Conserved Protein Domain Family
holin_tox_secr
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TIGR01593: holin_tox_secr 
toxin secretion/phage lysis holin
This model describes one of the many mutally dissimilar families of holins, phage proteins that act together with lytic enzymes in bacterial lysis. This family includes, besides phage holins, the protein TcdE/UtxA involved in toxin secretion in Clostridium difficile and related species. [Protein fate, Protein and peptide secretion and trafficking, Mobile and extrachromosomal element functions, Prophage functions]
Links
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Statistics
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PSSM-Id: 273708
Aligned: 10 rows
Threshold Bit Score: 96.222
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAD02037  16 FNInLGGVMNMTISFLSEhiFIKLVILTISFDTLLGCLNAIKSR--KFNSSFGIDGGIRKVAMIACIFFLSVVDILTKFN 93  Peptoclostridium di...
P58701    12 VVF-LGTLFTWIFGAWDM--PIVTLLVFIFLDYLTGVIKGCKSK--ELCSNIGLRGITKKGLILVVLLVAVMLDRLLDNG 86  Clostridium perfrin...
P24811    10 FET-LDLARVYLFGGVKY---LDLLLVLSIIDVLTGVIKAWKFK--KLRSRSAWFGYVRKLLNFFAVILANVIDTVLNLN 83  Bacillus subtilis s...
P58702     9 ILG-FGAIFGYLFGEVDL--LVKVLVCFIVADYISGLLASGYLG--ELSSKMGFKGIAKKIAILILVAIAHQIDLILGTH 83  Listeria monocytoge...
O34883    11 LAV-SVSAAGFFFGGFQY--SFLILLSLMAIEFISTTLKETIIH--KLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQ 85  Bacillus subtilis s...
AAC79564   8 YEV-LNIVRVFYEHGIDEhlSVCLLIEMIGSDIVLGVSRAWAFH--ELSSFKFRKGLVSHLATSLFVIIFYPFALFMHLG 84  Streptococcus phage...
Q38008     1 ----MLYNIMLEVAKGDY---ITILFALILFDFITGFLKAWKWK--VTDSWTGLKGVIKHTLTFIFYYFVAVFLTYIHAM 71  Streptococcus phage...
P07539     4 IAW-MQHFLETDETKLIY--WLTFLMVCMVVDTVLGVLFAKLNPniKFSSFKIKTGVLIKVSEMILALLAVPFAVPFPA- 79  Bacillus phage PZA
CAC21535   2 FEF-FHSLMETDDTKVYF--LLGIIGVLNIVDFFFGFINAKFNKsiAYKSSKTIDGIMRKMKFTIMAILFIPVSVLMPEP 78  Bacillus phage GA-1
CAD35391   6 FNF-LRSVVQTEDGLVLY--ALTLIVSMEIIDFVTGTIAAIINPdiEYKSKIGINGLLRKISGVLLLMILIPASVLLPEK 82  Streptococcus phage...

AAD02037  94 fLFMLPQDCINflrlqhlgiseffsiLFILYESVSILKNMCLCGLPVPkRLKEKIVVLLDAMTDEM 159 Peptoclostridium difficile
P58701    87 -AWMFRTLIAY---------------FYIMNEGISILENCAALGVPIP-EFLRQALKQLNNKNNIK 135 Clostridium perfringens str. 13
P24811    84 -GVLTFGTVL----------------FYIANEGLSITENLAQIGVKIP-SSITDRLQTIENEKEQS 131 Bacillus subtilis subsp. subtilis...
P58702    84 -NTTRDAVIF----------------FYLANELISILENFVRMGMKVP-EVLKNLILIFDAKSGED 131 Listeria monocytogenes EGD-e
O34883    86 -GSIRDLAIM----------------FYILYESVQIVVTASSLGIPVP-QMLVDLLETLKNKFKRK 133 Bacillus subtilis subsp. subtilis...
AAC79564  85 --SVIDTFIY----------------AMMAAYGSSILANLSSLGVKFPyIDRYIRLNIDKEKFILL 132 Streptococcus phage O1205
Q38008    72 aVGQILLVIIN------------------LYYALSIMENLAVMGVFIPkFMTARVQEELQKYTAQL 119 Streptococcus phage Cp-1
P07539    80 -GLPLLYTVYT---------------ALCVSEIYSIFGHLRLVDDKSD---FLEILENFFKRTSGK 126 Bacillus phage PZA
CAC21535  79 iGLGALYVFYF---------------GYIYAELNSILSHLKLSEDGKEtEVFLDFINTFFNSTKGD 129 Bacillus phage GA-1
CAD35391  83 tGFVFLHSIYLgy------------iAFTFNLSLKIIRKLKGNVTLF--QPIVKVFQRLLEKDDDT 134 Streptococcus phage VO1
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