Conserved Protein Domain Family
cobJ_cbiH

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TIGR01466: cobJ_cbiH 
precorrin-3B C17-methyltransferase
This model represents precorrin-3B C17-methyltransferase, one of two methyltransferases commonly referred to as precorrin-3 methylase (the other is precorrin-4 C11-methyltransferase, EC 2.1.1.133). This enzyme participates in the pathway toward the biosynthesis of cobalamin and related products. Members of this family may appear as fusion proteins with other enzymes of cobalamin biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Statistics
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PSSM-Id: 273641
Aligned: 13 rows
Threshold Bit Score: 346.211
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAB72411     325 LAIIGTGPGGSQWMSPEVKEILQSATDLVGYKTYLDLVGS-LADGK--QRHESDNREEIARATMALDLAATgR-YVAVVS 400 Nostoc sp. PCC ...
O29534        10 LYVVGIGPGKEELMTLKAKRAIEEADYIVGYQTYVDRISH-LIEGK--KVVTTPMRKELDRVKIALELAKE-H-VVALIS 84  Archaeoglobus f...
Q58223         2 LYVVGIGSGNERHFTKEAEEILNKVDLIVCYKNYKKFVER-LN--K--PIYTTGMTREIDRVDYALKEAKD-K-DVALVS 74  Methanocaldococ...
Q05590         2 LSVIGIGPGSQAMMTMEAIEALQAAEIVVGYKTYTHLVKA-FTGDK--QVIKTGMCREIERCQAAIELAQAgH-NVALIS 77  Salmonella ente...
O27454         2 IRIIGIGP-ARDDITIRALRALEDSDVVIGYARYIRQIED-LLDGK--EVIRSGMGDEIERVELAIEKHREgL-DVALVS 76  Methanothermoba...
CAD17769       5 LYLVSVGPGTRELIPPMVKTALDAADVIVAYDLYLTWIAP-WIT-Ak-DIRTLPLTQERGRAELAIAEARAgR-TVALIS 80  Ralstonia solan...
CAB61497       5 VAVAGLGPGAEDLVTPEVRAALAEATDVVGYIPYVARVAP--RPGL--ALHPSDNRVELERARLALDLAARgR-RVVVVS 79  Paracoccus deni...
WP_011714681   6 IYLVGLGPGAEAHMTARAREAIADADVVIGYTTYIRLVQP-LLSHQ--QVVKKGMAEELDRCEEAIVFAKQgK-KVALIS 81  Magnetococcus m...
WP_005874266  37 IIVAGIGPGGASDITPAVLSAIGRSDVVVGYKYYFRFIEPyLRPDT--HCVDTGMKKERQRAEEAFGYALSgK-TVCVIS 113 Porphyromonas g...
WP_010903136  83 LVAVGLGPGRPEGMTDRATAALADAEHIVGYTTYVDLLPD-EITDDaeEIYDTPMCGEVSRTEEAVDRALAgN-HVAIIG 160 Halobacterium s...
WP_010901077   5 IYIAGIGPGDPDHMTPAAEKALSSCEVIIGFTLYISFLRD-RFPNA--KFESSGMTNELARARRAIELAEGgI-TVGLVS 80  Thermoplasma ac...
WP_010910120   5 LTVIGLGPGNADQVTPEASRAVAEAKFFYGYKPYLDRL-D-LRPDQ--TRVASDNREELARSKDALIKAAEgH-EVAVVS 79  Mesorhizobium loti
WP_010923825   6 LYIVGIGPGSKEQRTIKAQEVLEKSNVIIGYNTYLRLISD-VLDGKk-EVIGARMKEEIFRANTAIEKALEsNnTVALVS 83  Sulfolobus solf...
BAB72411     401 SGDPGIYAMAAAVFEVLDYHFKp--EWesiN----IHVAPGISAMQAAAATIGAPLGHDFCAISLSDILKPWSIIEQRIA 474 Nostoc sp. PCC ...
O29534        85 GGDPSIYGILPLVIEYAVEKKV---DV---E----IEAIPGVTAASAASSLLGSAISGDFAVVSLSDLLVPWSVVEKRLL 154 Archaeoglobus f...
Q58223        75 SGDATIYGLASLAYEINAVKGY---NV---D----IKVVPGITACSLASAILGSPLNHDFVVISFSDLLTPLETILKRFR 144 Methanocaldococ...
Q05590        78 SGDAGIYGMAGLVLELVSKQKL---DV---E----VRLIPGMTASIAAASLLGAPLMHDFCHISLSDLLTPWPVIEKRIV 147 Salmonella ente...
O27454        77 SGDPGVYGMANVFFQIFDKYSG----I---E----FEVIPGVTAVNYAASKLGAPL-HDFAVISLSDILTPLSEIMAKIR 144 Methanothermoba...
CAD17769      81 SGDIGIYAMAALAFEAMAEHDTf-------D----VQVIPGITSANACASLLGSPLSHDFATLSLSDLLCPWAWIETRAR 149 Ralstonia solan...
CAB61497      80 SGDPGVFAMASALFEALEGCENt------pD----IRILPGITAMLAASARLGAPLGHDFCAINLSDNLKPWALIEKRLR 149 Paracoccus deni...
WP_011714681  82 SGDVGIYGMAGPTYEVLFKSGW---SP---DsgiaVEVVPGCTALSSCASLVGAPLGHDFCSISLSDLLTPWPVIAKRLN 155 Magnetococcus m...
