4M5G,2BMB,2CG8


Conserved Protein Domain Family
folK

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TIGR01498: folK 
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2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
This model describes the folate biosynthesis enzyme 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. Alternate names include 6-hydroxymethyl-7,8-dihydropterin diphosphokinase and 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (HPPK). The extreme C-terminal region, of typically eight to thirty residues, is not included in the model. This enzyme may be found as a fusion protein with other enzymes of folate biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Statistics
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PSSM-Id: 273658
Aligned: 21 rows
Threshold Bit Score: 132.012
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4M5G_A         7 AYIAIGsNLASPLEQVN-AALKALGDIPeS-HILTVS--SFYRTPPL-GPQDQPD-YLNAAVALET-S-LAPE-ELLNHT 77  Escherichia col...
P72736        16 AVVGLGgNIGPVLDNLQ-GAIAELALVAgI-EVERCS--SWYRSRAF-GPP-QPD-YINGCVTLRV-S-LSPP-ELLQTL 85  Synechocystis s...
WP_021438489   7 AVIALGsNLENPAQQVR-AALDTLSSHPdI-RLKQAS--SLYMTAPV-GYDNQPD-FVNAVCTVST-T-LDGI-ALLAEL 77  Neisseria menin...
WP_010892769  15 AYVGLGaNLGPAEMTLR-AAIAALDQLPlT-RLRIAS--SLYRTPPW-GRQDQAE-FVNAVAALET-G-LAPL-ALLDAL 85  Xylella fastidiosa
WP_011712026   8 VLVAFG-ASLNPLYHLE-LGLRRLHALL-G-IVAI-S--DVYQSRPVnGAVGDPP-FLNGAVRLEQ-A-PEPW-ALRALL 76  Magnetococcus m...
WP_002851803  30 ALIGLGsNIEPEKKRFD-MLFRVMMDDK---RFKILStsPMLINEAF-GFKEQKD-FTNAVMLIQT-N-LHAR-ALLKVL 100 Campylobacter j...
WP_000984287  25 VVLGLGsNLKNPLKILKsCFLYFKN----HsKIGKIFssPIYINPPF-GYTNQPN-FYN-ATIILK-TsLGLR-HFFALV 95  Helicobacter py...
WP_010893957  43 llsLGS-NVRPR-YYLR-QAEAALHAFFg----EVLFs-PVYRTLAV-GFD-GPD-FLNsAAMVHT-A-M-PLsDLHAWL 108 Xylella fastidiosa
WP_000574955 101 AFIALGsNMGDKQANLK-QAIDKLRARG-I-HILKEs--sVLATEPW-GGV-EQDsFANQVVEVET-W-LPAQ-DLLETL 170 Streptococcus p...
KAJ75656       3 GYVALGsNVGDPYANLV-KARNYLNED--P-QIQVVAssKLYETDPY-GYTDQDD-FLNAVLKIDTsY-T-AE-ELLAVT 73  Enterococcus fa...
4M5G_A        78 QRIE-LQQGRVRk-AE--RWGPRTLDLDIMLF-GNE-VINTERLTVPHYDM-KNR-G-F-MLWPL-FEIAP 137 Escherichia coli K-12
P72736        86 LAIE-QKFGRIR--LE--KWGPRTLDLDLIFY-GDR-QLEQARLTIPHPQM-QYR-P-F-VLVPL-AEIAP 144 Synechocystis sp. PCC 68...
WP_021438489  78 NRIE-ADFGRER--SF--RNAPRTLDLDIIDF-DGI-SSDDTRLTLPHPRA-HER-S-F-VIRPL-AEILP 136 Neisseria meningitidis
WP_010892769  86 LEVE-CFHGRVR--LPgdRWGPRTLDLDLLLY-GEQ-VLDLPRLRVPHPHL-HVR-A-F-VVVPL-AEIAA 146 Xylella fastidiosa
WP_011712026  77 RQIE-AEQGRERg-DN--PNAPRTLDLDIALM-GSQ-IMDEPLLRIPDPHW-LAR-P-F-VALPM-AQLAA 136 Magnetococcus marinus
WP_002851803 101 LYYE-VKFKRKR--TF--KNAPRTLDLDLLYFsQKV-KRDK-WCEVPHKGA-KER---VsVILPL-GMI-- 157 Campylobacter jejuni
WP_000984287  96 FYIE-RRFGRARkrDF--KDAPRTLDIDIIAF-NQV-ILRQNDLTLPHPKWsERDsV-L-VPLTL-QQILf 158 Helicobacter pylori
WP_010893957 109 HALE-ERYGRDRa-VP--RFGNRTLDVDVVFY-GDL-IVKEPGGEYCIPRR-ELK-HsF-VLKPL-VDVAP 169 Xylella fastidiosa
WP_000574955 171 LAIEsE-LGRVR--EV--HWGPRLIDLDLLFV-EDQ-ILYTDDLILPHPYI-AER-L-F-VLEsL-QEIAP 229 Streptococcus pneumoniae
KAJ75656      74 QGIE-QAMKRKK--LI--HWGPRIIDIDILLL-GGQsVTLP-HLQVPHQEL--TK-RsF-VLIPLsDVYAE 133 Enterococcus faecalis MTUP9
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