Conserved Protein Domain Family
cas3_core
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TIGR01587: cas3_core 
CRISPR-associated helicase Cas3
This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Links
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Statistics
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PSSM-Id: 273707
Aligned: 7 rows
Threshold Bit Score: 381.802
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P38036       309 LTVIEAPTGSGKTETALAYAW---KL-IDQQIADSVIFALPTQATANAMLTRMEAsashLfSSpNLILAHGNSrfnhlfQ 384 Escherichia col...
WP_010956474 255 LLLVRAPTGAGKTDAALLWAS---HQ-IKHRKADRLIIAMPTRFTTNALALSVSS----T-LS-STGLYHSSA------W 318 Porphyromonas g...
WP_010869875 221 FVMLFAPCGRGKTEGALLWAL---NA-LKNFKRNKIILAMPTQVTSNAMYDRLVK----IfGE-ENVGLFHGK------S 285 Methanocaldococ...
WP_010885336 246 DVILYAPTGYGKTEAALLWANknaHR-TKKGISSRIFYILPYKASINAMHRRLLE----MfKDpGLVGLLHSS------S 314 Pyrococcus hori...
WP_010879367  40 IFVIEAPTGYGKSTISATIAA---YS-L--QEELKSIIAFPLRTLLEDQYNKFKG----LfGN-KLG------------- 95  Archaeoglobus f...
WP_010868140  40 FLVIQAPTGYGKTTLSLSLAL---HSlKDSSLFDRVIHVLPMRSIIEDIDRTAKE----AfG------------------ 94  Pyrococcus abyssi
WP_010880192 239 CLVVVAPTGYGKTEAGFIFLK---D---------KGFFTLPFRVSANGIYERARA----VfG--ENVGLLHSs-----sL 295 Aquifex aeolicus

P38036       385 S---IksrAITEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLP-----VKHRFIRGLGIGRSVLIVDEVHA 456 Escherichia col...
WP_010956474 319 T---Q---NFSSKIDNGEIALEQARYYHNQARLLQTPITVCTIDHLLSSLTLc----DEEHQTITFALANACLVIDEADF 388 Porphyromonas g...
WP_010869875 286 FiklR---DSKEIEDEDDLEEIRDENFKGN--VFFKPITITTIDHVIYSFVHg----FSQADFALGNIQNSVIIFDEVHY 356 Methanocaldococ...
WP_010885336 315 --------GIYLYSSSLEYKRLLSLYGK-----IYSPIKITTPFQIMKAFFG-----VGFFEITLVELINSLLIFDEIHA 376 Pyrococcus hori...
WP_010879367  96 ----K---RYMHNPDSPYLIKPVTLTTIDTLALTLFGIPPEDLDKAVKYWDGtssgsLGHYLFSQASVALSNIVLDEVHL 168 Archaeoglobus f...
WP_010868140  95 F---S---RTKMMGSSEEFLHLFPLNITTVDTFTWDILKLNTKKITQVERGRe----FGYDYLTQASILTSLVIFDEAHF 164 Pyrococcus abyssi
WP_010880192 296 I---ElmkKEEDELDTNTFEGIWKNYQHS--KSFAYPLTVCTPDQIMPFVFK-----FSGYEKYLALLSYSRIVIDELQV 365 Aquifex aeolicus

P38036       457 YDTYMNGL--LEAVLKAQA-DVGGSVILLSATLPmkqkqKLLDTYGLHTDPVENNSAYPLI--Nwrgvngaqrfdllahp 531 Escherichia col...
WP_010956474 389 YDQFTQAN--ILVLLEVLK-YWKVPILLMSASLP-----DNIVQEYRKIGYDIKHILEDTS--D---------------- 442 Porphyromonas g...
WP_010869875 357 YEKYTLEH--LLTLFDILR-RMDIPHLLMSGTLP-----NFLMNNLEGYELVVDEEGLNYK--Pfkl------------- 413 Methanocaldococ...
WP_010885336 377 YESNILGI--ILAMLELLK-EKRAKALVMTATFP-----KFLEELIKSILNPKELKTPP-E--Ead-------------- 431 Pyrococcus hori...
WP_010879367 169 LADSTKSLn-FLFALMHAAiDNDQKLVLMSATIPea-lkKRIKEFNPDVCMVEFNESFDRKfvEer-------------- 232 Archaeoglobus f...
WP_010868140 165 ILEEPRMKtaFLAVLRFLM-ENNVPIIIMTATLSrg-yfELFKKYAQNNGYYFEPEPLVPD------------------- 223 Pyrococcus abyssi
WP_010880192 366 YAPYTMAF--IVKALEVIK-DFGSKFMVMTATFP-----EFLRRFFEKMEIP-FKEFPELK--Pr--------------- 419 Aquifex aeolicus

