1G2I,1OI4


Conserved Protein Domain Family
PfpI
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TIGR01382: PfpI 
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intracellular protease, PfpI family
The member of this family from Pyrococcus horikoshii has been solved to 2 Angstrom resolution. It is an ATP-independent intracellular protease that crystallizes as a hexameric ring. Cys-101 is proposed as the active site residue in a catalytic triad with the adjacent His-102 and a Glu residue from an adjacent monomer. A member of this family from Bacillus subtilis, GSP18, has been shown to be expressed in response to several forms of stress. A role in the degradation of small peptides has been suggested. A closely related family consists of the thiamine biosynthesis protein ThiJ and its homologs. [Protein fate, Degradation of proteins, peptides, and glycopeptides]
Links
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Statistics
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PSSM-Id: 273591
Aligned: 8 rows
Threshold Bit Score: 233.849
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1G2I_A         2 KVLFLTANEFEDVELIYPYHRLKEEGHEVYIAS---FERGTITG--------------KHGYSVKVDLTFDKVNPEEFDA 64  Pyrococcus hori...
Q58377        34 VLMVIAPKDFRDEELFEPMAVFESNGLKVDVVS---TTKGECVG--------------MLGNKITVEKTIYDVNPDDYVA 96  Methanocaldococ...
WP_010885770   2 KVLFLTANEFEDVELIYPYHRLKEEGHEVYIAS---FERGTITG--------------KHGYSVKVDLTFDKVNPEEFDA 64  Pyrococcus hori...
WP_010964309   3 NLIILVEDGFEDIELLYPLYRLREAGYDVTLVGt--GSKYNYTG--------------THGYIVDVDASAEEIDENNYDG 66  Clostridium ace...
WP_001701138  18 KIAVLITDEFEDSEFTSPADEFRKAGHEVITIE---KQAGKTVKg------------kKGEASVTIDKSIDEVTPAEFDA 82  Shigella dysent...
WP_003112987  10 VLVITANTGIERDELLEPLKTLKQQGATVTHATiegGEAQTWVHd------------sEKDLIVNSDARLQGLRAEDYDL 77  Pseudomonas aer...
AAD56430       9 KILFLTGDFAEDYETMVPFQALQAVGHHVDAVCp-gKRAGDKVKtaihdfegdqtyteKPGHQFTLNATFDDVDASRYDA 87  Burkholderia ce...
1OI4_A        25 KIAVLITDEFEDSEFTSPADEFRKAGHEVITIE---KQAGKTVKg------------kKGEASVTIDKSIDEVTPAEFDA 89  Escherichia col...

1G2I_A        65 LVLPGGRA-PERVRLNEKAVSIARKXFSEGKPVASICHGPQILISAGVLRGRKGTSYPG--IKDDXINAGVEWVDa--E- 138 Pyrococcus hori...
Q58377        97 IVIVGGIGsKEYLWNNTKLIELVKEFYNKNKVVSAICLSPVVLARAGILKGKKATVYPApeAIEELKKAGAIYED---Rg 173 Methanocaldococ...
WP_010885770  65 LVLPGGRA-PERVRLNEKAVSIARKMFSEGKPVASICHGPQILISAGVLRGRKGTSYPG--IKDDMINAGVEWVDa---e 138 Pyrococcus hori...
WP_010964309  67 VIIPGGSA-SYKLRTNDDVKRIIRHMKEKDKLLAVICDGNYVLISAKVLSGHKVTCTEA--ISDDVINAGGEYVRi---g 140 Clostridium ace...
WP_001701138  83 LLLPGGHS-PDYLRGDNRFVTFTRDFVNSGKPVFAICHGPQLLISADVIRGRKLTAVKP--IIIDVKNAGAEFYDq--Ev 157 Shigella dysent...
WP_003112987  78 LLVPGGTVnADTLRQDSEARRLVREFSEAGKTVAAICHGPWLLIDAGVARGKTLTSYSS--VRIDLTNAGADWVDt--Rv 153 Pseudomonas aer...
AAD56430      88 LAIAGGRA-PEYLRLDPNVIALVRAFAEAGKPIAAICHAAQLLAAADVIRGKRISAYPA--CAPEVKLAGGEYADipvDa 164 Burkholderia ce...
1OI4_A        90 LLLPGGHS-PDYLRGDNRFVTFTRDFVNSGKPVFAICHGPQLLISADVIRGRKLTAVKP--IIIDVKNAGAEFYDq--Ev 164 Escherichia col...

1G2I_A       139 VVVDGN---WVSSRVPADLYAWXREFVKLLK 166 Pyrococcus horikoshii
Q58377       174 VVVDGN---VITAKSPDYARLFGLEVLKAIE 201 Methanocaldococcus jannaschii DSM 2661
WP_010885770 139 VVVDGN---WVSSRVPADLYAWMREFVKLLK 166 Pyrococcus horikoshii
WP_010964309 141 NCVDKN---IITAKMQVNLPQFMSDIFQYLN 168 Clostridium acetobutylicum
WP_001701138 158 VVDKDQ---LVTSRTPDDLPAFNREALRLLG 185 Shigella dysenteriae
WP_003112987 154 KVCPANgwtLITSRNPGDLQAFNEAIGEALQ 184 Pseudomonas aeruginosa
AAD56430     165 AVTDAP---FVNAPVWAENPAWVSQFLALLG 192 Burkholderia cepacia
1OI4_A       165 VVDKDQ---LVTSRTPDDLPAFNREALRLLG 192 Escherichia coli K-12
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