Conserved Protein Domain Family
MiaB-like-B

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TIGR01578: MiaB-like-B 
MiaB-like tRNA modifying enzyme, archaeal-type
This clade of sequences is closely related to MiaB, a modifier of isopentenylated adenosine-37 of certain eukaryotic and bacterial tRNAs (see TIGR01574). Sequence alignments suggest that this equivalog performs the same chemical transformation as MiaB, perhaps on a different (or differently modified) tRNA base substrate. This clade is a member of a subfamily (TIGR00089) and spans the archaea and eukaryotes. The only archaeal miaB-like genes are in this clade, while eukaryotes have sequences described by this model as well as ones falling within the scope of the MiaB equivalog model. [Protein synthesis, tRNA and rRNA base modification]
Statistics
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Structure
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PubMed ReferencesClick to see Conserved Features Help

TIGR01578 is classified as a model that may span more than one domain.
TIGR01578 is the only member of the superfamily cl36934
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAM04574            2 KVYLESFGCSASLASAEIMKASVERLGHELLNpaAAGEAEVYICNSCTVKYTTEQKILYKIRSMGEKGVQVIVSGCMPEV 81  Methanosar...
Q58277             13 RVYVEGYGCVLNTADTEIIKNSLKKHGFEVVN--NLEEADIAIINTCVVRLETENRMIYRINELKNLGKEVVVAGCLPKA 90  Methanocal...
FlyBase:CG6550-PA  72 KVFVKTWGCAHNNSDSEYMAGQLAAYGYRLSg--K-EEADLWLLNSCTVKNPSEDTFRNEIESGMRNGKHVVVAGCVPQG 148 fruit fly
WP_010903362        3 RYHIETYGCTSNRGESRDIERRLRDAGHHKVE--TAADADVAILNTCTVVEKTERNMLRRAKELADETADLIVTGCMALA 80  Halobacter...
WP_010917596        2 KIYFEAYGCTLNQGETALYVNKLLNEGNTLVS--NPKEADLSIIGTCAVIKKTEDHMMARIQNLSRFGKVEVIGCLAPVK 79  Thermoplas...
AAM04574           82 QLEEILHANPEAHILGVNAISRLGELLSSIEQrrmeglpaggHLELRTSEPLGFLNVPRERSNPNIHICQISQGCNFACS 161 Methanosar...
Q58277             91 LKNKVKGFLHIYPREAHKAGEILKNYVEKHYR----------MPYIEEDINKTLYKKLDYLKPSLITPLPICEGCIGNCS 160 Methanocal...
FlyBase:CG6550-PA 149 APKSDYLNG--LSVIGVQQIDRVVEVVEETLKghsvqllqnkKKVHGRRVAGAPLSLPKVRKNPLIEIISINSGCLNQCT 226 fruit fly
WP_010903362       81 QGEAFADADVDAQVLHWDDVP---------------------EAVTN-GECPTTTPDAEPILDGVVGILPIARGCMSNCS 138 Halobacter...
WP_010917596       80 GKTMVEDNVSVIEKDRFRS-------------------------------FQEVIDEVSPVNAEIVSGIPINQGCTGKCN 128 Thermoplas...
AAM04574          162 YCIVKHARGKLRSFPPEKIVKDIRSAVADGCREIWLTSQDDSQYGMDTGVK-LPELL-R-MISEIPGDFKVRVGMMNPFS 238 Methanosar...
Q58277            161 YCIVKIARGGLISYPREKIVNKAKELINKGAKCLLITAQDTACYGFDIGDN-LANLL-N-ELTQIKGEFIMRVGMMHAKN 237 Methanocal...
FlyBase:CG6550-PA 227 YCKTKHARGDLASYPPEEVVERARQSFAEGCCEIWLTSEDTGAYGRDIGSS-LPELL-WqLVEVIPEHCMLRVGMTNPPY 304 fruit fly
WP_010903362      139 YCITKQATGRVDSPPVEENVEKARALVHAGAKEIRITGQDTGVYGWDTGERkLPELLeR-IATEIEGEFRVRVGMANPGG 217 Halobacter...