P38036       532 eqlpprFSIQPEPICLADMLPDLTMLERM-I-AAANAGAQVCLICNLVDVAQVCYQRLKELNN-----TQvDIDLFHARF 604 Escherichia col...
WP_010956474 443 ------IERARFSLIEKRDVSEISQMQDL-L-QLCLDRGSAIIFANTVDRAQAYYQWFLENGH-----EE-EVILYHSRY 508 Porphyromonas g...
WP_010869875 414 ----kcSENHLIWKEDDEWKVNENIINEI-I-ENYKKGLSQAIILNTVERAREFYKAVRDKVP-----A----ILYHSQF 478 Methanocaldococ...
WP_010885336 432 -----kFTRHR----VNVIDGDIRTLD---S-EEFPGPRPILIACNTVNTSIEVYSKLKESGA-----N---VMLIHGRF 490 Pyrococcus hori...
WP_010879367 233 -----rKKKYRINLIALASVEKFGSLERI-LlEGSKKFSKITVVFNTIGDAVYFYNNIKEKIP-----EF-KKLLLHSRF 300 Archaeoglobus f...
WP_010868140 224 -------ENDPFIKRESKKNFEIQFKTGNpL-DFIDSAKRNAIIVNSVKRAVEIFDQAKEDAPklgfeEE-EIMLIHGRM 294 Pyrococcus abyssi
WP_010880192 420 ------H-NVKL---LEDTLGSESSIN-L-I-RSLSEEGKVLVIVNTVRKAQELSLLLN--AP-----------VLHSRF 473 Aquifex aeolicus

P38036       605 TLNDRREK--ENRVISNFGKng--krNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHRKYRpa-gfE 679 Escherichia col...
WP_010956474 509 TETDKIEK--EAQLLLRLGRsawdndRANGVAILTQIGEMSVNISADIMISDLCPIDRLTQRCGRLCRFSRKIG-----D 581 Porphyromonas g...
WP_010869875 479 AYKDRVKKedEIFTLEEMRKs----qNKPYVIVATQVIEISLDMSVDVMYSELSPPDALGQRAGRLHRKGKDWRen--gK 552 Methanocaldococ...
WP_010885336 491 TYGDREDK--EKMLMNSLSD------FD--FVVATQVIEVSLDIDFGSIITEPAPLDALIQRFGRVNR--RGFGkp--rD 556 Pyrococcus hori...
WP_010879367 301 SEMDREKK---AELLAEMKK------SEKFVIVTTQVIEAGVDISSNLFITEIAPASSLIQRLGRFLRYGEREG-----E 366 Archaeoglobus f...
WP_010868140 295 KPSHKARL---IEKLREWKN------KESFLIIGTQAVEAGVDFSVDVMITDAAPINSLIQRFGRVARYDEKNA-----E 360 Pyrococcus abyssi
WP_010880192 474 LQKHRAKK--E-EEIKEFFSs-----GEKGVWVTTQLAEVSLDLDADFLVTELSTIDSLIQRMGRCNR--KGIKdienpN 543 Aquifex aeolicus

P38036       680 IPVATILLP-DG---------EgygrhehIYSNVRVMWRTQQHIEEL 716 Escherichia coli K-12
WP_010956474 582 LYIIRPMRE-GN---------L-------FPAPYYQNVGPSQKLEPN 611 Porphyromonas gingivalis
WP_010869875 553 EYKLKIFLP-YK---------H-------LPYSKELIEKTINHIKFY 582 Methanocaldococcus jannaschii
WP_010885336 557 VYVLTKGSEdDK---------N-------VYRPYDVVEETVKILREI 587 Pyrococcus horikoshii
WP_010879367 367 VYIWYEVDD-RGelarwkddrY-------KVYDYSLTALTLEKLAEM 405 Archaeoglobus fulgidus
WP_010868140 361 IIIIEDAPV-H-------------------PYDGKKVERTIALMKES 387 Pyrococcus abyssi
WP_010880192 544 VYVFTQEPS-GKg----------------SVYPKELLELTRKALTEG 573 Aquifex aeolicus
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