WP_005874266 114 SGDAGIYGMAPLIYEMKRAKGV---EM---D----IEVLPGISAFQKAASLLGAPIGHDLCLISLSDLMTPWPIIEKRIV 183 Porphyromonas g...
WP_010903136 161 SGDPNVYALAGLALEITESKGAtpsML---D----FEVVPGVPAAQSCGARLGAPLVNDSVSISLSDHLTPMPEIESRLH 233 Halobacterium s...
WP_010901077  81 SGDAGIYGIAAPVLEMAERRKS---EV---K----IEIIPGISALSSAASLLGSPLTNDFAVISMSDLLTPLDTIMKRVE 150 Thermoplasma ac...
WP_010910120  80 GGDPGVFAMAAAVCEAIEAGPA---EWravD----VAVVPGITAMLAVAARIGAPLGHDFCAISLSDNLKPWELIELRLL 152 Mesorhizobium loti
WP_010923825  84 SGDPQVYGMAGLVYDLIARRNL---DL---D----VEVVPGVTAALAAAARLGSPLSLDFVVISLSDLLIPREEILHKVT 153 Sulfolobus solf...
BAB72411     475 AAAKADFVIAFYNPVSKERTWQLTAAKNILLQYRKp-STPIVLARNIGRPGQTVKVITLDQLAAd------sADMRTVIL 547 Nostoc sp. PCC ...
O29534       155 YALSGDFVVAIYNPSSRRRKENFRKAMEIVRRFRG--DAWVGVVRNAGREGQQVEIRRVSEVDE--------VDMNTILI 224 Archaeoglobus f...
Q58223       145 CALEGDFVICIYNPLSKRRKEPFLKAMEILAEFAKdkDYIIGIVKNAGRNKEEVVITNFKDLYKnlekylefIDMNTILI 224 Methanocaldococ...
Q05590       148 AAGEADFVICFYNPRSRGREGHLARAFDLLAASKSa-QTPVGVVKSAGRKKEEKWLTTLGDMDFe------pVDMTSLVI 220 Salmonella ente...
O27454       145 AAAESGMIIALYNPLGKRRKRPFREAVEILRSLLPp-QTPVGIVRTVDG-APDVRIVDLESLDEs------lVDMSTIVL 216 Methanothermoba...
CAD17769     150 HIAQADLAVVLYNVQSRQRQEGVYRILDILLEHKRa-ETLCGIVHNAYRDGQAAEIVTLAELRTr------rFDMLTSLV 222 Ralstonia solan...
CAB61497     150 LAAEADFAMAFYNPRSKARPEGFARVLEILREACGp-DRLISFARAVSTPDEALNTVTLAEARPe------mADMRTVVI 222 Paracoccus deni...
WP_011714681 156 AAACSDFVIALYNPKSGRRTEQIVAAQKILLHHRSg-KTPVAIVKSAYRPRQSVVMTTLKKMVDe------eIGMLSTVL 228 Magnetococcus m...
WP_005874266 184 AAASADFVTAIYNPKSEGRYWQLYRFVEIFMQYRSa-DTPVGLVRQAGREEEQVTVTTLGEFDPe------vVDMFTVVL 256 Porphyromonas g...
WP_010903136 234 AVASEEFTISIYNPWSRKRRENFQKACEILLAHRDa-DTPVGIVHGAGREDEEVEITTLGELESyge--tdlIDMTTTVV 310 Halobacterium s...
WP_010901077 151 AFAKADIVTVIYNPRGSRFPDNIRKAVDIFLRYRNp-ETAVGIVRNAYRERQSVTITTLSNLNIe------dIDMLTTVI 223 Thermoplasma ac...
WP_010910120 153 AAAGAGFVIALYNPISKARPWQLGRAFECLTAILPg-TTPVIFGRAAGRPDERIEVYLLADVDAq------kADMATCII 225 Mesorhizobium loti
WP_010923825 154 KAAEADFVIVFYNLIN---ENLLIEVMDIISKHRKp-NTPVGLVKSAYRNNENIIITTLSSWKEym----neISMSTTMI 225 Sulfolobus solf...
BAB72411     548 VGSTRTRSIqrsdgSISVYTPRRYT 572 Nostoc sp. PCC 7120
O29534       225 VGNSETKVV-----DGKMFTPRGYS 244 Archaeoglobus fulgidus DSM 4304
Q58223       225 IGNSSTKII-----NGKMITPRGYL 244 Methanocaldococcus jannaschii DSM 2661
Q05590       221 VGNKTTYVQ-----DGLMITPRGYT 240 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
O27454       217 VGNVTTYTR-----DGQMITPRGYA 236 Methanothermobacter thermautotrophicus str. Delta H
CAD17769     223 IGNRFTRRK-----RGWIYTPRGYG 242 Ralstonia solanacearum GMI1000
CAB61497     223 LGNSATRRa-----GAWVYTPRSVP 242 Paracoccus denitrificans PD1222
WP_011714681 229 IGNGETFVK-----EGIMITPRGYA 248 Magnetococcus marinus
WP_005874266 257 VGNSQSYCY-----EGHFITPRGYY 276 Porphyromonas gingivalis
WP_010903136 311 IGNAETYVF-----DDRMVTPRGYE 330 Halobacterium salinarum
WP_010901077 224 IGNSETFVY-----RNMMATRRGYG 243 Thermoplasma acidophilum
WP_010910120 226 IGSPETRIIkrgdkRALVYTPRSAA 250 Mesorhizobium loti
WP_010923825 226 IGNSLTYRY-----KNYMITPRGYE 245 Sulfolobus solfataricus
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