WP_010917596      129 FCVSHIARGKLVSRKPEKIAGQIKILLQRGIKEIKITSLDTAAYGKDIGLR-LPHLI-R-TITEIGDDFRLRVGMMEPKN 205 Thermoplas...
AAM04574          239 VLPILDGLVDAFD-SDKVFKLLHLPIQSASHSVLKKMNRLHKMDAVDEIITKFRARFEDLSLFTDIIVGFCDETDEDFEE 317 Methanosar...
Q58277            238 AELILDELIEVYQ-NEKVGKFLHLPLQSGDDEILKRMKRGYTVDEFKDIVNEFRRKIKNLCFTTDIIVGFPGETEEQFQN 316 Methanocal...
FlyBase:CG6550-PA 305 ILEHLEEVANVLQ-HPRVYSFLHVPVQSGSDSVLGEMKREYCRQDFEHVVDFLRERVPGVTIATDIICGFPTETEDDFEE 383 fruit fly
WP_010903362      218 VHGIREELAAVFAeHDEIYNFLHAPVQSGSDDVLADMRRQHEVSQYRDIVETFNDTLGEWTLSTDFIVGFPTEDDDDHEA 297 Halobacter...
WP_010917596      206 TLEIVDDLISAYR-SEKVFKFLHLPVQSGDDYVLEVMNREYTVSDFIRITGKFREAFPDSTLSTDLIIGYYAENDDSFEK 284 Thermoplas...
AAM04574          318 TIEWVKKYRPEKINISRYSPRPHTKAFSFRNLDSRISVQRSHELH----------------------------------- 362 Methanosar...
Q58277            317 TLEVLRELKPDYIHGAKYSQRKGTEAAKMKQIDTKIRKRRSEILD----------------------------------- 361 Methanocal...
FlyBase:CG6550-PA 384 TMTLCAKYRFPSLFINQFFPRPGTPAAKMDRIPANLVKKRTKRLTdlfysyepyadrvgeiytvlvtevshdklhyvghn 463 fruit fly
WP_010903362      298 SMDLLRETRPEKINVTRFSKRPGTDAAELKGLGGQTKKDRSKAMT----------------------------------- 342 Halobacter...
WP_010917596      285 TVQLIEKIRPEIINVTKFSPRELTADFEKRPKPTNILKEQDRMIA----------------------------------- 329 Thermoplas...
AAM04574          363 KVCEQIKLGSKQEMIGWKGRVFVSk---yTEIGDVLTrtd-----------ayrPVVISGSDl---KPGEYANVEITGAK 425 Methanosar...
Q58277            362 KLRRELSYLNNKKYIGKAMKVLVLd----EGKGYTDNf----------------KVVKFEGG----EVGEFRKVKITDAK 417 Methanocal...
FlyBase:CG6550-PA 464 KSYEQVLLPMRDNLLGTRVHVRITsaskfSMVGEILDderdwtrcaknqelpnvQVQTRSREr---LIQRYFGIALVLGS 540 fruit fly
WP_010903362      343 ELKMDVVGEAHESMVGTRRDVLVVe----EGTGDSVKcydg----------ayrQVIVQNATdhglEPGDFATVEVTSHQ 408 Halobacter...
WP_010917596      330 DMHKEILQEKFSNLIGKTEFVLITe----NGKGRSMIgrdh----------ayrPIVIMDKTr---K-FEFHQVEITGFE 391 Thermoplas...
AAM04574          426 PGYFLGRII 434 Methanosarcina acetivorans C2A
Q58277            418 TFGLKGELI 426 Methanocaldococcus jannaschii DSM 2661
FlyBase:CG6550-PA 541 LAFLIQLVV 549 fruit fly
WP_010903362      409 TVYAFAEPV 417 Halobacterium salinarum
WP_010917596      392 NTSLIGRII 400 Thermoplasma volcanium
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