604 alaaaakagemsdalknevMNSEDASLASQEGLEIRGNDARHLLMTKLMRTNRSNVIVLRNMVTPQDIDEFLEGEIREEC 683 Caenorhabditis ele...
AAF23589  488 GK-FGAVNRVIIYQEKQGEEED---AEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVyDQERFDNSDLSA 559 human
NP_525123 563 SK-FGTVSRVIIFNEKQTENEDddeAEIIVKIFVEFSAGAEAMRGKEALDGRFFGGRRVVAELyDQGIFDQGDLSG 637 fruit fly
NP_491176 684 GKyGNVIDVVIANFASSG----------LVKIFVKYSDSMQVDRAKAALDGRFFGGNTVKAEAyDQILFDHADYTG 749 Caenorhabditis elegans
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