2AZN


Conserved Protein Domain Family
rib_reduct_arch

?
TIGR01508: rib_reduct_arch 
Click on image for an interactive view with Cn3D
2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1'-reductase, archaeal
This model represents a specific reductase of riboflavin biosynthesis in the Archaea, diaminohydroxyphosphoribosylaminopyrimidine reductase. It should not be confused with bacterial 5-amino-6-(5-phosphoribosylamino)uracil reductase. The intermediate 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine in riboflavin biosynthesis is reduced first, and then deaminated, in both Archaea and Fungi, opposite the order in Bacteria. The subsequent deaminase is not presently known and is not closely homologous to the deaminase domain (3.5.4.26) fused to the reductase domain (1.1.1.193) similar to this protein but found in most bacteria.
Statistics
?
PSSM-Id: 130572
View PSSM: TIGR01508
Aligned: 5 rows
Threshold Bit Score: 299.799
Threshold Setting Gi: 6225946
Created: 8-Oct-2014
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2AZN_A         4 PYIISNVGXTLDGKLATINND-SRISCEEDLIRVHKIRANVDGIXVGIGTVLKDDPRLTVHKI-----KSDR----NPVR 73  Methanocaldococ...
Q58085         9 PYIISNVGMTLDGKLATINND-SRISCEEDLIRVHKIRANVDGIMVGIGTVLKDDPRLTVHKI-----KSDR----NPVR 78  Methanocaldococ...
P95872         5 PYVIIFSTVSIDGRLATKTGY-SELSCPYDKQRQHEIRSEVDAVMVGANTVRVDNPSLTVKYG-----KNRR----NPIR 74  Sulfolobus solf...
WP_010902910   1 MHVVVNAAMSADGKLSTRRREqVTLSGDADFERVDELRASVDAVMVGVGTVLADDPSLTLDDSghvaaREERgespHPAR 80  Halobacterium s...
O28272         3 PYVFVNVAASLDGKISDESRKqLRISCEEDLRIVDRLRAESDAIMVGIGTVLADDPRLTVKSAelrekRQKDgkepNPLR 82  Archaeoglobus f...
2AZN_A        74 IVVDSKLRVPLNARVLNKDAKTIIATTEDTNEEkekK---IKILEDxGVEVVKCGRGKVDLKKLXDILYDKGIKSILLEG 150 Methanocaldococ...
Q58085        79 IVVDSKLRVPLNARVLNKDAKTIIATTEDTNEE---KekkIKILEDmGVEVVKCGRGKVDLKKLMDILYDKGIKSILLEG 155 Methanocaldococ...
P95872        75 VVVTRSFNLDPSYKIFTTPPSTVIYTSNYES-E---K---VEEFIRkGVIVRKFLHLDDLLEDLYDNF---NVRRLMVEG 144 Sulfolobus solf...
WP_010902910  81 VVADSHARTPPDARLLDGAAETYVLVAEAEPVE---H---RESLEAaGATVVVAGENRVDLPSALDALESRGVDRLMVEG 154 Halobacterium s...
O28272        83 VVVDSRCRVPLTARILNDEARTLVAVSRIAPEE---K---VREVKK-VAEVAVFGEERVELSALLEFLHRKGVRRLMVEG 155 Archaeoglobus f...
2AZN_A       151 GGTLNWGXFKEGLVDEVSVYIAPKIFGGKEAPTYVDGEGFKTvdecvKLELKNFYRLGEGIVLEFKV 217 Methanocaldococcus jannaschii
Q58085       156 GGTLNWGMFKEGLVDEVSVYIAPKIFGGKEAPTYVDGEGFKTvdecvKLELKNFYRLGEGIVLEFKV 222 Methanocaldococcus jannaschi...
P95872       145 GGHLIWWFIKDNLYDEIRITISPRIFG--NGVSFTQGEGFIGed-spRLELIDAKICECGNEVHLTY 208 Sulfolobus solfataricus P2
WP_010902910 155 GGELIFSLFAEELVDELSVFVAPQLIGGRDAPTLADGDGFVAef--pTFELTGVDRLDDGVLLAYDC 219 Halobacterium salinarum
O28272       156 GGTLISSLISQNLVDEIRIYYGPIFIGGRDSPTVCDGESFLK-----KCRIEKIERIGEGFAVTARF 217 Archaeoglobus fulgidus DSM 4304
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap