4AY7


Conserved Protein Domain Family
mtaA_cmuA
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TIGR01463: mtaA_cmuA 
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methyltransferase, MtaA/CmuA family
This subfamily is closely related to, yet is distinct from, uroporphyrinogen decarboxylase (EC 4.1.1.37). It includes two isozymes from Methanosarcina barkeri of methylcobalamin--coenzyme M methyltransferase. It also includes a chloromethane utilization protein, CmuA, which transfers the methyl group of chloromethane to a corrinoid protein.
Links
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Statistics
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PSSM-Id: 273639
Aligned: 5 rows
Threshold Bit Score: 496.654
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4AY7_A    11 SEFTLKTRLLAALKGEPVDKVPVCSVtqTGIVELMDVVGAPWPEAHTNPELMAKLALANHELSGLEAVRLPYXLTVLVEA 90  Methanosarcina mazei
CAA62995   2 SEFTLKTRLLAALEGKPVDKVPVCSVtqTGIVELMDKVGAAWPEAHTNPELMAKLAIANYELSGLEAVRLPYCLTVLGEA 81  Methanosarcina barkeri
CAA62996   2 AEYTPKERLYRALRKQQVDRMPAVCFtqTATVEQMEACGAYWPEAHSDAEKMATLAEAAHTVVGFEAVRVPFDITAEAEF 81  Methanosarcina barkeri
AAC46230   3 SEMTPTRRVMAAVLGGRVDYVPPANPlaQTTTELMQICNASWPKAHFDSKMMADLAAAPYEICGIEAARPQFDISLEAEV 82  Methanosarcina barkeri
AAK01347   5 PKMTSRERLFAAVTMQTLPDQVPCVP--LLMTRGIREGGITVDQALRDGEASAHAKIKALKKFGGDVIIPGTDLFTPVEC 82  Hyphomicrobium chlo...

4AY7_A    91 MG-CEINMGTKNrQ-PSVTGHPYPKDLEGAAVPADL----LQRGRIPVVLEAIKIIREKVGPDVPIVGGMEGPVTVASDL 164 Methanosarcina mazei
CAA62995  82 MG-CEINMGTKN-RqPSVTASPYPKNLDGAVVPADL----LQRNRIPAVLEAIKIVREKVGPDVPIIGGMEGPVTLASDL 155 Methanosarcina barkeri
CAA62996  82 FG-CGIKAGDLK-QqPSVIK-PSVKNLEDLEKLKNYn---LKEGRIAVVLEAVKILSEKYGKEIPIIGSMIGPFSLA-QH 154 Methanosarcina barkeri
AAC46230  83 LG-CKLDWNKPD-R-PPVTG-PAYTDPADITWPDNL----EEAGRIPVVLGAIEELRKRYDGMLPVIPVLTSPFTVAGHI 154 Methanosarcina barkeri
AAK01347  83 VEgCELDYLPYA-Q-PSLVKHPTPTKEAFYRYKEKYlregFKPSERVLQIQRARTMIARRKDTHAMPTPVGGPITRAQLM 160 Hyphomicrobium chlo...

4AY7_A   165 VSVKSFMKWSIKKTDLLEQALDIATEASIIYANAMVEAGADVIAIADPVASPDLMSPDSFRQFLKSRLQKFASs---VNS 241 Methanosarcina mazei
CAA62995 156 ISVKSFMKWSIKKTDLFEQALDISAEAAIAYANAMVEAGADVIAIADPVASPDLMSPETFKQFLQSRLQKFSAg---VNS 232 Methanosarcina barkeri
CAA62996 155 INGDAWFGNLFTGEEIVPALLDFCSDFNVAYAKAMVENGADTIAIIDPTASYELIGGEFYEKYALPYQKKIVDamkeLDV 234 Methanosarcina barkeri
AAC46230 155 AGVENLVRWTKTDPEKAHAFIEAATDFVIAYGKLQTAYGAHILFPADPSASGDLISGETYKEFVLPAHKRMAKe---ISC 231 Methanosarcina barkeri
AAK01347 161 TGSSEFLSYISDDPDYAKEVTELALDIVKNVCRMMFEAGIDVCNILDPFNSSDILPPDTYREFGLPYQKRLFAyikeIGG 240 Hyphomicrobium chlo...

4AY7_A   242 VTVLHICGNVNPILSDMADCGFEGLSVEEKIG-SAkKGKEVIGTRARLVGNVSSPFTLLPG----PVDKIKAEAKEALEG 316 Methanosarcina mazei
CAA62995 233 VTVLHICGKVNAILSDMADCGFEGLSVEEKIGtAA-EGKKIIGDRARLVGNISSPFTLLPG----PIDKIKAEAKVALEG 307 Methanosarcina barkeri
CAA62996 235 ATVLHICGNTTNGLGIMDKTGVNGISVDQKVDiKT-ATGNVKN--ALIVGNLDPVAVLWNG----TPEEIAEVSKKVLDA 307 Methanosarcina barkeri
AAC46230 232 PLILHICGDTSKLLPYIKQSGIDCFSFDAVP--VW-YCRQVMGNEMSILGSLDVIDLMPNG----TPEQVYNRTRECILQ 304 Methanosarcina barkeri
AAK01347 241 IGFTHTCTFTQPIWRDIANNGCFNFNGDMYPG-MD-HAKRAIGGQISLMGTLSPFSTFMHGwttdVANKVKKLAAEVGYN 318 Hyphomicrobium chlo...

4AY7_A   317 GIDVLAPGCGIAPMTPLENVKALVAARDEFYA 348 Methanosarcina mazei
CAA62995 308 GIDVLAPGCGIAPMTPLENVKALVAARDEYYA 339 Methanosarcina barkeri
CAA62996 308 GVGLLTVGCGTVSMTPTVNLQKMIECAKSHTY 339 Methanosarcina barkeri
AAC46230 305 GADIVGTACDVSFGTSLENLRAYVRACKETPI 336 Methanosarcina barkeri
AAK01347 319 GGLIVMPGCDIDWTIPDENLKAMIETCASIKY 350 Hyphomicrobium chloromethanicum
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